Protein Homeostasis in Health and Disease
April 26 - 30, 2022
Abstract Deadline: February 4, 2022


Judith Frydman, Stanford University
F. Ulrich Hartl,
Max Planck Institute of Biochemistry, Germany
Richard Morimoto, Northwestern University


** We are pleased to announce we will be hosting this meeting safely in-person, with a virtual participation option. **

COVID-19: All participants planning to attend in-person will be required to provide documentary proof of full vaccination AND first booster (when eligible) with an FDA or EMA approved vaccine. Additional safety measures will be in line with current NY and federal guidelines. For more information, see COVID-19 Policies and Protocols.


Proper expression, folding, transport, and clearance of proteins are critical for cell function and organismal health. Chaperones and enzymes that post-translationally assist newly synthesized proteins help ensure that they are correctly folded and functional, or are degraded. Translocation machineries, proteasomes, and autophagic activities are critical for subcellular localization and for degradation as necessary. Stress and aging challenge the robustness of these chaperone and clearance networks leading to protein mismanagement, overload, and cellular dysfunction. In humans, this is associated with the accumulation and aggregation of misfolded and aggregation-prone proteins, a feature of numerous neurodegenerative, metabolic, and oncogenic diseases.

You are invited to participate in the 2022 meeting on Protein Homeostasis in Health & Disease. Groundbreaking work - on molecular chaperones, the unfolded protein response, stress responses, and how these processes are implicated in disease - has first been presented at this meeting over the past three decades. The 2022 meeting provides an opportunity to showcase the latest research in this area and will feature talks by leading investigators.

The meeting will begin after dinner at 7:30 p.m. on Tuesday, April 26, and conclude with lunch on Saturday, April 30, 2022.

Sample Schedule Outline

Topics & Session Chairs:

Integrative Stress Signaling in Biology, Aging and Disease
Chairs: Ritwick Sawarkar, University of Cambridge, United Kingdom
               Keith Blackwell,
Harvard Medical School

Protein Aggregation in Aging and Neurodegenerative Diseases
Chairs: Ellen Nollen, University of Groningen, Netherlands
               Ruben Busnadiego, 
University of Gottingen, Germany

Molecular Mechanisms of Chaperones
Chairs: Rachel Klevit, University of Washington
               Johannes Buchner,
Technical University of Munich, Germany
               David Agard, 
University of California San Francisco

Mechanisms of Autophagy and Proteasome Degradation
Chairs: Malene Hansen, Buck Institute
               Ivan Dikic, 
University of Frankfurt, Germany

Intrinsically Disorder Proteins, Phase Transitions and Stress
Chair: Jim Shorter, University of Pennsylvania

Folding at the Ribosome and Triage Mechanisms
Chairs: Shu-ou Shan, California Institute of Technology
               Toshi Inada, University of Tokyo, Japan

Organellar Proteostasis and Spatial Quality Control in Aging and Disease
Chairs: David Ron, University of Cambridge, United Kingdom
               Thomas Langer,
University of Cologne, Germany
               Johan Auwerx, Swiss Federal Institute of Technology Lausanne, Switzerland

Restoring Proteostasis in Aging and Disease
Chairs: Ursula Jakob, University of Michigan
               Jeff Kelly,
Scripps Research Institute

The format of the meeting will include eight oral sessions and two poster sessions. Each oral session will include invited speakers and speakers selected from submitted abstracts. For this reason, abstracts from accomplished junior and senior investigators are warmly invited. The abstracts should focus on new and unpublished data. The organizers will select abstracts for oral or poster presentations. The status (talk/poster) of abstracts will be posted on our web site (below) as soon as decisions have been made. We have applied for funds from government and industry to partially support graduate students and postdocs. Please apply in writing via email to Samantha Mastronardi and state your financial needs; preference will be given to those who submit abstracts.

All questions pertaining to registration, fees, housing, meals, transportation, visas, abstract submissions, or any other matters may be directed to Samantha Mastronardi.

Social Media: The designated hashtag for this meeting is #cshlprotein. Note that you must obtain permission from an individual presenter before live-tweeting or discussing his/her talk, poster, or research results on social media. Click the Policies tab above to see our full Confidentiality & Reporting Policy.

This conference is supported in part by funds provided by the National Institute on Aging of the National Institutes of Health.


In-Person Fees (Housing packages closed as of April 12, 2022)
Academic/Media Private Room/Private Bath Package: $1,655 (Subject to availability.)
Academic/Media Private Room/Shared Bath Package: $1,555
Academic Shared Room Package: $1,415
Academic/Media No-Housing Package: $1,055
Student Package*: $1,315
Student No-Housing Package: $955
Corporate Private Room/Private Bath Package: $2,115
Corporate No-Housing Package: $1,515

*Student Housing is default double occupancy. Please enquire about availability and fees to upgrade to private room.

Room packages close 2 weeks before the meeting start date

Rules for Virtual Participation: Virtual participation will include access to the oral sessions via Zoom, access to the digital poster sessions and access to the Slack discussion channel, and the Leading Strand video archive.

Presenters: Individuals submitting abstracts and facing financial barriers should firstly request financial aid (see above). Permission to present your talk or poster virtually will be given only in exceptional circumstances and on a case-by-case basis. If you think you are eligible for an exemption from the requirement to present in person, please provide a justification in writing via email to Samantha Mastronardi.

Non-presenting participants: We plan to broaden access to the conference by allowing certain categories of non-presenting participants to attend virtually at reduced fees. Categories include: 
1. Individuals from low & middle income countries; 
2. Individuals from non-LMIC countries in Asia, Australasia, Africa or South America; 
3. Individuals from US & Canadian minority serving institutions; 
4. Individuals with a demonstrable financial barrier; 
5. Individuals with family obligations or other special circumstances. 
For categories 4 & 5 above, please provide a justification via email to Samantha Mastronardi

Virtual Fees
Academic Virtual Package: $295
Student Virtual Package: $180
Corporate Virtual Package: $435

Late Fees (registrations submitted after 5:00pm ET on April 20th)

Academic Virtual Package: $395
Student Virtual Package: $280
Corporate Virtual Package: $535