Protein Homeostasis in Health and Disease
April 21 - 25, 2020
Abstract Deadline: February 14, 2020


Judith Frydman, Stanford University
F. Ulrich Hartl,
Max Planck Institute of Biochemistry, Germany
Richard Morimoto, Northwestern University

Proper expression, folding, transport, and clearance of proteins are critical for cell function and organismal health. Chaperones and enzymes that post-translationally assist newly synthesized proteins help ensure that they are correctly folded and functional, or are degraded. Translocation machineries, proteasomes, and autophagic activities are critical for subcellular localization and for degradation as necessary. Stress and aging challenge the robustness of these chaperone and clearance networks leading to protein mismanagement, overload, and cellular dysfunction. In humans, this is associated with the accumulation and aggregation of misfolded and aggregation-prone proteins, a feature of numerous neurodegenerative, metabolic, and oncogenic diseases.

You are invited to participate in the 2020 meeting on Protein Homeostasis in Health & Disease. Groundbreaking work - on molecular chaperones, the unfolded protein response, stress responses, and how these processes are implicated in disease - has first been presented at this meeting over the past three decades. The 2020 meeting provides an opportunity to showcase the latest research in this area and will feature talks by leading investigators.

The meeting will begin after dinner at 7:30 p.m. on Tuesday, April 21, and conclude with lunch on Saturday, April 25, 2020.

Session Chairs & Invited Speakers:

Integrative Stress Signaling in Aging and Disease
Chairperson: Jonathan Weissman, University of California, San Francisco
Keith Blackwell, Harvard Medical School
Ursula Jakob, University of Michigan Medical School

Chaperone Mechanisms I
Chairperson: F. Ulrich Hartl, Max Planck Institute of Biochemistry, Germany
Elke Deuerling, University of Konstanz, Germany
Lila Gierasch, University of Massachusetts, Amherst

Protein Aggregation in Aging and Neurodegenerative Diseases
Chairperson: Rick Morimoto, Northwestern University
Sheena Radford, University of Leeds, UK

Stress Granules and Phase Transitions
Chairperson: Simon Alberti, Technical University Dresden, Germany
Manajit Hayer-Hartl, Max Planck Institute, Martinsried, Germany

Chaperone Mechanisms II
Chairperson: Judith Frydman, Stanford University
Rachel Klevit, University of Washington

Clearance Mechanisms
Chairperson: Ivan Dikic, Goethe University Frankfurt, Germany
Dan Southworth, University of California, San Francisco

Organellar Proteostasis and Spatial Quality Control
Chairperson: Peter Walter, University of California, San Francisco
David Ron, University of Cambridge

Correcting Proteostasis in Aging and Disease
Chairperson: Gergely Lukacs, McGill University
Jeff Kelly, The Scripps Research Institute

Panel Discussion - New Mechanisms for Disseminating Scientific Information

Partial support provided by:

The format of the meeting will include eight sessions consisting of invited and short talks, chosen from the submitted abstracts, and two poster sessions. All speakers and chairs are strongly encouraged to stay for the entire meeting. The organizers will decide the suitability of each abstract for oral or poster presentation, but please specify if you prefer a poster. Abstracts should contain only new and unpublished material and must be submitted electronically by the abstract deadline. Selection of material for oral and poster presentation will be made by the organizers and individual session chairs. Status (talk/poster) of abstracts will be posted on our web site as soon as decisions have been made by the organizers.

All questions pertaining to registration, fees, housing, meals, transportation, visas, abstract submission or any other matters may be directed to Catie Carr.

We are eager to have as many young people as possible attend since they are likely to benefit most from this meeting. We have applied for funds from government and industry to partially support graduate students and postdocs. Apply in writing to Catie Carr stating need for financial support - preference is given to those submitting abstracts.

inBIO workshop

There will be a 1-day inBIO workshop held on Tuesday, April 21, prior to the start of the meeting.

This full-day workshop is aimed for scientists who see potential commercial value in their research discoveries and want to learn the basics of entrepreneurship. Participants will hear from biotech investors, communications specialists, and business development experts, who will provide attendees with the opportunity to learn the fundamentals of launching an academic spin-out company. After speaking sessions attendees can participate in a mock pitch and receive feedback from speakers.

Applications should be submitted by March 30 (click here to apply).

All questions regarding the inBIO workshop may be directed to Michael Gurtowski.


Academic Package: $1,560
Graduate/PhD Student Package:
Corporate Package: $2,055 
Academic/Student No-Housing Package:
Corporate No-Housing Package: $1,380 

Regular packages are all-inclusive and cover registration, food, housing, parking, a wine-and-cheese party, cocktail reception, and lobster banquet. No-Housing packages include all costs except housing. Full payment is due four weeks prior to the meeting.