Protein Homeostasis in Health and Disease
Rescheduled to November 11 - 14, 2020 Virtual Meeting
Revised Abstract Deadline: August 21, 2020


Judith Frydman, Stanford University
F. Ulrich Hartl,
Max Planck Institute of Biochemistry, Germany
Richard Morimoto, Northwestern University


The current COVID-19 situation is challenging and difficult for all of us - we hope this virtual conference will allow colleagues to share and discuss their latest research, while under travel and stay-at-home restrictions.


The 2020 meeting on Protein Homeostasis in Health & Disease is going fully virtual. The meeting has been rescheduled and will now begin late morning on Wednesday, November 11, and conclude late afternoon on Saturday, November 14, 2020. Groundbreaking work - on molecular chaperones, the unfolded protein response, stress responses, and how these processes are implicated in disease - has first been presented at this meeting over the past three decades. The 2020 meeting provides an opportunity to showcase the latest research in this area and will feature talks by leading investigators.

Proper expression, folding, transport, and clearance of proteins are critical for cell function and organismal health. Chaperones and enzymes that post-translationally assist newly synthesized proteins help ensure that they are correctly folded and functional, or are degraded. Translocation machineries, proteasomes, and autophagic activities are critical for subcellular localization and for degradation as necessary. Stress and aging challenge the robustness of these chaperone and clearance networks leading to protein mismanagement, overload, and cellular dysfunction. In humans, this is associated with the accumulation and aggregation of misfolded and aggregation-prone proteins, a feature of numerous neurodegenerative, metabolic, and oncogenic diseases.

Day Time (EST Session # Session Name
Wednesday 10:00 am - 1:00 pm 1 Integrative Stress Signaling in Aging and Disease
Wednesday 2:00 pm - 5:00 pm 2 Chaperone Mechanisms I
Thursday 10:00 am- 1:00 pm 3 Protein Aggregation in Aging and Neurodegenerative Disease
Thursday 2:00 pm - 5:00 pm 4 Clearance Mechanisms
Friday 10:00 am- 1:00 pm 5 Chaperone Mechanisms II
Friday 2:00 pm - 5:00 pm 6 Stress Granules and Phase Transitions
Saturday 10:00 am- 1:00 pm 7 Organellar Proteostasis and Spatial Quality Control
Saturday 2:00 pm - 5:00 pm 8 Proteostasis in Aging And Disease
Throughout Meeting Virtual Poster Session
Virtual Icebreaker Wednesday, 5:30 pm

Session Chairs & Invited Speakers:

Simon Alberti, Technical University Dresden, Germany
Keith Blackwell, Harvard Medical School
Elke Deuerling, University of Konstanz, Germany
Ivan Dikic, Goethe University Frankfurt, Germany
Judith Frydman, Stanford University
Lila Gierasch, University of Massachusetts, Amherst
F. Ulrich Hartl, Max Planck Institute of Biochemistry, Germany
Manajit Hayer-Hartl, Max Planck Institute, Martinsried, Germany
Ursula Jakob, University of Michigan Medical School
Jeff Kelly, The Scripps Research Institute
Rachel Klevit, University of Washington
Gergely Lukacs, McGill University
Rick Morimoto, Northwestern University
Sheena Radford, University of Leeds, UK
David Ron, University of Cambridge
Dan Southworth, University of California, San Francisco
Jonathan Weissman, Whitehead Institute and MIT/HHMI

The format of the meeting will include eight sessions consisting of invited and short talks, chosen from the submitted abstracts, and a virtual poster session throughout the meeting. The organizers will decide the suitability of each abstract for oral or poster presentation, but please specify if you prefer a poster. Abstracts should contain only new and unpublished material and must be submitted electronically by the abstract deadline. Selection of material for oral and poster presentation will be made by the organizers and individual session chairs. Status (talk/poster) of abstracts will be posted on our web site as soon as decisions have been made by the organizers.

All questions pertaining to registration, fees, abstract submission or any other matters may be directed to Catie Carr.

We are eager to have as many young people as possible attend since they are likely to benefit most from this meeting. We have applied for funds from government and industry to partially support graduate students and postdocs. Apply in writing to Catie Carr stating need for financial support - preference is given to those submitting abstracts.

Late Pricing: (registrations submitted after 4:01 p.m. EDT on November 6, 2020)

Late Virtual Academic Package: $385
Late Virtual Graduate Student Package: $275
Late Virtual Corporate Package: $525

Virtual 4 day live meeting + 6 weeks archive access

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~50 talks / 8 sessions
(late am/early pm)
~20 total hours with interactive Q&A
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~200 posters with
dedicated slack channels for each poster
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Digital program in PDF format
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Leading Strand video archive access to talks
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Twitter for meeting news & general comments