Protein Homeostasis in Health and Disease
April 24 - 28, 2024
Abstract Deadline: February 20, 2024


Judith Frydman, Stanford University
Malene Hansen, 
Buck Institute for Research on Aging
F. Ulrich Hartl, Max Planck Institute of Biochemistry, Germany
Richard Morimoto, Northwestern University

Proper expression, folding, transport, and clearance of proteins are critical for cell function and organismal health. Chaperones and enzymes that post-translationally assist newly synthesized proteins help ensure that they are correctly folded and functional, or are degraded. Translocation machineries, proteasomes, and autophagic activities are critical for subcellular localization and for degradation as necessary. Stress and aging challenge the robustness of these chaperone and clearance networks leading to protein mismanagement, overload, and cellular dysfunction. In humans, this is associated with the accumulation and aggregation of misfolded and aggregation-prone proteins, a feature of numerous neurodegenerative, metabolic, and oncogenic diseases.

You are invited to participate in the 16th meeting on Protein Homeostasis in Health & Disease. Groundbreaking work - on molecular chaperones, the unfolded protein response, stress responses, and how these processes are implicated in disease - has first been presented at this meeting over the past three decades plus. The 2024 meeting provides an opportunity to showcase the latest research in this area and will feature talks by leading investigators.

The meeting will begin after dinner at 7:30 p.m. on Wednesday, April 24, and conclude with lunch on Sunday, April 28, 2024. 

Topics & Session Chairs:

Cell Stress Response Signaling in Biology, Aging and Disease 
David Ron, University of Cambridge
Lea Sistonen, University of Turku

Chaperone Mechanisms 
Johannes Buchner, Technical University of Munich
Helen Saibil, Birkbeck College

Co-translational Folding and Ribosome Quality Control Mechanisms 
Toshi Inada, University of Tokyo
Elke Deuerling, University of Konstanz

Stress Granules, Phase Transitions and Intrinsically Disordered Proteins
Simon Alberti, Technical University Dresden
Manajit Hayer-Hartl, Max Planck Institute of Biochemistry Martinsried

Degradation Mechanisms – Autophagy Lysosomal Pathway and the Ubiquitin Proteasome System 
Ana Maria Cuervo, Albert Einstein College of Medicine
Dan Finley, Harvard Medical School

Misfolding and Aggregation in Aging and Neurodegenerative Diseases 
Anne Bertolotti, MRC Laboratory of Molecular Biology
Byron Caughey, Rocky Mountain Laboratory, NIAID

Organellar Proteostasis and Spatial Quality Control in Aging and Disease
Johannes Hermann, University of Kaiserslautern
Thomas Langer, Max Planck Institute for Biology of Aging Cologne

Therapeutic Strategies for Protein Conformational Diseases of Aging
Jeff Kelly,
Scripps Research
Peter Walter,
Altos Laboratories

Panel Discussion: Preparing for Diverse Careers in Science

The format of the meeting will include eight oral sessions and two poster sessions. Each oral session will include invited speakers and speakers selected from submitted abstracts. For this reason, abstracts from accomplished junior and senior investigators are warmly invited. The abstracts should focus on new and unpublished data. The organizers will select abstracts for oral or poster presentations. The status (talk/poster) of abstracts will be posted on our web site (below) as soon as decisions have been made. We have applied for funds from government and industry to partially support graduate students and postdocs. Please apply in writing via email to Kelley McGrath and state your financial needs; preference will be given to those who submit abstracts.

All questions pertaining to registration, fees, housing, meals, transportation, visas, abstract submissions, or any other matters may be directed to Kelley McGrath.

Social Media: The designated hashtag for this meeting is #cshlprotein. Note that you must obtain permission from an individual presenter before live-tweeting or discussing his/her talk, poster, or research results on social media. Click the Policies tab above to see our full Confidentiality & Reporting Policy.

This conference is supported in part by funds provided by the National Institute on Aging of the National Institutes of Health.


Academic/Media Private Room/Private Bath Package: $1,775
Academic/Media Private Room/Shared Bath Package: $1,665
Academic Shared Room Package: $1,515
Academic/Media No-Housing Package: $1,130
Student Package*: $1,410
Student No-Housing Package: $1,025
Corporate Private Room/Private Bath Package: $2,270
Corporate No-Housing Package: $1,625

*Student Housing is default double occupancy. Please enquire about availability and fees to upgrade to private room.

Room packages close 2 weeks before the meeting start date

Rules for Virtual Participation: Virtual participation will include access to the oral sessions via Zoom, access to the digital poster sessions and access to the Slack discussion channel, and the Leading Strand video archive.

Presenters: Individuals submitting abstracts and facing financial barriers should firstly request financial aid (see above). Permission to present your talk or poster virtually will be given only in exceptional circumstances and on a case-by-case basis. If you think you are eligible for an exemption from the requirement to present in person, please provide a justification in writing via email to Kelley McGrath.

Non-presenting participants: We plan to broaden access to the conference by allowing certain categories of non-presenting participants to attend virtually at reduced fees. Categories include: 
1. Individuals from low & middle income countries; 
2. Individuals from non-LMIC countries in Asia, Australasia, Africa or South America; 
3. Individuals from US & Canadian minority serving institutions; 
4. Individuals with a demonstrable financial barrier; 
5. Individuals with family obligations or other special circumstances. 
For categories 4 & 5 above, please provide a justification via email to Kelley McGrath.

Virtual Fees:
Academic Virtual Package: $340
Grad Student Virtual Package: $210

Corporate Virtual Package: $505

Late Fee (Registrations submitted after 5:00 p.m. ET on April 18, 2024)

Late Academic Virtual Package: $440
Late Student Virtual Package: $310
Late Corporate Virtual Package: $605