Protein Homeostasis in Health and Disease
Rescheduled to November 13 - 17, 2020
Revised Abstract Deadline: August 21, 2020


Judith Frydman, Stanford University
F. Ulrich Hartl,
Max Planck Institute of Biochemistry, Germany
Richard Morimoto, Northwestern University


COVID-19: Because of the ongoing COVID-19/SARS-CoV-2 outbreak, CSHL and the organizers have reached the difficult decision to postpone the meeting on Protein Homeostasis in Health and Disease originally scheduled for April 21-25, 2020 until November 13-17, 2020. We realize this is very inconvenient for you and hope you understand how difficult this decision has been to make. We are very much hoping that many of you will be able to participate in November and that you are able to change your travel plans with minimal cost and disruption.

We hope you understand this decision and sincerely regret how this may impact your upcoming plans.

If we do not hear from you we will assume you are still planning to attend the meeting. If you are unable to attend, we ask that you let us know as soon as possible (by March 27) to be eligible for a full refund.Thereafter our normal cancellation policies will apply.


Proper expression, folding, transport, and clearance of proteins are critical for cell function and organismal health. Chaperones and enzymes that post-translationally assist newly synthesized proteins help ensure that they are correctly folded and functional, or are degraded. Translocation machineries, proteasomes, and autophagic activities are critical for subcellular localization and for degradation as necessary. Stress and aging challenge the robustness of these chaperone and clearance networks leading to protein mismanagement, overload, and cellular dysfunction. In humans, this is associated with the accumulation and aggregation of misfolded and aggregation-prone proteins, a feature of numerous neurodegenerative, metabolic, and oncogenic diseases.

You are invited to participate in the 2020 meeting on Protein Homeostasis in Health & Disease. Groundbreaking work - on molecular chaperones, the unfolded protein response, stress responses, and how these processes are implicated in disease - has first been presented at this meeting over the past three decades. The 2020 meeting provides an opportunity to showcase the latest research in this area and will feature talks by leading investigators.

The meeting has been rescheduled and will now begin after dinner at 7:30 p.m. on Friday, November 13, and conclude with lunch on Tuesday, November 17, 2020.

Session Chairs & Invited Speakers:

Integrative Stress Signaling in Aging and Disease
Chairperson: Jonathan Weissman, University of California, San Francisco
Keith Blackwell, Harvard Medical School
Ursula Jakob, University of Michigan Medical School

Chaperone Mechanisms I
Chairperson: F. Ulrich Hartl, Max Planck Institute of Biochemistry, Germany
Elke Deuerling, University of Konstanz, Germany
Lila Gierasch, University of Massachusetts, Amherst

Protein Aggregation in Aging and Neurodegenerative Diseases
Chairperson: Rick Morimoto, Northwestern University
Sheena Radford, University of Leeds, UK

Stress Granules and Phase Transitions
Chairperson: Simon Alberti, Technical University Dresden, Germany
Manajit Hayer-Hartl, Max Planck Institute, Martinsried, Germany

Chaperone Mechanisms II
Chairperson: Judith Frydman, Stanford University
Rachel Klevit, University of Washington

Clearance Mechanisms
Chairperson: Ivan Dikic, Goethe University Frankfurt, Germany
Dan Southworth, University of California, San Francisco

Organellar Proteostasis and Spatial Quality Control
Chairperson: Peter Walter, University of California, San Francisco
David Ron, University of Cambridge

Correcting Proteostasis in Aging and Disease
Chairperson: Gergely Lukacs, McGill University
Jeff Kelly, The Scripps Research Institute

Panel Discussion - New Mechanisms for Disseminating Scientific Information

Partial support provided by:

The format of the meeting will include eight sessions consisting of invited and short talks, chosen from the submitted abstracts, and two poster sessions. All speakers and chairs are strongly encouraged to stay for the entire meeting. The organizers will decide the suitability of each abstract for oral or poster presentation, but please specify if you prefer a poster. Abstracts should contain only new and unpublished material and must be submitted electronically by the abstract deadline. Selection of material for oral and poster presentation will be made by the organizers and individual session chairs. Status (talk/poster) of abstracts will be posted on our web site as soon as decisions have been made by the organizers.

All questions pertaining to registration, fees, housing, meals, transportation, visas, abstract submission or any other matters may be directed to Catie Carr.

We are eager to have as many young people as possible attend since they are likely to benefit most from this meeting. We have applied for funds from government and industry to partially support graduate students and postdocs. Apply in writing to Catie Carr stating need for financial support - preference is given to those submitting abstracts.

inBIO workshop

We hope to reschedule the 1-day inBIO workshop held on Friday November 13, prior to the start of the meeting.

This full-day workshop is aimed for scientists who see potential commercial value in their research discoveries and want to learn the basics of entrepreneurship. Participants will hear from biotech investors, communications specialists, and business development experts, who will provide attendees with the opportunity to learn the fundamentals of launching an academic spin-out company. After speaking sessions attendees can participate in a mock pitch and receive feedback from speakers.

Applications should be submitted by October 16 (click here to apply).

All questions regarding the inBIO workshop may be directed to Michael Gurtowski.


Academic Package: $1,560
Graduate/PhD Student Package:
Corporate Package: $2,055 
Academic/Student No-Housing Package:
Corporate No-Housing Package: $1,380 

Regular packages are all-inclusive and cover registration, food, housing, parking, a wine-and-cheese party, cocktail reception, and lobster banquet. No-Housing packages include all costs except housing. Full payment is due four weeks prior to the meeting.