Neurodegenerative Diseases: Biology & Therapeutics
November 28 - December 1, 2018


Richard Ransohoff, Third Rock Ventures
Scott Small, Columbia University
John Trojanowski, University of Pennsylvania School of Medicine
Li-Huei Tsai, Massachusetts Institute of Technology

Abstract Book

You are cordially invited to participate in the tenth meeting on Neurodegenerative Diseases to be held at Cold Spring Harbor Laboratory. The meeting will begin with dinner and the first session on the evening of Wednesday, November 28, 2018, and will conclude with lunch on Saturday, December 1.

A primary goal of the meeting is to provide a forum where medical scientists from academia can interact with scientists from the biopharmaceutical industry, thus forging a community of academic and industry researchers who recognize that they have much to learn from each other. Rational drug discovery for neurodegenerative diseases has begun to yield compounds and treatments that are now entering clinical settings. For human studies utilizing these compounds and treatments to be maximally informative, it is crucial that scientists from academia and industry meet regularly to exchange data and ideas.

This meeting will consist of six to seven oral sessions plus one poster session. The aim is to populate half of each oral session with speakers from academia and the other half from industry; speakers will be invited as well as selected from submitted abstracts.

Tentative Topics:
  • Propagation of Neurodegenerative Disease
  • Network Mechanisms of Neurodegenerative Disease
  • Neuroinflammation & Glial Biology of Neurodegeneration
  • ApoE and Lipid Metabolism
  • RNA Metabolism in Neurodegenerative Disease
  • The Endolysosome, Autophagy and Other Targets in Therapeutics
Confirmed Session Chairs:
Aaron Gitler, Stanford University
Joachim Herz, UT Southwestern
Virginia Lee, University of Pennsylvania
Richard Ransohoff, Third Rock Ventures
Scott Small, Columbia University
Li-Huei Tsai, Massachusetts Institute of Technology

Confirmed Speakers:
Frank Bennett, Ionis Pharmaceuticals
David Borchelt, University of Florida
Ted Dawson, The Johns Hopkins University School of Medicine
Gil Di Paolo, Denali Therapeutics
Karen Duff, Columbia University
Li Gan, Gladstone Institutes/UCSF
Michael Heneka, Das Universitätsklinikum Bonn
Eliezer Masliah, NIH National Institute on Aging
Zissimos Mourelatos, University of Pennsylvania
Jorge Palop, Gladstone Institutes/UCSF
Steven M. Paul, Weill Cornell Medicine
Madga Polymenidou, University of Zurich
Beth Stevens, Harvard University 
Paul Taylor, St. Jude Children's Research Hospital
Laura A. Volpicelli-Daley, The University of Alabama at Birmingham
Berislav Zlokovic, Keck School of Medicine of USC

Keynote Speaker:
Alison Goate, Ichan School of Medicine at Mount Sinai

Abstracts should contain only new and unpublished material and must be submitted electronically by the abstract deadline. Selection of material for oral and poster presentations will be made by the organizers and individual session chairs. The status of abstracts (i.e., talk or poster) will be posted as soon as decisions have been made by the organizers. Please bring this announcement to the attention of any of your colleagues who may be interested in participating in the meeting.

All questions pertaining to registration, fees, housing, meals, transportation, visas, abstract submission or any other matters should be directed to Catie Carr at

Cold Spring Harbor Laboratory is eager to have as many young people as possible attend this meeting. As such, we have some funds set aside to partially support students and postdocs. Please register and apply in writing to Catie Carr at stating your eligibility and need for financial support. Preference will be given to those submitting abstracts.

We look forward to seeing you at Cold Spring Harbor Laboratory at the end of November 2018.

Partial support for this meeting provided by: Amgen, Biogen


Regular packages are all-inclusive and cover registration, food, housing, parking, a wine-and-cheese party, cocktail reception, and lobster banquet. No-Housing packages include all costs except housing. Full payment is due four weeks prior to the meeting.