Forty Years of mRNA Splicing: From Discovery to Therapeutics

October 22 - 25, 2017


Mila Pollock, Cold Spring Harbor Laboratory
Phil Sharp, Massachusetts Institute of Technology
Joan Steitz, Yale University/HHMI 

The meeting will be held in Grace Auditorium at Cold Spring Harbor commencing 1:45 pm on Sunday, October 22, and finish Tuesday after dinner, with departures the following morning, October 25, after breakfast.

Themes include:
  • History and Overview
  • Biology of Spliceosome
  • Introns, Exons and Alternative splicing
  • Spliceosome Complexes
  • Diseases of mRNA splicing
  • Therapeutic approaches to mRNA Splicing diseases
Session Chairs:
Manuel Ares, University of California, Santa Cruz
Claire Moore, Tufts University
James Darnell, The Rockefeller University
Walter Gilbert, Harvard University
Walter Keller, Biozentrum, University of Basel, Switzerland
Ryszard Kole, Sarepta Therapeutics
Timothy Nilsen, Case Western Reserve University
Stuart Orkin, Dana-Farber Cancer Institute
Charles Query, Albert Einstein College of Medicine
Michael Rosbash, Brandeis University
Woan-Yuh Tarn, Academia Sinica, Taiwan

Confirmed Speakers:
John Abelson, California Institute of Technology
Jean Beggs, University of Edinburgh, UK
Douglas Black, University of California, Los Angeles
Benjamin Blencowe, University of Toronto, Canada
Christopher Burge, Massachusetts Institute of Technology
Soo-Chen Cheng, Academia Sinica, Taiwan
Robert Darnell, The Rockefeller University/HHMI/NY Genome Center
Gideon Dreyfuss, HHMI, University of Pennsylvania School of Medicine
Xiang-Dong Fu, University of California, San Diego
Mariano Garcia-Blanco, University of Texas Medical Branch at Galveston
Brenton Graveley, University of Connecticut Health Center
Michael Green, University of Massachusetts/HHMI
Christine Guthrie, University of California, San Francisco
Nouria Hernandez, University of Lausanne, Switzerland
Magda Konarska, The Rockefeller University
Alberto Kornblihtt, University of Buenos Aires, Argentina
Adrian Krainer, Cold Spring Harbor Laboratory
Reinhard Luehrmann, Max Planck Institute of Biophysical Chemistry, Germany
Kristen Lynch, University of Pennsylvania
Thomas Maniatis, Columbia University
James Manley, Columbia University
Melissa Moore, Moderna Therapeutics
Siddhartha Mukherjee, Columbia University Medical Center
Kiyoshi Nagai, MRC, UK
Karla Neugebauer, Yale University
Richard Padgett, Cleveland Clinic
Nikolaus Rajewsky, Max Delbrück Center for Molecular Medicine, Germany
Richard Roberts, New England BioLabs
Phillip Sharp, Massachusetts Institute of Technology
Yigong Shi, Tsinghua University, China
Jon Staley, University of Chicago
Joan Steitz, Yale University/HHMI
Bruce Stillman, Cold Spring Harbor Laboratory
James Watson, Cold Spring Harbor Laboratory
Larry Zipursky, University of California/HHMI

Gil Ast, Tel Aviv University, Israel
Pierre Chambon, IGBMC, France
Michael R. Lerner, Dermatology Surgical and Medical, San Diego
Iain Mattaj, EMBL, Heidelberg, DE
Mila Pollock, Cold Spring Harbor Laboratory
Erik Sontheimer, University of Massachusetts Medical School
David Spector, Cold Spring Harbor Laboratory
Juan Valcarcel Juarez, Centre for Genomic Regulation, Barcelona, Spain
Charles Weissman, University of Zurich, Switzerland

For these unique meetings, we invite speakers who made many of the seminal discoveries that began the field, as well as those who are working on the topic now.  We also invite historians of science who have examined the topic, setting it in its scientific and societal context.  Like the previous meetings in the series, this meeting will provide an excellent opportunity to look in-depth at a topic and share the stories that are often missing from academic accounts.

We anticipate the meeting will interest a broad range of individuals, including scientists, clinicians, historians, activists, and science journalists

While abstracts are NOT being accepted for this meeting, we invite participants who would like to present posters at the meeting to alert us via email to Val Pakaluk.  Plan on a maximum size of 4ft x 4ft (1.22m x 1.22m) for your poster.

We have applied for funds from industry and other sponsors to partially offset attendance costs for those in real financial need.  Apply in writing to Val Pakaluk stating your need for financial support.

We look forward to seeing you at Cold Spring Harbor in October.

Financial support provided by: 

Major Sponsors   Biogen and Moderna Therapeutics


Gold Sponsors    Alnylam Pharmaceuticals and New England BioLabs


The CSHL/Genentech Center Conferences on the History of Molecular Biology & Biotechnology aim to explore important themes of discovery in the biological sciences, bringing together scientists who made many of the seminal discoveries that began the field with others whose interests may include the current status of the field, the historical progress of the field, and/or the application of these techniques and approaches in biotechnology and medicine.

Previous meetings in the series have included:

  • Biotechnology: Past, Present & Future (2008)
  • History of Restriction Enzymes (2013)
  • Messenger RNA: From Discovery to Synthesis and Regulation in Bacteria and Eukaryotes (2014)
  • Plasmids: History & Biology (2014)
  • The Evolution of Sequencing Technology: A Half-Century of Progress (2015)
  • HIV/AIDS Research: Its History & Future (2016)

Regular Pricing
Academic Package $1,165
Graduate/PhD Student Package $975
Corporate Package $1,475
Academic/Student No-Housing Package $795
Corporate No-Housing Package $995

Regular packages are all inclusive and cover registration, food, housing, parking, wine-and-cheese party, lobster banquet, etc. No Housing packages include all costs except housing. Full payment is due 4 weeks prior to the meeting.