Protein Homeostasis in Health and Disease
April 18 - 22, 2016
Abstract Deadline: January 29, 2016


Judith  Frydman, Stanford University         
F. Ulrich  Hartl,
Max Planck Institute of Biochemistry, Germany
Harm H. Kampinga, UMCG & RuG, The Netherlands         
Richard  Morimoto, Northwestern University         
Peter  Walter,
University of California, San Francisco/HHMI

Proper expression, folding, transport, and clearance of proteins are critical for cell function and organismal health. Chaperones and enzymes that post-translationally assist newly synthesized proteins help ensure that they are correctly folded and functional, or are degraded. Translocation machineries, proteasomes, and autophagic activities are critical for subcellular localization and for degradation as necessary. Stress and aging challenge the robustness of these chaperone and clearance networks leading to protein mismanagement, overload, and cellular dysfunction. In humans, this is associated with the accumulation and aggregation of misfolded and aggregation-prone proteins, a feature of numerous neurodegenerative, metabolic, and oncogenic diseases.  

You are invited to participate in the 2016 meeting on Protein Homeostasis in Health & Disease, marking the 25th anniversary of the first Cold Spring Harbor meeting in 1991 related to heat shock and the role of molecular chaperones. Over the past twenty-five years, the field has exploded and much groundbreaking work - on molecular chaperones, the unfolded protein response, stress responses, and how these processes are implicated in disease - has first been presented at this meeting. This year's meeting provides an opportunity to showcase the latest research in this area and to feature several keynote talks by leading investigators who have contributed to the development of the field and who will put their current efforts in the context of past developments.

The meeting will begin after dinner at 7:30 p.m. on Monday, April 18, and conclude with lunch on Friday, April 22, 2016.

  • Synthesis and Folding of Proteins
  • Regulation and Properties of Proteostasis Networks
  • Spatial and Organellar Quality Control
  • Degradation Mechanisms
  • Novel Properties and Functions of Chaperones
  • Functional and Pathogenic Aggregates
  • Aging and Diseases of Prooteostasis

Keynote Speakers:

Costa Georgopoulos, University of Utah School of Medicine
F. Ulrich Hartl, Max-Planck Institute of Biochemistry, Germany
Susan Lindquist, Whitehead Institute for Biomedical Research
Richard Morimoto, Northwestern University
Peter Walter, University of California, San Francisco/HHMI

Discussion Leaders:

David Agard, University of California San Francisco/HHMI
Anne Bertolotti, MRC LMB, UK
Jeffrey Brodsky, University of Pittsburgh
Johannes Buchner, Technische Universitaet Muenchen, Germany
Bernd Bukau, University of Heidelberg, Germany
Elizabeth Craig, University of Wisconsin
Elke Deuerling, University of Constance, Germany
Christopher Dobson, University of Cambridge, UK
Jason Gestwicki, University of California, San Francisco - School of Medicine
Lila Gierasch, University of Massachusetts
Ursula Jakob, University of Michigan
Jeffery Kelly, The Scripps Research Institute
Rachel Klevit, University of Washington
Ron Kopito, Stanford University
John Lis, Cornell University
Kazuhiro Nagata, Kyoto Sangyo University, Japan
Tom Rapoport, HHMI/Harvard Medical School
Lea Sistonen, Turku Centre for Biotechnology - Abo Akademi University University, Finland
Jonathan Weissman, UCSF/HHMI

The format of the meeting will include eight sessions consisting of invited and short talks, chosen from the submitted abstracts, and two poster sessions. All speakers and chairs are strongly encouraged to stay for the entire meeting. The organizers will decide the suitability of each abstract for oral or poster presentation, but please specify if you prefer a poster.

Abstracts should contain only new and unpublished material and must be submitted electronically by the abstract deadline. Selection of material for oral and poster presentation will be made by the organizers and individual session chairs. Status (talk/poster) of abstracts will be posted on our web site as soon as decisions have been made by the organizers.

We are eager to have as many young people as possible attend since they are likely to benefit most from this meeting. We have applied for funds from government and industry to partially support graduate students and postdocs. Apply in writing to Val Pakaluk stating need for financial support - preference is given to those submitting abstracts.

We hope to see you at Cold Spring Harbor in April.


Academic Package $1,425
Graduate/PhD Student Package $1,185
Corporate Package $1,835
Academic/Student No-Housing Package $965
Corporate No-Housing Package $1,230

Regular packages are all-inclusive and cover registration, food, housing, parking, a wine-and-cheese party, cocktail reception, and lobster banquet. No-Housing packages include all costs except housing. Full payment is due four weeks prior to the meeting.