The Evolving Concept of Mitochondria:
From Symbiotic Origins to Therapeutic Opportunities

October 18 - 21, 2018


Anu Suomalainen, University of Helsinki, Finland
John E. Walker
, MRC Mitochondrial Biology Unit, University of Cambridge, United Kingdom
Douglas C. Wallace, Children's Hospital of Philadelphia & University of Pennsylvania
Mila Pollock, Cold Spring Harbor Laboratory

Since it was first observed within cells at the end of the nineteenth century, our bacterial endosymbiont, the mitochondrion, has been interrogated from many perspectives.  Initially described as a cytoplasmic structure, then as the source of energy, later an organismal entity, and recently a component of many diseases, the multi-faceted mitochondrion has engendered fascination from a broad spectrum of physical, chemical, biological, and medical perspectives.  

What is this cell-within-a-cell? Where did it come from? What is its relevance to our health and well being? How will mitochondrial knowledge affect the future?  These are the questions we hope to discuss in this stimulating meeting of modern mitochondriacs who will discuss past, current state and future prospects through their important contributions to the field. 

The meeting on The Evolving Concept of Mitochondria: From Symbiotic Origins to Therapeutic Opportunities will begin at 7:00 PM on Thursday, October 18th and conclude Sunday, October 21st at 4:30 PM.

  • Mitochondrial Biology, Bioenergetics, Biogenesis and Disease
  • The Origins of the Organelle
  • Complex I - from Structure to Disease
  • Mitochondrial DNA: Structure, Function and Inheritance
  • Mitochondrial Expression System and Proteome
  • Mitochondrial Protein Import Systems and Metabolic Transporters
  • Mitochondrial Diseases, Past and Present
  • Mitochondrial Regulation of Metabolism
  • Mitochondria, Calcium Signaling and Cell Death
  • Mitochondrial Dynamics and Quality Control
  • Novel Approaches to Mitochondrial Therapy
  • Preserving the History of Mitochondria Research

Session Chairs:
Valerio Carelli, University of Bologna School of Medicine, Italy
Anne Chomyn, California Institute of Technology
Marni Falk, Children's Hospital of Philadelphia
Maria Falkenberg, University of Gothenburg, Sweden
Toren Finkel, University of Pittsburgh
György Hajnoczky, Thomas Jefferson University
Ferdinando Palmieri, University of Bari Aldo Moro, Italy
Vincent Procaccio, University of Angers, France
Peter Rich, Institute of Structural & Molecular Biology, UK
Anu Suomalainen, University of Helsinki, Finland
John Walker, MRC Mitochondrial Biology Unit, UK
Douglas Wallace, Children's Hospital of Philadelphia

Confirmed Speakers:
Alexey Amunts, Stockholm University, Sweden
Paolo Bernardi, University of Padua, Italy
Charles Brenner, The University of Iowa
David Chan, California Institute of Technology
Navdeep Chandel, Northwestern University, Feinberg School of Medicine
Patrick Chinnery, MRC Mitochondrial Biology Unit, UK
J. Antonio Enriquez, Spanish National Centre for Cardiovascular Research, Spain
Michael Gray, Dalhousie University, Canada
Claes Gustafsson, University of Gothenburg, Sweden
Marcia Haigis, Harvard Medical School
Mary Herbert, Newcastle University, UK
Henry Higgs, Dartmouth University
Judy Hirst, MRC Mitrochondrial Biology Unit, UK
Howy Jacobs, University of Tampere, Finland
Laurie Kaguni, Michigan State University
Emine Koç, Marshall University
Carla Koehler, University of California, Los Angeles
Edmund Kunji, MRC Mitochondrial Biology Unit, University of Cambridge, UK
Nick Lane, University College London, UK
Nils-Göran Larsson, Karolinska Institute, Sweden
Jennifer Lippincott-Schwartz, HHMI/Janelia Farm Research Campus
Dan Mishmar, Ben-Gurion University of the Negev, Israel
Vamsi Mootha, Massachusetts General Hospital
Carlos Moraes, University of Miami
Michael Murphy, Medical Research Council, UK
David Nicholls, Buck Institute for Research on Aging
Nikolaus Pfanner, University of Freiburg, Germany
Rosario Rizzuto, University of Padua, Italy
Agnes Rötig, L'institut Imagine, France
Jared Rutter, HHMI/University of Utah School of Medicine
Leonid Sazanov, Institute of Science & Technology, Austria
Eric Schon, Columbia University
Luca Scorrano, University of Padua, Italy
Orian Shirihai, University of California, Los Angeles
Eric Shoubridge, McGill University/MNI, Canada
Bruce Spiegelman, Dana-Farber Cancer Institute
James Stewart, Max Planck Institute for Biology of Ageing, Germany
Anu Suomalainen, University of Helsinki, Finland
Aleksandra Trifunovic, University of Cologne, Germany
John Walker, MRC Mitochondrial Biology Unit, University of Cambridge, UK
Douglas Wallace, Children's Hospital of Philadelphia
Richard Youle, National Institutes of Health
Ian Young, Australian National University, Australia
Massimo Zeviani, MRC Mitochondrial Biology Unit, UK

For these unique science history meetings, we invite speakers who made many of the seminal discoveries that began a field as well as those currently working in that field. We also invite historians who have examined the scientific and societal context of the field. Like the previous meetings in the series, this meeting will provide an excellent opportunity to look in-depth at the history of a topic in biology and share stories that may be missing from purely academic accounts.

Registrations are warmly welcomed from scientists, clinicians, historians, activists, and journalists. You must be registered in order to present a poster. Once registered you will receive a confirmation email containing the link for abstract submission. If you wish to present a poster, please plan on a maximum size of 4ft x 4ft (1.22m x 1.22m). Click the Information tab above for details on presenting posters at CSHL meetings.

Thanks to our corporate sponsors for their generous support of this meeting:

PLATINUM sponsor
GOLD sponsor
SILVER sponsor
BRONZE sponsor Mitobridge (an Astellas company), Modis Therapeutics, Neurovive

We have applied for funds from industry and other sponsors to partially offset registration costs for some attendees. Please apply in writing via email to Val Pakaluk and state your financial needs.

Social Media
The designated hashtag for this meeting is #cshhist18. Note that you must obtain permission from an individual presenter before live-tweeting or discussing his/her talk, poster, or research results on social media. Click the Policies tab above to see our full Confidentiality & Reporting Policy.

We look forward to seeing you at Cold Spring Harbor in October.

Financial support provided by:

Academic Package $1190
Graduate/PhD Student Package $1000
Corporate Package $1,505
Academic/Student No-Housing Package $815
Corporate No-Housing Package $1,015

Regular packages are all-inclusive and cover registration, food, housing, parking, a wine-and-cheese reception, and lobster banquet. No-Housing packages include all costs except housing. Full payment is due four weeks prior to the meeting.