YEAST GENETICS & GENOMICS
July 21 - August 10, 2015
Application Deadline: May15, 2015

Instructors:
Grant Brown, University of Toronto, Canada
Maitreya Dunham, University of Washington
Marc Gartenberg, Robert Wood Johnson Medical School

See the roll of honor - who's taken the course in the past

The Yeast Genetics & Genomics course is a modern, state of the art laboratory course designed to teach students the full repertoire of genetic approaches needed to dissect complex problems in the yeast Saccharomyces cerevisiae. Combinations of classical and modern genetic approaches are emphasized, including the isolation and characterization of mutants, tetrad analysis, complementation, and mitotic recombination. Students will learn array-based methods, next generation sequencing, and genome-based methods of analysis facilitated by the yeast genome sequence, the deletion collection, and other genomic resources available to the community. Molecular genetic techniques, including yeast transformation, gene replacement by PCR, construction and analysis of gene fusions, and generation of mutations, will also be emphasized.

Students will use classical approaches and modern whole genome sequencing to gain experience in identifying and interpreting various kinds of genetic interactions including suppression and synthetic lethality (including SGA). Students will be immersed in yeast genomics and will perform and interpret experiments using DNA arrays, whole genome sequencing, and multiplexed DNA barcode sequencing. Students will gain first-hand experience in modern cytological approaches such as epitope tagging and imaging yeast cells using indirect immunofluorescence, GFP-protein fusions and a variety of fluorescent indicators for different subcellular organelles. Lectures on fundamental aspects of yeast genetics will be presented along with seminars given by prominent experts in the field on topics of current interest.

Speakers this year include:
Anastasia Baryshnikova, Princeton University
Amy Caudy, University of Toronto, Canada
Douglas Fowler, University of Washington
Alison Gammie, Princeton University
Susan Gasser, Friedrich Miescher Institute for Biomedical Research, Switzerland
James Haber, Brandeis University
Michael Hampsey, Rutgers University
Mark Hochstrasser, Yale University
Danny Lew, Duke University
Rob Nash, Stanford University
Corey Nislow, University of British Columbia, Canada
Mark Rose, Princeton University
Frank Rosenzweig, University of Montana
Pamela Silver, Harvard Medical School
Ken Wolfe, Trinity College Dublin, UK

Applications are especially welcome from:
• Professors and instructors who wish to incorporate yeast into their undergraduate genetics classrooms
• Scientists trained in mathematical, computational, and/or engineering disciplines who are transitioning into bench science
• Researchers from small labs or institutions where it would otherwise be difficult to learn the fundamentals of yeast genetics/genomics

We anticipate this course will be supported with funds provided by National Science Foundation and the Howard Hughes Medical Institute

Cost (including board and lodging): $4,705