This online mini-course will consist of a series of morning lectures and afternoon sessions on how to engineer mouse models for a variety of biological questions. The mini-course will be two-tiered, with lecture-only participants attending only morning sessions (10 am to 1 pm EDT), and full participants attending both morning lectures and the afternoon workshops (10 am to 5 pm EDT). The morning sessions each day will include lectures by prominent mouse engineers and the afternoon workshop sessions will include small group discussion of approaches with experts, problem-solving and other trouble-shooting and nuts-and-bolts discussions. This mini-course is targeted to graduate students, postdoctoral trainees and other science professionals who are interested in using engineered mouse models in their research in areas such as stem cell biology, development, cancer, and human disease. The goal of the mini-course is to enable participants to:

• Become familiar with important online tools and databases for mouse genetics
• Compare different strategies of genetic engineering, including CRISPR
• Learn the principles of designing custom alleles
• Understand principles of germline transmission and the strategies for breeding, genotyping and phenotyping
• Know how to use and design genetic lineage tracing models 
• Learn the power and challenges of inducible transgenic systems
• Implement reporters, tags, and other modifications

2021 Lecturers:

Direna Alonso Curbelo, Memorial Sloan Kettering Cancer Center
Richard Behringer, University of Texas MD Anderson Cancer Center

Jeffrey Bush, University of California, San Francisco 

Kat Hadjantonakis, Memorial Sloan Kettering Cancer Center
Jacob Hanna, Weizmann Institute of Science

Simon Hippenmeyer, IST Austria 
Alexandra Joyner, Memorial Sloan Kettering Cancer Center

Mark Lewandoski, National Cancer Institute/NIH
Stephen Murray, The Jackson Laboratory

Jan Parker-Thornburg, MD Anderson Cancer Center
Janet Rossant, The Hospital for Sick Children

Thom Saunders, University of Michigan
Magdalena Zernicka-Goetz, University of Cambridge

Support & Stipends

• Major support for this course is provided by the National Cancer Institute.
• This course is supported in part by grants from Helmsley Charitable Trust and Howard Hughes Medical Institute through the Science Education Program.
• Scholarship support provided by Regeneron Pharmaceuticals.

Stipends are available to offset tuition costs as follows:

• US applicants (National Cancer Institute).
• Interdisciplinary Fellowships (transitioning from outside biology) & Scholarships (transitioning from other biological disciplines) (Helmsley Charitable Trust).
• International applicants (Howard Hughes Medical Institute).

        

Please indicate your eligibility for funding in your stipend request submitted when you apply to the course. Stipend requests do not affect selection decisions made by the instructors. 

Participation Levels & Pricing:

Full Participant (selective)               

Academic rate $500
Graduate student rate  $350
Corporate rate $850

Full participants will be selected from the pool of applicants by the instructors on the basis of CSHL's standard selection criteria for courses (see Information tab). Full participants will have access to the online lectures during the AM sessions and extended nuts-and-bolts discussion with the experts in the PM sessions. Applicants must apply above and provide 1) a ~250 word statement of research interest, and 2) a 1-2 page Curriculum Vitae. Applicants may also submit a financial aid request when applying. No fees are due until you have completed the full application process and are accepted into the course.

Before applying, ensure you have:

1. ~250 word Research statement (REQUIRED)
2. 1-2 page Curriculum vitae/resume (REQUIRED)
3. Financial aid request (optional). 
4. References NOT REQUIRED
   More details.

.