The Ubiquitin Family
April 27 - 30/May 1, 2020

You must register for the meeting in order to submit abstracts.
After registering you will be sent a web link for abstract submission by email.
You may copy and paste your abstract from Word, Google Docs, or Notepad; abstracts are limited to ~2900 characters.

Virtual Meeting program information: An preliminary PDF of the program abstract book will be sent approximately 5 days prior to the first day of the meeting.  The final, hyperlinked abstract book will be available for download on the first morning of the meeting.

**Please check your email for the length of your talk, poster instructions, links to the webinar, and how to prepare and submit your poster PDF for the virtual poster session. 

Abstract Status

Presenting Author

Abstract Title

Talk/Poster

Adams, Michael

Structural insights into Legionella effector ubiquitin ligase SdeA and its antitoxin SidJ

poster

Agrata, Rashmi

Ubiquitin deamidation by Burkholderia pseudomallei inactivates enzyme~Ub complexes to hijack host cells

poster

Aminu, Bayonle A

Targeted protein degradation using ubiquitin variant induced proximity

poster

An, Hyunjung

Cell cycle-dependent E2F function is engaged to FBXO1-mediated stability regulation via ubiquitin/proteasome degradation pathway

poster

Andersen, Josh L

A novel UBA-centric mechanism of regulation for the non-receptor tyrosine kinase TNK1

poster

Ansari, Mohammad Y

Parkin loss and impaired autophagy promotes mitochondrial dysfunction in osteoarthritis

poster

Babik, Sandor

Interrogating the interactions of K48 linked ubiquitin chains with UCH37 by NMR spectroscopy and molecular modelling

poster

Baker, Heather

Identify key cytosolic QC E3(s) involved in triaging misfolded proteins for degradation

poster

Barroso-Gomila, Orhi

Identification of proximal SUMO-dependent interactors using SUMO-ID

poster

Beck, David B

Somatic mutations in UBA1 cause VEXAS syndrome, an adult-onset severe inflammatory disease with myeloid dysplasia, through loss of cytoplasmic ubiquitylation

talk

Behrends, Christian

Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling

talk

Bhogaraju, Sagar

Structural basis for the inhibition of pathogenic serine ubiquitination by the Legionella meta-effector SidJ

poster

Bianchi, Marzia

Ubiquitin expression and effects of downregulation of ubiquitin levels in primary and metastatic gastric cancer cells

poster

Bolten, Marcel

Investigating the built-in thermal switch of the Rsp5 E3 ubiquitin ligase

poster

Bortolotti, Francesca

Cardioprotective factors selected in vivo from an AAV secretome library

poster

Bradner, James

Molecular glues for intractable targets

talk

Buel, Gwen

Structure of E3 ligase E6AP with a proteasome binding site provided by substrate receptor hRpn10

talk

Carbonneau, Seth

An IMiD-inducible degron provides reversible regulation for chimeric antigen receptor expression and activity

poster

Carosi, Julian M

Retromer regulates the lysosomal clearance of MAPT/tau

poster

Chaikovsky, Andrea C

The AMBRA1 E3 ligase adaptor regulates cyclin D protein stability

talk

Chang, Chunmei

Reconstitution of cargo-induced LC3 lipidation in mammalian selective autophagy

talk

Chatrin, Chatrin

Structural insights into ADP-ribosylation of ubiquitin C-terminus by Deltex E3 ligases

talk

Chica, Nathalia

Genome-wide mapping of the autophagy dynamics control network

poster

Cho, Yong-Yeon

STAT2 destabilization by FBXW7 suppresses melanoma proliferation

poster

Coates, Hudson W

The mammalian cholesterol synthesis enzyme squalene monooxygenase is proteasomally truncated to a constitutively active form

poster

Cohen, Shenhav

Mechanistic insights into Atad1―An AAA-ATPase complex required for protein degradation in atrophying muscles

talk

Collins, Mahlon A

Genetic mapping of ubiquitin-proteasome system activity in large yeast populations

poster

Cotton, Thomas

Structural basis for K63-ubiquitin chain formation by the Gordon-Holmes syndrome E3 ligase RNF216

poster

Coulson, Judy M

S18-phosphorylation of USP7 regulates interaction with TCEAL4 that defines specific complexes and potentially distinct USP7 functions

poster

Coyne, Erin

Non-catalytic role of USP19 in the regulation of glucocorticoid receptor protein stability

poster

Crews, Craig

PROTACs and targeted protein degradation―The first two decades

talk

Damgaard, Rune B

The Met1-linked ubiquitin-specific DUB OTULIN protects the liver against cell death, inflammation, fibrosis, and cancer

talk

Das, Aniruddha

UFD-2 modulates the E4 activity of the chaperone-assisted E3 ligase CHN-1/CHIP to regulate organismal proteostasis and lipid metabolism

poster

Das, Arupratan

Glaucomatous optineurin-E50K mutation causes human retinal ganglion cell death by causing mitophagy defects

poster

Das, Chitta

Atypical ubiquitination catalyzed by a bacterial effector and its regulation

talk

Dasgupta, Anirban

Substrate recognition activates dimeric UBR7-PHD finger for unique mode of ubiquitin transfer

poster

Date, Swapneeta

COPI coatomer recognizes ubiquitin signals and facilitates proper localization of SNARE proteins

poster

Deckert, Annika

Identification and validation of human proteins that control tau seeding

poster

Diefenbacher, Markus E

Inhibition of USP28 overcomes cisplatin-resistance of squamous tumors by suppression of the Fanconi anemia pathway

poster

DiFraia, Domenico

Spatial and solubility characterization of the aging brain proteome in a short-lived vertebrate

poster

Donato, Alessandra

Discovery of a novel neuroprotective molecule and beneficial effects of proteasome inhibition during oxidative stress

poster

dos Santos Passos, Carolina

Genetically-encoded sensors to detect nucleosome ubiquitination in live cells

talk

Du, Jiale

A cryptic site on the proteasome-associated deubiquitinase UCH37/UCHL5 is required for chain editing and degradation

talk

Dunkerley, Karen

Phosphorylated ubiquitin targets substrate ubiquitination―Phosphorylated parkin directs auto-ubiquitination

talk

Edmunds, Lia R

Acetylation of outer mitochondrial membrane ubiquitin inhibits PARKIN-mediated mitophagic signaling.

poster

Edskes, Herman

Innate immunity to yeast prions―Proteasome control of [URE3] prion propagation by degradation of anti-prion proteins Cur1 and Btn2 in Saccharomyces cerevisiae

poster

Egbert, Christina M

The ubiquitin-binding non-receptor tyrosine kinase TNK1 is regulated by a MARK-mediated interaction with 14-3-3

poster

Ehrlich, Elana

Comparative proteomics in KSHV―The RTA dependent ubiquitome

poster

Eichhorn, Pieter

c-Met activation leads to the establishment of a TGFβ regulatory network required for bladder cancer invasion

poster

Eisenberg-Lerner, Avital

The E3 ligase ASB6 regulates T cell activity to balance effector and suppressor functions

poster

Enenkel, Cordula

Nuclear export of proteasomes in yeast

poster

Fischer, Eric S

Multivalent interactions in ubiquitin ligase targeting and regulation

talk

Flagg, Matthew P

Structure-misfunction analysis―A genetic path to still-functional quality control substrates

talk

Franklin, Tyler G

Deciphering ubiquitin signaling in pathogen-derived E3 ubiquitin ligases

poster

Garshott, Danielle M

Deciphering the ribosome-ubiquitin code―Regulatory ubiquitylation acts to alter ribosome abundance upon collisions during translation initiation

talk

Genschik, Pascal

The Arabidopsis F-box protein FBW2 degrades AGO1 to avoid spurious loading of illegitimate small RNA

poster

Gestwicki, Jason

Driving protein degradation by protein-protein interactions at termini

talk

Goldberg, A.L.

Raising cyclic GMP activates 26S proteasomes, ubiquitination, and protein degradation and has therapeutic effects in zebrafish and mouse models of neurodegenerative diseases

talk

Hanna, John

Structures of chaperone-containing assembly intermediates reveal coordinated mechanisms of proteasome biogenesis

talk

Harding, Olivia

ALS-linked mutations in TBK1 differentially disrupt Parkin-dependent mitophagy

talk

Harper, Wade

Mechanisms of selective organellophagy

talk

Hartmann, Oliver

Targeting protein stability in lung cancer―Uncovering the ubiquitin system for therapy

poster

Hertel, Alexandra

USP32 regulates non-proteolytic LAMTOR1 ubiquitination and Ragulator function

talk

Hoppe, Thorsten

Posttranscriptional regulation of endoplasmic reticulum proteostasis by ER-associated RNA silencing (ERAS)

talk

Huibregtse, Jon

The mechanism and function of extracellular signaling by ISG15

talk

Hung, Ka Ying Sharon

A bidirectional switch coordinates allosteric control of UBP6 and the proteasome

talk

Hunkeler, Moritz

Cryo-EM structure of HUWE1 reveals functional organization of large HECT ligase

poster

Hur, Sun

Invited talk

talk

Iljina, Marija

Entropic inhibition―How the activity of a AAA+ machine is modulated by its substrate-binding domain

poster

Ivanov, Dmitri

How proximity of three RING domains mediates autoubiquitination of the TRIM5α retroviral restriction factor

poster

Ivanova, Saska

TP53INP2 protein modulates autophagy and apoptosis through autophagy receptors and ubiquitination

poster

Jha, Sweta

Cross-talk between UPS and autophagy in C. elegans

poster

Joazeiro, Claudio

Mammalian ribosome-associated quality control

talk

Julian, Ryan

Spontaneous isomerization of Tau as an indicator of autophagic flux in Alzheimer’s disease

poster

Kang, Yuanrong

The role of co-opted ATG11 autophagy scaffold protein in RNA virus replication

poster

Kapadia, Akshay

Site-specific phosphorylation affects intracellular trafficking, clearance and proteotoxicity of the Alzheimer’s disease associated Amyloid-beta peptide

poster

Kochenova, Olga V

The p97Ufd1-Npl4 complex cooperates with Ubxn7 and Faf1 to disassemble vertebrate replisomes

talk

Kong, Jennifer

Defects in a membrane-tethered ubiquitination pathway cause a wide spectrum of birth defects

talk

Kotter, Sebastian

Cardiac titin ubiquitination and degradation by autophagy and the ubiquitin-proteasome-system

poster

Kozicka, Zuzanna

CR8 is a molecular glue degrader that depletes cyclin K

talk

Kraut, Daniel A

Proteasomal conformation controls unfolding ability

poster

Kulagin, Kirill

Mutations found in the butanol-resistant strains decrease the activity of the yeast proteasome master-regulator Rpn4

poster

Langlois, Christine R

DIA-based systems biology approach unveils E3-ligase dependent responses to a metabolic shift

poster

Lechauve, Christophe

miR-451 function on ULK1-mediated autophagy of free α-globin in β-thalassemia

poster

Lechtenberg, Bernhard C

Molecular characterisation of RNF216 reveals novel insights into RBR E3 ligase mechanism and regulation

talk

Lee, Ga-Eun

Regulation of RIP3 phosphorylation levels may potentiate to regulate cancer cell proliferation and necroptosis

poster

Lee, Min Jae

How are ubiquitin, proteasome, and autophagy intertwined?―A case of aggrephagy and proteaphagy

poster

Lee, Shun-Hsiao

Study on the ubiquitin switch of transcription-coupled DNA repair

poster

Li, Yi

SPSB1 plays a role in inflammation-induced muscle atrophy by targeting TβRII

poster

Li, Ying

NMR studies on the functional dynamics of deubiquitinase A

poster

Lima, Christopher

Architectures and activities of Ub/Ubl ligase and receptor complexes

talk

Liu, Qi

Development of inhibitors for human deubiquitinases

poster

Liu, Xing

Role of NEDD8 in ubiquitinating CRL substrates with distinct sizes

poster

Loix, Melanie

Disturbed lipophagy skews foamy macrophages towards a disease-promoting phenotype in multiple sclerosis

poster

Lu, Xiuxiu

An extended conformation for K48-linked ubiquitin chains revealed by the ternary hRpn2:Rpn13:K48-diubiquitin structure

poster

Maculins, Timurs

Multiplexed proteomics of autophagy deficient macrophages reveals enhanced antimicrobial immunity via the oxidative stress response

poster

Mahan, Sarah

Monitoring real-time dynamics, mechanism, and phenotype of targeted protein degradation compounds

poster

Maier, Carina

A novel DUB controls the SREBP2–cholesterol biosynthesis pathway in squamous cell carcinoma

poster

Manford, Andrew G

Structural basis and regulation of the reductive stress response

talk

Mariappan, Malaiyalam

USP20/33 deubiquitinate nascent tail-anchored membrane proteins at the ER

talk

Marino, Antonio

Landscape of protein post-translational modifications in the aging brain―Dysregulation, cross-talk and site competition

poster

Marotta, Valeria E

OTUD6B regulates KIFC1-dependent centrosome clustering and breast cancer cell survival

poster

Marshall, Richard S

Autophagic degradation of 26S proteasomes is controlled by multiple ubiquitylation and aggregation events

talk

Martin, Andreas

Ubiquitin binding modulates the conformational dynamics and substrate degradation of the 26S proteasome

talk

Maspero, Elena

Small-molecule NEDD4 inhibitors for prostate cancer treatment

talk

McEwan, Colten M

Quantitative D2O proteomics reveals a mechanistic link between ATG9A and p62/SQSTM1 in basal autophagy

poster

Medina, Gisselle N

Impairment of the deISGylation activity of foot-and-mouth disease virus Lpro causes attenuation in vitro and in vivo

poster

Meinander, Annika

drICE restrains DIAP2-mediated inflammatory signalling and intestinal inflammation

poster

Merbl, Yifat O

Proteasome profiling―Global view of degradation in cancer

talk

Metcalf, Melissa

XBP-1s and TFEB: a new link between the UPRER and autophagy

poster

Metzger, Meredith

The degradation of misfolded mitochondrial proteins requires the ubiquitin-proteasome system and mitochondrial proteases

talk

Meyn, Vanessa

The deubiquitinating enzymes USP1 regulate endothelial barrier function by RhoB regulation

poster

Mohamed, Weaam

The human GID complex engages two independent modules for substrate recruitment

poster

Monda, Julie

Targeting the leftovers―Integrative characterization of orphan protein degradation

poster

Mu, Tingwei

Cytosolic Hsp90β acts downstream of Grp94 in the endoplasmic reticulum to promote endoplasmic reticulum-associated degradation of GABAA receptors

poster

Mucha, Bartosz

Regulation of pro-tumorigenic hnRNPK function by K63 polyubiquitylation

poster

Mukherjee, Rukmini

Phosphoribose linked serine ubiquitination regulates autophagosome–lysosome fusion

talk

Muli, Christine S

Binding site discovery of a peptidomimetic probe on proteasome ubiquitin receptor, Rpn-13

poster

Nadel, Cory

Intersecting post-translational modifications regulate pathogenic tau clearance by the CHIP ubiquitin ligase

poster

Negi, Hitendra

Understanding the destabilized core of viral ubiquitin

poster

Niederkorn, Madeline R

The deubiquitinase USP15 modulates cellular redox and is a therapeutic target in acute myeloid leukemia

poster

Norberg, Erik

The deubiquitinase JOSD2 is a positive regulator of glucose metabolism

poster

Ohtake, Fumiaki

TRIP12 promotes PROTAC–induced degradation through K29/K48 branched ubiquitin chains

talk

Ordureau, Alban

Quantitative proteomics reveals an induced housekeeping mitophagy program upon neuronal differentiation

talk

Ori, Alessandro

ProteasomeID―in situ identification of proteasome interactions by proximity-dependent biotinylation

talk

Osei Amponsa, Vasty

Contribution of hRpn13 or UCHL5 to clearance of ubiquitinated proteins and RA190 cytotoxicity

poster

Otten, Gisela

How cells ubiquitylate cytosol-invading bacteria

talk

Pahor, Nikolett

Deubiquitination in lung cancer - Focusing on the role of Ubiquitin-specific protease 10 (USP10)

poster

Pan, Man

Mechanistic insight into substrate processing and allosteric inhibition of human p97

poster

Passmore, Lori A

Insights into monoubiquitination by the FA core complex in DNA crosslink repair

talk

Perera, Rushika

New functions for autophagy in promoting immune evasion in pancreatic cancer

talk

Perez, Jessica M

ISG15 proteomics reveals differences in lysine selectivity of the human Herc5 and mouse Herc6 ISG15 ligases

poster

Pinch, Benika

A strategy to assess the cellular activity of E3 ligases against neo-substrates using electrophilic probes

poster

Pinto-Fernandez, Adan

Deletion of the deISGylating enzyme USP18 enhances tumour cell antigenicity and radiosensitivity

poster

Podieh, Fabienne

Ubiquitination stabilizes dynamic endothelial cell-cell contacts

poster

Polo, Simona

Hecw controls oogenesis and neuronal homeostasis by promoting the liquid state of ribonucleoprotein particles

talk

Poole, Daniel

The regulation of ATG9A-mediated autophagy by an ULK1-independent ATG13 complex

poster

Potts, Ryan

Structural basis for substrate recognition and chemical inhibition of oncogenic MAGE ubiquitin ligases

talk

Pruneda, Jonathan

Discovery and characterization of novel ubiquitin-targeted effector proteins in pathogenic bacteria

talk

Raman, Malavika M

The p97-UBXD8 complex regulates lipid metabolism at ER-mitochondria contact sites

talk

Reissland, Michaela

Novel deubiquitylases regulating β-catenin stability in colorectal cancer

poster

Rizvi, Zeba

Plasmodium cullins undergo neddylation and cullin1 forms an E3 ubiquitin ligase

poster

Roach, Tiffany G

Molecular mechanism for the regulation of ubiquitin-binding adaptor proteins

poster

Ruggiano, Annamaria

Dynamics of post-translational modifications during repair of DNA-protein crosslinks by the protease SPRTN

talk

Schepers, Jana

Atg11 and Atg17 as potential players in LD dynamics and α-synuclein sensitivity in S. cerevisiae

poster

Schulman, Brenda A

E3 ubiquitin ligase mechanisms

talk

Seylani, Allen

GCN5L1 Interacts with WHAMM and KIF5B To regulate autolysosome tubulation

poster

Sheban, Daoud

SUMO-dependent regulation of the chromatin landscape in naïve pluripotency

poster

Shmueli, Merav D

PSME4 abrogates anti-tumor immunity and promotes resistance to immunotherapy in NSCLC

poster

Simonsen, Anne

Regulation of PRKN-independent mitophagy by lipid-binding kinases

talk

Singh Gautam, Amit Kumar

Decoding the degradation initiation by the proteasome

poster

Slabicki, Mikolaj E

Small molecule-induced polymerization triggers degradation of BCL6

talk

Smith, Christopher

The UBE2G2 binding region is the only domain of ancient ubiquitous protein 1 (AUP1) indispensable for ER-associated protein degradation

poster

Sohn, Eun Jung

MicroRNA expression by regulating autophagy in Schwann cells.

poster

Stanga, Daniela

CRISPR gene-engineered CYBBkoTHP-1 cells highlight the crucial role of NADPH-induced reactive oxygen species in regulating inflammasome activation through autophagy and autophagy-related processes

poster

Stier, Anna

Phosphorylation of the E3 ubiquitin ligase CUL4B regulates actin cytoskeletal dynamics during mitosis

poster

Stolz, Alexandra

Critical functions of FAM134 family members in endoplasmic reticulum remodeling, ER-phagy and collagen quality control

talk

Sulkshane, Prasad

Dual role of the ubiquitin-proteasome system in mitochondrial homeostasis―A caregiver and an undertaker

poster

Swaim, Caleb

Small molecule inhibitors of SARS-CoV-2 PLpro block de-ISGylation, ISG15 secretion and signaling, and viral replication

poster

Tan, Ee Phie

An autophagy activator extends healthspan and lifespan in C. elegans

talk

Thery, Fabien

Ring finger protein 213 assembles into a sensor for ISGylated proteins with antimicrobial activity

poster

Thys, An

Serine 165 phosphorylation of SHARPIN regulates the activation of NF-κB

poster

Tian, Yuan

The role of COP9 signalosome subunit 5 in neuroinflammation

poster

Tokheim, Collin

Genetic fusions favor tumorigenesis through degron loss in oncogenes

talk

Tolay, Nazife

Comparative profiling of stress granule clearance reveals differential contributions of the ubiquitin system

poster

Tong, Yufeng

The mechanism of linkage-specific substrate recognition by ubiquitin-specific protease, 9X (USP9X)

poster

Trost, Matthias

The E3 ubiquitin ligase RNF115 regulates phagosome maturation and host response to bacterial infection

poster

Ulman, Adi

Altered protein abundance and localization inferred from sites of alternative modification by ubiquitin and SUMO

poster

van Wijk, Sjoerd

USP22 controls necroptosis by regulating receptor-interacting protein kinase 3 (RIPK3) ubiquitination

talk

Vervoorts, Jorg

AMPK-dependent activation of the Cyclin Y/CDK16 complex controls autophagy

poster

Wang, Meng

ATF6 activation restores function of epilepsy-associated GABAA receptors

poster

Watanabe, Masashi

A substrate-trapping strategy to find E3 ubiquitin ligase substrates

poster

Werner, Achim

A novel CRL3-regulated neurodevelopmental signaling axis revealed by human disease mutation screening

talk

Wertz, Ingrid E

Characterizing deubiquitinase inhibitors to maximize therapeutic benefit

talk

West, Christopher M

Skp1 modifications control the profile of F-box protein subcomplexes in the human pathogen Toxoplasma gondii

poster

Whittsette, Angela

EMC promotes the forward trafficking of neuroreceptors

poster

Wiener, Reuven

From E1 to E2―Deciphering the mechanism of UFM1 conjugation

talk

Wilfling, Florian

Intrinsic autophagy receptors―A way to dispose of macromolecular machines

talk

Witus, Sam R

BRCA1/BARD1 site-specific ubiquitylation of nucleosomal H2A is directed by BARD1

talk

Wohlever, Matthew L

Mechanistic studies of mitochondrial membrane proteostasis

poster

Wolf, Elmar

Targeting the oncogenic function of MYC with bi-functional degrader molecules

talk

Wolf, Lucie M

Gone with the WNT---WNT dependent ubiquitination and endoplasmic reticulum associated degradation (ERAD) of EVI/WLS

poster

Wrobel, Lidia

VCP/p97 regulates autophagy initiation

poster

Yu, Yuanyuan

K29-linked ubiquitin signaling regulates stress response and cell cycle

poster

Zhang, Wubing

Protein intrinsic features predict the tractability of targeted protein degradation

poster

Zhang, Xiaohong (Mary)

HDAC6 regulates radiosensitivity of non-small cell lung cancer by promoting degradation of Chk1

poster

Zhang, Xiaoyu

Discovery of small molecule-mediated protein degradation pathways

poster

Zhao, Minglei

Structural insights into the priming and elongation of ubiquitination by Ubr1

talk

Zheng, Qingyun

Seesaw conformations of Npl4 in the human p97 complex and the inhibitory mechanism of a disulfiram derivative

poster

Zivkovic, Dusan

Structural and functional study of the proteasome complexes in spermatogenesis using modern mass spectrometry approaches

poster

Zuidema, Dalen M

Quantitative proteomic investigation of post-fertilization sperm mitophagy in novel cell free system

poster