|
Presenting Author |
Abstract Title |
Presentation |
|
Ahel, Ivan |
Molecular mechanisms underlying specificity of ADP-ribosylation signalling |
talk |
|
Anagho, Holda A |
Characterizing ADP-ribosylation in breast cancer cell lines after DNA damage stimulation using mass spectrometry |
poster |
|
Ahmed, Zamal |
Loss of nuclear GRB2 signaling is synthetically lethal with PARP inhibitor |
poster |
|
Bai, Peter |
Applicability of clinically available PARP inhibitors in COVID-19 disease |
virtual poster |
|
Bai, Peter |
PARP2 poly(ADP-ribosyl)ates nuclear factor erythroid 2-related factor 2 (NRF2) affecting nuclear translocation |
virtual poster |
|
Bejan, Daniel |
Rational design and characterization of a PARP16 probe |
poster |
|
Bell, Nicholas A |
Single molecule studies of DNA binding by PARP1 and PARP2 reveal real-time DNA condensation and double-strand break bridging dynamics |
talk |
|
Belotserkovskaya, Rimma |
Overcoming resistance of BRCA1/53BP1-deficient cells to PARP inhibition |
talk |
|
Beneyton, Adele |
Roles of DYNLL1 in double-strand break repair and synthetic lethality in BRCA1-deficient breast and ovarian cancers |
virtual poster |
|
Brady, Rosie M |
Fork protection complex factor Timeless integrates PAR dynamics to regulate replication fork speed |
poster |
|
Buch-Larsen, Sara C |
A first draft of the tissue-specific mouse ADP-ribosylome |
poster |
|
Carter-O'Connell, Ian O |
TLC-MALDI-TOF as a platform for identifying novel, site-specific, peptide-based poly (ADP-ribose) polymerase inhibitors |
talk |
|
Challa, Sridevi |
Development and characterization of PAR-trackers—New tools for detecting poly(ADP-ribose) |
poster |
|
Cheng, Shang-Jung |
PAR-binding ability of PARP13 is critical for the proper assembly of stress granules |
virtual poster |
|
Cleveland, Don W. |
Scrambling the genome in cancer—Chromothripsis and extrachromosomal DNA |
talk |
|
Cohen-Armon, Malka |
The notion of 'PARP1-inhibition halting cancer by halting DNA repair' is revisited |
virtual poster |
|
Coulson-Gilmer, Camilla L |
Nucleoside supplementation rescues PARG inhibitor sensitivity in ovarian cancer models |
talk |
|
Dantzer, Francoise |
Towards specific functions of PARP3 in differentiation events |
talk |
|
Dawson, Valina |
Neurotoxic actions of poly(ADP-ribose) |
talk |
|
Deng, Ou |
Integrative functional proteomics reveals PARPi response markers in ovarian carcinoma |
talk |
|
Dhahri, Hejer |
PARP1 regulates RNA polymerase II elongation |
poster |
|
Diehl, Katharine |
New insights into the regulation of SIRT6 and its interplay with PARP1 |
talk |
|
Edwards, Andrea |
Exploring oncohistone mutations at functional sites of ADP-ribosylation in breast cancers |
talk |
|
Eleazer, Rebekah |
PARP1 regulates circRNA biogenesis though control of transcriptional dynamics |
talk |
|
Elsborg, Jonas |
Investing the functional role of PARP1 serine auto-modification in a DNA repair context |
poster |
|
Fehr, Anthony R |
Deletion of PARP12 rescues macrodomain mutant murine hepatitis virus replication in primary macrophages and the livers of infected mice but does not rescue MHV replication or virulence following brain infection |
talk |
|
Feijs, Karla LH |
Detecting mono(ADP-ribosyl)ation in mammalian cells |
poster |
|
Filippov, Dmitri |
Chemical ADP-ribosylation of arginine or histidine |
talk |
|
Fondufe-Mittendorf, Yvonne N |
The role of PARP1 in RNA biogenesis |
talk |
|
Fouquerel, Elise |
PARP1 binds to and is activated by R-loops |
talk |
|
Frigon, Leonie |
Structural and functional analysis of the human PARP4 catalytic domain |
poster |
|
Galera Prat, Albert |
Protein engineering approach to enhance activity assays of mono-ADP-ribosyltransferases through proximity |
virtual poster |
|
Gonzalez Leal, Claudia P |
PARP1 activity mediates recruitment of the m6A methyltransferase METTL3 upon UV damage |
poster |
|
Gupta, Dipika |
A single molecule imaging approach to uncovering molecular determinants underlying PARPi sensitivity |
poster |
|
Gupte, Rebecca |
PARP1 modulates macrophage function during diet-induced obesity |
talk |
|
Hananya, Nir |
Synthesis of ADP-ribosylated histones reveals site-specific impacts on chromatin structure and function |
talk |
|
Hendriks, Ivo A |
Development of improved mass spectrometry methodology for the site-specific study of ADP-ribosylation |
poster |
|
Hoch, Nicolas C |
IFN-induced, SARS-CoV-2 macrodomain-sensitive ADP-ribosylation requires cooperation between PARP14 and the PARP9/DTX3L complex |
talk |
|
Hottiger, Michael |
The mitochondrial NAD transporter SLC25A51 regulates NAD+ compartmentalization and cellular ADP-ribosylation |
talk |
|
Illuzzi, Giuditta |
In vitro cellular profiling of AZD5305, novel PARP1-selective inhibitor and trapper |
talk |
|
Jones, Aarin |
NAD+-dependent, PARP1-mediated U2AF ADP-ribosylation in embryonic stem cells |
talk |
|
Kasprzyk, Renata |
Cell-permeable nucleotide tools for exploration of protein ADP-ribosylation pathways |
poster |
|
Kim, In-Kwon |
Mechanism of the metal and substrate selectivity of human ARH3 |
poster |
|
Kliza, Katarzyna W. |
An interaction landscape of ADP-ribosylation signaling |
talk |
|
Kordon, Magda |
Detection of DNA damage using STRIDE as a new PD biomarker in liquid biopsies and FFPE tissue sections |
poster |
|
Krastev, Dragomir B |
The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin |
talk |
|
Kraus, W. Lee |
The role of PARPs, NAD+, and site-specific ADP-ribosylation in the control of complex biological processes |
talk |
|
Kwon, Minjung |
Regulatory roles of transcription factor ADP-ribosylation in breast cancer biology |
poster |
|
Langelier, Marie-France |
HPF1 dynamically controls the PARP1/2 balance between initiating and elongating ADP-ribose modifications |
poster |
|
Laspata, Natalie |
PARP1 binds to and is activated by R-loops |
poster |
|
Lavrik, Olga |
Regulation of PARP1/2 activities by HPF1 and other PARP’s partner proteins |
virtual poster |
|
Lehtio, Lari |
Small molecule inhibitors for human mono-ADP-ribosyltransferases with nanomolar potencies |
talk |
|
Leung, Anthony |
Poly(ADP-ribose)—A trigger and target for biomolecular condensate regulation |
talk |
|
Liu, Zhiyan Silvia |
Therapeutic targeting of spliceosome mutant leukemias through PARP inhibition |
poster |
|
Lopez-Mosqueda, Jaime |
Poly-ADP-ribosylation modifies DNA-protein crosslinks to signal for SPRTN-dependent degradation |
talk |
|
Luger, Karolin |
Still surprising after all these years—Chromatin binding and activation of PARP1 |
talk |
|
Mahadevan, Jyothi |
A spatiotemporal atlas of endogenous PARP1 and PARP2 using live cell single molecule microscopy |
virtual poster |
|
Maiuri, Tamara |
Opposing effects of wild-type and mutant huntingtin protein on PARP1 activity are associated with dysregulated PAR signaling in Huntington’s disease patients |
poster |
|
Maksimainen, Mirko |
Small molecule inhibitors for human mono-ADP-ribosyltransferases with nanomolar potencies |
virtual poster |
|
Matthews, Jason B |
Loss of PARP7 prevents mammary tumor growth in Parp7H532A catalytic mutant mice |
talk |
|
Melikishvili, Manana |
Functional characterization of PARP1—Nucleic acid interactions |
poster |
|
Mohapatra, Jugal |
Serine ADP-ribosylation marks nucleosomes for ALC1-dependent chromatin remodeling |
poster |
|
Muoio, Daniela |
PARP1 and PARP2 cooperation in the prevention of oxidative stress-mediated telomere crisis |
talk |
|
Nguyen, Dang H |
Therapeutic targeting of spliceosome mutant leukemias through PARP inhibition |
talk |
|
Nielsen, Michael L |
Characterizing ADP-ribosylation dynamics using quantitative mass spectrometry |
talk |
|
Pascal, John M |
Structural biology of PARP family proteins |
talk |
|
Pillay, Nisha |
Structural basis for tankyrase activation by polymerisation |
talk |
|
Poirier, Guy G. |
Characterization of PARP-1 automodification using UVPD and EThcD |
talk |
|
Prosz, Aurel |
Detection of molecular signatures of homologous recombination deficiency in upper gastrointestinal cancer |
virtual poster |
|
Quenet, Delphine |
Investigating PARP protein function on the maintenance of centromere structure and function |
poster |
|
Richards, Frederick J |
Regulation of Rad52-dependent replication fork recovery through site-specific ADP-ribosylation of PolD3 |
talk |
|
Rieth, Sonja |
Identifying direct protein targets of distinct ARTD-members in living cells |
poster |
|
Rodriguez Morales, Abigail |
DNA-PKcs kinase activity regulates transcriptional networks in activated macrophages |
poster |
|
Rothenberg, Eli |
Single-molecule visualization of replication forks response to PARPi |
talk |
|
Rouleau-Turcotte, Elise |
Captured snapshots of PARP1 in the active state reveal the mechanics of PARP1 allostery |
talk |
|
Rudolph, Johannes |
Inhibitors of PARP—Number crunching and structure gazing |
virtual poster |
|
Russo, Lilian |
The SARS-CoV-2 Nsp3 macrodomain reverses PARP9/DTX3L-dependent ADP-ribosylation induced by interferon signaling |
virtual poster |
|
Sanderson, Daniel J |
Structure-based design of a potent and selective inhibitor of PARP7 |
talk |
|
Scheidereit, Claus |
TSG101 associates with PARP1 and is essential for PARylation and PAR-dependent DNA damage-induced NF-κB activation |
talk |
|
Schuller, Marion |
Molecular basis and cellular consequences of DNA base ADP-ribosylation by the bacterial toxin DarT |
talk |
|
Silvers, Clarissa |
Using TLC-MALDI-TOF and tandem mass spectrometry to decode proximal substrate recognition in the PARP family |
poster |
|
Singh, Sasha A |
The RiboMaP mass spectral annotation method identifies sources of variability in ADPr ribosylation proteomics data |
virtual poster |
|
Slade, Dea |
PHF3 ADP-ribosylation fine tunes gene expression |
talk |
|
Smith, Susan |
Mechanism of tankyrase-mediated resolution of telomere cohesion |
talk |
|
Song, Moon Jung |
EBV viral processivity factor, EA-D facilitates virus lytic replication by inducing degradation of poly (ADP-ribose) polymerase 1 |
virtual poster |
|
Stokes, MiKayla |
Exploring the role of PARP7 in adipogenesis |
talk |
|
Sukhanova, Mariya V |
DNA repair proteins and poly(ADP-ribose) chain structure influence the liquid-liquid phase separation of Fused in Sarcoma (FUS) in vitro |
virtual poster |
|
Tashiro, Kyuto |
Chemoenzymatic synthesis of Asp, Arg, Cys, Glu, Ser, and Tyr- ADPr peptides |
talk |
|
Tsai, Hsin-Yu |
Role of the ADP-ribosylhydrolase activity of SARS-CoV-2 Nsp3 macrodomain 1 in regulating protein translation |
poster |
|
Vela-Rodriguez, Carlos |
Reconstitution of the DTX3L-PARP9 complex reveals determinants for high affinity heterodimerization and multimeric assembly |
virtual poster |
|
Wang, Yingfei |
PARP-1 and its associated nuclease in DNA replication and cancer growth |
virtual poster |
|
Weerasekara, Vajira |
LKB1 links NAD+ availability with mitochondrial function and PARP activity |
poster |
|
Whitaker, Amy |
Exploring the role of PARP-1-mediated ADP-ribosylation in diet-induced obesity |
poster |
|
Xue, Huijun |
A two-step mechanism governing PARP1-DNA retention by PARP-1 inhibitors |
virtual poster |
|
Yelamos, Jose |
Understanding the specific functions of PARP-1 and PARP-2 in c-Myc-driven tumors |
virtual poster |
|
Yu, Yonghao |
The catalytic and scaffolding functions of PARP1 |
talk |
|
Zambidis, Elias |
Far beyond just a WNT inhibitor: XAV939 globally reprograms the proteome of human naïve stem cells |
talk |
|
Zha, Shan |
PARP inhibitors traps PARP2 at nicks and catalytically inactive PARP2 leads to lethal anemia in mice by selectively interfering with DNA replication |
talk |
|
Zhang, Zhengrui |
A unique macrodomain ADP-ribosyl glycohydrolase in Legionella pneumophila |
talk |
|
Zheng, Minyan |
PARP14 hydrolyses NAD+ during TLR-induced inflammation and aging |
poster |