|
Presenting Author |
Abstract Title |
Talk/Poster |
|
Adriaenssens, Elias |
BAG3 Pro209 mutants associated with myopathy and neuropathy relocate chaperones of the CASA-complex to aggresomes |
poster |
|
Ahlstedt, Brittany |
Investigating the role of p97-UBXN1 in regulation of the unfolded protein response |
poster |
|
Alao, John-Paul |
Investigation of the mechanistic details of the Hsp90Ec molecular chaperone protein remodeling mechanism |
poster |
|
Albert-Gasco, Hector |
Investigating changes in the translatome resulting from UPR modification in neurodegenerative diseases |
poster |
|
Alberti, Simon |
Phase separation of Ded1 promotes an adaptive translational switch from housekeeping to stress protein production |
talk |
|
Alderson, Reid |
Structural insights into the function and dysfunction of HSP27 in health and disease |
poster |
|
Ali, Asif |
Sis1 modulates Hsf1 activity by surveying the status of cellular proteostasis |
poster |
|
Almasy, Katherine M |
Selective modulation of ER proteostasis to inhibit Dengue virus propagation |
poster |
|
Amici, David R |
C16orf72 is a regulatory nexus in the global stress response network |
poster |
|
Andersson, Rebecca |
Image-based identification and analysis of the nucleolus-associated protein aggregation site in yeast |
poster |
|
Apaja, Pirjo |
Ubr1 and SQSTM1 enhance endosomal quality control against proteotoxic stressors |
poster |
|
Aragones Bargallo, Gemma |
P62-associated-autophagy as a protective mechanism against advanced glycation end products (AGEs)-derived toxicity |
poster |
|
Avezov, Edward |
Stress-induced endoplasmic reticulum-intrinsic disaggregation machinery |
poster |
|
Beatrix, Birgitta |
Cryo-EM structure of early nascent chain modifying enzymes on the ribosome |
poster |
|
Ben-Zvi, Anat |
Gonadotropin-releasing hormone receptor related 2 (gnrr-2) regulates somatic proteostasis in Caenorhabditis elegans |
poster |
|
Ben-Zvi, Anat |
HLH-1/MYOD modulates muscle proteostasis in Caenorhabditis elegans |
poster |
|
Ben-Zvi, Anat |
Mutant C. elegans mitofusin leads to selective removal of mtDNA heteroplasmic deletions across generations |
poster |
|
Bikovtseva, Agata |
Elucidation of proteostasis defects caused by osteogenesis imperfecta mutations in the collagen-α2(I) C-propeptide domain |
poster |
|
Bisbee, Heather |
Understanding the dual roles of UCH37 in proteasomal degradation and translation |
poster |
|
Blackwell, Keith |
Maintenance of protein and lipid homeostasis by the Nrf1/SKN-1a proteasome recovery response |
talk |
|
Blair, Laura J |
Chaperoning tau pathogenesis |
poster |
|
Bolon, Daniel |
Comprehensive fitness maps of Hsp90 show widespread environmental dependence |
talk |
|
Boos, Felix |
When mitochondrial proteins go astray—The mitoprotein-induced stress response connects proteostasis programs across compartments |
talk |
|
Bott, Laura |
A multi-modal biosensor for monitoring proteostasis in stress and aging |
poster |
|
Brandman, Onn |
Viscoadaptation controls intracellular reaction rates in response to heat and energy availability |
talk |
|
Brar, Karinder |
Understanding novel aspects of PERK signalling |
poster |
|
Brás, Inês |
Systematic comparison of the molecular mechanisms underlying the spreading of pathology in different neurodegenerative diseases |
poster |
|
Brechtel, Teal M |
Chaperone titration as a mechanism of amyloid appearance |
poster |
|
Bregnard, Thomas A |
Conformational exchange at a C2H2 zinc-binding site facilitates redox sensing by the PML protein |
poster |
|
Broch Trentini Schmidt, Debora |
Ribosome-associated quality control can facilitate antigen presentation of folding-efficient proteins |
poster |
|
Butcher, Adrian J |
Protein interactions in the PERK kinase insert loop can regulate eIF2α-P production in ER stress |
poster |
|
Calakos, Nicole |
Cholinergic interneurons require tonic activation of the ISR to maintain integrity of dopamine signaling |
poster |
|
Cascarina, Sean |
LCD-Composer―An intuitive, composition-centric method enabling the identification and detailed functional mapping of low-complexity domains |
poster |
|
Catic, Andre |
The intrinsically disordered proteome as a determinant of blood stem cell aging |
poster |
|
Chakraborty, Kausik |
Acute endoplasmic reticulum stress at developmental stages have a long lasting effect on proteostasis and health in C. elegans |
poster |
|
Chaplot, Kriti |
The neural chaperone proSAAS phase-separates into cytoplasmic spheres which efficiently sequester TDP43 |
talk |
|
Chatterjee, Snehajyoti |
Nascent protein folding is critical for long-term memory |
poster |
|
Chen, Jiandong |
Hypothermia induces regression of tumors with temperature-sensitive mutant p53 |
poster |
|
Chernoff, Yury |
Interplay between the chaperone and spatial control machineries in heritable protein aggregation |
poster |
|
Chinchankar, Meghna N |
A novel proteostasis adaptation in the long-lived Caenorhabditis elegans rpn-10 proteasome subunit mutant |
poster |
|
Chiosis, Gabriela |
Protein connectivity-based dysfunctions—From mechanisms to actionable targets |
talk |
|
Chuah, Janelle |
How do A11+ oligomers from neurodegenerative diseases impair the proteasome? |
poster |
|
Church, Rachel |
Discovery and development of first-in-class orally bioavailable USP19 inhibitors with in vivo efficacy in metabolism and muscle wasting models |
talk |
|
Ciesielski, Szymon J |
Exploring the role of the Gly-rich region in J-domain protein function and specialization |
talk |
|
Clausen, Lene |
Folliculin variants linked to Birt-Hogg-Dubé syndrome are targeted for proteasomal degradation |
poster |
|
Cohen, Shenhav |
Novel signaling hub of insulin receptor dystrophin glycoprotein complex and plakoglobin regulates muscle size |
talk |
|
Collart, Martine |
Not4 and Not5 regulate translation elongation dynamics and protein homeostasis |
talk |
|
Cooper, John P |
Age-dependent dynamics of proteasome capacity across proteostasis networks during replicative aging |
poster |
|
Culver, Jacob A |
Nascent tail-anchored membrane proteins are rescued for insertion despite ubiquitination in the cytosol |
poster |
|
Cupo, Ryan R |
Skd3 (human ClpB) is a human protein disaggregase that chaperones the mitochondrial intermembrane space |
talk |
|
D J, Vidyadhara D |
Auxilin knockout mice―A model for Parkinsonism with dopamine dysregulation and synucleinopathy |
talk |
|
Dagdas, Yasin |
A cross-kingdom conserved ER-phagy receptor maintains endoplasmic reticulum homeostasis during stress |
poster |
|
Danieli, Alberto |
p62/SQSTM-1 mediated condensation at the crosstalk between the ubiquitin proteasome system and selective autophagy |
poster |
|
Das, Srijit |
Maternal stress impacts progeny survival and development in C. elegans |
poster |
|
Deuerling, Elke |
Ribosome-associated chaperone machines |
talk |
|
Dikic, Ivan |
Ubiquitin networks in regulation of proteostasis and autophagy |
talk |
|
Dikovskaya, Dina |
Novel method for measuring protein turnover in live cells, and its application for the oxidative stress response transcription factor Nrf2 |
poster |
|
Douglas, Peter M |
Age onset phosphorylation of a minor actin variant promotes intestinal barrier dysfunction |
talk |
|
Emanuelsson, Cecilia |
The oligomeric form of the antiamyloidogenic DNAJB6 dissociates at lower concentrations |
Poster |
|
Encalada, Sandra E |
Neuronal vulnerability in familial prion disorders―Endo-lysosomal and cytoskeletal trafficking pathways that make or break intracellular aggregates |
poster |
|
Fajner, Valentina |
The ubiquitin ligase Hecw controls oogenesis and neuronal homeostasis by modulating phase transition of ribonucleoprotein particles |
poster |
|
Fernandes, Camila |
Unveiling the role of the cochaperone stress inducible protein 1 in proteostasis of pluripotent stem cells |
poster |
|
Francisco, Stephany M |
Proteomic analysis of tissue-specific protein aggregation signatures throughout mammalian aging |
poster |
|
French, Rachel L |
Regulation of the initial stages of TDP-43 aggregation through its RNA binding domains |
poster |
|
Frydman, Judith |
Maintaining proteostasis—Pathways and principles of protein quality control |
talk |
|
Fujita, Tomoya |
The landscape of ribosome elongation states revealed by footprint extension in bacteria |
poster |
|
Gaczynska, Maria |
New peptide based pharmacophore activating the proteasome and attenuating Alzheimer’s disease progression and pathology |
poster |
|
Gaglia, Giorgio |
HSF1 phase transition mediates stress adaptation and cell fate decisions |
talk |
|
Gersing, Sarah |
Evolutionarily conserved chaperone-mediated proteasomal degradation of a disease-linked aspartoacylase variant |
poster |
|
Ghosh, Rupam |
In vivo structural biology of metastable proteins using sensitivity enhanced NMR |
poster |
|
Gierasch, Lila |
How do Hsp70s recognize their substrates? The origins of selective promiscuity |
talk |
|
Goldberg, Alfred |
Raising cyclic GMP activates 26S proteasomes, ubiquitination, and protein degradation and has therapeutic effects in zebrafish and mouse models of neurodegerative diseases |
talk |
|
Gomez, Alexa |
Preventing immunoglobulin G aggregation using nucleic acids |
poster |
|
Gomez-Pastor, Rocio |
HSF1 and tumor suppressor p53, a dangerous relationship in Huntington’s disease |
poster |
|
Goncalves, Conrado C |
The human small heat shock protein HSPB1 prepares protein aggregates for disaggregation by HSP70 |
poster |
|
Goncalves, Davi L |
Disruption of cellular redox status impacts spatial protein quality control |
poster |
|
Greka, Anna |
Small molecule targets TMED9 and promotes lysosomal degradation to reverse proteinopathy |
poster |
|
Grizel, Anastasiia V |
Dissection of the aggregation and phase separation properties of the Sup35 prion domain |
poster |
|
Groh, Carina |
Stop thinking black and white: Proteome-wide measurement of protein folding upon mitoprotein-induced stress |
poster |
|
Gruijs da silva, Lara Aletta |
Control of TDP-43 phase transitions by ALS/FTD-linked TDP-43 hyperphosphorylation |
poster |
|
Guo, Xiaoyan |
Mitochondrial stress is signaled to the cytosol by an OMA1-DELE1-HRI pathway |
talk |
|
Gupta, Arpit |
The S. cerevisiae Hsp70 Ssa3 reduces alpha-synuclein toxicity through modulation of autophagy |
poster |
|
Gyparaki, Melina Theoni |
Tau forms oligomeric complexes on microtubules that are distinct from pathological oligomers in disease |
poster |
|
Halliday, Mark |
Investigating the mechanism of action of the neuroprotective and UPR inhibiting drug trazodone |
poster |
|
Hartl, F. Ulrich |
Chaperone functions in protein quality control and implications in neurodegenerative disease |
talk |
|
Harvey, Brandon K |
A high throughput screen to identify regulators of endoplasmic reticulum calcium and protein homeostasis |
poster |
|
Hayer-Hartl, Manajit |
Repairing the photosynthetic enzyme Rubisco |
talk |
|
He, Haiyan |
Homeostatic regulation of circuit plasticity in vivo by neuronal membrane-specific proteasomes |
poster |
|
Hebert, Daniel N |
Cellular substrates of the endoplasmic reticulum protein quality control sensors UGGT1 and UGGT2 |
poster |
|
Hetz, Claudio |
Improving ER proteostasis delays brain aging |
talk |
|
Higuchi-Sanabria, Ryo |
More than a load control—Cytoskeletal form and function during aging |
talk |
|
Hoppe, Thorsten |
ER-associated rna silencing (ERAS) mediates ER quality control, viral defense and longevity |
talk |
|
Houry, Walid A |
Functional cooperativity between the trigger factor chaperone and the ClpXP proteolytic complex |
poster |
|
Huang, Yunjie |
Degradation of misfolded cystic fibrosis transmembrane-conductance regulator (CFTR) is regulated by an ER lumen co-chaperone, DNAJB9/ERdj4 |
poster |
|
Hughes, Daniel |
The PERK kinase insert loop is a target for selective modulation of PERK signalling without systemic toxicity |
poster |
|
Hutten, Saskia |
Nuclear import receptors directly bind to arginine-rich dipeptide repeat proteins and suppress their pathological interactions |
poster |
|
Iljina, Marija |
Single-molecule spectroscopy reveals allosteric pathways involving the substrate-binding domain of ClpB. |
poster |
|
Ipenbeg, Inbal |
Neuronal aggresome formation as driver of neurodegeneration in multiple sclerosis |
poster |
|
Jagadeesan, Chandhuru |
Toxicity of nuclear targeted polyQ protein and its effect on proteostasis in yeast |
poster |
|
Jain, Kanika |
Diabetes mellitus induces a selective ER stress response in the anucleate platelet |
poster |
|
Janowska, Maria K |
Activation of human small heat shock protein HSPB5 by zinc―Taking advantage of a multitude of possibilities |
poster |
|
Jiang, Yajun |
Structural basis for client recognition and activity of Hsp40 chaperones |
talk |
|
Jinn, Sarah |
Detection of α-synuclein oligomers by protein misfolding cyclic amplification (PMCA) |
poster |
|
Joachimiak, Lukasz A |
Auto-regulatory J-domain interactions control Hsp70 recruitment to the DNAJB8 chaperone |
talk |
|
Johansson, Jan |
A reduction-activated molecular chaperone |
talk |
|
Jones, Joe |
The role of the proteotoxic stress response in c-Myc driven cancer initiation |
poster |
|
Joshi, Suhasini |
Alzheimer’s disease is a protein connectivity-based dysfunction |
poster |
|
Kandola, Tejbir S |
A simple sequence pattern governs Q-rich protein aggregation |
poster |
|
Karamyshev, Andrey L |
Regulation of aberrant protein production (RAPP) as a mechanism to maintain homeostasis of secretory and membrane proteins |
poster |
|
Kazmirchuk, Tom |
Ubiquitin-independent degradation of nutrient transporter proteins by the ILF pathway |
poster |
|
Kim, Hyunhee |
Discovery of Aβ42 aggregation modulators through a protein folding biosensor and high-throughput screening in yeast |
poster |
|
Kitamura, Akira |
Aggregation process of carboxyl terminal fragments of TDP-43 protein |
poster |
|
Klevit, Rachel |
Quasi-order—A new way to think about small heat shock proteins |
talk |
|
Knoeringer, Katharina |
Mislocalization of mitochondrial proteins to the ER–Friend or foe of cellular homeostasis? |
poster |
|
Kny, Melanie |
Interleukin-1β induced cardiac and skeletal muscle atrophy are mediated by different protein degradation systems |
poster |
|
Kostova, Kamena |
GIGYF2 and 4EHP inhibit translation initiation of defective messenger RNAs to assist ribosome-associated quality control |
talk |
|
Kracht, Matthias |
Ubiquitin-independent disassembly of a PP1 regulatory complex during PP1 biogenesis by VCP/p97—Focus on adapter function |
poster |
|
Kraemer, Lena |
To degrade or not to degrade, that’s the question—Proteasome inhibition rescues mitoprotein-induced stress |
poster |
|
Krishna, Shefali |
Long-lived proteins in the mitochondria and their role in aging |
talk |
|
Kulichikhin, Konstantin Y |
Comparison and interconversion of prion strains formed by Sup35 derivatives in yeast and mammalian cells |
poster |
|
Kulka, Linda Anna Michelle |
The proteasome shuttling factors HR23A and HR23B modulate the pattern of exosomal markers in a polyglutamine disease model |
poster |
|
Lambeth, Tyler R |
Isomers and fibrils―Wrenches in the gears of lysosomal digestion |
poster |
|
Lapierre, Louis |
Lipid droplets modulate selective autophagy receptor SQST-1/SQSTM1 dynamics and aging |
poster |
|
Lee, Changhan |
A metabolite binding protein moonlights as a bile-responsive chaperone |
poster |
|
Lee, Juhyung |
USP19-DNAJC5 axis drives unconventional secretion of misfolded cytosolic proteins independent of chaperone-mediated autophagy |
poster |
|
Lee, Kanghyun |
Structural basis for recognition of the Hsp90 closed state by the TPR-containing co-chaperone FKBP51 |
poster |
|
Leikin, Sergey |
Role of COPI coat in procollagen export from endoplasmic reticulum |
poster |
|
Lencer, Wayne |
Mechanisms of action for the IBD-risk gene INAVA—An enhancer of protein ubiquitination affecting the intestinal epithelial barrier |
poster |
|
Li, Jian |
Germline-specific roles of HSF1 and its regulation by stress and IGF-1 signaling |
poster |
|
Liao, Jui-Yun |
Physical interactions between E. coli Hsp90, DnaK and CbpA, an E. coli J-domain protein |
poster |
|
Lieberman, Raquel |
Molecular details of protein misfolding in myocilin-associated glaucoma |
poster |
|
Litberg, Ted |
Mechanism of chaperone nucleic acids |
poster |
|
Liu, Yumeng |
The cooperative remodeling of the targeting factor GET3 by the ER membrane receptor GET1/2 complex for TA membrane protein insertion |
poster |
|
Lizama, Britney N |
PINK1-VCP neuroprotection against mutant Tau pathology |
poster |
|
Lukacs, Gergely L |
Cystic fibrosis—From basic defects to combinatorial pharmaco-chaperone therapy |
talk |
|
Maciuba, Kevin A |
Complementary chaperone activities steer nascent multi-domain protein folding |
poster |
|
Madhavan, Aparajita |
Pharmacologic IRE1-Xbp1 activators restore glucose homeostasis through distinct multi-tissue effects |
talk |
|
Makareeva, Elena |
Unexpected pathways of cell stress response to procollagen misfolding in osteoblasts |
poster |
|
Mallucci, Giovanna |
Interaction between the mitochondrial protein ATAD3 with the PERK kinase insert loop regulates eIF2α-P production through a non-canonical mechanism |
talk |
|
Mariappan, Malaiyalam |
Signal sequences dictate the recruitment of distinct chaperones for protein folding in the endoplasmic reticulum |
talk |
|
Martin, Jack |
Cisplatin induces aberrant stress granules―Implications for ototoxicity |
poster |
|
McKenna, Michael |
The endoplasmic reticulum P5A-ATPase is a transmembrane helix dislocase |
poster |
|
Meng, Wenli |
Functional regulation of Hsp70 allostery by post-translational modifications (PTMs) |
poster |
|
Mitra, Rishav |
Topological complexity of client determines the mechanism of the ATP-independent chaperone Spy |
poster |
|
Miwa, Tsukumi |
Small heat shock protein IbpA is an aggregation-sensor to self-regulate its own expression at post-transcriptional levels |
poster |
|
Mogk, Axel |
Structure of the AAA+ protease MecA/ClpC/ClpP from the major pathogen Staphylococcus aureus |
talk |
|
Mohl, Gregory |
Elucidating the mechanisms controlling toxicity of pathological tau in neurons |
poster |
|
Morimoto, Richard |
Organismal proteostasis—Intertissue stress signaling in aging and disease |
talk |
|
Morrow, Chris |
Aggresome-mediated quiescence neural stem cell activation |
poster |
|
Mu, Tingwei |
Proteostasis regulators restore function of epilepsy-associated GABAA receptors |
poster |
|
Muller, Martin |
Protein quality control of readthrough products in C. elegans |
poster |
|
Munch, Christian |
eIF2α and mTORC1 cause converging translational rearrangements |
talk |
|
Nezich, Catherine |
Executing a robust compound triage strategy to assess pharmacological modulators of TFEB activity |
poster |
|
Nguyen, Thu-Lan L |
Substrate specificity of the yeast Hsp70 cochaperone, Ydj1, reflects multiple substrate binding sites |
poster |
|
Nielsen, Sofie V |
Using saturated mutagenesis and multiplexed assays to study substrate specificity in protein quality control |
poster |
|
Nussbaum-Krammer, Carmen |
HSP110 dependent disaggregation machinery generates toxic spreading-competent α-synuclein species |
talk |
|
Nyathi, Yvonne |
Identification of deubiqutinating enzymes that play a role in SGTA mediated membrane protein quality control |
poster |
|
OBrien, Jonathon |
A novel identification algorithm for isotopically labeled peptides reveals systematic differences in protein turnover rates between mice and naked mole rats |
poster |
|
O'Driscoll, Emily E |
Dissecting the mechanisms behind the proteolytic cleavage of Huntingtin using genome-wide CRISPR/Cas9 knockout screens |
poster |
|
Paull, Tanya |
Poly-ADP-ribosylation drives loss of protein homeostasis in ATM and Mre11 deficiency |
poster |
|
Perez, Valerie A |
The multi-domain architecture of DnaJC7 modulates Tau aggregation |
poster |
|
Picard, Didier |
An incompressible Hsp90 level defines the threshold of life for mammals |
poster |
|
Picard, Didier |
The mitochondrial Hsp90 paralog Trap1 forms an OXPHOS-regulated tetramer and is involved in maintaining mitochondrial metabolic homeostasis |
talk |
|
Piette, Benjamin L |
The human Hsp70/J domain protein interactome |
poster |
|
Pincus, David |
Sis1 connects the proteostasis network to the heat shock response |
talk |
|
Plate, Lars |
Targeting Dengue and Zika virus through pharmacologic modulation of ER proteostasis |
poster |
|
Pozhidaeva, Alexandra |
Insights into the mechanisms of selective promiscuity of Hsp70 chaperones |
poster |
|
Prestegard, Karina S. |
A new mouse model of PKU presenting with oxidative stress |
poster |
|
Puller, Gabrielle C |
Substrate binding by DnaJ, a cochaperone of the E. coli Hsp70 homolog, DnaK |
poster |
|
Radford, Sheena |
Structural and cellular features that control the aggregation of α-synuclein into amyloid |
talk |
|
Rahmani, Negar |
Hsp104 N-domain interactions and amyloid clearance in Saccharomyces cerevisiae |
poster |
|
Rainbolt, Kelly |
Neural stem cells engage ribophagy early in differentiation for proteome remodeling |
talk |
|
Ram, Babul |
HSF1 represses amyloidogenesis and supports protein translation to enable the malignant phenotypes of NF1-deficient tumor cells |
poster |
|
Ramachandran, Kapil |
Mechanisms of neuronal proteostasis through plasma membrane neuroproteasomes |
talk |
|
Raman, Malavika |
The p97 AAA-ATPase regulates ER-mitochondria contact sites |
poster |
|
Ratnaparkhi, Girish |
FAF1 is a regulator of protein homeostasis in a Drosophila model of amyotrophic lateral sclerosis |
poster |
|
Rawat, Prashant |
Stress-induced nuclear condensation of NELF drives global transcriptional downregulation |
talk |
|
Ricci, Daniela |
The interdomain helix between the kinase and RNase domains of IRE1 transmits the conformational change that underlies ER stress-induced activation |
poster |
|
Rodriguez, Karl A |
HspB1 improves lifespan and stress resistance in an invertebrate model through SKN-1/NRF2-associated pathways |
poster |
|
Rohland, Lukas |
Conformational dynamics of DnaK throughout its ATPase cycle |
poster |
|
Romani, Mario |
NAD+ boosting reduces age-associated amyloidosis and restores mitochondrial homeostasis in muscle |
poster |
|
Ron, David |
Tuning the activity of the ER chaperone BiP to changing levels of unfolded ER protein |
talk |
|
Rosarda, Jessica D |
Small-molecule modulators of ER proteostasis reduce secretion of the inflammatory cytokine IL-1β |
poster |
|
Rothstein, Thomas L |
FAIM inhibits and reverses aggregation of mutant proteins associated with neurodegenerative diseases |
talk |
|
Ryder, Bryan D |
Auto-regulatory J-domain interactions control Hsp70 recruitment in the oligomeric DNAJB8 co-chaperone |
poster |
|
Sabusap, Carleen Mae P |
Identification of CFTR proteostasis profiles regulating pharmacologic rescue of protein misfolding mutations |
poster |
|
Sadat, Anwar |
Negatively charged chaperonin cage catalyzes protein-folding and evolves to aid mutational buffering in vivo |
poster |
|
Sala, Ambre |
Embryo integrity regulates maternal proteostasis and stress resilience |
poster |
|
Sala, Simona |
The E3 ubiquitin ligase HECW1 in neuronal homeostasis |
poster |
|
Samuelson, Andrew |
Transcriptional regulation of the proteostatic network |
poster |
|
Santiago, Alec M |
Consequences of thiol oxidative stress on cytosolic proteostasis in yeast |
poster |
|
Sasaki, Kanae |
The regulatory mechanism of the mammalian Golgi stress response |
poster |
|
Scheeler, Stephen M |
Modulating FKBP51 and autophagy lowers Huntingtin levels |
poster |
|
Schisler, Jonathan C |
The protein quality control enzyme CHIP regulates microtubule dynamics |
poster |
|
Schlieker, Christian |
Torsin ATPase mutations trigger the formation of FG-rich nuclear envelope compartments that effectively sequester nuclear chaperones to offset nuclear proteostasis |
talk |
|
Schneider, Kara L |
Variation in processing of misfolding proteins |
talk |
|
Schoof, Michael |
eIF2B conformation and assembly state regulates the integrated stress response |
talk |
|
Shalgi, Reut |
Chaperone network perturbations modulate neurodegeneration-related protein aggregation |
talk |
|
Shcherbik, Natalia |
Proteotoxic stress promotes entrapment of ribosomes and misfolded proteins in a shared cytosolic compartment |
talk |
|
Shcherbik, Natalia |
Cooperativity between the ribosome-associated chaperone Ssb/RAC and the ubiquitin ligase Ltn1 in ubiquitination of nascent polypeptides |
poster |
|
Silva, Maria Catarina |
Experimental therapeutic approaches for autophagy activation in human tauopathy neurons |
poster |
|
Simpson, Mariska |
IRE1α can directly bind cholera toxin subdomain A1 |
poster |
|
Singh Gautam, Amit Kumar |
Deciphering a second code in proteasome degradation |
poster |
|
Sirtori, Riccardo |
HSPA8 knock-down induces the accumulation of neurodegenerative disorder-associated proteins |
poster |
|
Sisto, Angela |
Development and characterization of a new cellular screening model to target autophagy as a therapeutic strategy in axonal CMT |
poster |
|
Smethurst, Daniel GJ |
Iron-mediated degradation of ribosomes under oxidative stress is attenuated by manganes |
poster |
|
Smith, Heather |
Astrocyte unfolded protein response induces a specific reactivity state that causes non-cell-autonomous neuronal degeneration |
poster |
|
Solley, Sabrina C |
Roles of the unfolded protein response in the mammalian cell cycle |
poster |
|
Son, Ahyun |
G-quadruplexes act as sequence-dependent chaperones in cells |
poster |
|
Sontag, Emily M |
Clearance of nuclear and cytosolic aggregates at nuclear-vacuolar junctions |
poster |
|
Southworth, Daniel |
AAA+ spirals—Distinct mechanisms of Hsp100 protein unfolding machines visualized by cryo-EM |
talk |
|
Srinivasan, Vignesh |
USP14—The proteasome associated deubiquitinating enzyme a potential mediator of crosstalk between protein quality control mechanisms |
poster |
|
Stojkovska, Iva |
ER proteostasis dysfunction in novel Parkinson's disease iPSC midbrain models that naturally overexpress wildtype α-synuclein |
poster |
|
Strauch, Annika |
Structural and functional insights in two thermophilic small heat shock proteins (sHsps) |
poster |
|
Sui, Xiaojing |
Understanding how the proteome metastability relates to aging in C. elegans |
poster |
|
Sweeney, Katelyn M |
Genome-wide CRISPR-Cas9 knockout screen reveals novel modifiers of TDP-43 aggregation |
poster |
|
Taguchi, Hideki |
Nascent chain-induced translation abortion at the N-terminal regions and its impact on biased amino acid usage in proteomes. |
talk |
|
Tiwari, Satyam |
Characterization of a recombinant reporter chaperone substrate for FRET measures of aggregated, unfolded, misfolded and native states |
poster |
|
Tolay, Nazife |
Comparative profiling of stress granule clearance reveals differential contributions of the ubiquitin system |
poster |
|
Trinkaus, Victoria |
Analysis of alpha-synuclein inclusions by cryo-electron tomography |
poster |
|
Tsai, Francis T |
YcjX—A potential transducer of stress responses |
talk |
|
Tsioras, Konstantinos |
Proteome-wide degradation dynamics in patient motor neurons reveal a novel functional interaction between VCP and SOD1 |
poster |
|
Turker, Fulya |
Regulation of the mammalian neuronal membrane proteasomes (NMP) and the signaling role of the NMP-derived peptides |
poster |
|
van den Boom, Johannes |
Ubiquitin-independent disassembly of a PP1 regulatory complex during PP1 biogenesis by VCP/p97—Focus on adapter function |
talk |
|
Vargas Mardones, Gabriela |
Stabilization of HERPUD1 triggers endoplasmic reticulum hormesis |
poster |
|
Vendredy, Leen |
Functional identification and characterization of the human HSPB8 promoter |
poster |
|
Vierstra, Richard D |
Autophagy, ubiquitylation, and aggregation converge to maintain the proteostasis of 26S proteasomes and the Cdc48/p97 disaggregase |
talk |
|
Voegtle, Nora |
Mitochondrial unfolded protein response―Identification of molecular mechanisms to activate mitochondrial protein import and maintain organelle integrity |
poster |
|
Vogel, Christine |
Integrative systems profiling identifies new signatures of neurodegeneration and novel roles of the core proteasome |
talk |
|
Walker, Alyssa |
Colonization of the C. elegans gut with human enteric bacterial pathogens leads to proteostasis disruption that is rescued by butyrate |
poster |
|
Wang, Lan |
Structure of the AAA protein Msp1 reveals mechanism of mislocalized membrane protein extraction |
poster |
|
Wang, Lihui |
Ribosome UFMylation links translocation-associated quality control to endoplasmic reticulum protein homeostasis |
poster |
|
Wang, Ray Y |
The molecular mechanism of chaperone-regulated GR function revealed by cryo-EM |
talk |
|
Wang, Wenzhang |
Protease LONP1 restores impaired mitochondrial protein homeostasis in Alzheimer's disease |
poster |
|
Wanker, Erich E |
Heterooligomeric p97—ASPL protein assemblies play a functional role in mRNA splicing in mammalian cells |
talk |
|
Weaver, Benjamin P |
Widespread non-canonical caspase functions in development and stress response |
poster |
|
Welsh, Christofer M |
Characterization of a membrane stress response to stabilize intracellular trafficking in C. elegans |
poster |
|
Wentink, Anne |
Molecular dissection of amyloid disaggregation by the human Hsp70 chaperone machinery |
poster |
|
Westermark, Gunilla T |
The Bri2-BRICHOS domain reduces IAPP amyloid formation in cultured human islets |
poster |
|
Wiseman, Luke C |
Pharmacologic IRE1/XBP1s activators promote multi-tissue benefits in obesity |
poster |
|
Wohlever, Matthew L |
Mechanistic studies of Msp1 in membrane proteostasis |
poster |
|
Woods, Christopher |
Long-range effects of a disease-associated HSPB5 mutation on structure and dynamics |
poster |
|
Work, Jeremy J |
Quantitative analysis of the ubiquitin proteasome system under proteolytic and folding stressors |
poster |
|
Wright, Madison T |
Investigating protein quality control mechanisms of thyroglobulin folding and secretion |
poster |
|
Wu, Kevin |
ATP-independent chaperone—Beyond a holdase |
poster |
|
Yakubu, Unekwu M |
Systematic mutations in Drosophila melanogaster Hsp110 reveal a novel metazoan chaperoning mechanism |
poster |
|
Yang, Yang |
Knockout mouse models reveal tissue-specific requirements for mitochondrial Hsp70 co-chaperones |
poster |
|
Ye, Yihong |
An integrin receptor complex mediates filamentous Tau-induced activation of primary astrocytes |
poster |
|
Yeger-Lotem, Esti |
The landscape of molecular chaperones across human tissues reveals a layered architecture of core-variable chaperones |
poster |
|
Yohda, Masafumi |
Structural dynamics and amyloid disaggregation mechanism of Hsp104 from the thermophilic fungus, Chaetomium thermophilum |
talk |
|
Yoo, Haneul |
Hsp104/70 bi-chaperone system readily restores heat-induced Pab1 condensates to functional units relative to heat-denatured protein aggregates |
poster |
|
Yoon, Jimin |
Impacts of the host cell’s ER proteostasis network on HIV envelope glycoprotein mutational tolerance |
poster |
|
Young, Jason |
Selective binding of HSC70 and its co-chaperones to structural hotspots on CFTR |
talk |
|
Yuste Checa, Patricia |
Purification and characterization of the extracellular chaperone clusterin |
poster |
|
Zerovnik, Eva |
Preventive effect of some antioxidant substances via inhibition of amyloid fibrils formation; in vitro study of the cystatins amyloid formation |
poster |
|
Zhang, Ke |
Poly(ADP-ribose) modulates the liquid-liquid phase separation and cytotoxicity of C9orf72 dipeptide repeat proteins |
talk |
|
Zhang, Peng |
MAPK signaling regulates NRF1 to maintain protein homeostasis |
poster |
|
Zhang, Youwen |
Identification of Rassf1 as ATF4 target gene during endoplasmic reticulum stress |
poster |
|
Zhang, Youwen |
Modulation of diet-induced body weight gain by propensity of fibroblasts to endoplasmic reticulum stress |
poster |
|
Zhao, Pei |
Spatial CoVariance (SCV) reveals the potential therapeutic roles of the ER GRP94/Hsp90 chaperone and redox systems for rescue of alpha-1 antitrypsin deficiency |
poster |
|
Zhao Yanyan |
CryoEM reveals the stochastic nature of individual ATP binding events in a group II chaperonin |
poster |
|
Zhou, Kai |
Protein conformational changes in adaptation to persistent stress |
poster |
|
Zhu, Feimei |
The coordination of HSF1 and NRF1 promotes protein homeostasis |
poster |
|
Zhu, Yi |
NAD+ synthase Nmnat restores neuronal integrity by neutralizing phosphorylated Tau and mutant Htt aggregates-induced progressive toxicity |
poster |