|
Presenting Author |
Abstract Title |
Talk/Poster |
|
Affandi, Trisiani |
PKCδ regulates the DNA damage response to irradiation through regulation of chromatin accessibility and DNA double stranded break repair |
poster |
|
Agresti, Alessandra |
Nucleosomes effectively shield DNA from radiation damage in living cells |
talk |
|
Alabert, Constance |
Disruption and restoration of euchromatin and heterochromatin in cycling cells |
talk |
|
Andrs, Martin |
Reactive oxygen species induce R-loop-dependent replication stress in human cells |
poster |
|
Aparicio, Oscar |
Differential requirement of Dbf4 C-terminal Zn-finger in firing of Centromere-proximal versus Forkhead-activated replication origins in S. cerevisiae |
talk |
|
Arana, Mercedes |
Faithful DNA ligation by DNA ligase 1 and its role in maintaining genome integrity |
poster |
|
Arbona, Jean-Michel |
Uncovering the positioning and strength of DNA replication origins in human cell lines using mathematical modeling |
poster |
|
Audit, Benjamin |
Replication initiation plasticity in conserved replication timing domains |
poster |
|
Baris, Yasemin |
Human DNA replication with purified proteins |
talk |
|
Bertolin, Agostina |
HLTF mediates irreversible replication fork arrest in checkpoint-deficient human cells |
poster |
|
Bleichert, Franziska |
Chromosomal recruitment mechanism for the metazoan initiator ORC |
talk |
|
Botchan, Michael |
Does licensing occur in mitosis?—Evidence from live cell imaging in Drosophila |
talk |
|
Bracci, Alexa |
Evolutionary dynamics and impact of DNA replication timing in great apes |
talk |
|
Caballero, Madison |
Comprehensive analysis of DNA replication timing in genetic diseases and gene knockouts identifies MCM10 as a novel regulator of the replication program |
poster |
|
Canal, Berta |
Characterising replication fork stalling and restart with purified proteins |
poster |
|
Chanou, Anna |
Single molecule analysis of nucleosome positioning in replication origins |
poster |
|
Chen, Boning |
Spatiotemporal kinetics of CAF-1-dependent chromatin maturation reveals mechanisms of replication-coupled chromatin assembly |
talk |
|
Chen, Chunlong |
Both single-molecule optical replication mapping and single-cell replication-timing support a stochastic model of eukaryotic replication |
talk |
|
Chen, Xin |
Deciphering how DNA replication establishes asymmetric epigenetic information in cell fate determination |
talk |
|
Chesnokov, Igor |
Humanized Drosophila model of the Meyer-Gorlin syndrome reveals conserved and divergent features of the Orc6 protein |
poster |
|
Claussin, Clemence |
Replicon-seq—A new method to study sister replication fork movement and replication/transcription conflicts |
talk |
|
Coleman, Kate E. |
Trapping of USP1 at replication forks induces DNA replication stress and genomic instability |
talk |
|
Collier, James |
Cohesin topologically entraps DNA through two distinct pathways |
poster |
|
Coster, Gideon |
The mechanism of replication stalling and recovery within repetitive DNA |
talk |
|
Crain, Aaron |
Histone methyltranseferase Set8/KMT5A and H4K20 mutants have distinct developmental phenotypes in Drosophila melanogaster |
talk |
|
Crossley, Madzia P |
Cytoplasmic RNA-DNA hybrids derived from genomic R-loops activate the innate immune response |
talk |
|
de Oliveira Vitarelli, Marcela |
Standardization of sequencing based techniques for the study of Trypanosoma cruzi replication dynamics |
poster |
|
Deegan, Tom D |
A conserved mechanism for regulating replisome disassembly in eukaryotes |
talk |
|
Dhoonmoon, Ashna |
Genome-wide CRISPR synthetic lethality screen identifies a role for the ADP-ribosyltransferase PARP14 in DNA replication dynamics controlled by ATR |
poster |
|
Dibitetto, Diego |
Fork slowing and reversal as an adaptive response to perturbed ATR signaling |
talk |
|
Do, Brian T |
A myeloid maturation program initiated by nucleotide depletion through replication stress |
talk |
|
Doksani, Ylli |
Increased incidence of replication fork reversal at mammalian telomeric repeats |
poster |
|
Dolce, Valeria |
Fork stability relies on replisome-associated repriming |
poster |
|
Duderstadt, Karl E |
Mobile origin licensing factors confer resistance to transcription conflicts |
talk |
|
Dungrawala, Huzefa M |
CRL4DCAF14 regulates replication fork stability to promote genome integrity |
talk |
|
Dutta, Anindya |
MicroDNA (small eccDNA) levels are dependent on MMEJ, repressed by c-NHEJ, and stimulated by DNA double-strand break |
talk |
|
Eckhardt, Bruna |
Understanding yeast chromatin replication using in vitro reconstitutions |
poster |
|
Edwards, Matthew |
Delayed DNA replication in haploid human embryonic stem cells |
poster |
|
Enemark, Eric |
Structure of an MCM ring encircling bona fide melted DNA illustrates a key aspect of replication initiation |
talk |
|
Fox, Catherine |
The Fkh1 forkhead associated domain promotes ORC binding to a subset of DNA Replication origins in budding yeast |
talk |
|
Fu, Haiqing |
Dynamics of replication origin over-activation |
poster |
|
Fujisawa, Ryo |
Multiple UBX proteins support replisome disassembly by mammalian p97-UFD1-NPL4 |
poster |
|
Gali, Vamsi |
Insights into the mechanism of nascent DNA protection by budding yeast Rif1 |
poster |
|
Gambus, Aga A |
Replisome unloading in human somatic cells |
talk |
|
Gerbi, Susan |
The steroid hormone ecdysone drives re-replication in DNA puffs of the fly Sciara |
talk |
|
Gerhardt, Jeannine |
Error-prone repair of stalled replication forks drive mutagenesis in haploinsufficient BRCA1 cells |
talk |
|
Gilbert, David |
Cohesin-mediated loop anchors confine the location of human replication origins |
talk |
|
Glaser, Samson |
A single molecule approach to understanding sister chromatid cohesion establishment |
poster |
|
Gopaul, Diyavarshini |
MCPH1 protects nascent DNA from over-degradation at stalled replication forks |
talk |
|
Greenberg, Roger |
PCNA-Ub directs SNM1A nuclease to promote recombination dependent break induced telomere synthesis |
poster |
|
Greiwe, Julia |
Structural mechanism for the selective phosphorylation of DNA-loaded MCM double hexamers by the Dbf4-dependent kinase |
talk |
|
Gupta, Shalini |
A helicase-tethered ORC flip enables bidirectional helicase loading |
talk |
|
Hamperl, Stephan |
Single-copy locus isolation identifies distinct chromatin proteomes of early- and late-firing DNA replication origins |
talk |
|
He, Yiwei |
Rpd3 and Sir2 independently regulate single-copy versus multi-copy origins |
poster |
|
Hiraga, Shin-ichiro |
Requirement for SAF-A/HNRNPU in establishing an open chromatin structure needed for multiple steps in DNA replication |
talk |
|
Hiratani, Ichiro |
Establishment of the late-replicating inactive X chromosome during differentiation |
talk |
|
Hoffman, Rachel A |
Helicase activation and DNA unwinding in the context of chromatin |
poster |
|
Houseley, Jon |
Using TrAEL-seq to profile DNA replication under stress |
poster |
|
Isik, Esin |
Role of MutSβ and MutLβ proteins in the restart of R-loop-stalled replication forks in human cells |
poster |
|
Janscak, Pavel |
Reactive oxygen species induce R-loop-dependent replication stress in human cells |
talk |
|
Jaremko, Matt J |
The dynamic human Origin Recognition Complex |
talk |
|
Jenkinson, Fiona |
Dephosphorylation of the pre-initiation complex is essential for replication origin firing |
talk |
|
Jenkyn-Bedford, Michael |
A conserved mechanism for regulating replisome disassembly in eukaryotes |
poster |
|
Jiang, Yangyang Kate |
Mechanisms of Rad5-mediated mutagenic repair of undamaged ssDNA |
poster |
|
Jones, Rebecca |
MCM7 polyubiquitylation and replisome unloading in human somatic cells |
poster |
|
Josephides, Joseph M |
Addressing scalability and stochasticity in single-cell replication timing analyses with Kronos_scRT |
poster |
|
Kar, Ananya |
Inhibition of CDK4/6 induces MCM unloading during the G1 phase |
poster |
|
Kara, Neesha |
Genome-wide detection of DNA replication and DNA damage in mammalian cells using TrAEL-seq |
poster |
|
Kaushik, Aditi |
Alteration of Smc3/Scc2 interaction prevents pre-acetylated cohesin from loading onto DNA |
talk |
|
Kavlashvili, Tamar |
Helicase uncoupling elicits nascent strand degradation in Xenopus egg extracts |
talk |
|
Kee, Younghoon |
Regulation of FACT histone chaperone in mitigation of replication stress |
poster |
|
Kerem, Batsheva |
3D genome organization contributes to genome instability at fragile sites |
talk |
|
Kochenova, Olga V |
p97Ufd1-Npl4 cooperates with Ubxn7 to disassemble replisomes during vertebrate replication termination |
talk |
|
Krishnamoorthy, Archana |
RADX prevents genome instability by confining replication fork reversal to stalled forks |
poster |
|
Krishnamoorthy, Vidhya |
A new AAA+ ATPase complex in DNA replication protein quality control |
talk |
|
Kumar, Charanya |
Reconstitution of R-Loop-replisome collisions reveals distinct modes of eukaryotic leading strand restart at G-quadruplexes and RNA: DNA hybrids |
talk |
|
Kurat, Christoph F |
Establishment and function of the chromatin landscape around eukaryotic chromosome replication origins |
talk |
|
Lalonde, Maxime |
Investigating the role of transcription-replication conflicts in endogenous cellular reprogramming and cell fate decisions |
poster |
|
Lambert, Sarah |
RNA:DNA hybrids from Okazaki fragments safeguard fork integrity by modulating KU-mediated barrier to nascent strands degradation |
talk |
|
Lebdy, Rana |
GNL3 defines a new link between the control of DNA replication and replication forks stability |
talk |
|
Leffak, Michael |
Microsatellite instability initiates gross chromosomal rearrangements at SINEs and high frequency mutagenesis |
poster |
|
Lehmann, Carl P |
The Mgs1/WRNIP1 ATPase is important for the prevention of unwanted recombination at damaged replication forks |
poster |
|
Li, Huilin |
Rad24-RFC loads the 911 clamp onto ssDNA in the opposite orientation of RFC loading PCNA |
talk |
|
Lim, Chew Theng |
Multiple pathways for MCM loading by ORC |
poster |
|
Liu, Wenpeng |
Functions of BRCA2 and RAD51 important for fork reversal and stabilization |
talk |
|
Liu, Xingchen |
Investigating the mechanism of the eukaryotic sliding clamp loader |
poster |
|
Liu, Yaqun |
OKseqHMM—A bioinformatics toolkit to analyze genome-wide replication fork directionality, replication initiation and termination |
poster |
|
Lopes, Massimo |
Stress-induced proliferation bursts in haematopoietic stem cells alter DNA replication dynamics, challenging genome stability |
poster |
|
Madireddy, Advaitha |
Understanding the mechanisms driving genomic instability in adult T-cell leukemia/lymphoma |
poster |
|
Magrino, Joseph |
Two PCNA variants drive the same disease through separate mechanisms |
poster |
|
Mann, Anjali |
Understanding the role of Polθ in chromosomal DNA replication under stressful conditions |
talk |
|
Marechal, Alexandre |
SMARCAL1 ubiquitylation controls its association with RPA-ssDNA and promotes fork stability |
talk |
|
Marheineke, Kathrin |
Polo-like kinase 1 (Plk1) regulates replication origin firing and phosphorylates Rif1 during unchallenged S phase |
talk |
|
Masai, Hisao |
Mechanisms of membrane association of Rif1 and its role in replication timing regulation |
poster |
|
Massey, Dashiell |
High-throughput analysis of DNA replication in single human cells reveals confined variability in the location and timing of replication initiation |
poster |
|
Mattiroli, Francesca |
Mechanism of CAF-1 dependent nucleosome assembly during DNA replication |
poster |
|
McClure, Allison |
Rad53 checkpoint kinase regulation of DNA replication fork rate via Mrc1 phosphorylation |
poster |
|
McCluskey, Kaley A |
Improvements in the accuracy of protein colocalization in CoSMoS microscopy |
poster |
|
Mechali, Marcel |
Metazoan DNA replication origins |
talk |
|
Mei, Liu |
The consequences of differential origin licensing dynamics in distinct chromatin environments |
talk |
|
Merrikh, Houra |
Investigating the mechanisms behind R-Loop induced lethality upon replication-transcription conflicts |
talk |
|
Miller, Thomas C |
How does CDK phosphorylation of the Origin Recognition Complex inhibit MCM helicase loading during S-phase? |
talk |
|
Miura, Hisashi |
Integrative data analysis approach to understand the developmental dynamics of the chromosome organization and DNA replication timing |
poster |
|
Mohamed, Taha |
RADX forms higher-order oligomers to maintain replication fork stability |
poster |
|
Mohana-Natarajan, Vaishnavi |
H2B ubiquitination regulates DNA replication fork dynamics in human cells |
poster |
|
Moiseeva, Tatiana N. |
Using mAID-mediated depletion of DNA polymerase epsilon to uncover its role in the initiation of DNA replication in human cells |
poster |
|
Mosammaparast, Nima |
Mass spectrometry-based analysis of nascent DNA (MS-BAND) permits rapid quantitation of DNA replication dynamics in diverse systems |
talk |
|
Muellner, Julius |
Functional interaction between Rad5 and Rrm3 helicase activities in the prevention of DNA double-strand breaks in yeast |
poster |
|
Muñoz, Sergio |
RAD51 restricts over-replication by hindering the progression of forks emerging from re-fired origins |
talk |
|
Nasrin, Farhana |
DDX5-mediated destabilization of DREAM complex affects cell cycle gene expression and cell proliferation in breast and colon cancer |
poster |
|
Nieduszysnki, Conrad A |
Single molecule detection of replication fork pause sites in budding yeast |
poster |
|
Nieduszysnki, Conrad A |
Single molecule DNA replication dynamics of the human genome |
talk |
|
Nieminuszczy, Jadwiga |
ACTINg at forks to counteract replicative stress and preserve genome stability |
poster |
|
Noble, Tyler D |
Mapping genomic binding locations of TICRR and MTBP to study origin selection |
poster |
|
Nordman, Jared |
ORC and Rif1 associate with the Nup107-160 complex linking nucleoporins to replication initiation |
talk |
|
O'Farrell, Patrick |
Determinative timing of origin firing |
talk |
|
Ozono, Eiko |
A genome-wide siRNA screen to identify enhancers and suppressors of DNA damage caused by cyclin E overexpression |
poster |
|
Parkash, Vimal |
Dual mechanisms by which a family B DNA polymerase sense a ribonucleotide |
talk |
|
Pasero, Philippe |
Loss of RNase H activity impairs the processing and restart of stalled replication forks |
poster |
|
Penengo, Lorenza |
The Interferon/ISG15 system controls DNA replication fork stability and rescues viability in BRCA-deficient mouse ESCs |
talk |
|
Peycheva, Mihaela |
The levels of MCM complexes are the major regulator of DNA replication timing in B cells |
poster |
|
Philip, Jasmin |
Cdc6 is differentially regulated by PP2A-Cdc55, Cdc14 and Sic1 for origin licensing |
talk |
|
Pike, Alexandra M |
Dissecting the roles of single-stranded binding proteins in eukaryotic DNA replication |
poster |
|
Polo Rivera, Cristian |
Pif1-family helicases define an alternative pathway for CMG helicase disassembly in budding yeast |
poster |
|
Poovathumkadavil, Divyasree |
Ubiquitin chain type and Ubxd7 create the platform for selective replisome disassembly by p97 during S-phase |
poster |
|
Prasanth, Supriya G |
Orc6 at replication fork enables efficient mismatch repair |
talk |
|
Priyanka, PRIYANKA |
A long noncoding RNA HMS recruits a RNA binding protein to stabilize the 3’ untranslated region of HOXC10 oncogene |
poster |
|
Prorok, Paulina |
Mechanism of replisome response to stress |
poster |
|
Qian, Chegmin |
USP7/PCNA/PAF15-Ub2 complex facilitates the first-wave of DNA methylation maintenance |
talk |
|
Quinet, Annabel |
Temporally distinct post-replicative repair mechanisms fill PRIMPOL-dependent ssDNA gaps in human cells |
poster |
|
Rampazzo, Lucia |
BRCA2 preserves chromosomal stability modulating RAD51 activity at centromeres |
poster |
|
Rausch, Cathia |
Cytosine base modifications regulate DNA duplex stability and metabolism |
poster |
|
Regan-Mochrie, Gemma |
Regulation of DNA replication by sumoylation of the Origin Recognition Complex |
poster |
|
Reusswig, Karl-Uwe |
Characteristics, constraints, and consequences of unscheduled replication in G1 |
talk |
|
Reuter, Maximilian |
Mechanisms of MCM2-7 loading and initial DNA melting at near base-pair resolution |
poster |
|
Reyes Lamothe, Rodrigo |
Single-molecule live cell characterization of subunit dynamics in the eukaryotic replisome |
poster |
|
Ribeyre, Cyril |
The organizer of chromatin topology RIF1 ensures cellular resilience to DNA replication stress |
poster |
|
Richards, Logan R |
Rif1 interacts with ORC and the Nup107-160 subcomplex, coupling replication initiation to nucleoporins |
poster |
|
Safaric, Barbara |
The fork protection complex recruits FACT to reorganize nucleosomes during replication |
poster |
|
Saito, Yuichiro |
MCMBP promotes hexamer formation of the replicative MCM2–7 complex |
talk |
|
Saleh, Almutasem |
The structural basis of MCM2-7 double hexamer activation and substrate localization by the Cdc7-Dbf4 kinase revealed by several cryo-EM structures |
talk |
|
Sanchez, Humberto |
DNA replication origins retain mobile licensing proteins |
poster |
|
Sanchez, Humberto |
Single-molecule visualization of MCM loading on chromatin |
poster |
|
Sanders, Jordan B |
N-methyl carboline 3-carboxamide is a putative inhibitor of the eukaryotic replicative helicase |
poster |
|
Sarni, Dan |
Topoisomerase 1 dependent R-loop deficiency drives accelerated replication and genomic instability |
poster |
|
Scaramuzza, Shaun |
TRAIP is an essential E3 ubiquitin ligase required to resolve DNA replication - transcription collisions |
poster |
|
Schirmeisen, Kamila |
Novel functions of the S.pombe nuclear basket in promoting Recombination-Dependent Replication. |
poster |
|
Schuck, Percy L |
CST interacts with the cohesin complex and promotes chromosome cohesion |
poster |
|
Scully, Ralph |
SLX4 regulates homologous recombination at stalled replication forks |
talk |
|
Sheu, Yi-Jun |
Prevalent and dynamic binding of the cell cycle checkpoint kinase Rad53 to gene promoters |
poster |
|
Sidorova, Julia |
Innate immunity mediator STING modulates nascent DNA metabolism at stalled forks in human cells |
talk |
|
Silva, Andriele |
In-silico analysis of Cdc6, Cdc4 and Clb2 protein-protein interactions during cell cycle |
poster |
|
Simon, Itamar |
Chromosomal coordination and differential structure of asynchronous replicating regions |
talk |
|
Simpson, Trey |
A dynamic single-molecule approach to directly visualize the molecular mechanisms of DNA-binding proteins |
poster |
|
Smith, Christopher |
The role of FACT in parental nucleosome inheritance |
poster |
|
Smogorzewska, Agata |
Fanconi anemia pathway deficiency drives copy number variation in squamous cell carcinomas |
talk |
|
Spenkelink, Lisanne M |
Single-molecule visualization of replisome-cohesin encounters |
poster |
|
Stein, MaryElizabeth |
Not one-size-fits-all—G-quadruplex mutagenesis variability underscores the impact of sequence and structure on DNA polymerase fidelity |
poster |
|
Stoy, Henriette |
Direct visualization of transcription-replication conflicts reveals post-replicative DNA:RNA hybrids |
talk |
|
Su, Zhangli |
Cell survival after ORC deletion—Epigenetic dysregulation dependent on CTCF, cohesin and polycomb group proteins and endo-reduplication in normal livers |
poster |
|
Taglialatela, Angelo |
REV1-Polζ maintains the viability of homologous recombination-deficient cancer cells through mutagenic repair of PRIMPOL-dependent ssDNA gaps |
poster |
|
Takahashi, Saori |
Single-cell genome-wide DNA replication profiling of early embryonic development in mice |
poster |
|
Tanaka, Seiji |
Role(s) of Schizosaccharomyces specific N-terminal domain of Sld3 |
poster |
|
Theulot, Bertrand |
Genome-wide mapping of replication fork velocity in S. cerevisiae using nanopore sequencing |
poster |
|
Tian, Mengxue |
Integrative analysis of DNA replication origins in human cells from 98 profiling datasets to determine association of highest confidence origins with ORC binding sites and transcription start sites |
poster |
|
Tirado-Class, Neysha N |
DCAF14 promotes replication fork progression to maintain genome integrity |
poster |
|
Tramantano, Michael C |
CIZ1 is a novel ORC1 interacting protein that functions in replication initiation |
talk |
|
Turner, Jesse L |
Genetic dissection of early replication control elements implicates the pluripotency transcriptional regulatory network controls replication timing in mouse embryonic stem cells |
poster |
|
Twayana, Shyam Sundar |
Translesion polymerase eta both facilitates DNA replication and promotes increased human genetic variation at common fragile sites |
talk |
|
Ubhi, Tajinder |
Cytidine deaminases promote DNA replication stress resistance in pancreatic cancer cells |
poster |
|
Uhlmann, Frank |
Establishment of sister chromatid cohesion during DNA replication |
talk |
|
Ummethum, Henning |
Proximity labeling as a tool to study transcription-replication conflicts |
poster |
|
Urban, Jennifer A |
Developing genomic systems to study DNA replication-coupled asymmetric histone incorporation in male Drosophila melanogaster germline stem cells |
poster |
|
van Oijen, Antoine M |
Single-molecule studies of the yeast replisome |
talk |
|
Varon, Mor |
The helicase Rrm3 is essential for replication progression through leading strand G4 rich sites in Saccharomyces cerevisiae |
poster |
|
Vouzas, Athanasios |
Promoter-specific regulatory mechanisms, but not the level or length of transcription elongation, drive early replication timing |
poster |
|
Weissmann, Florian |
Towards in vitro reconstitution of human DNA replication initiation |
poster |
|
Whale, Alex J |
Stimulation of adaptive gene amplification by origin firing under replication fork constraint |
poster |
|
Williams, Jessica S |
Molecular basis for processing of topoisomerase 1-triggered DNA damage by Apn2/APE2 |
poster |
|
Wittig, Kimberlie |
TICRR/TRESLIN protein expression is cell cycle regulated by the CRL4DTL E3 ubiquitin ligase |
poster |
|
Wu, Alex |
TRAIP's association with the replisome requires multiple interactions and leading strand synthesis |
poster |
|
Xia, Yisui |
TIMELESS-TIPIN and UBXN-3 promote replisome disassembly during DNA replication termination in C. elegans |
talk |
|
Yang, Dongxiao |
Structure of PCNA from the thermophilic fungus Chaetomium thermophilum bound to the PIP peptide from the DNA polymerase δ subunit PolD4 |
poster |
|
Yates, Mailyn |
SMARCAL1 ubiquitylation by the RFWD3 Fanconi anemia protein regulates its activity at DNA replication forks |
poster |
|
Zeng, Jingkun |
Oncogene-induced endoreduplication in p53 proficient cells |
poster |
|
Zhang, Liying |
Comprehensive OK-Seq analysis reveals unconventional features of replication initiation sites in Tetrahymena |
poster |
|
Zhang, Tianpeng |
Break induced telomere synthesis—A novel mechanism of homology-directed DNA repair |
poster |
|
Zhao, Xiaolan |
Understanding Smc5/6—From functions to structures |
talk |
|
Zhou, Zhixiong |
How asymmetric DNA replication achieves high and symmetrical fidelity |
talk |
|
Zhu, Xu-Dong |
CSB functions at stalled forks to regulate both fork restart and fork protection in the absence of BRCA1/2 |
poster |
|
Zou, Lee |
PARP inhibitors selectively kill BRCA1/2-deficient cells by inducing trans-cell-cycle ssDNA gaps |
talk |