|
Presenting Author |
Abstract Title |
Talk/Poster |
|
Agarwal, Suneet |
Hematopoietic cell transplantation without radiation or DNA alkylating agents in bone marrow failure with short telomeres |
poster |
|
Agrawal, Ritvija |
Investigating how telomeres tether to and move along the nuclear membrane during meiosis |
poster |
|
Ahmed, Shawn |
Pot1 proteins regulate a novel form of Transgenerational Epigenetic Inheritance |
talk |
|
Allsopp, Richard |
The longevity associated allele of FOXO3 protects against telomere attrition during aging |
talk |
|
Apte, Manasi |
Revealing the secrets of telomerase minus HAATI survivors in S. pombe |
talk |
|
Aquilanti, Elisa |
Rapid sensitivity to telomerase inhibition in a subset of leukemia cell lines |
poster |
|
Azarm, Kameron |
Persistent telomere cohesion prevents premature senescence in aging and ALT cells |
poster |
|
Azzalin, Claus |
Telomeric replication stress in ALT cells—Causes and management |
talk |
|
Barnes, Ryan P |
Targeted oxidative telomere base damage induces growth arrest and senescence in normal human cells |
talk |
|
Barry, Raymond M |
Elucidating the mechanism by which Rap1 protects from obesity |
poster |
|
Barsourk, Adam |
Is nucleotide excision repair essential for telomere preservation following UV exposure? |
poster |
|
Batista, Luis FZ |
Posttranscriptional modulation of TERC by PAPD5 inhibition rescues hematopoietic development in X-linked dyskeratosis congenital |
talk |
|
Baxley, Ryan M |
Chronic Mcm10 deficiency causes defects in telomere maintenance in human cells |
talk |
|
Beattie, Tara |
Understanding the telomere-initiated DNA damage response during cellular senescence |
poster |
|
Beemon, Karen L. |
hTERT negatively regulated by TERT antisense promoter-associated (TAPAS) long noncoding RNA |
talk |
|
Benslimane, Yahya |
Genome-wide CRISPR screens reveal novel genetic vulnerabilities to telomerase inhibition and telomere erosion |
talk |
|
Bose, Sreyashree |
A role for the novel telomerase-associated lncRNA TER2AS in telomere maintenance |
talk |
|
Bosso, Giuseppe |
Multiple cancer pathways regulate telomere protection |
poster |
|
Braun, Hanna |
Evolutionary diversity of the telosome—What proteins bind to the chromosome ends of butterflies? |
poster |
|
Briod, Anna-Sophia |
Probing the telomere environment with BioID reveals RADX, which is important for telomere replication |
poster |
|
Butter, Falk |
ZBTB10 binds the telomeric variant repeat TTGGGG and interacts with TRF2 |
poster |
|
Cano, Maria Isabel N |
Replication protein A1 is the Leishmania spp. telomere end-binding protein |
talk |
|
Castillo-Gonzalez, Claudia M |
A new role for POT1 proteins in reproductive development |
poster |
|
Chakrabarti, Kausik |
Novel aspects of Telomerase RNA regulation in kinetoplastid pathogen, Trypanosoma brucei |
poster |
|
Chang, Sandy |
Replisome-mediated A-NHEJ repair of dysfunctional telomeres lacking POT1a/b-TPP1 occurs independent of the MRN complex |
poster |
|
Chartrand, Pascal |
Single-molecule imaging of endogenous hTR at telomeres and Cajal bodies |
talk |
|
Chen, Lu |
A core TERT promoter mechanism in human carcinogenesis repurposed from evolution |
poster |
|
Chen, Yuan-Yin |
The C-circle biomarker is secreted by alternative-lengthening-of-telomeres positive (ALT+) cancer cells inside exosomes and provides a blood-based diagnostic for ALT activity |
poster |
|
Chevalier, Manon |
Cell-cycle specific telomere profiling reveals NuMA as an important player in telomere dynamics and localization throughout mitosis |
talk |
|
Cicconi, Alessandro |
BRIT1 phosphorylation modulates the interaction with TRF2 and the DNA damage response and repair at dysfunctional telomeres lacking TPP1-POT1 |
poster |
|
Clatterbuck Soper, Sarah F |
DAXX localizes ATRX to suppress alternative lengthening of telomeres in osteosarcoma |
poster |
|
Cleal, Kez |
Chromothripsis during telomere crisis is independent of NHEJ and consistent with a replicative origin |
talk |
|
Coulon, Stephane |
Telomerase repairs broken replication forks at telomeres |
talk |
|
de Lange, Titia |
TREX1 and APOBEC3B induce chromothripsis and kataegis during telomere crisis |
talk |
|
Decottignies, Anabelle |
Specific death of ALT cells through TSPYL5 depletion |
talk |
|
Dewhurst, Sally M |
Defining a genomic signature of telomere crisis |
poster |
|
Dietz, Sabrina F |
TEBP-1 and TEBP-2 are novel telomere binding proteins in Caenorhabditis elegans< |
poster |
|
Doksani, Ylli |
Telomere damage induces the formation of intramolecular loops |
talk |
|
Epum, Esther A |
RAD51 modulates the RAD52-RPA interaction to promote capping of double-stranded breaks by de novo telomere healing |
talk |
|
Evans, Alys |
Investigating the role of DNA polymerase theta in telomeric stability and the escape from crisis |
poster |
|
Feigon, Juli |
Structure of telomerase with telomeric DNA |
talk |
|
Feng, Xuyang |
Understanding the mechanism of CST-mediated telomerase termination in human cells |
talk |
|
Feretzaki, Marianna |
Recruitment of telomeric lncRNA TERRA to chromosome ends |
talk |
|
Fernandes, Rita |
The THO complex counteracts TERRA R-loops and TERRA association with telomeres |
poster |
|
Ferreira, Miguel G |
Telomerase deficiency leads to cancer regression in a melanoma zebrafish model |
talk |
|
Ferrer, Alejandro |
Evaluation of the pathogenicity of missense variants in hTERT using computational protein modeling and functional assays |
poster |
|
Frank, Lukas |
Recruiting PML to telomeres induces alternative lengthening of telomeres activity |
poster |
|
Friedman, Katherine L. |
Mapping hotspots of de novo telomere addition in the yeast genome |
poster |
|
Gagos, Sarantis |
Alternative lengthening of telomeres in neoplasia—Increased genomic flexibility and the role of polyploidization in maintenance of cancer genome integrity |
poster |
|
Garcia, Daniela |
Pop1, Pop6 and Pop7, subunits of RNase P/MRP, affect telomerase RNA in vivo |
talk |
|
Gaysinskaya, Valeriya |
Rare synonymous mutation in DKC1 causes TR insufficiency and familial pulmonary fibrosis |
poster |
|
Geiller, Helene E |
Genetic loss of ATRX combined with telomere stress is sufficient to initiate ALT activity |
poster |
|
Geli, Vincent |
Conditional expression of telomerase under the control of the p21 promoter as a model of senescence bypass and much more |
talk |
|
Gillespie, Abigail E |
Telomere length regulation in budding yeast relies on elongation of collapsed forks by telomerase |
poster |
|
Glousker, Galina |
Changes in telomeric chromatin composition upon POT1 3’-overhang deprotection |
poster |
|
Graniel, Jacqueline V |
A mouse model for a telomeropathic mutation in ACD/TPP1 |
poster |
|
Grill, Sherilyn A |
Two separation-of-function isoforms of human TPP1 and a novel intragenic RNA dictate telomerase regulation in somatic and germ cells |
poster |
|
Gu, Peili |
Role of Pot1b in the maintenance of global telomere length |
poster |
|
Gu, Yuchao (Jessica) |
Transcriptional regulation of the telomerase reverse transcriptase in stem cells and the germline |
poster |
|
Guettler, Sebastian |
Targeting the substrate binding domains of tankyrase to probe its functions at telomeres and in cell signaling |
poster |
|
Gunja, Sethu Madhava Rao R |
Poly(A)-specific ribonuclease (Parn) knockout zebrafish variants showed variable telomere lengths. |
poster |
|
Hasegawa, Kazuteru |
Loss of TERT compromises stem cell self-renewal independent of enzyme activity |
talk |
|
Hayashi, Makoto |
A single defined sister chromatid fusion destabilizes cell cycle through micronuclei formation |
talk |
|
Henslee, Gabrielle C |
Identification and characterization of novel ACD variants |
poster |
|
Hentschel, Jendrik |
Telomere DNA G-quadruplex folding within actively extending human telomerase |
talk |
|
Hoang, Song-My |
Transitional control of telomeric homology directed repair by Poly ADP-Ribose metabolism |
poster |
|
Hockemeyer, Dirk |
Using genetically engineered stem cell models to study cancer associated POT1 mutations |
talk |
|
Huang, Chenhui |
Speedy A regulates telomere-LINC complex connection via interacting with SUN1 |
poster |
|
Huang, Franklin W |
Integrated analysis of telomere content and genomic alterations across the cancer cell line encyclopedia (CCLE) |
talk |
|
Huggenberger, Susanna |
EXO1 resection at G-quadruplex structures facilitates resolution and replication at telomeres |
talk |
|
Ishikawa, Fuyuki |
Telomere-binding proteins Taz1 and Rap1 regulate DSB repair and suppress gross chromosomal rearrangements in fission yeast |
talk |
|
Johnson, Brad |
Modeling fibrotic pathologies of dyskeratosis congenita to evaluate potential therapies |
poster |
|
Jones, Celina Y |
The effect of telomere length on Ku’s essential role in human cells |
talk |
|
Jones-Weinert, Corey |
Telomeric replication stress and ncRNA transcription |
poster |
|
Karimian, Kayarash |
Measuring telomerase processivity using PacBio Sequencing |
poster |
|
Keener, Rebecca |
Tel1 and Mec1 use distinct pathways for DNA damage response signaling and telomere length regulation |
talk |
|
Klein, Shir |
The role of Rnr3, the Minor isoform of the large subunit of the RNR complex, in DNA repair and telomere length maintenance |
poster |
|
Kupiec, Martin |
Two alternative modes of action for yeast telomerase |
talk |
|
Kyriacou, Eftychia |
Why centromeres fall apart on meiotic entry, and how telomeres put them back together |
poster |
|
Lai, Tsung-Po |
Telomere-based senescence in the human placenta and fetal membranes at parturition |
poster |
|
Laster, Brenda H. |
Intratumoral long-term in vivo telomerase inhibition—An innovative cancer treatment |
poster |
|
Lazzerini Denchi, Eros |
Mechanism of TZAP-mediated telomere length regulation |
poster |
|
Lee, Jennifer Jaeun |
Brca2 abrogation engages with the alternative lengthening of telomeres via break-induced replication |
poster |
|
Li, Bibo |
The oligonucleotide-binding activity of RAP1 is essential for monoallelic VSG expression and cell viability in Trypanosoma brucei |
talk |
|
Lieberman, Paul |
Elevated telomere dysfunction in S47P African-American variant of TP53 |
poster |
|
Lim, Ci Ji |
Biochemical studies of human CST complex and its interactions with telomeric substrates |
talk |
|
Liu, Jia-Cheng |
Swc4 is a novel telomere regulator in Saccharomyces cerevisiae |
poster |
|
Liu, Jun-Ping |
Effect of peptidomimetic telomere dysfunction inhibitor (TELODIN) on the stress-induced stem cell premature senescence and fibrogenesis |
poster |
|
Logeswaran, Dhenugen |
Conservation and evolution of Metazoan telomerase RNA |
talk |
|
Lorbeer, Franziska K |
Modeling dyskeratosis congenita in human pluripotent stem cells |
poster |
|
Lottersberger, Francisca |
DNA-PKcs activity protects telomeres through stimulating Apollo-dependent overhang generation |
talk |
|
Lue, Neal |
The roles of telomere and cell cycle regulatory proteins in controlling an ALT-like pathway in Ustilago maydis |
poster |
|
Lundblad, Vicki |
The preferred substrate for telomerase in wild type yeast is a regressed replication fork |
talk |
|
Lustig, Arthur |
A role for yeast Rad59 in Mre11A470 motif telomere rapid deletion and size homeostasis |
poster |
|
MacNeil, Deanna |
N-terminal residues of human dyskerin are required for interactions with telomerase RNA that prevent RNA degradation |
talk |
|
Mangaonkar, Abhishek i |
Incidence and clinicopathologic implications of variants in genes affecting telomere structure and function in myeloid neoplasms |
poster |
|
Markiewicz-Potoczny, Marta |
The Shelterin complex is largely dispensable in pluripotent embryonic stem cells |
talk |
|
Mattarocci, Stefano |
Interplay between Rad5 and Srs2 helicases and Rad51 to assist telomere replication |
talk |
|
MENDEZ BERMUDEZ, AARON |
TRF2 maintains heterochromatic integrity during replicative senescence |
poster |
|
Meunier, Marion A |
Identifying novel protein surfaces on the Polymerase alpha-Primase complex |
poster |
|
Mirman, Zachary K |
The role of CST/Polα/Primase in DSB repair |
poster |
|
Moeller, Corinne A |
The RPA complex inhibits the activity of the t-RPA complex at replication forks |
poster |
|
Mojiri, Anahita |
Human telomerase mRNA treatment restores function in progeria iPSC- derived endothelial cells |
poster |
|
Momtareen, Taizina |
Investigation of helicases, exonucleases, and TERRA non-coding RNAs in telomere maintenance in S. cerevisiae |
poster |
|
Montero, Juan Jose |
TERRA regulate the transcriptional landscape of pluripotent cells through TRF1-dependent recruitment of PRC2 |
talk |
|
Myong, Sua |
Position of oxidative damage controls telomere conformation and telomerase extension activity |
poster |
|
Naeger, Anna |
Functional characterization of the human telomeric proteome during telomere replication |
poster |
|
Nageshan, Rishi Kumar |
Spindle dynamics dictate whether chromatin entanglements are resolved or further entangled |
talk |
|
Nagpal, Neha |
Restoring telomerase RNA in telomere diseases using small molecules |
talk |
|
Nandakumar, Jayakrishnan |
Combining conservation and species specificity to determine how human telomerase binds telomeres |
talk |
|
Neuhoefer, Patrick |
TERT+ acinar stem cells—A cell-of-origin for pancreatic cancer |
poster |
|
Neumann, Hannah |
Identification of yeast telomerase RNA transporters using mass spectrometry |
poster |
|
O'Sullivan, Roderick |
RAD51AP1 is a critical mediator of alternative lengthening of telomeres |
talk |
|
Padmanaban, Shilpa |
Filling in the gaps in our definition of the human telomerase recruitment complex |
poster |
|
Pasquier, Emeline |
Chromatin organization at telomeres in S. cerevisiae |
poster |
|
Patrick, Eric |
Direct observation of processive telomerase catalysis using high-resolution optical tweezers |
poster |
|
Pellman, David |
Mechanisms for rapid genome evolution |
talk |
|
Penev, Alex |
Dual mechanisms regulate hTERT expression in pluripotent cells |
talk |
|
Perez-Martinez, Lara |
Npl3 regulates R-loops at short telomeres to prevent premature senescence |
talk |
|
Pohl, Thomas J |
Viability in response to heat stress requires shelterin rearrangement and telomere shortening |
talk |
|
Qiao, Feng |
Quality control mechanism of telomerase RNA folding |
talk |
|
Qin, Jian |
SENP3 negatively regulates dykserin SUMOylation and the levels of telomerase RNA |
poster |
|
Raffa, Grazia Daniela |
The TGS1 hypermethylase negatively regulates telomere elongation |
poster |
|
Rai, Rekha |
Characterization of the mechanisms of catastrophic telomeric attrition in the absence of TRF2B and RAP1 |
poster |
|
Roake, Caitlin |
Disruption of telomerase RNA maturation kinetics precipitates disease |
talk |
|
Rosas Bringas, Fernando R |
Investigating the function of G-quadruplexes at telomeres |
poster |
|
Rubtsova, Maria P |
Integrator is involved in the human telomerase RNA biogenesis |
poster |
|
Sahin, Ergun |
Telomere dysfunction induces sirtuin repression that drives telomere-dependent disease |
talk |
|
Sanchez-Alonso, Patricia |
Partial characterization of mutants interrupted in a lncRNA gene suggest TER was found in Ustilago maydis |
poster |
|
Sandhu, Ranjodh |
The conserved TELR surface of shelterin protein TPP1 controls telomerase processivity at telomeres |
talk |
|
Sanford, Samantha L |
Investigating the impact of oxidized and therapeutic dNTPs on telomerase activity |
poster |
|
Savage, Sharon A |
Central nervous system manifestations of very short telomeres |
talk |
|
Schmidt, Jens C |
Direct observation of processive telomerase catalysis using high resolution optical tweezers |
talk |
|
Schratz, Kristen E |
The cancer phenotype of short telomere syndromes |
talk |
|
Sfeir, Agnel J |
Genome-wide screen identifies genetic vulnerabilities in cells expressing mutant POT1 |
poster |
|
Shubin, Calla |
Examining origin firing and telomere length in S. cerevisiae |
poster |
|
Silva, Bruno A |
FANCM restricts R-loop-induced telomeric replication stress in ALT cells |
poster |
|
Simpson, Mark |
Telomere-dysfunction induced cellular senescence during gestation, labor onset, and parturition in humans |
poster |
|
Smith, Susan |
Overlapping but distinct mechanisms for resolution of human ribosomal DNA and telomeres in mitosis |
talk |
|
Sommer, Aurore |
The CST complex—A role in the alternative lengthening of telomeres? |
poster |
|
Songyang, Zhou |
Identification and study of human telomerase regulators |
talk |
|
Stern, Josh L. |
Cancer types that commonly harbor TERT promoter mutations display enhanced expression of mesenchymal genes, including the transcription factor SNAIL2, which can regulate TERT mRNA expression |
talk |
|
Stevens, Katie |
Together we are stronger—The importance of partnering with patients through Team Telomere |
poster |
|
Stewart, Jason A |
Human CST interacts with the MCM2-7 complex and negatively regulates replication origin licensing |
talk |
|
Stinus Ruiz de Gauna, Sonia |
Investigating the role of human telomeres in post-mitotic nuclear reorganization |
poster |
|
Stone, Michael D |
Structural dynamics and heterogeneity in the essential three-way junction of human telomerase RNA |
poster |
|
Sun, Chongkui |
The macroH2A1.2 histone variant links ATRX loss to alternative telomere lengthening |
poster |
|
Takasugi, Taylor N |
Loss of Pot1b promotes telomere length elongation |
poster |
|
Tan, Kar-Tong |
Catching chromosomal ends in cancer genomes with long reads |
talk |
|
Tang, Mengfan |
Human Rif1 interact with TRF2 and is required for the maintenance of heterochromatin state of telomere |
poster |
|
Teixeira, Maria Teresa |
Interplay between DNA damage checkpoints and stress-induced response to control ROS levels during replicative senescence |
poster |
|
Thadani, Rahul R |
The torsional state of telomeres |
poster |
|
Thompson, Ashley S |
Prevalence of RTEL1 germline mutations in disease and the general population |
poster |
|
Tomita, Kazunori |
Age-related telomere shortening in human putamen |
talk |
|
Turkalo, Timothy K |
Strand-seq analysis reveals no genome-wide stability role for ATRX or RTEL1 in hPSCs |
poster |
|
Vessoni, Alexandre |
Telomere dysfunction and oncogene stress induce different fates in human embryonic stem cells |
poster |
|
Wagner, Tina |
Telomere folding is defective in senescent cells due to altered histone modifier expression |
poster |
|
Wang, Fang |
Characterization of telomeric repeat-containing RNA (TERRA) transcripts during mouse early embryo development |
poster |
|
Wang, Hong |
TIN2 is an architectural protein stabilizing TRF1-mediated telomeric DNA-DNA pairing at the single-molecule level |
talk |
|
Wong, Judy |
Effects of single nucleotide polymorphisms in telomerase reverse transcriptase on telomere length maintenance and progression of chronic obstructive pulmonary disease |
poster |
|
Wong, Lee |
The roles of H3.3 and ATRX in driving ALTernative lengthening of telomeres in cancers |
talk |
|
Wood, Michael |
Impact of chromosomally integrated human herpesvirus 6 release on telomere stability |
poster |
|
Wu, Yangxiu |
Development of a proteomic classifier to identify telomere maintenance mechanisms in human cancer |
talk |
|
Wu, Zhenfang |
Structural insights into telomerase inhibition and telomere capping by CST in budding yeast |
talk |
|
Wu, Zhi-Jing |
Telomere maintenance in single chromosome yeast |
poster |
|
Xu, Dawei |
The TERT locus genotypes of rs2736100-CC/CA and rs2736098-AA genotypes in the TERT locus predict shorter survival in renal cell carcinoma |
poster |
|
Yang, Zhe |
Break induced replication promotes fragile telomere formation |
talk |
|
Young, Pierce G |
Identification of methyltransferase NOP2a as a novel gene involved in telomere length set point in Arabidopsis thaliana |
poster |
|
Yu, Eun Young |
Telomere trimming and DNA damage as signatures of high risk neuroblastoma |
talk |
|
Yun, Maximina H |
Telomere length is exclusively maintained by the ALT mechanism in a vertebrate, the newt Pleurodeles waltl |
talk |
|
Zappulla, David |
A 4-bp core-enclosing helix in TLC1 RNA is essential for telomerase activity and binding to TERT |
talk |
|
Zhang, Dong |
FANCM suppresses DNA replication stress at ALT telomeres by disrupting TERRA R-loops |
poster |
|
Zhang, Fan |
ETV5 and c-Myc cooperate to activate hTERT promoter in a repressive chromatin context via composite ETS/E-box sites |
poster |
|
Zhang, Huaiying |
Phase transition drives telomere clustering |
talk |
|
zhang, jiamin |
Alternative lengthening of telomeres through two distinct break-induced replication pathways |
talk |
|
Zhang, Tianpeng |
Defining telomere proteome and dynamics in response to damage |
talk |
|
Zhu, Jiyue |
Humanizing telomerase reverse transcriptase (Tert) gene in mice |
poster |
|
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