Presenting Author

Abstract Title

Presentation

Abadie, Kathleen V

Flexible control of T cell memory and self renewal by a reversible epigenetic switch

talk

Abbate, Maria Francesca

Computational detection of antigen-specific B-cell receptors following immunization

poster

Abou-Daya, Khodor

Simultaneous snRNA&ATACseq characterizes specific innate immune memory

talk

Aizawa, Yasunori

Development of master iPSCs with switchable HLA genes by mega-base-scale genome engineering

poster

Allen, Greg M

Synthetic cytokine circuits drive targeted infiltration and proliferation of T cells in immune-excluded tumors

talk

Altan-Bonnet, Gregoire

Building models of CAR-T signal integration, using automatized/dynamic high-dimensional experimental profiling

talk

An, Andy

Post-COVID symptoms and endotypes are associated with the inability to modulate the trajectory of immune and hemostatic pathways

poster

Ankomah, Pierre O

Single cell profiling of blood immune cell substate kinetics in early sepsis reveals progressive decrease in monocytic myeloid-derived suppressor cells

talk

Arazi, Arnon

Quantifying cellular cooperativity and inferring the extracellular signals driving it

poster

Arzoomand, Aron

Profiling early life immune-microbe interactions to determine vaccine and allergen responses

poster

Aurich, Theo

Engineering of stem cell-derived CAR-macrophages carrying payloads to remodel the tumor microenvironment

poster

Badger, Jonathan H

Applying machine learning to predict clinical response from intestinal microbiota in melanoma patients undergoing anti-PD1 treatment

poster

Banerjee, Amitava

Quantitative modeling and analysis of TCR cross-reactivity

talk

Baskaran, Janani

Studying the evolution of tumor-associated macrophages in a 3D spheroid model of the early melanoma tumor microenvironment

poster

Behr, Felix M

Co-stimulatory signals via CD28 And CD27 collaborate to regulate IL-2 production in CD8⁺ T cells

poster

Berenson, Anna

Mapping cooperativity and antagonism between transcription factors at immune response gene promoters

poster

Bobrowski, Tesia

The liver-infiltrating immune landscape in chronic Norway rat hepacivirus infection at single cell resolution

poster

Boudjeniba, Cheima

Meta-analysis on independent Sjögren disease cohorts identifies consensus gene modules aimed to help stratify patients and predict response to treatment

poster

Bullock, Margaret Elise

Mathematical modeling of the dynamic structure of circulatory CD4+ memory T cell subsets

poster

Butchy, Adam A

Large-scale discrete executable modeling of alveolar macrophages

poster

Caron, Daniel P

Multimodal hierarchical classification allows for efficient annotation of CITE-seq data

poster

Chan, Kwan Pui

Longitudinal single-cell RNA sequencing reveals B cell repertoire differences induced by wild-type measles virus compared to live-attenuated measles vaccine

poster

Chau, Chiu Wang

Organoid-modeling of SARS-CoV-2 cytokine storm and vasculitis

poster

Chaudhuri, Shuvam

Mediator complex subunit 1 promotes differentiation and function of a tumor-specific T regulatory cell population

poster

Cheemalavagu, Neha

Modeling and modulating STAT activation features that predict expression of cytokine-specific gene sets

poster

Chen, Guangbo

Cytokines surge in the blood years before a cancer diagnosis in elderly individuals

poster

Chen, James

Using network modeling of tissue resident Tregs to facilitate the development of novel therapeutics in autoimmune diseases

poster

Chen, Qi

Systems-level analysis reveals baseline immune profiles associated with cancer metastasis and clinical outcomes in children with solid tumors

poster

Chen, Yvonne

Engineering next-generation T Cells for cancer immunotherapy

talk

Cheong, Jin Gyu

Epigenetic memory of COVID-19 in innate immune cells and their progenitors

poster

Chevrier, Nicolas

Organism-wide analysis of sepsis reveals mechanisms of systemic inflammation

talk

Chin, Christopher R

Epigenetic states of germinal center B cells determined by single cell multiomics analysis can predict B cell fate

talk

Clatworthy, Menna

Temporal profiling of human lymphoid tissues reveals coordinated defence to viral challenge

talk

Clifford, Robert

qMAST—A single cell transcriptomic pipeline for analyses of quantitative phenotypes

poster

Cruz de Casas, Paulina

Lymphatic migration of unconventional T cells promotes site-specific immunity in distinct lymph nodes

talk

Cruz, Agustin A

Discovery of novel Treg modulators by integrating gene expression profiling with computational modeling and functional assays

talk

Das, Jishnu

Multi-dimensional integration of protein interactomes with genomic and molecular data discovers distinct RA endotypes

talk

Davis, Mark

Regulatory T cell subsets in autoimmunity, immune organoids, and analyzing T cell responses at scale

talk

Dolatshahi, Sepideh

Uncovering the spatiotemporal dynamics of placental IgG transfer toward precision prenatal vaccination

talk

Eksi, Ece M

Multiplex imaging of localized prostate tumors reveals changes in mast cell type composition and spatial organization of AR-positive cells in the tumor microenvironment

talk

El Bejjani, Anthony

Modeling the heterogeneous interferon response of human airway epithelium at single cell resolution

poster

Fan, Jingyu

Systematic analysis of simple and composite transcriptional elements encoded in immune cis-regulomes using massively parallel reporter assays

poster

Fangal, Vrushali D

Network dynamics of the immune system for understanding asthma heterogeneity

poster

Farber, Donna

Development of adaptive immunity in human tissues

talk

Fazli, Mehran

Gene bundling—Deriving optimal clusterings of gene-correlation networks in sepsis

poster

Feldman, Erik

Towards the incorporation of an immune-state metric into routine clinical assessment

poster

Ford, Rhodes

Tumor microenvironmental signals reshape chromatin landscapes to limit the functional potential of exhausted T cells

poster

Forlin, Rikard

Testosterone-induced changes in transcriptional responses to stimulation during female-to-male sex-reassignment

talk

Fowell, Deborah

Spatiotemporal regulation of T cell activation niches—Integrating intravital multiphoton imaging with spatial and temporal scRNAseq

talk

Freeman, Samuel S

Evolution of peripheral and intratumoral T cell dynamics in chemoimmunotherapy-treated ovarian cancer

poster

Gao, Shengyu

Cooperative regulation of T helper cell tolerance by TGF-β and PD-1 in immune-homeost

poster

George, Alex

A lymph node slice culture model to characterize T cell activation dynamics and anti-viral responses in human tissue

talk

Gerber, Georg

Joint inference of human immune gene expression and gut microbiome topics and their interactions

poster

Gerlach, Carmen

CX3CR1 is a graded and universal differentiation marker unifying human and murine T cell differentiation

poster

Germain, Ronald N.

Tipping points in biology—Quantitative and temporal control of responses from the cell level to organismal survival upon infection

talk

Gharia, Asmaysinh

PEDOT:PSS coated electrodes for electroporation of monocytes

poster

Glaser, Katharina

Dissecting the cellular events that control swarming dynamics of neutrophil populations.

talk

Gottschalk, Rachel A

Systematic prediction of STAT-cooperating pathways that support cytokine-specific gene expression

talk

Gounari, Fotini 

Molecular redundancies of TCF-1 with LEF-1 and cooperation with HEB, Ikaros and Runx1 in DP thymocytes

poster

Guha Roy, Priyamvada

Integration of a structurally resolved protein network with signaling cascades uncovers immunomodulatory molecular phenotypes in infectious disease

poster

Haj Dezfulian, Mohamamd

Identification of CD4+ T cell antigens in Sjögren's disease using TScan-II

talk

Herati, Ramin

SARS-CoV-2 infection and mRNA vaccination induce molecularly distinct memory CD4+ T cells

poster

Hoffmann, Alexander

Macrophage states defined by the dynamic responses to stimuli

talk

Horns, Felix

Engineering RNA export for measurement and control of living cells

talk

Hu, Dan

Increased expression of Hsp70.2 in multiple sclerosis and its regulation of T_H17 function

poster

Huang, Helen

T-dependent B-cell selection and proliferation—A systems analysis of signal I and signal II integration

poster

Huang, Linglin

Dynamic immune landscapes during melanoma progression reveal a role for endogenous opioids in driving T cell dysfunction

talk

Jiang, Jenny

High-throughput and high-dimensional single-cell profiling of T cells

talk

Jiang, Ya

Distinguishing transcriptional and post-transcriptional regulation in human naïve and memory CD8⁺ T cells

poster

Joglekar, Alok V

An integrated analysis of the antigen-specific T cell landscape in autoimmunity

talk

Johnson, Jeanette

Inferring cellular and molecular processes in single-cell data with non-negative matrix factorization using Python, R, and GenePattern Notebook implementations of CoGAPS

poster

Kaminski, James

CAR-T cell infusion results in activation of CD160+/NKG2D+/CCL5+ non-CAR CD8+ cytotoxic 'bystander' T cells in both non-human primates (NHP) and patients receiving B-cell-directed CAR-Ts

poster

Kaminski, James

Targeting CNS lymphoma with intravenous axicabtagene ciloleucel and elucidating the transcriptional program of CAR-T cells trafficking to the tumor site

poster

Karnaukhov, Vadim

TCRen—Predicting TCR recognition of unseen epitopes based on residue-level pairwise statistical potential

poster

Katko, Alexander

genome-wide transcriptional regulatory network of human immunological memory using single-cell multiome-seq

poster

Kaur, Charandeep

Comparison of activation induced markers to detect antigen specific CD8+ T cells

poster

Ke, Ziying

Single-cell transcriptomics identifies key components in metabolic pathways of drug perturbed CD4+ T cells

poster

Kedlian, Veronika

A spatial thymus human cell atlas mapped to a continuous tissue axis

talk

Khan, Aly

Deciphering anti-tumor immune responses with systems immunology and genomics

poster

Khan, Muhammad Zuhaib

Exploiting CRISPR activator associated reporter system to study genetic essentialities involved in B cell lymphomagenesis

poster

Kim, Green

Cynomolgus macaque model for COVID-19 Omicron variant infection

poster

Kim, Hyun Je

Single-cell RNA sequencing identifies distinct transcriptomic signatures between PMA/ionomycin- and αCD3/αCD28- activated primary human T cells activation

poster

Kim, YeEun

Protein expression of terminal deoxynucleotidyl transferase (TdT) identifies a lymphoid-primed progenitor population in human bone marrow

poster

Kleemann, Kilian

Microglial-specific miR-155 deletion enhances interferon-dependent response to neurodegeneration and mitigates cognitive impairment in a mouse model of Alzheimer’s disease

talk

Koguchi, Yoshinobu

Pan-cancer single cell RNA-sequencing analysis of the tumor microenvironment reveals a broad-spectrum of balance between immune suppression and activation among different cancer types

poster

Kokai, David

Investigating the relationship between HLA genotype and mutational signatures in carcinogenesis—A large mutagenesis study

poster

Krausgruber, Thomas

Single-cell and spatial transcriptomics reveal aberrant lymphoid developmental programs driving granuloma formation

talk

Kruszelnicki, Sonia M

Influence of the microbiota on lung-specific macrophage programming

poster

Kutmon, Martina Summer

Different B cell activation patterns in asymptomatic and symptomatic COVID-19 patients

poster

Lagattuta, Kaitlyn

Quantifying how TCR sequence variation affects T cell fate at single-cell resolution

talk

Lanser, Toby B

Nasal αCD3 upregulates type-I IFN responses in T-cells in EAE

poster

Lee, Colin

Time, tissue and treatment associated heterogeneity in tumour-residing migratory DCs modulate anti-tumour cytolytic activity

poster

Leslie, Christina S

Decoding immune cell states in single cell and spatial data

talk

Liu, Can J

Immune imprints by acute influenza infection impact the outcome of subsequent local immune response

poster

Liu, Candace

Pixie—A pipeline for robust phenotyping of highly multiplexed tissue imaging data using pixel-level clustering

poster

Lukacisin, Martin

Interferon rewiring during immune aging

poster

Lundsgaard, Emma Alberte

Comprehensive mapping of the SARS-CoV-2 virus-host microRNA interactome

poster

McKinney, Eoin

Multi-Omic analysis identifies metabolic enhancement of immune memory by lysine deacetylase inhibition during immunisation and infection

talk

Meler, Ainara M

HDAC7 instructs the germinal center program and its underexpression is involved in Diffuse large B cell lymphoma

poster

Meyer, Kerstin

Human SARS-CoV-2 challenge resolves innate and adaptive immune responses at single cell resolution

poster

Miller-Jensen, Kathryn

Exploring the regulation of macrophage heterogeneity across tissue contexts

talk

Milo, Tomer

A lymph-node microdomain theory for T cell quality control

poster

Mitra, Sneha

Role of regulatory T cells in colorectal cancer

poster

Morath, Katharina

Activation-neutral gene editing of CD4 T cells in human ex vivo tonsil cultures

poster

Mule, Matthew P

Multicellular immune networks of disease activity and clinical outcome in vasculitis

poster

Nagashima, Kazuki

Mapping the T cell repertoire to a complex defined gut bacterial community

talk

Nahman, Ornit

Comparative analysis of normalization methods for spatial transcriptomic data

poster

Nguyen, Diep

Dynamic fractional control of interferon production in viral infection

poster

Obradovic, Aleksandar

Discovery and inhibition of Treg tumor-infiltration master regulator proteins by virtual inference of protein activity

poster

OH, Taehwan

Digital spatial profiling in lungs of cynomolgous macaques experimentally infected with SARS-CoV-2

poster

Oyler Yaniv, Alon

The spread of interferon-γ in melanomas is highly spatially confined, driving non-genetic variability in tumor cells

talk

Oyler-Yaniv, Jennifer O

Crosstalk and plasticity in infection-induced programmed cell death

poster

Paculova, Hana

Integrative gene regulatory network analysis of Ikaros tumor suppression in IKZF1-mutated B cell acute lymphoblastic leukemia cells

poster

Pagane, Nicole M

Tissue-specific optimization of T cell activation in draining lymph nodes

poster

Pankow, Alec P

A comparative study of primary and immortalized in vitro air-liquid interface culture models of the human airway epithelium evaluating cellular heterogeneity and gene expression at single cell resolution

poster

Park, Kyemyung

Self-reactivity drives self-tolerance in the periphery—A suggestion by fractal IL-2-mediated CD4+ T cell regulatory circuits

poster

Parker, Ivana

Multilevel proteomics reveal epigenetic markers influencing BCG-mediated macrophage activation

poster

Pease, Nicholas A

Analysis of signaling-coupled transcription factor networks regulating human B cell fate dynamics

poster

Pekkarinen, Pirkka T

Innate immune response after cardiac arrest—The INNATUS study

poster

Peters, Moritz

CITR-Seq—A robust method to generate paired T cell receptor repertoires in mice

poster

Philips, Rachael L

STAT1 gain of function mutation impairs immune response to viral infections

poster

Pompano, Rebecca

Modeling adaptive immunity using lymph nodes and microfluidics

talk

Pritykin, Yuri

Regulatory genomics of T cell activation and differentiation

poster

Rahimikollu, Javad

SLIDE—Significant latent factor interaction discovery and exploration across immunological domains

poster

Rane, Sanket

How are the gatekeepers of the immune system maintained throughout life?

poster

Ravichandran, Sathyabaarathi

Pre-vaccination CD56^dim CD16+ NK cell abundance and T_h1/T_h17 ratio predict responsiveness to conjugated pneumococcal vaccine in older adults

poster

Ray, John

Systematic discovery of autoimmune disease-causal regulatory variants and their effects on T cell function

talk

Rengarajan, Michelle

A comprehensive thyroid cellular atlas reveals thyrocyte-stromal-immune interactions that drive tissue infiltrative autoimmunity

talk

Reyes, Miguel

Microscale combinatorial stimulation of human myeloid cells reveals inflammatory priming by viral ligands

talk

Rodriguez, Lucie

Immune system perturbations in patients with severe long COVID

poster

Roskin, Krishna M

B cell repertoire in children with skin barrier dysfunction supports altered IgE maturation associated with allergic food sensitization

poster

Saez-Rodriguez, Julio

Knowledge-based machine learning to extract molecular mechanisms from single-cell and spatial multi-omics

talk

Schrom, Edward C

Spatial patterning analysis of cellular ensembles (SPACE)—A general framework for characterizing spatial relationships among cell types in tissues

poster

Schroter, Juliane

Studying T-lymphocyte dynamics in disease—Inferring population reference functions normalizing for natural age-dependent changes

poster

Scott, Charlotte

The good, the bad and the beautiful side of Kupffer cell activation in infection

talk

Scott, Milcah C

Single cell molecular readouts coupled with migration assays to test unifying core tissue resident memory CD8+ T cell identity

talk

Sheu, Katherine

Inferring the single-cell transcriptome dynamics of macrophages reveals context-dependent dynamical features that generate high stimulus-response specificity

poster

Shrock, Ellen

Germline-encoded amino acid-binding motifs drive public antibody responses

talk

Singh, Apeksha

Model-aided dissection of the inflammation-associated dysregulation of hematopoietic progenitor cell fate specification

poster

Singh, Harinder

Assembly and modeling of a dynamic gene regulatory network that regulates human B cell fate dynamics

talk

Son, Minjun

NF-κB dynamics encode the spatial and temporal information of local infection and immune cells

poster

Song, Baobao (Annie)

High-throughput workflow leveraging spectral flow cytometry and CITE-seq to characterize human bone marrow across race and gender

poster

Song, Baobao (Annie)

Live bacterial ligands universally regulate mTOR activity but are not essential for homeostatic innate immunity

poster

Stark, Jessica

Antibody-lectin chimeras for glyco-immune checkpoint blockade

talk

Subramanian, Ayshwarya

The immune checkpoint molecule Tim-3 regulates microglial function and Alzheimer’s disease pathology

talk

Subramanian, Naeha

Hallmarks of peripheral and tissue immunity in Lyme disease identified by a deep multiomic investigation in humans

poster

Sugimura, Rio

PD-L1 regulates inflammatory macrophage development from human pluripotent stem cells by maintaining interferon gamma signaling

poster

Szabo, Peter A

Human infant and adult T cells exhibit distinct programs of residency, activation, and effector function across tissues

talk

Tan, Ziyang

Persistent T cell expansions are found in the peripheral blood of patients with pediatric solid tumor using longitudinal single cell profiling

poster

Tang, Rui

Quantitative dissection of T cell and cancer cell interactions within the tumor microenvironment

poster

Thakar, Juilee

Executable models of pathways built using single-cell RNA seq data reveal immune signaling dysregulations in people living with HIV and atherosclerosis

talk

Tingvall-Gustafsson, Johanna

Liana—A tool for 3D interaction-based annotation of distal regulatory elements to genes

poster

Tripathi, Shubham

Systems-level analysis of co-stimulatory and co-inhibitory signaling between CD8+ T cells and antigen-presenting cells

poster

Tsang, John S.

Systems immunology of human immune set points

talk

Vaidehi Narayanan, Haripriya

Regulation of NFκB cRel dynamics in B-cells modulates clonal expansion and selection in the antibody repertoire

poster

van Dorp, Christiaan H

A variational deep-learning approach to modeling memory T-cell dynamics

poster

Vistain, Luke

Proximity sequencing—A highly-multiplexed method to measure extracellular proteins, protein complexes, and mRNA in single cells

poster

Wang, Andrew

Single-cell NF-κB activation dynamics encode innate immune memory

poster

Wang, Wei

Comprehensive single cell sequencing analysis of paired tissue and blood samples from HCC patients treated with neoadjuvant anti-PD-1 therapy reveals treatment-induced clonal T cell dynamics

poster

Wayman, Joseph

An atlas of gene regulatory networks for T memory cells in youth and old age

poster

Wilder, Catera

A stimulus-contingent positive feedback loop enables IFN-β dose-dependent activation of pro-inflammatory genes

poster

Wong, Harikesh S

Non-coding fragility within interleukin-2 feedback circuitry shapes autoimmune disease risk

talk

Woo, YoungMin

The effect of Fingolimod on circulating B cells in cynomolgus macaque

poster

Xu, Qin

SARS-CoV-2 mRNA vaccination induces B cell responses in the tonsils and adenoids of children

poster

Yang, Zi

Single-cell genomics study of autoimmune liver disease pathogenesis

poster

Yim, Isaiah

Investigating the TNFα-IL-10 immune regulatory feedback dynamics in THP1 macrophages

poster

Yu, Bingfei

Decoding and rewiring immune recognition at the single-cell level

talk

Zaucha, Magdalena

Yellow fever vaccination as a model to study variability in immune responses to RNA viral infections

poster

Zhang, Bingjie

Multimodal characterization of antigen-specific CD8+ T cells across SARS-CoV-2 vaccination and infection

poster

Zhang, Yi

MetaTiME—Meta-components of the tumor immune microenvironment

poster

Zhang, Yi

Systematic quantification of IL-1-induced human blood response of immune cells with single-cell multi-omics to predict immunotherapy prognosis

poster

Zhanzak, Zhuldyz

Using predicted immunopeptidomics to target antigen-specific T cell receptor repertoires

poster

Zhu, Biqing

Single cell characterization of immune mediated autoimmunity in Parkinson’s disease

poster

Zhu, Hongya

Identification of key transcription factors that specify different naïve CD8+ T cell subsets

poster

Zhu, Hongya

Identifying dysregulated monocytes in ME/CFS patients using single cell RNA-seq profiles

poster

Zwijnenburg, Anthonie J

CD8+ T cell differentiation and activation represent distinct axes of diversification

poster