84th Symposium: RNA Control & Regulation
May 29 - June 3, 2019

You must register for the meeting in order to submit abstracts.
After registering you will be sent a web link for abstract submission by email.
You may copy and paste your abstract from Word, Google Docs, or Notepad; abstracts are limited to ~2900 characters.

Program information: An electronic version of the program abstract book will be sent three working days prior to the first day of the meeting, and hard copies will be available for collection upon your arrival at Cold Spring Harbor Laboratory. First night and keynote speakers are informed of their session date and time, otherwise program information is only available upon release of the electronic version of the abstract book. The reason we do this is to try and maximize interactions by encouraging participants to stay for the duration of the meeting.

Please check your email for talk length, poster instructions, and how to have your poster printed at CSHL for collection upon arrival. 

Abstract Status

Presenting Author

Abstract Title

Talk/Poster

Abdelmohsen, Kotb

Transcriptome signature of cellular senescence

poster

Abdel-Wahab, Omar I

Understanding and targeting spliceosomal gene mutations in cancer

talk

Adelman, Karen L

Regulating transcription elongation at promoters and enhancers

talk

Agrawal, Shipra

Differential splicing of APOL1 mRNA is associated with glomerular disease and with therapy

poster

Aguilera, Andres

New cellular functions preventing co-transcriptional R loops and associated genome instability

talk

Akhtar, Asifa

Dosage compensation of the X chromosome—An intricate epigenetic phenomenon involving chromatin regulators and long non-coding RNAs

talk

Amit, Roee

Synthetic 5’ UTRs can either up- or down-regulate expression upon RBP binding

poster

Andergassen, Daniel

In vivo Firre and Dxz4 deletion elucidates roles for autosomal gene regulation

poster

Andreassi, Catia

3’UTR cleavage of transcripts localized in in sympathetic neuron axons

poster

Arake de Tacca, Luisa M

PTBP1 mRNA isoforms and regulation of their translation

poster

Aravin, Alexei

Programmable DNA and RNA processing by prokaryotic Argonaute proteins

poster

Arraiano, Cecilia

New roles for sRNAs and RNA chaperones

poster

Atianand, Maninjay

The role of long noncoding RNAs in innate immunity and inflammation

poster

Bai, Rui

Structures of the fully assembled Saccharomyces cerevisiae spliceosome before activation

poster

Baker, Alison

Examining the oncogenic role of ADAR1 in breast cancer

poster

Barron, Lindsey A

Understanding the role of Mediator kinase in  uterine fibroid tumorigenesis

poster

Bartel, David

The dynamics of cytoplasmic mRNA metabolism

talk

Bass, Brenda L.

Understanding the roles and regulation of Dicer in antiviral defense

talk

Baumann, Bethany

Examination of the small RNA landscape in prostate epithelium reveals abundance of PIWI-interacting RNAs and regulation by vitamin D

poster

Baymuradov, Ulugbek

The ENCODE transcriptome pipelines—Reproducible, portable tools for RNA-seq analysis

poster

Beltran, Toni

Heritable small RNAs mediate short-term but not long-term epigenetic variation in C. elegans

poster

Bhat, Prashant

Determining the function and mechanism of the MALAT1 long non-coding RNA in co-transcriptional splicing

poster

Bhatt, Bharat

Deregulated long non coding RNA, Malat1, regulates host-mycobacterial interactions

poster

Bi, Xianju

RNA targets ribogenesis factor WDR43 to chromatin for transcription and pluripotency control

poster

Bicknell, Alicia A

miRNAs enable mRNA therapeutics to selectively program cancer cells to self-destruct

poster

Biscarini, Silvia

LncRNAs in motor neuron differentiation and physiopathology

poster

Blumberg, Amit

Characterizing RNA stability genome wide through combined analysis of PRO-seq and RNA-seq data

poster

Bofill-De Ros, Xavier

TUT4/7 targets RISC-associated miRNAs for DIS3L2 degradation

poster

Bonasio, Roberto

Protein–RNA interaction mapping reveal a new RNA-based function of TET2

poster

Boreikaite, Vytaute

Investigating protein-protein interactions within the nuclease module of the budding yeast cleavage and polyadenylation factor complex

poster

Bradley, Robert K

RNA isoform screens reveal the essentiality and tumor suppressor activity of ultraconserved poison exons

talk

Bradley, Thomas

FilTar—A context specific miRNA target prediction pipeline incorporating transcriptomic data to reannotate 3’ UTRs and filter non-expressed targets

poster

Brennecke, Julius

Avoiding genetic auto-immunity in the piRNA pathway

talk

Bridgewater, Hannah E

Analysis of positive selection CRISPR knockout screens using broad-spectrum anticancer compounds for selection versus targeted compounds for selection

poster

Brockdorff, Neil

Chromosome silencing by Xist RNA

talk

Brodersen, Peter

Plant DICER-LIKE2 is a cytoplasmic sensor of viral RNA

poster

Cao, Jun

Nanopore and poly(A)-sequencing reveals a new role for RBFOX2 in alternative polyadenylation regulation

poster

Carone, Dawn M

Effect of pericentric satellite RNA on nuclear protein distribution and cell division

poster

Cartegni, Luca

Inhibition of signaling and tumor growth in treatment-refractory lung cancer by induction of natural secreted soluble decoy RTK variants

poster

Casteels, Tamara

Epigenome-wide RNAi screen identifies a repressor of insulin expression in alpha cells

poster

Cervantes, Marlene

Nucleolar BMAL1 interacts with Box C/D small nucleolar RNA protein NOP58 to regulate pre-ribosomal RNA processing

poster

Chan, Jia Jia

Circular RNAs in acute myeloid leukemia

poster

Chang, Howard

Genome regulation by long noncoding RNAs

talk

Chang, Kung-Chi

Assessing the role of the long non-coding RNA MaTAR25 in mammary tumor progression

poster

Chaubey, Divya

Maternal control of brain development—Role of long non-coding RNA durga in dendrite dynamics during development

poster

Cheikhi, Amin

Single cell flow imaging analysis of muscle satellite cells reveals age-dependent storage of Pax7 mRNAs in processing bodies

poster

Chen, Leilei Polly

Understanding the mechanisms of fine-tuning A-to-I RNA editing in cancer

poster

Chen, Lingling

Lnc-ing RNA processing and function

talk

Chen, Mengnuo

tRNA m1A methyltransferase TRMT6 promotes liver cancer stemness

poster

Chen, Peiwei

Rhino-Deadlock-Cutoff (RDC) complex is required for piRNA silencing and genomic integrity during Drosophila spermatogenesis

poster

Choi, Heejin

Chromosome 18 pachytene piRNA required for sperm head morphogenesis

poster

Choi, Jeongyoon

Towards unravelling tertiary structure of a mammalian long non-coding RNPs

poster

Choudhari, Ramesh

Identification and functional characterization of tumor-specific X-linked genes in breast cancer

poster

Conti, Elena

Molecular mechanisms of poly(A) tail length regulation

talk

Courchaine, Edward M

Symmetrically dimethylated arginine mediates condensation of Cajal bodies

poster

Dai, Lisheng

A robust approach for forward genetic discovery of cellular factors in primary microRNA processing

poster

Darnell, Robert B.

Cell-specific RNA CLIP

talk

Das, Sankha Subhra

MicroRNA expression profiling and comprehensive analysis of differentially expressed microRNAs in hemoglobin E-β-thalassemia

poster

De Zoysa, Meemanage D

The effect of U2 snRNA pseudouridylation on pre-mRNA splicing in S.cerevisiae

poster

Dean, Caroline

Antisense-mediated chromatin regulation

talk

Deryusheva, Svetlana

SnoRNA guide activities real and ambiguous

poster

Ding, Fangyuan

Constitutive splicing and economies of scale in gene expression

poster

Ding, Yiliang

RNA structure-dependent activation of endonuclease RISC promotes miRNA cleavage in vivo

poster

Dobin, Alexander

Inferring cell-type-specific splicing, RNA editing, alternative polyadenylation and transcription initiation from single-cell RNA-seq data

poster

Dong, Xianjun

Circular RNAs—A novel link between genetic susceptibility and Parkinson’s disease?

poster

D'Orazio, Karole N

Endonucleolytic cleavage of problematic mRNAs by Cue2 to rescue stalled ribosomes

poster

Doudna, Jennifer

Diverse Cas proteins from the CRISPR family tree

talk

Dreyfuss, Gideon

Telescripting—U1 snRNP suppression of premature transcription termination as a new layer of gene regulation

talk

Duda, Katarzyna J

RNA methylation in mammalian heterochromatin

poster

Duffy, Erin E

Solid phase chemistry to covalently and reversibly capture thiolated RNA

poster

Elchert, Alexandra R

CRISPR genome editing strategies to elucidate function of piRNA pathway genes in ovarian somatic sheath cells (OSC)

poster

Elguindy, Mahmoud M

PUMILIO, but not RBMX, binding is required for regulation of genomic stability by noncoding RNA NORAD

poster

Enganti, Ramya

Mechanisms of ribosomal RNA gene regulation in Arabidopsis thaliana

poster

Erhardt, Sylvia

Centromeric tRNA methylation by Dnmt2 is required for chromosome segregation in mitosis

poster

Fabry, Martin

piRNA-guided co-transcriptional silencing coopts nuclear export factors

poster

Fan, Xiaojuan

Most circular RNAs are potentially translated

poster

Fei, Qili

Cell cycle regulation by the m6A reader YTHDF2

poster

Fitzsimmons, Christina M

Elucidating the modification status of tRNAs in response to environmental and metabolic stress

poster

Flynt, Alex

Metabolism of endogenous and exogenous RNAs in the two-spotted spider mite

poster

Fonseca Cardenas, Alejandro

Differential nuclear/cytoplasmic accumulation of transcripts in response to nitrate in Arabidopsis thaliana roots

poster

Fu, Xiang-Dong

Chromatin-associated RNAs and RNA binding proteins in transcription control

talk

Gaffen, Sarah

Regulation of Interleukin-17 signaling by Arid5a and Regnase-1/MCPIP1

poster

Gainetdinov, Ildar

Understanding the molecular mechanisms of target RNA recognition and regulation by piRNAs

poster

Gandhi, Minakshi

lincNMR regulates nucleotide metabolism via a YBX1 - RRM2 axis in cancer

poster

Garcia, David M

The prion form of a pseudouridine synthase drives accelerated proliferation and aging

poster

Garg, Salil

Networks of enhancers and microRNAs drive variation in cell states

poster

Gasser, Susan

LSM2-8 and XRN-2 contribute to the silencing of H3K27me3-marked genes through targeted RNA decay

talk

Genzor, Pavol

Lost in expression—The aberrant lives of piRNA pathway genes in cancer

poster

Ghalei, Homa

A conserved Bcd1-snoRNA interaction is required for box C/D snoRNP assembly

poster

Gladfelter, Amy

RNA structure encodes identity and material properties of biomolecular condensates

talk

Godneeva, Baira

The SUMO ligase Su(var)2-10 induces co-transcriptional repression of piRNA target

poster

Goh, Sho

An atlas of single-base-resolution N6-methyl-adenine methylomes

poster

Gokhale, Nandan S

Altered m6A modification of cellular transcripts influences Flaviviridae infection

poster

Gopinath, Srikar K

Dynamic expression of tRNA-derived small RNAs define cellular states

poster

Gordon, Katrina

Export and trafficking of Argonaute 2 complexes in mouse

poster

Greer, Eric L

Identification of the m6Am methyltransferase PCIF1 reveals the location and functions of m6Am in the transcriptome

poster

Grewal, Shiv

Epigenetic genome control by RNA-based mechanisms

talk

Gutbrod, Michael

Dicer regulates the abundance of major satellite transcripts, the formation of pericentromeric heterochromatin, and chromosome segregation

poster

Haase, Astrid D

Exploring the sequence space of PIWI-interacting small RNAs (piRNAs)

poster

Haberman, Nejc

Hidden fragments of RNA in the transcriptome

poster

Hacisuleyman, Ezgi

Proximity-based labeling to understand translation spatially and temporally in neurons

poster

Hafner, Markus

Loss of DHX36 helicase activity leads to accumulation of translationally inactive target mRNAs with G-rich structures in untranslated regions

poster

Hale, Caryn R

Neuronal mRNA-binding proteins FMRP and Elavl3/4 are involved in the generation and dendritic localization of neuronal mRNAs isoforms.

poster

Hallacli, Erinc

RNA homeostasis deregulation in Parkinson’s disease

poster

Han, Cecil

DDX3X as a novel regulator in endogenous double-stranded RNA and immune modulator in cancer

poster

Hang, Jing

Aberrant spliceosome expression and altered alternative splicing events correlate with maturation deficiency in human oocytes

poster

Hao, Qinyu

Nucleolus-enriched repeat-containing noncoding RNA regulates rDNA transcription

poster

Hartenian, Ella

Enhanced Xrn1 activity broadly represses RNA polymerase II occupancy at mammalian but not viral promoters during herpesvirus infection

poster

He, Chuan

RNA methylation in gene expression regulation

talk

Hertz, Laura M

Hepatitis C virus infection downregulates miR-122 and leads to an increase in lipogenesis through NF-κB-inducing kinase

poster

Hirose, Tetsuro

Construction mechanism of membraneless nuclear bodies with architectural noncoding RNAs

talk

Hoek, TIm A

Single molecule imaging uncovers rules governing nonsense-mediated mRNA decay

poster

Holling, Aaron

Novel roles for the RNA binding protein ARS2

poster

Irmady, Krithi

RNA-binding proteins in Parkinson's disease

poster

Jaffrey, Samie

Encoding the fate and function of mRNA with reversible epitranscriptomic modifications at internal sites and mRNA caps

talk

Jalloh, Binta

A Drosophila RNA binding protein dNab2 regulates splicing of Sex lethal & neuronal circuitry required for courtships

poster

Jian, Kang

A mechanism for LLPS of ALS/FTLD-causing FUS modulation by ATP and nucleic

poster

Joshua-Tor, Leemor

Molecular and structural basis of the interaction of Gtsf1/arx with tRNA in the piRNA pathway

talk

Josipovic, Natasa

Regulating the anti-inflammatory potency of primary human cells via two circRNAs

poster

Kang, Minjeong

Collective expression of cellular dsRNAs as a predictive marker of cellular responses to a DNA-demethylating agent

poster

Keinath, Melissa C

Developing modification mapping assays using Oxford Nanopore technology

poster

Khuperkar, Deepak R

Multi-color single molecule imaging uncovers extensive heterogeneity in mRNA decoding

poster

Kim, Dongwan

HBV hijacks TENT4 to stabilize its RNA via mixed tailing

poster

Kim, Haedong

MicroRNA arm switching regulated by uridylation

poster

Kim, Sujin

Investigation on establishing PKR and mitochondrial dsRNAs as pathophysiological markers for osteoarthritis

poster

Kim, Young Jin

Allele-specific inhibition of nonsense-mediated mRNA decay in cystic fibrosis

poster

King, Benjamin L

Temporal expression patterns of non-coding regulatory genes during zebrafish cardiac regeneration

poster

Kneuss, Emma

piRNA precursor export in Drosophila germ cells requires a specialized machinery

poster

Knupp, David J

NOVA2-mediated regulation of circRNAs during mammalian neural development

poster

Kornblihtt, Alberto

Epigenetics in SMN2 alternative splicing—Towards a combined therapy of spinal muscular atrophy

talk

Kotaja, Noora

DICER controls the expression of major satellite repeat transcripts during spermatogenesis

poster

Krainer, Adrian

Targeted modulation of splicing or NMD for disease therapy

talk

Krajewska, Malgorzata

CDK12 loss in cancer cells affects DNA damage response genes through premature cleavage and polyadenylation

poster

Kretov, Dmitry

A negative feedback loop between Dicer and miR-144 dampens canonical microRNA biogenesis and maximizes the Ago2-dependent processing of miR-451 during vertebrate erythropoiesis

poster

Ku, Jayoung

Antibody immobilized polymer brush platform for viral dsRNA detection

poster

Ku, Yongsuk

Multiple dsRNA binding proteins regulate cell death induced by a DNA-demethylating agent in colorectal cancer

poster

Kwak, Yeonui

Global reprogramming of poly-(A) tail metabolism in macrophage immune response

poster

Kwok, Zhi Hao H

Oncogenic role of the FTX locus in colon cancer

poster

Kwon, Junsu

Investigating mechanisms of SALL4 re-activation in hepatocellular carcinoma

poster

Lakshmanan, Vairavan

All’s well that ends well—Polyadenylation centered gene regulation in planarian stem cells

poster

Latifkar, Arash

Loss of Sirtuin 1 alters the secretome of breast cancer cells by impairing lysosomal integrity

poster

Lau, Nelson C

Har-P, a short P-element variant, weaponizes P-transposase to severely impact Drosophila gonad development

poster

Lee, Jeannie

Xist deletional analysis reveals an interdependency between Xist RNA and Polycomb complexes for spreading along the inactive X

talk

Lee, Jong-Sun

Antisense-mediated transcript knockdown triggers premature transcription termination

poster

Lee, Joo-Hyung

Elucidating the functional protein interactomes for enhancer RNAs

poster

Lee, Seung Kyu K

A dual-activity topoisomerase complex interacts with piRNA machinery to promote transposon silencing and germ cell function

poster

Lee, Shih-Han

Gain of additional BIRC3 protein functions through 3′UTR-mediated protein complex formation

poster

Lee, Young-suk

N6-methyladenosine demethylase FTO orchestrates motile ciliogenesis by stabilizing foxJ1 mRNA

poster

Lehmann, Ruth

RNA organization within phase transitioned germ granules

talk

Lehtiniemi, Tiina

The pivotal role of the endonuclease SMG6 in the control of male germ cell transcriptome

poster

Lei, Ming

Structural insights into the preribosomal RNA processing by yeast RNase MRP

poster

Lin, Xianzhi

Human Poly(A)+ RNA 3' proximitome revealed by RiboPro

poster

Lin, Yi

Regulated self-assembly of low complexity domains by methionine oxidation

poster

Ling, Jonathan

Annotation-free analysis of alternative splicing across tens of thousands of RNA-Seq datasets reveals cell type-specific exons

poster

Liu, Haibin

Genome-wide effect of a long noncoding RNA lnc-FANCI-2 on gene expression in cervical cancer cells

poster

Liu, Jun

m6A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer

poster

Liu, Jun-Jie

CasX enzymes comprise a distinct family of RNA-guided genome editors

poster

Ljungman, Mats

Splicing-uncoupled transcription

poster

Lopez-Mejia, Isabel C

Contribution of the SR protein Srsf2 to white adipose tissue (dys)function in obesity and insulin resistance

poster

Lu, Jian

Adaptive evolution and function of uORFs in Drosophila

poster

Luehrmann, Reinhard

Structural insights into the roles of metazoan-specific splicing factors in the human spliceosome

talk

Luo, Yicheng

Molecular mechanism for specific recruitment of RDC complex to piRNA clusters

poster

Lynch, Kristen

Regulation of alternative splicing in T cell activation and viral infection

talk

Ma, Weirui

mRNA determines the three-dimensional organization of TIS11B RNA granules

poster

Mahat, Jay

Nascent RNA sequencing in single cells

poster

Mangilet, Anchilie F

Elucidating the role of plant U1 snRNP complex in transcription and post-transcriptional gene regulation

poster

Mangone, Marco

miRNA activity contributes to accurate RNA splicing in C. elegans intestine and body muscle tissues

poster

Manley, James

Mechanisms and targets of mutant SF3B1 in myelodysplastic syndromes and cancer

talk

Maquat, Lynne

Nonsense-mediated mRNA decay in health and disease

talk

Martienssen, Robert

The chromosomal impact of small RNAs

talk

Marx, Stephen

RNA profiling clarifies the molecular pathways for parathyroid neoplasia and for other traits

poster

Mayr, Christine

Regulation of 3′UTR-mediated protein-protein interactions

talk

McKnight, Steven

Do low complexity sequences adopt labile structural order in living cells?

talk

Mendell, Joshua

Regulation and function of noncoding RNAs in mammalian physiology and disease

talk

Meyer, Cindy

40S subunits of stalled ribosomes are selectively de-ubiquitinated by the G3BP1-USP10 complex to prevent degradation

poster

Mikedis, Maria M

DAZL promotes spermatogonial differentiation by enhancing translation of its targets in undifferentiated spermatogonia

poster

Mishra, Vibhor

Functional analysis of a dsRNA synthesizing twin RNA polymerase complex

poster

Mitra, Sanga

Exploring the sequence diversity of piRNAs—The tip of the iceberg?

poster

Monahan, Jack

A long read tale—polyA tail length and terminal modifications at single molecule resolution

poster

Mukherjee, Pooja

Co-translational assembly of mammalian nuclear multisubunit complexes

poster

Nagai, Kiyoshi

Getting missing pieces for complete understanding of pre-mRNA splicing—The 5′ splice site transfer from the U1 snRNP triggers Brr2 relocation for human spliceosome activation

talk

Narlikar, Geeta

Regulation of heterochromatin condensates by RNA and DNA

talk

Nechooshtan, Gal

Processing by RNase 1 is responsible for formation of distinct tRNA and Y RNA fragments in the extracellular environment

poster

Neugebauer, Karla

Coordination of RNA processing events in vivo

talk

Nnadi, Chidinma

Probing co-transcriptional RNA folding mechanism  in engineered O. sativa twister ribozyme variants

poster

Olthof, Anouk

The minor spliceosome regulates alternative splicing across minor introns through the major spliceosome

poster

Onoguchi-Mizutani, Rena

Characterization of heat-responsible novel nuclear body containing MALAT1, a long noncoding RNA

poster

Ouyang, Zhengqing

LISA—Accurate reconstruction of cell trajectory and pseudo-time for massive single cell RNA-seq data

poster

Palencia, Andrés

Metal-captured inhibition of pre-mRNA processing activity by CPSF3 eliminates Cryptosporidium Infection

poster

Parker, Roy

RNP granules in health and disease

talk

Passmore, Lori A

The intrinsic structure of poly(A) RNA determines the specificity of deadenylation

talk

Patrick, Kristin

The RNA binding protein hnRNP M is a critical regulator of innate immune gene expression in macrophages

poster

Pikaard, Craig

Mechanisms of RNA channeling from DNA transcription to Argonaute loading in the siRNA-directed DNA methylation pathway

talk

Piwecka, Monika

Dissecting circRNA and pre-miRNA expression at single-cell level in the pituitary gland

poster

Polaski, Jacob T

The origins and consequences of UPF1 variants in pancreatic adenosquamous carcinoma

poster

Pomaville, Monica M

The METTL3-METTL14 complex regulates cell viability in Neuroblastoma

poster

Proudfoot, Nicholas

Different mechanisms define lncRNA and protein coding gene transcription units in mammalian cells

talk

Qiu, Chen

Distinct RNA-binding modules in a single PUF protein cooperate to determine RNA specificity

poster

Raesch, Felix

eIF4E-transporter (4E-T)-bound mRNAs are stored in a silenced and deadenylated form

poster

Rambout, Xavier

Transcriptional coactivator PGC-1α contains a novel CBP80-binding motif that orchestrates efficient target-gene expression

poster

Rando, Oliver J

Small RNA dynamics during mammalian spermatogenesis

talk

Ray, Atreyei

The human nudix hydrolase NudT12 specifically binds RNA and remove 5’-NAD(H) caps

poster

Roche, Benjamin

RNA polymerase I regulation by RNA interference in cellular quiescence relies on a novel class of long non-coding RNAs

poster

Rodriguez, Antony

Targeting microRNA let-7 function in pulmonary disease

poster

Rozhkov, Nikolay

Retrotransposon activation as a hallmark of ALS patients with TDP-43 pathology

poster

Sacchi, Nicoletta

The RUNX1-miR -221- KIT—A determinant of single cell decisions that collectively drives or hinders granulopoiesis

poster

Sarkar, Debina

The long non-coding RNA hMaTAR17 is a new driver of tumour progression.

poster

Saruuldalai, Enkhjin

The interplay between MYC and CpG methylation determines the expression of nc886, a two-faced human non-coding RNA in cancer

poster

Schaening Burgos, Cassandra

Pseudouridine in bacterial mRNAs

poster

Schaffer, Amos

RNA editing in cancer cell lines

poster

Schorn, Andrea J

tRNA-derived small RNAs in genome stability

poster

Seydoux, Geraldine

Regulation of RNA granule assembly by intrinsically disordered proteins

talk

Shang, Renfu

Operon arrangements facilitate nuclear processing (microprocessing) of mammalian miRNAs with suboptimal structures

poster

Sharp, Phillip

Condensates, bursts of transcription and feedback networks

talk

Shen, Xiulong

Efficient electroporation of neuronal cells using synthetic oligonucleotides—Activation of human Frataxin expression

poster

Shetty, Sunil

TORC1 antagonizes ribosome recycling repression to promote protein synthesis

poster

Shi, Hailing

N6-methyladenosine (m6A) facilitates hippocampus-dependent learning and memory through YTHDF1

poster

Shi, Xianle

DDX18 promotes human pluripotency through phase separation control of ribosome biogenesis

poster

Singer, Robert

Imaging mRNPs in living cells

talk

Singh, Jasleen

Converting DNA information into double-stranded RNA in a coupled reaction

poster

Skourti-Stathaki, Konstantina

R-loops enhance Polycomb repression at a subset of developmental regulator genes

poster

Song, Yangyang

RNA editing-mediated functional switch of COPA drives cancer development

poster

Spector, David

Targeting long non-coding RNAs to impact breast cancer progression

talk

Stein, Chad

The Integrator complex regulates protein-coding gene expression

poster

Steinberger, Jutta

Tracing MYC expression for small molecule discovery

poster

Steitz, Joan

Deciphering target-directed miRNA degradation

talk

Su, Shuaikun

Ribosome profiling reveals that topoisomerase TOP3B enhances translation of specific mRNAs

poster

Sun, Qinyu

MicroRNA-independent role of a microRNA-host gene-encoded lncRNA in serum-stimulated cell cycle re-entry

poster

Sun, Shuying

Identification of Genetic Modifiers of Repeat-Associated Non-AUG (RAN) Translation in C9ORF72-ALS/FTD

poster

Suzawa, Masataka

Subcellular localization-dependent phosphorylation of human TNRC6A differently regulates AGO binding and RNA silencing activities

poster

Swift, Michael

Destiny? Understanding B cell fate decisions using lineage tracing and single cell transcriptomics

poster

Tan, Meng How

An RNA editing atlas in human colorectal cancer reveals a novel oncogenic ADAR1/MDM2/BRAF network

poster

Tang, Sze Jing J

Cis- and trans-regulatory roles of ADAR proteins on splicing

poster

Tay, Yvonne

A feedforward regulatory loop between the RNA-binding protein LARP1 and MYC promotes colorectal cancer development

poster

Teng, Chong

Dicer-like 5 deficiency confers temperature-sensitive male sterility in maize

poster

Thomas, James D

RNA isoform screens reveal the essentiality and tumor suppressor activity of ultraconserved poison exons

poster

Torres-Padilla, Maria-Elena E

Transposable elements in early mammalian development—Do they burst?

talk

Ulitsky, Igor

Sequences and pathways determining subcellular localization of long RNAs

talk

Valle-Garcia, David

PCIF1 catalyzes m6Am mRNA methylation to regulate gene expression

poster

Vidigal, Joana

Optimizing CRISPR tools for high-throughput screening

poster

Virtanen, Anders

Poly(A)-specific ribonuclease (parn) knockout zebrafish variants showed variable telomere lengths

poster

Wan, Ruixue

Structures of the catalytically activated yeast spliceosome reveal the mechanism of branching

poster

Wang, Jingjing

MiR-205 promotes hair follicle stem cell activation by enhancing cell migration and targeting mechanic ion channel Piezo1

poster

Wang, Yang

Genome-wide screening of NEAT1 regulators reveals cross-regulation between paraspeckles and mitochondria

poster

Wang, Yongbo

Global survey of alternative splicing events in lung adenocarcinoma identifies novel oncogenic splice variants

poster

Weeks, Kevin

Structure-based discovery of new functions in large RNAs

talk

Wei, Guifeng

Systematic allelic analysis defines the interplay of key pathways in X chromosome inactivation

poster

Wei, Jiangbo

Differential m6A, m6Am, and m1A demethylation mediated by FTO in cell nucleus and cytoplasm

poster

Weldon, Carika

The detection of 7-deazaguanine in RNA using nanopore sequencing—Progress towards detection of naturally occurring G-quadruplexes in cells

poster

Weng, Zhiping

An atlas of polymerase III-transcribed Alu elements across human cell types and tissues

poster

Whipple, Amanda J

Maternally expressed miRNAs affect synaptic signaling in neurons

poster

Wilkinson, Max

Structural basis for 5′ splice site transfer during spliceosome activation

poster

Wilusz, Jeremy

Unexpected outputs of many protein-coding genes

talk

Withers, Johanna

Deletion analysis of a viral lncRNA expressed by Kaposi’s sarcoma-associated herpesvirus reveals regions important for packaging and release of viral genomic DNA

poster

Wu, Pei-Hsuan (Xuan)

An evolutionarily conserved piRNA-producing locus required for male mouse fertility

poster

Wu, Qiushuang

Translation affects mRNA stability in a codon dependent manner in human cells

poster

Wulf, Madalee

Nanopore-ReCappable Seq—Identifying full length transcripts in eukaryotic mRNA using direct RNA Nanopore sequencing

poster

Wysocka, Joanna K

Regulation of RNA transcription by enhancers

talk

Xiang, Kehui

The mechanistic requirements for coupling between poly(A)-tail length and translational efficiency reveal critical roles of cytoplasmic poly(A)-binding proteins

poster

Xiao, Meisheng

An improved method for circular RNA purification that efficiently removes linear RNAs containing G-quadruplexes or structured 3’ ends

poster

Xie, Mingyi

Near-infrared fluorescent Northern blot

poster

Xiong, Feng

Dynamic m6A deposition on nascent RNA transcripts

poster

Xu, Guang

Nascent pre-rRNA sorting via phase separation drives the assembly of dense fibrillar components in the human nucleolus

poster

Yan, Qingqing

Mapping native R-loops genome-wide using a targeted nuclease approach

poster

Yang, Acong

3’ uridylation confers miRNAs with novel non-canonical target repertoires

poster

Yang, Ze

Novel biological functions of 3’UTR that independent of its cognate CDS in mESCs

poster

Young, Richard

Phase-separated condensates in RNA biosynthesis

talk

Yu, Allen

Probing the role of a highly expressed long non-coding RNA in hepatocellular carcinoma

poster

Yu, Lulu

Oncogenic splicing factor SRSF3 regulates ILF3 alternative splicing to promote cancer cell proliferation and transformation

poster

Zhang, Bin

A comprehensive expression landscape of RNA binding proteins (RBPs) across 16 human cancer types

poster

Zhang, Feng

Harnessing nature’s diversity for gene editing and beyond

talk

Zhang, Xiaoou

Characterization of TSS-proximal enhancers in the human genome

poster

Zhao, Yixin

Studying mRNA half life using PRO-seq and RNA-seq

poster

Zhou, Chan

Genome-wide maps of m6A circRNAs Identify widespread and cell-type-specific methylation patterns that are distinct from mRNAs

poster

Zhou, Xiaoming

Role of dynamic cross-β interaction of low complexity head domains in neurofilament assembly

poster

Zhu, Pan

COOLAIR—The intimate relationship with chromatin environment and transcriptional output

poster

Zinad, Hany

Noncoding RNAs in the regulation of phosphate homeostasis

poster