Single Cell Analysis
November 13 - 16, 2019

You must register for the meeting in order to submit abstracts.
After registering you will be sent a web link for abstract submission by email.
You may copy and paste your abstract from Word, Google Docs, or Notepad; abstracts are limited to ~2900 characters.

Program information: An electronic version of the program abstract book will be sent three working days prior to the first day of the meeting, and hard copies will be available for collection upon your arrival at Cold Spring Harbor Laboratory. First night and keynote speakers are informed of their session date and time, otherwise program information is only available upon release of the electronic version of the abstract book. The reason we do this is to try and maximize interactions by encouraging participants to stay for the duration of the meeting.

Please check your email for talk length, poster instructions, and how to have your poster printed at CSHL for collection upon arrival. 

Abstract Status

Presenting Author

Abstract Title

Talk/Poster

Alban, Tyler J

CITE-seq identifies unique myeloid derived suppressor cells (MDSCs) population signatures in glioblastoma patients that do not respond to immune checkpoint inhibition

poster

Anand, Praveen

Single cell RNA-seq reveals developmental plasticity with coexisting oncogenic states and immune evasion programs in ETP T-ALL

poster

Anderson, Courtney M

Incorporation of spatial mapping by a multiplex in situ hybridization technology into single cell RNA sequencing workflows

poster & flash talk

Bansal, Nidhanjali

Sensitivity of gene fusion detection from high-throughput SMART-seq chemistry on the ICELL8 cx System

poster

Barberan Soler, Sergio

Highly accurate small-RNA sequencing of single cells (RealSeq-SC)

poster

Barnes, Spencer D

Single-cell RNA sequencing identifies fibro-inflammatory perivascular stromal cells controlling adipose tissue inflammation in obesity

poster

Bell, Claire

Simultaneous capture of DNA and mRNA from single mammalian cells in droplets

talk

Best, Tyler K

The NIH Common Fund, Human Biomolecular Atlas Program (HuBMAP)—Building a framework for mapping the human body

poster

Blibaum, Ash

Mercury—High quality visualization and reproducible exploratory analysis of scRNA-seq data

poster

Blibaum, Ash

ProtoCell—Automated identification of cell types in single-cell RNA-seq data using prototypical neural networks

poster & flash talk

Bolduc, Nathalie

Unprecedented sensitivity with SMART-Seq single cell technology

poster

Brase, Logan

Identification of transcriptional profiles of the MS4A gene cluster and their association with Alzheimer's disease

poster

Cai, Long

seqFISH+—in situ transcriptome profiling

talk

Cao, Chen

Comprehensive single-cell transcriptome lineages of a proto-vertebrate

talk

Cao, Guoshuai

Lattice light-sheet microscopy multi-dimensional analyses (LaMDA) of T-cell receptor dynamics predict T-cell signaling states

poster

Chatterjee, Deeptiman

Constructing a comprehensive transcriptomic atlas of developing follicular epithelial cells in adult Drosophila ovary

poster & flash talk

Chen, Xiaoyin

Shared and specific long-range projections across transcriptionally-defined neuronal subtypes revealed by in situ barcode sequencing

talk

Chialastri, Alex J

Simultaneous high-throughput single-cell sequencing of DNA methylation, chromatin accessibility and mRNA from the same cell enables marker-free generation of cell type-specific epigenetic landscapes

poster & flash talk

Davila-Velderrain, Jose

Integrative single-cell analysis reconstructs the quantitative cell state landscape of the human developing cortex

talk

DePasquale, Erica A

DoubletDecon—Deconvoluting doublets from single-cell RNA-sequencing data

poster

Dey, Siddharth S

Simultaneous quantification of protein-DNA contacts and transcriptomes in single cells

talk

Dhuppar, Shivnarayan

Investigating central dogma in the context of nuclear architecture and cell cycle at single-cell resolution

poster & flash talk

Di Chiaro, Pierluigi

Molecular dissection of cellular heterogeneity in pancreatic adenocarcinoma by transcriptomic profiling

poster

Dobin, Alexander

STARsolo—Single-cell RNA-seq data analysis beyond gene expression

poster & flash talk

Duvall, Eliza

Single cell transcriptome and chromatin conformation analysis reveal pancreatic hormone lineage decisions

talk

Eum, Hye Hyeon

Tumor promoting macrophages prevail in the malignant ascites of advanced gastric cancer

poster

Feng, Di

Single Cell Explorer, collaboration-driven tools to leverage large-scale single cell RNA-seq data

poster

Fischer, Stephan

How well defined are reference cell types in the brain?

poster

Ford, Matthew J

Single cell RNA sequencing reveals developmental origins of mouse oviduct epithelial cell heterogeneity

poster

Gao, Shouguo

Comparative single-cell transcriptomic analysis of the hematopoietic system between human and mouse

poster

Garcia, Hernan G

Transcriptional control strategies for pattern formation in embryonic development

talk

George, Nikhil Oommen

Differential 3’UTR usage along the olfactory bulb neurogenic lineage

poster

Gerecsei, Tamas

Novel techniques for probing single cell adhesion and single cell isolation

talk

Gonzalez-Reiche, Ana S

Spatiotemporal dynamics of calvarial suture development revealed by integrated analysis of single-cell and whole transcriptome data

poster

Groves, Sarah

Network control of phenotypic plasticity in small cell lung cancer

poster

Gupta, Anushka

Mapping adipogenesis in humans using single-cell and single-nuclei RNA-sequencing

poster

Han, Guangchun

vGATE—An R package to automatically define cell types/states and cell-of-origin for single cell RNAseq data

poster

Han, Jungmin

Friend or foe—Missing data imputation in single cell analysis

talk

Han, Kyung Yeon

Combined single-cell quantification of genome and transcriptome in breast cancers

poster

Harris, Benjamin

Methods and statistics for differential co-expression in single cell RNA sequencing data

poster

He, Jian

Single-cell RNA-Seq reveals naïve B cells associated with better prognosis of hepatocellular carcinoma

poster

Henry, Gervaise

A cellular atlas of human prostate disease

poster

Hertel, Laura

Single-cell transcriptome analysis of CD34+ stem cell-derived myeloid cells infected with human cytomegalovirus

talk

Hertzano, Ronna

The gEAR portal—Gene Expression Analysis Resource

poster

Hill, Matthew C

Hippo pathway deletion in adult resting cardiac fibroblasts initiates a cell state transition with spontaneous and self-sustaining fibrosis

poster

Hong, Yourae

Single cell transcriptome profiling in colorectal cancer reveals tumor heterogeneity and intrinsic tumor cell signatures associated with the consensus molecular subtype

poster

Horvath, Anelia

Genetic variation regulatory networks from single cell RNA sequencing

poster

Hu, Alex K

Increased T-cell exhaustion in antigen-specific CD8 T-cells from early-onset type 1 diabetic subjects after teplizumab treatment

poster

Hu, Peng

Massively parallel, time-resolved single-cell RNA sequencing with scNT-seq

poster

Iwabuchi, Sadahiro

Single-cell RNA sequencing identifies the common and unique cell population between in an in vitro and in vivo cultured condition

poster

Jeney, Csaba

Homogeneous, single-cell level protein and protein complex detection

poster

Johnson, Radia M

Combinatorial single cell analysis to link genotype to phenotype in colorectal cancer

poster

Jonsson, Vanessa

Uncovering T cell dynamics over the course of chimeric antigen receptor (CAR) T cell therapy

talk

Kabeer, Farhia

Quantifying breast cancer heterogeneity and clonal fitness using single cell timeseries population dynamics

poster

Kaymaz, Yasin

A hierarchical random forest approach for cell type projections across single-cell RNAseq datasets

poster

Keren, Leeat

Unraveling the tumor immune microenvironment using multiplexed ion beam imaging

talk

Ko, Kyung Dae

Computational pipeline to infer the gene regulatory network during cell differentiation from scRNA-seq analysis

poster & flash talk

Lam, Gabriel

Cell-type-specific genomics reveals histone modification dynamics in mammalian meiosis

poster

Lee, Je H

In situ transcriptome accessibility sequencing (INSTA-seq) reveals in vivo mRNA-protein interactions

talk

Legant, Wesley

Lattice light sheet microscopy—Innovations, applications and future directions

talk

Li, David W

Oxidative stress-induced KLF4 activates inflammatory response through IL17RA and its downstream targets in retinal pigment epithelial cells

poster

Li, Siran

BAG-seq—Copolymerization of nucleic acids into balls of acrylamide gel (BAG) for single-cell DNA/RNA sequencing

talk

Lim, Wei Keat

Eliminating spurious correlations from regularized single cell RNA-seq data

poster & flash talk

Liu, Shiwei

Optimization of a whole genome amplification method for single Plasmodium falciparum parasite sequencing

talk

Liu, Yang

RISC—Robust integration of single-cell RNA-seq datasets with different extents of cell cluster overlap

poster

Liu, Zhen

Probing apoptosis signaling proteins in single living cells enables precise efficacy evaluation of anti-cancer drugs

poster & flash talk

Martelotto, Luciano

When Frankenstein meets Van Helsing—A workflow for snRNA/ATAC-Seq from the same nuclei prep for 10x Genomics platform

poster & flash talk

McFaline, Jose L

Massively multiplexed chemical transcriptomics at single-cell resolution

talk

Mellis, Ian A

Perturbation panel profiling identifies transcription factors that enhance directed changes of cell identity

talk

Menoni, Carmen

Three dimensional nanoscale  molecular imaging by extreme ultraviolet laser ablation mass spectrometry

talk

Mitroi, Daniel N

Single nuclei RNA-seq analysis of white matter from human vascular dementia

poster

Mohammadi, Shahin

Multi-resolution single-cell state characterization via joint archetypal/network analysis

poster

Morita, Ritsuko

The origin and induction processes of hair follicle stem cells

talk

Musser, Jacob

Whole-body single-cell RNA sequencing reveals components of elementary neural circuits in a sponge

talk

Mycko, Marcin

Transcriptomic analysis of the cell released circulating exosomes reveals biomarkers of the multiple sclerosis activity

poster & flash talk

Nomura, Seitaro

Integrative single-cell analysis to dissect heart failure biology

poster & flash talk

Osmanbeyoglu, Hatice U

Integrative computational framework for linking cell surface proteins to downstream transcriptional programs in single cells

poster

Pantoja Angles, Aaron

Coupling FluidFM technology with multi-omic analyses for understanding the effect of PI5P on chromatin

poster

Patrick, Ralph

Decoding the identify and flux of cardiac cells in injury and homeostasis at single-cell resolution

poster

Peng, Tao

GLUER—Integrative analysis of multi-omics data at single-cell resolution

poster

Periwal, Vipul

Cell lineage inference from Drosophila blastoderm gene expression

poster & flash talk

Prieto-Vila, Marta

Single-cell analysis identified a LEF-1 positive drug-resistant subpopulation in luminal subtype of breast cancer cells

poster & flash talk

Qiu, Wei-Lin

Defining multistep cell fate decision pathways during pancreatic development at single-cell resolution

poster & flash talk

Qiu, Xiaojie

Mapping vector field of single cells

talk

Ranjan, Bobby

scConsensus—An approach combining semi-supervised and unsupervised clustering for cell type annotation in single-cell RNA-seq data

poster & flash talk

Reichart, Daniel

Single nuclei RNA sequencing in non-diseased and diseased human cardiac tissue

poster & flash talk

Rose, Kevin P

Developmental map of otic mesenchyme cell populations of the inner ear

poster

Sahu, Sombeet K

Analytical methods to identify tumor heterogeneity and rare subclones in single cell DNA sequencing data from targeted panels

poster

Salomonis, Nathan G

A neutropenia-associated transcription factor mutation differentially impacts target genes in the cell-states traversed during granulocyte specification and commitment

poster

Samaroo, Harry D

Establishment of human induced pluripotent stem cell derived dopaminergic neurons for in vitro modeling of Parkinson’s disease pathobiology

poster

Sauka-Spengler, Tatjana

Reverse engineering of the global neural crest gene regulatory network in vivo

talk

Schwartz, Gregory W

TooManyCells identifies rare targeted-therapy-resistant T-ALL cells

poster

Sharma, Siddhartha M

Applying single cell analysis techniques to characterize the role of MAIT cells in ulcerative colitis

poster

Shu, Chang

Single cell transcriptome mapping reveals cell type-specific effects on gene expression by acute delta9-tetrahydrocannabinol in humans

poster

Streets, Aaron

Imaging and sequencing protein-DNA interactions in single cells

talk

Sun, Yu-Chi

Gene expression correlates of cortical projections revealed by in situ sequencing

poster

Susztak, Katalin

Single-cell transcriptomics of the mouse kidney reveals potential cellular targets of kidney disease

talk

Takeuchi, Fumihiko

Accounting for cell type composition in bulk transcriptome and methylome data by using scRNA-seq reference

poster

Tang, Ming

A suite of tools for working with single-cell ATAC-seq data

poster

Varma, Parul

Single cell genomics identifies cell-type specific molecular changes in precision-models of genetic epilepsies

poster

Vasdekis, Andreas E

Cellular noise and metabolism, as a matter of fat

poster

Vijay, Priyanka

Benchmarking of normalization and imputation workflows across real and simulated scRNA-seq data.

poster

Vorholt, Julia

From single-cell perturbation to subcellular analysis using fluidic force microscopy

talk

Vystavel, Tomas

In situ structural biology—Enabled by focused ion beam cryo-lamellae preparation and electron tomography

poster & flash talk

Wang, Jie

Cross-species transcriptomic and epigenomic analysis reveals key regulators of injury response and neuronal regeneration in vertebrate retinas

poster & flash talk

Wang, Linghua

Multiplex single cell profiling to dissect the tumor immune microenvironment in human cancers

poster

Wang, Ruiping

Cell-of-origin analysis of metastatic gastric cancer uncovers the origin of inherent intratumoral heterogeneity and a fundamental prognostic signature

poster

Wang, Rujin

SCOPE—A normalization and copy number estimation method for single-cell DNA sequencing

poster

Wangsanuwat, Chatarin

A probabilistic framework for cellular lineage reconstruction using single-cell 5-hydroxymethylcytosine sequencing

poster

Wen, Yanrong

Tracking EGFR signaling pathway and its crosstalk of apoptosis pathway via multiplexed single cell analysis

poster

Willie, Elijah S

To cluster or not to cluster—Assessing clusterability in scRNA-seq data

poster

Wu, Chi-Yun

Recovery of genetic and epigenetic heterogeneity using single-cell DNA and methylome sequencing

poster

Xu, Yichi

Reconstruction of an invariant lineage in chordate embryogenesis

talk

Yamawaki, Tracy M

A comparison of high-throughput single-cell RNAseq methods for profiling immune cells

poster

Yang, Tao

AdRoit—Accurate and robust information-theoretic deconvolution from bulk tissue transcriptomes

poster

Ye, Xiaofei

Normal and malignant germinal center B cell maps revealed by single-cell RNA sequencing

poster

Yeo, Jin-Hee

Reconstruction of tumor-immune microenvironment using a syngeneic CT26 mouse tumor transplant model

poster

Zhang, Chunling

Limitations of single cell RNA-seq

poster

Zhang, Xiuwei

Simulating multiple faceted variability in single cell RNA sequencing

poster

Zhao, Juanjuan

Single nucleus RNA-seq and ATAC-seq survey of cell diversity and functional maturation in postnatal mammalian hearts

poster

Zhu, Qian

Giotto, a pipeline for integrative analysis and visualization of single-cell spatial transcriptomic data

talk

Zhu, Qin

Single cell analyses reveal developmental bottleneck and two waves of blood progenitor formation from arterial endothelium

talk