|
Presenting Author |
Abstract Title |
Talk/Poster |
|
Acevedo, Monica L |
The role of RNA helicase DDX3X in RNA metabolism during respiratory syncytial virus replication |
poster |
|
Ahmed, Nujhat |
Genome-wide identification of human proteins that regulate alternative polyadenylation |
poster |
|
Akay, Alper |
U6 snRNA m6A methylation is required for effective cis- and trans-splicing |
poster |
|
Ali, Mohammed |
Investigating differential intron sensitivity to PUF60, a gene that is deleted or amplified in developmental syndromes and cancers |
poster |
|
Altieri, Jessie |
Regulatory mechanisms of exitron splicing and intron retention |
poster |
|
Ares, Manuel |
Spliceosomes convert lariats to true intron circles through a third transesterification when disassembly is delayed |
talk |
|
Armstrong, Matthew |
Modulation of CFTR intron 22 alternative polyadenylation (APA) usage may have therapeutic potential for the treatment of certain 3’ CFTR PTC variants |
poster |
|
Awaya, Tomonari |
Splice-switching small molecule RECTAS2.0 showed promising therapeutic effect in disease models of cardiac Fabry disease caused by GLA c.936+919G>A Taiwanese mutation |
poster |
|
Bachand, Francois |
Proximity-dependent biotinylation map of the RNAPII CTD reveals that the primary role of Serine 2 phosphorylation is in the suppression of cryptic antisense transcription and not in RNA 3’ end processing |
talk |
|
Bak-Gordon, Pedro G |
A novel small molecule binder of Ku70 induces selective lethality of U2AF1S34F leukemia cells |
poster |
|
Barr, Keaton |
Transcriptional roadblocks promote a novel pathway of mRNA 3′-end formation independent of cleavage factors |
talk |
|
Barua, Atish |
CFIm25 affects cell cycle progression during monocyte-macrophage differentiation by activating the NFkb-p21 pathway |
poster |
|
Bashari, Ariel |
Targeting the hnRNPH/F splicing factors by decoy oligonucleotides for cancer therapy |
poster |
|
Bechara, Elias |
A circular-linear cooperative RNAs network regulates cardiomyocyte differentiation by the RNA binding protein Sam68 |
poster |
|
Begg, Bridget |
Coordination of nuclear RNA processing by speckle–localized kinase TAOK2 |
poster |
|
Belchikov, Natan |
A single-cell, long-read, isoform-resolved case–control study of frontotemporal dementia reveals cell-type specific and broad splicing dysregulation in post-mortem human brain |
talk |
|
Bentley, David |
U170K depletion shows U1snRNP enhances use of strong 5’ splice sites and suggests a major role of exon definition in human splicing |
poster |
|
Bergfort, Alexandra |
Protein occupancy of exon-exon junctions and consequences for downstream splicing |
poster |
|
Bermudez, Yahaira |
Mapping of the protective ribonucleoprotein complex that provides stability in the face of KSHV-mediated global RNA decay |
poster |
|
Bertrand, Edouard |
Imaging co-translational mRNA sorting—How a single mRNA generates distinct polysomes with different fates |
talk |
|
Beseiso, Dana |
Investigating functional transcription start site (TSS) switching in breast cancer |
poster |
|
Beusch, Irene |
Functional genomics of the human spliceosome in haploid cells reveals its in vivo operating principles |
talk |
|
Bhatnagar, Sanjana |
A parallelized reporter screen to uncover tissue-specific splicing activator and repressor sequences in a multicellular organism |
poster |
|
Bisotto, Elena |
Characterization of SRSF1’s protein domains functions in transcription and splicing |
poster |
|
Blake, Eleanor |
Visualising the regulation of P-element transposon mRNA by the piRNA pathway in vivo |
poster |
|
Blazek, Dalibor |
Dissecting role of CDK11 and SF3B1 in spliceosome assembly and activation |
poster |
|
Boudreault, Simon |
Innate immune sensing inhibits EIF4A2 isoform-specific nonsense mediated decay in response to dsRNA and viral infection |
poster |
|
Broglia, Laura |
RNA-RNA crosstalk regulates cardiomyocyte differentiation by the RNA binding protein Sam68 |
poster |
|
Brownmiller, Tayvia |
HNRNPH1's processing of EWSR1 pre-mRNAs suggests that its functions are appropriated during transformation to mediate the expression of a subset of EWSR1::FLI1 oncogenic fusions transcripts |
poster |
|
Burke, Giovanni L |
Uncovering the role of C2H2-zinc finger protein ZNF121 in regulating mRNA stability as a cofactor for the m6A reader protein YTHDF2 |
poster |
|
Burns, Philippa |
Serine starvation inhibits SRSF protein expression and modulates RNA splicing |
poster |
|
Cabaj, Maximilian |
PUM1-related disease severity is driven by the loss of either mRNA target binding or protein interactions |
poster |
|
Calvo-Roitberg, Ezequiel |
Kinetic barcoding—A novel tool to estimate multi-temporal RNA biogenesis kinetics |
poster |
|
Caputi, Massimo |
Circular RNAs generated from the HIV-1 transcript functionally interact with cellular miRNAs |
poster |
|
Carrocci, Tucker J |
Intron sequence determines gene output by modulating co-transcriptional splicing efficiency |
poster |
|
Cater, Timothy R |
The RBP CELF2 is an mRNA specific regulator of translation elongation |
poster |
|
Chakrabarti, Anob |
Staufen-associated RNA structures and 3’ UTR RNP assembly across mammalian brain development |
poster |
|
Chalivendra, Subbaiah |
Selected humanization of yeast U1 snRNP leads to global suppression of pre-mRNA splicing and mitochondrial dysfunction in the budding yeast |
poster |
|
Chanfreau, Guillaume |
Investigating the roles of Slu7 and Prp18 in promoting global splicing fidelity and efficiency in vivo in S. cerevisiae |
poster |
|
Chen, Yiwen |
Integrative functional genomic analyses reveal lnc-YINC/YBX1-controlled post-transcriptional regulatory circuits promoting tumorigenesis and radioresistance of cancer stem cells in glioblastoma |
poster |
|
Chi, Dora |
U2 snRNA mutations in human disease |
poster |
|
Chi, Ru Pin (Alicia) |
TENT5A modulates heat-stress response via poly(A) tailing of Atxn2 and Atxn2l transcripts |
talk |
|
Chorghade, Sandip |
Post-transcriptional silencing of the nuclear poly(A) binding protein is critical for postnatal maturation and function of the heart |
poster |
|
Ciesla, Maciej |
Splicing factors regulation in normal and malignant hematopoiesis—m6A-driven SF3B1 translation control steers splicing to direct genome integrity and leukemogenesis |
poster |
|
Cohen, Yuval l |
Inhibition of nonsense-mediated mRNA decay may improve stop codon read-through therapy for Duchenne muscular dystrophy |
poster |
|
Coltri, Patricia P |
The role of TDP43 and hnRNPK in the splicing of genes related to amyotrophic lateral sclerosis |
poster |
|
Dao, Khoa M |
Pervasive cryptic splicing confounds massively parallel reporter assays of 3’UTRs |
poster |
|
Dar, Showkat A |
Dynamic regulation of eukaryotic mRNA during cellular stress—Insights from full length RNA sequencing and computational analysis |
poster |
|
Dastpak, Mahtab |
A genome wide enhancement in transcriptional pause release in splicing factor mutant ES cells |
poster |
|
de Prisco, Nicola |
Alternative polyadenylation alters protein dosage by switching between intronic and 3'UTR sites |
poster |
|
Dixon, Hannah L |
UPF1 is required for productive pre-mRNA splicing of ribosomal protein genes |
poster |
|
Djuranovic, Sergej |
Role of U11/U12 minor spliceosome gene ZCRB1 in the control of nonsense mediated decay and genome maintenance |
talk |
|
Doffo, Maria J |
Exploring the role of intron retention in oocyte-to-embryo transition |
talk |
|
Donovan, Benjamin T |
Real-time visualization of spliceosome assembly in live cells |
talk |
|
Dossena, Francesco |
High-resolution coverage analysis detects and quantifies alternative mRNA processing events |
poster |
|
Dubiez, Etienne |
Structural basis for competitive binding of productive and degradative co-transcriptional classifier factors to the nuclear cap-binding complex |
poster |
|
Duffy, Erin E |
Neuronal activity acutely modulates RNA turnover to shape gene expression kinetics |
poster |
|
Fagg, William S |
Similarity between Quaking binding site sequences and the conserved branch point consensus allows Quaking to repress splicing by competing with SF1/BBP |
poster |
|
Fair, Benjamin J |
Pervasive splicing-mediated genetic and therapeutic perturbation of human gene expression |
poster |
|
Fan, Xiaojuan |
Accurate prediction of RNA translation with a deep learning architecture |
poster |
|
Fansler, Mervin M |
Comprehensive annotation of 3′UTRs from primary cells and their quantification from scRNA-seq data |
poster |
|
Faraway, Rupert |
RNA multivalency drives homeostasis of highly charged proteins |
talk |
|
Fica, Sebastian M |
FAM32A modulates a general scanning mechanism for 3´-splice site selection during the catalytic stage of splicing |
talk |
|
Fiszbein, Ana |
U1snRNP regulates the usage of alternative promoters by preventing premature cleavage and polyadenylation |
talk |
|
Flaherty, Juliana N |
Genetically separating the roles of METTL16 in SAM homeostasis and U6 snRNA methylation |
poster |
|
Fontaine, Emeline |
Exploring the inhibition of CPSF73 for the development of novel anticancer drugs |
poster |
|
Fujio, Hitomi |
Relationship between alternative polyadenylation and mRNA stability regulation—Insights from diverse 3'UTR variants |
poster |
|
Gainetdinov, Ildar |
Cleavage by most mammalian pachytene piRNAs does not influence the steady-state levels of target mRNAs, so why cleave at all? |
talk |
|
Gaither, Raquel |
Investigating the role of oncogenic mutation in PCBP1 protein dynamics and subcellular localization |
poster |
|
Gajduskova, Pavla |
Dissecting role of CDK11 and SF3B1 in spliceosome assembly and activation |
poster |
|
Gennarino, Vincenzo A |
Dosage sensitivity to Pumilio1 variants in the mouse brain reflects distinct molecular mechanisms |
poster |
|
Giri, Gilbert |
Navigating the roles of Cis and trans environment on species-specific gene expression |
poster |
|
Gizlenci, Ozge |
SR proteins orchestrate alternative splicing of ribosomal proteins as a key constituent of positive selection in B cells. |
poster |
|
Goda, Grant A |
Hyperactivation of an RNA binding protein by cancer-associated mutations |
talk |
|
Goh, W.S. Sho |
Identification of a m6Am reader and its function in mRNA transcription |
talk |
|
Gonatopoulos Pournatzis, Thomas |
Exon-resolution functional genomics uncovers critical exons for cell fitness |
talk |
|
Gordon, Jackson M |
Phosphorylation-dependent inhibition of PABPN1 during mitosis maintains poly(A) tail lengths |
talk |
|
Govindan, Ashwin |
A genetic screen for trans-acting factors regulating OGT intron retention |
poster |
|
Graille, Marc |
The human tRNAs and snRNA U6 N2-methylguanosine (m2G) writers are important for cell proliferation, protein translation and pre-mRNA splicing |
poster |
|
Gregersen, Lea H |
Co-transcriptional regulation by SCAFs |
poster |
|
Grozdanov, Petar |
The role of alternative polyadenylation in a TLR3-mediated mouse model of escalated alcohol consumption |
poster |
|
Gu, Shuo |
Dicer processing of pre-miR-138-2 is regulated by uridylation |
poster |
|
Guerra-Moreno, Angel M |
RBM10-mediated alternative splicing controls bladder cancer cell proliferation |
talk |
|
Gupta, Ankit |
TUT4/7 and terminal uridylation—A defense mechanism modulating coronavirus replication |
poster |
|
Gupta, Kavi |
Improved modeling of RNA-binding protein motifs in an interpretable neural model of RNA splicing |
poster |
|
Gupta, Yogesh |
A cryptic pocket in METTL3-METTL14 regulates the conversion of adenosine (A) to N6-methyladenosine (m6A) and RNA binding |
talk |
|
Gutman, Danielle |
Mapping and validating functional elements in 5’UTRs of human genes |
poster |
|
Haberman, Nejc |
Abundant capped RNAs are derived from mRNA cleavage at 3’UTR G-quadruplexes |
poster |
|
Haimowitz, Adam |
The role of intergenic spatial proximity in regulating alternative splicing outcomes |
poster |
|
Harvey, Leon |
Investigating the role of RNA helicases in splicing changes caused by cancer-associated SF3B1 mutations |
poster |
|
He, Xueyang |
Modeling the effects of cancer-associated spliceosome mutations and identifying driving intronic features using deep-learning neural networks |
poster |
|
Heller, Elizabeth A |
Regulation of alternative splicing via changes in histone post-translational modifications |
poster |
|
Heyd, Florian |
Alternative splicing-coupled to nonsense-mediated decay control cold-induced expression of RNA chaperones |
talk |
|
Heyd, Florian |
Immediate early splicing after T cell activation is controlled by hnRNPC |
poster |
|
Hohmann, Ulrich |
A conserved mechanism licenses mRNA for nuclear export |
talk |
|
Holmes, Megan |
Co-regulation of alternative splicing by splicing regulators |
poster |
|
Hong, Jiayin |
Gene bodies and nascent RNA—Key players in maintaining chromatin accessibility to large molecules |
talk |
|
Hoskins, Aaron A |
The kinetic mechanism of small molecule-enhanced 5' splice site recognition |
talk |
|
Hu, Rong-Chi |
MBNL overexpression rescues cardiac phenotypes in myotonic dystrophy type 1 mouse model |
poster |
|
Huang, Yuling |
Cooperative regulation of the smooth muscle cell alternative splicing program by RBPMS and coregulatory RNA binding proteins |
poster |
|
Hulsey Stubbs, Sarah |
Ebola virus targets nonsense mediated decay components to promote infection |
talk |
|
Hulver, Molly J |
Modeling CDK12 and CDK13 loss-of-function to investigate their roles in alternative polyadenylation and neoantigen expression |
poster |
|
Hwang, Astra E |
A novel approach to study co-transcriptional splicing timing through Nanopore long-read sequencing of lariat intermediates in humans |
poster |
|
Hwang, Hun-Way |
A twin UGUA motif directs the balance between gene isoforms through CFIm and the mTORC1 signaling pathway |
poster |
|
Ietswaart, Robert |
Genome-wide quantification of RNA flow across subcellular compartments reveals determinants of the mammalian transcript life cycle |
talk |
|
Ihn, Sean J |
Exogenous mRNA induces G3BP1/2-dependent stress granule formation through PKR/phospho-eIF2α-dependent and -independent pathways |
poster |
|
Ishigami, Yuma |
Specificity, synergy, and mechanisms of splice-modifying drugs |
poster |
|
Islam, MD Rafikul |
Decoding MUSK exon 10 splicing regulation involving neuromuscular signal transmission |
poster |
|
Jagannatha, Pratibha |
High-throughput RBP-wide screen to characterize the effect of RBP binding on polyA site selection |
poster |
|
Jagannatha, Pratibha |
STAMP—A novel method for elucidating protein-RNA interactions at isoform resolution |
talk |
|
Jeong, Bohye |
Translational regulation of photoreceptor-specific mRNA by Musashi 1 and Musashi 2 proteins for photoreceptor maintenance |
poster |
|
Ji, Zhe |
Deep learning human polyadenylation sites at the nucleotide resolution reveals molecule determinants governing site usage and relevance in diseases |
poster |
|
Jin, Lan |
AAV vector expressing multiple U7-snRNA-fused antisense sequences mediates efficient dystrophin exon51 skipping |
poster |
|
Johnson, Peter |
3'UTR-directed, kinase proximal mRNA decay inhibits C/EBPβ phosphorylation/activation to suppress senescence in tumor cells |
poster |
|
Johnson, Sara |
Small molecule screening identifies HSP90 as a regulator of RNA foci in Myotonic Dystrophy Type 1 |
talk |
|
Jonas, Stefanie |
Basis of gene-specific transcription regulation by the Integrator complex |
talk |
|
Kabbani, Lyna |
The role of IGF2BP3 in RISC target site selection during acute MLL B-lymphoblastic leukemia |
poster |
|
Kalsotra, Auinash |
ESRP2–microRNA-122 axis directs the postnatal onset of hepatic polyploidization and maturation |
talk |
|
Kang, Bowei |
Infernape—Uncovering cell-type-specific and spatially resolved alternative polyadenylation in brain development |
poster |
|
Karginov, Timofey |
TRA2β’s ultraconserved poison exon governs T cell receptor signaling to shape T cell fate |
poster |
|
Karni, Rotem |
RBFOX2 modulates a metastatic signature of alternative splicing in pancreatic cancer |
poster |
|
Karp, Ilana |
RNA binding protein Khdrbs1 regulates hematopoietic stem and progenitor cell formation |
poster |
|
Kejiou, Nevraj S |
Pyruvate kinase M (PKM) binds ribosomes in a poly-ADP ribosylation dependent manner to induce translational stalling |
poster |
|
Kerkhofs, Martijn |
A novel pathway to regulate splicing in neurons—NUAK1 regulates neuronal splicing events through its interaction with nuclear speckle protein SON |
poster |
|
Khokhar, Eraj S |
Nascent RNA sequencing enables the identification of cryptic splice sites |
poster |
|
Kim, Minseon |
Definition of nuclear stabilization activities of mRNA export factors |
poster |
|
Kim, Yoona |
Is the TREX-2 complex an unidentified mRNA export receptor? |
poster |
|
Kostin, Beathrice |
The first functional analysis of a long non-coding RNA transcribed by RNA polymerase I which controls gene expression during parasite development within the insect vector |
talk |
|
Kral, Alexander |
Regulation of AURKA alternative splicing by SRSF1 in PDAC |
poster |
|
Krick, Keegan |
Depolarization-induced alternative splicing in neurons |
talk |
|
Kubaczka, Maria Guillermina |
Insights on how light regulates alternative polyadenylation in plants |
poster |
|
Kwon, Young-Soo |
RNA-binding protein L1TD1 stimulates translation of noninteracting mRNAs |
poster |
|
Lareau, Liana |
Engineering poison exons for allele-specific silencing to treat Huntington's disease |
poster |
|
Larson, Daniel |
Detection of a sequence signature for recursive splicing |
poster |
|
Lawson, Michael R |
Defining the pathways of eukaryotic translational quality control |
poster |
|
Le Hir, Herve |
A majority of EJCs are disassembled independently of translation |
talk |
|
Lee, Amanda |
Context-specific dependency on the splicing factor TRA2A in cancer |
poster |
|
Lee, Seung Kyu K |
Topoisomerase 3b enhances stability of maternal mRNAs that are essential for neurodevelopment of progeny |
poster |
|
Lee-yow, Yannick C |
Investigating the functional relationship between circular and linear RNA isoforms in neuronal differentiation |
poster |
|
Lehman, Jesse W |
Temporal regulation of mRNA biogenesis in immune responses |
poster |
|
Levdansky, Yevgen |
Deadenylation kinetics of mixed tailing at single-nucleotide resolution |
poster |
|
Lin, Yizhu |
Directed protein evolution of an RNA editor for single molecule RNA-binding protein co-occupancy |
talk |
|
Ling, Jonathan |
A flexible and cost-effective method for generating custom 10x beads to capture alternative splicing events at single cell resolution |
poster |
|
Lipinski, Karli A |
Structure and function of the newly identified yeast splicing factor Fyv6 |
poster |
|
Liu, Jingyi |
Unraveling cell-type-specific alternative cleavage and polyadenylation regulatory mechanisms governed by CLP1. |
talk |
|
Liu, Liang |
Disassembly of the mRNA 3’ processing complex and implications for human immunodeficiency virus (HIV) replication |
poster |
|
Liu, Lingjie |
DNA-sequence and epigenomic determinants of local rates of transcription elongation |
poster |
|
Liu, Lizhi |
Alternative polyadenylation of WDR33 pre-mRNA generates proteins that function with STING in innate immunity |
talk |
|
Liudkovska, Vladyslava |
Dissecting the RNA-binding protein landscape of human embryonic differentiation |
poster |
|
Lobel, Joseph H |
Principles and properties of intrinsically disordered regions in post-transcriptional control |
talk |
|
Longman, Dasa |
Physiological relevance and regulation of the NMD pathway in vivo. |
poster |
|
Ma, Tiantai |
Reading the snRNP—The 3' exonuclease TOE1 selectively processes snRNAs through recognition of Sm-complex assembly and 5’ cap trimethylation |
talk |
|
MacVeigh-Fierro, Daniel T |
m6A modifications leads to evasion of host shutoff in viral infection |
poster |
|
Maji, Suvrajit |
Structural analysis of protein-RNA interaction and photocrosslinking |
poster |
|
Mao, Xiaowen |
RNase L activation reduces nascent RNA production in the nucleus |
talk |
|
Martinez, Jose |
Defining the translatome in splicing factor mutated AML |
poster |
|
Mayeda, Akila |
EJC core-triggered compacted mRNP structure represses cancer-specific splicing in exitron |
talk |
|
McGurk, Michael P |
Interpreting splicing changes in terms of RBP binding |
talk |
|
McQuarrie, David |
ELAV forms a saturable complex on extended RNA, but can nucleate requiring multiple optimally spaced U-rich motifs |
poster |
|
Meissner, Jadwiga |
The function of 5' exon motifs in stabilizing the 5'SS within the yeast spliceosome |
poster |
|
Mikl, Martin |
Splicing diversity is affected by environment, splicing machinery and promoter identity |
poster |
|
Miles, Jacob M |
The secondary structure of a conserved RNA element impacts mRNA stability during KSHV lytic infection |
poster |
|
Miura, Pedro |
Coordination of alternative splicing and alternative polyadenylation revealed by targeted long-read sequencing |
poster |
|
Moakley, Daniel |
Reverse engineering neuron cell type-specific splicing-regulatory networks from single-cell transcriptomes |
poster |
|
Moore, Claire |
Targeting mRNA 3’ end processing to inhibit cancer cell stemness |
talk |
|
Murakami, Shino |
The ribosome links amino acid availability to gene expression through m6A |
talk |
|
Muralidharan, Charanya |
Suppression of the integrated stress response upregulates PD-L1 in pancreatic beta cells through post-transcriptional regulation by GOLM1 |
poster |
|
Murn, Jernej |
A paradigm for regulation at the effector interface with RNA-binding proteins |
poster |
|
Nabeel-Shah, Syed |
C2H2-zinc finger transcription factors bind directly to RNA and participate in diverse posttranscriptional regulatory processes |
talk |
|
Niederer, Rachel O |
Direct analysis of ribosome targeting illuminates thousand-fold regulation of translation initiation |
poster |
|
Niggl, Eva |
HNRNPC haploinsufficiency affects alternative splicing of ID-associated genes and causes neurodevelopmental disorder |
poster |
|
Norppa, Antto J |
Functional divergence of the paralogous RBM41 and U11/U12-65K proteins in the minor spliceosome |
talk |
|
Ntermentzaki, Georgia |
Depletion of Mettl3 in cholinergic neurons causes adult-onset neuromuscular degeneration |
talk |
|
Obado, Samson O |
Origins and division of labor in trypanosome RNA processing by expanded Mex67 paralogs |
poster |
|
Ohara, Hiroaki |
Branch points as potential targets of exon-skipping therapies for genetic disorders |
poster |
|
Pai, Athma A |
Gene length drives the coupling of mRNA 5’ and 3’ ends based on genomic order |
poster |
|
Palencia, Andrés |
Targeting cleavage and polyadenylation factors for the development of novel therapeutics |
talk |
|
Panthi, Asmita |
IRF7 alternative splicing—Its mechanistic basis, regulation, and role in modulating type -1 interferon response |
poster |
|
Park, Jiyeon |
BreastASMiner—A web server for investigating alternative splicing in breast cancer cell heterogeneity |
poster |
|
Partridge, Ruth |
Understanding the structure-function relationship of the master splicing regulator RBPMS |
poster |
|
Patrick, Kristin |
The splicing factor SRSF7 promotes transcription of Irf7 to activate antiviral gene expression in macrophages |
talk |
|
Pawellek, Andrea M |
Poly(A) binding protein PABPC1 is a target for the splicing modulator madrasin |
poster |
|
Peterson, Janel |
The role of MBNL in smooth muscle function and DM1 GI pathologies |
poster |
|
Peyda, Parham |
Combinatorial recognition of splicing regulatory motifs by a heteromeric assembly of RNA binding proteins |
talk |
|
Pilaka-Akella, Pallavi P |
Investigating neuronal-specific repression of alternative splicing by the conserved CELF protein UNC-75 in C. elegans |
talk |
|
Podszywalow-Bartnicka, Paulina |
Role of mRNA regulation by TIAR in leukemia cell resistance to therapy in the hypoxic bone marrow microenvironment |
poster |
|
Poff, Abigail J |
Investigating the impact of a DDX3X missense mutation on cortical development |
poster |
|
Qiu, Tina (Yi) |
Recombination and mutational bias shapes GC-content in the 5’ end of protein-coding mRNAs |
poster |
|
Rader, Stephen |
Intron accumulation—An evolutionarily conserved mechanism for stress adaptation |
poster |
|
Recinos, Yocelyn |
SpliceRush—An exon-centric screening platform for proximal and distal splicing-regulatory elements |
poster |
|
Rehman, Abid |
Uncovering single-cell isoform dynamics in the aging mouse brain using long-read nanopore sequencing |
poster |
|
Riabov, Daria |
Structure of the recycling human U5 snRNP |
poster |
|
Rio, Donald |
Deciphering the role of a disease-associated hnRNPA1 mutation in amyotrophic lateral sclerosis |
talk |
|
Ritter, Alexander J |
Long read subcellular fractionation and sequencing reveals the translational fate of full-length mRNA isoforms during neuronal differentiation |
talk |
|
Robalin, Nicolas A |
Defining the regulation and function of m5U in RNAs of breast cancer cells |
poster |
|
Rodgers, Margaret |
Visualizing co-transcriptional target search by a ribonucleoprotein using single-molecule fluorescence microscopy |
poster |
|
Roy, Raktim |
Functional relevance and molecular mechanism of intron retention in Drosophila melanogaster |
poster |
|
Ruan, Xiangbin |
PIE-seq—Identifying RNA-binding protein targets by dual RNA-deaminase editing and sequencing |
poster |
|
Sad, Marah |
Structural and functional characterization of a novel therapeutic target involved in cancer (human polyadenosine polymerase α, hPAP α) |
poster |
|
Saida, Naseeb |
TargRNA-seq—A novel method for targeted RNA-seq facilitated the discovery of novel translation regulatory elements |
poster |
|
Saltzberg, Joshua D |
Development of a general mathematical model enabling the determination of the kinetics of transcription and cotranscriptional RNA processing |
poster |
|
Seong, Minu |
Comprehensive RNA-seq analysis comparing astrocytes and GBM reveals that cell migration-related genes are differentially regulated by alternative splicing |
poster |
|
Shah, Raven |
Chemical transcriptomics—An in-situ method for transcriptome-wide profiling of small molecule-RNA engagement |
poster |
|
Shah, Sanjana |
Neoantigen discovery in OTS964-treated cells using the SpliceIOTM |
poster |
|
Shcherbii, Mariia v |
The role of U11/U12-65K cross-regulation pathway in cellular differentiation |
poster |
|
Sheehan, Charlie J |
Visualization of m6A residues in individual mRNAs |
poster |
|
Shenasa, Hossein |
Direct evidence of transcription elongation rates modulating RNA secondary structure and RBP binding |
talk |
|
Silva, Erick |
Investigating the interplay between alternative splicing and chromatin in splice-switching therapies |
poster |
|
Siraj, Md Afjalus |
Phosphorylation of ERK is controlled by exon missplicing in cancer |
poster |
|
So, Byung Ran |
A U1 snRNP-specific U1C protein regulates snRNP repertoire as a gatekeeper of the SMN complex |
poster |
|
Soles, Lindsey V |
The RNA degradation code—A destruction complex formed by U1 snRNP and mRNA 3′ processing factors surveils the mammalian transcriptome |
talk |
|
Srebrow, Anabella |
Impact of dengue virus on PML pre-mRNA processing |
poster |
|
Steinbrecht, David |
Modeling how mRNA flows through subcellular compartments |
poster |
|
Stevers, Meredith |
Splicing reporters for human U2 snRNA mutants in cells |
poster |
|
Stigliano, Jose |
Targeting histone acetylation to SMN2 intron 6 using CRISPR-dead Cas9 improves the antisense splicing-correcting therapy of spinal muscular atrophy |
poster |
|
Strasser, Katja |
Npl3 functions in mRNP assembly by recruitment of mRNP components to the transcription site and their transfer onto the mRNA |
talk |
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Takabe, Piia |
The role of RNA-binding proteins in platelet biogenesis |
poster |
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Tangiyan, Anna |
Characterization of recurrent cancer-associated missense mutations in RBM10 |
poster |
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Teixeira, Joana |
RNA repeat toxicity links lipid metabolism dysregulation to mitochondrial dysfunction |
talk |
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Thompson, Matthew G |
Novel recognition of m6A in viral RNA by an antiviral ISG |
talk |
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Timofeyenko, Ksenia |
Catsnap—A machine-learning tool revealing the plasticity of alternative splicing in plants and animals. |
poster |
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Tong, Liang |
Distinct mechanisms for the regulation of CPSF73 activity |
talk |
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Torres Ulloa, Leslie |
Genome-wide kinetic profiling of mRNA 3’ end cleavage |
poster |
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Tracey, Matthew |
Characterization of host splicing events induced by flavivirus infection and ER stress |
poster |
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Traugot, Conner |
N6-methyladenosine in 7SK small nuclear RNA underlies RNA Polymerase II transcription regulation |
talk |
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Tsai, Albert |
Profiling modified nucleosides in archaeal mRNA by mass spectrometry |
poster |
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Tse, Victor |
A bipartite RNA structure sensitizes Factor VIII exon 16 to splicing-sensitive hemophilia A-causing mutations |
poster |
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Valiya Chembazhi, Ullas |
Transcriptional and post-transcriptional landscapes of alcohol-associated human liver diseases |
poster |
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Viscardi, Marcus J |
Nanopore full-length mRNA sequencing supports endonucleolytic cleavage, but not deadenylation, as a mechanism of nonsense-mediated mRNA decay |
talk |
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Vivanco, Karinna O |
Poison exons in splicing factor genes control the tempo of neuronal differentiation |
talk |
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Vlaming, Hanneke |
5’ splice sites render mRNAs insensitive to Restrictor’s promiscuous activity on early elongating RNA Polymerase II |
talk |
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Vlasov, Pavel A |
Enhancer RNAs include multiple transcripts with long translatable open reading frames |
poster |
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Wan, Ledong |
Dysregulated spliceosomal components promote pancreatic cancer progression |
talk |
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Wan, Ting Chi Rebecca |
Long-read sequencing reveals alternative transcript isoforms of hepatocellular carcinoma (HCC) under hypoxic stress |
poster |
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Wang, Matthew C |
Understanding the role of alternative RNA splicing in Osimertinib resistance in lung adenocarcinoma |
poster |
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Wang, Yifan (Eva) |
RanBP2/Nup358 is required at the nuclear pore to SUMOylate Argonautes and repress cytokine mRNAs |
poster |
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Wang, Zefeng |
Translation of circular RNAs- regulatory mechanisms and therapeutic applications |
talk |
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Wang, Zhongshi |
Investigating the functionality of tri-snRNP variants in spliceosome assembly and activation |
poster |
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Wechsler, Theresa |
A kinetic framework for co-transcriptional messenger ribonucleoprotein (mRNP) assembly in S. cerevisiae |
talk |
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Wei, Lian-Huan |
Genome-wide CRISPR screens identify noncanonical translation factor eIF2A as an enhancer of SARS-CoV-2 programmed –1 ribosomal frameshifting |
talk |
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Weiss, Amanda N |
Investigating the role of alternative splicing in a model of human neuronal differentiation |
poster |
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Wiesner, Lennard W |
Exploring the thermodynamic landscape of nuclear speckles |
poster |
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Wilusz, Jeremy E |
IntS6 and the Integrator phosphatase module tune the efficiency of select premature transcription termination events |
talk |
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Wohlenberg, Chloe |
Novel requirement for a Parkinson’s-related factor in ribosome stalling-induced mRNA decay |
poster |
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Xiao, Meisheng |
Exon-resolution functional genomics uncovers critical exons for cell fitness |
poster |
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Xiao, Wen |
The lncRNA Malat1 is trafficked from the nucleus to the cytoplasm as a localized mRNA encoding small peptides in neurons. |
poster |
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Yang, Kevin |
The LSV-Seq method enables machine learning-assisted recovery of low-coverage splicing events across human tissues. |
poster |
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Yang, Lucia |
Perturbation of key RNA-binding proteins induces H3-3A mis-splicing in H3.3K27M-altered diffuse midline glioma |
poster |
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Yang, Suzhou |
Self-exonization of intronic repeats in C9orf72-ALS/FTD |
poster |
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Yang, Yanzhong |
Loss-of-function mutation in PRMT9 causes abnormal synapse development by dysregulation of RNA alternative splicing |
talk |
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Yin, Hong |
Explore RNA splicing dynamics from isoform-specific spatial patterns |
poster |
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Yu, Angela |
Deciphering sequence effects of splicing in health and disease with massively parallel reporter assays and machine learning |
talk |
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Yu, Tao |
Discovery of transcriptome-wide protein-RNA interactions in fixed cells and tissues by in situ STAMP without ectopic expression of transgenes |
poster |
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Yu, Yang |
Pcf11 facilitates heterochromatin formation by inducing Pol II pausing during piRNA-guided transposon silencing |
talk |
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Zamudio, Jesse R |
Mammalian Argonaute represses pericentromeric lncRNA to maintain genome stability |
talk |
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Zhang, Chaolin |
MAPT exon 10 splicing—From its evolutionary divergence to potential therapeutic modulations |
talk |
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Zhang, Jian |
Characterization of the SF3B1-SUGP1 interface reveals how numerous cancer mutations cause mRNA missplicing |
talk |
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Zhang, Qian |
Antisense H3-3AK27M splice-disruption therapy inhibits H3.3K27M -altered diffuse midline glioma growth |
poster |
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Zhang, Qiang |
An intricate regulatory network that controls expression of cleavage factor I proteins and homeostasis of global mRNA 3’UTR sizes |
talk |
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Zhang, Xiaochang |
Rbfox3/2 differentially splice transcription regulators and antagonize Ptbp1 in the developing neocortex |
poster |
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Zhang, Zhenwei |
Cryo-EM of human B-like spliceosomal complexes generated from exon-defined pre-B complexes |
talk |
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Zhao, Jingrong |
Molecular profiling of individual FDA-approved clinical drugs identifies modulators of nonsense-mediated mRNA decay |
poster |
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Zheng, Sika |
Nonsense-mediated mRNA decay counteracts TRP53 for progenitor cell maintenance and lineage progression |
talk |
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Zhou, Xiao A |
An AS-NMD-dominated uneconomic mechanism mediates rapid periodic fluctuations of mRNA levels during cell cycle transition |
poster |