|
Presenting Author |
Abstract Title |
Talk/Poster |
|
Ajiro, Masahiko |
Therapeutic manipulation of IKBKAP mis-splicing with a small molecule to cure familial dysautonomia |
poster |
|
Altieri, Jessie |
The influence of 4sU labeling on splicing efficiency |
poster |
|
Angarola, Brittany L |
Transcriptomic and cellular programs during aging and in breast cancer |
poster |
|
Ansari, Aseem |
Engaging RNA processing machinery through non-canonical marks on RNA polymerase II |
talk |
|
Ansari, Athar |
A termination-independent role of Rat1 in co-transcriptional splicing |
poster |
|
Arribere, Joshua A |
SMG-6 cleaves NMD targets at the ribosome |
talk |
|
Bae, Bongmin |
CRISPR-mediated knockout of neuronal long 3'UTRs in mESC-derived neurons |
poster |
|
Bak, Maciej |
A novel approach to detect multi-level effects of RNA-binding proteins on pre-mRNA processing |
poster |
|
Bangru, Sushant |
ESRP2–microRNA-122 axis directs the postnatal onset of liver maturation and polyploidization |
talk |
|
Baptissart, Marine |
Poly(A) tail dynamics during cell differentiation show transcript compartmentalization and specific post-transcriptional regulation |
talk |
|
Berry, Cameron W |
Developmentally regulated cleavage of transcript 3’ ends controls dynamic protein expression as germline stem cells differentiate |
poster |
|
Bhatnagar, Sanjana |
Deciphering a cis-regulatory code for tissue-specific alternative splicing |
poster |
|
Bhattacharya, Saikat |
The histone methyltransferase SETD2 governs co-transcriptional splicing by engaging pre-mRNA processing factors through its SHI domain |
talk |
|
Biancon, Giulia |
U2AF binding atlas dissects pathogenic RNA molecular mechanisms driven by U2AF1 mutations and affecting RNA granules |
talk |
|
Bibel, Brianna L |
Target binding triggers hierarchical phosphorylation of human Argonaute-2 to promote target release |
talk |
|
Bicknell, Alicia A |
High ribosome loading is associated with rapid mRNA decay among coding sequence variants in mammalian cells |
talk |
|
Boraas, Liana |
Non-coding mRNAs regulate focal adhesion protein organization |
talk |
|
Cain, James A |
Utilising the imprinted Mcts2/H13 locus as a model to study the role of intragenic CpG islands during alternative polyadenylation |
poster |
|
Carnesecchi, Julie |
Extending the Hox molecular repertoire—From transcription to mRNA splicing |
talk |
|
Carrocci, Tucker J |
Intron sequence modulates gene expression through co-transcriptional splicing |
talk |
|
Castaneda, Paula |
mRNA decapping by an ApaH-like phosphatase in trypanosomes |
poster |
|
Chembazhi, Ullas |
Mechanistic and functional differences in RNA binding and processing activities of the muscle- and non-muscle RBFOX2 isoforms |
poster |
|
Choquet, Karine |
Perturbation of U2 snRNA or 3’ splice sites disrupts multi-intron splicing order and coordination in human cells |
poster |
|
Chorghade, Sandip |
Dynamic expression of poly(A) binding protein N1 coordinates cardiac growth during development and disease |
poster |
|
Cichocka, Marlena |
Effect of hnRNP UL1 protein on replication-dependent histone gene repression |
poster |
|
Cortazar Osorio, Michael A |
Saturation genome editing as a tool to identify rules that govern NMD activity |
poster |
|
Cortes-Lopez, Mariela |
Massive parallel reporter assay decodes CD19 alternative splicing in CART-19 therapy resistance |
poster |
|
Damodaren, Nivedita |
Short vs long term effects from depletion of a splicing regulator—Identification of early splicing changes after rapid depletion of the RNA-binding protein Matrin-3 |
poster |
|
Dowdle, Megan E |
Exploiting evolutionary diversity within the bicaudal-C multi-KH RNA binding domain to illuminate how vertebrate Bicc1 recognizes its bipartite target site within Cripto-1 mRNA |
poster |
|
Draycott, Austin |
Lung cancer cells require dihydrouridine synthase 2 to sustain production of cysteine-rich oncoproteins |
talk |
|
Dziembowski, Andrzej |
TENT5 cytoplasmic non-canonical poly(A) polymerases regulate the innate immune response in animals |
talk |
|
Felton, Colette |
Detection of alternative isoforms of gene fusions using long-read RNA-seq |
poster |
|
Feng, Huijuan |
Complexity and graded regulation of neuronal cell type-specific alternative splicing revealed by single-cell RNA sequencing |
poster |
|
Feng, Qing |
Genome-wide impact of DExH-box RNA helicases on RNA splicing and quality control |
poster |
|
Fica, Sebastian M |
The human exon-ligation factor Prp18 engages the spliceosome core in a transcript-specific manner |
talk |
|
Fiszbein, Ana |
Widespread occurrence of hybrid internal-terminal exons in human transcriptomes |
talk |
|
Flamand, Mathieu |
m6A and YTHDF proteins control mRNA localization in neurons |
talk |
|
Fu, Xingyang |
A kinetic map of spliceosome activation |
poster |
|
Galej, Wojciech P |
Structural insights into branch point recognition in mammals |
talk |
|
Gao, Chen |
Functional impact of RBFox1c in cardiac pathological remodeling through targeted mRNA stability regulation |
poster |
|
Gentile, Gabrielle M |
Regulation and function of synaptosome-associated protein 23 alternative splicing during myogenesis |
talk |
|
Grozdanov, Petar |
Mechanism of polyadenylation site selection by CSTF2 in the brain |
poster |
|
Gutierrez, Pedro A |
A real-time fluorescence assay for CPSF73, the nuclease for pre-mRNA 3'-end processing |
poster |
|
Haimowitz, Adam |
The role of intergenic proximity in regulating alternative splicing outcomes |
poster |
|
Hegazy, Youssef A |
Characterization of R-loop structures in budding yeast |
poster |
|
Heyd, Florian |
Body temperature-controlled expression of antiviral response genes |
talk |
|
Hrabeta-Robinson, Eva B |
U2AF1 mutation suppresses oncogenic KRAS-induced senescence in human bronchial epithelial cells |
poster |
|
Hug, Nele RG |
A dual role for the RNA helicase DHX34 in NMD and pre-mRNA splicing and its impact on familial MDS and AML |
talk |
|
Hundley, Heather A |
Uncovering a molecular mechanism that regulates RNA editing during neural development |
poster |
|
Hutchins, Erica J |
Neural crest EMT is controlled via target degradation within P-bodies |
talk |
|
Hwang, Hun-Way |
Shift in MSL1 alternative polyadenylation in response to DNA damage protects cancer cells from chemotherapeutic agent-induced apoptosis |
talk |
|
Ibrahim, Fadia |
TERA-Seq—The true ends of RNA molecules tell a story |
talk |
|
IIDA, Kei |
Switching of OAS1 splicing isoforms mitigates SARS-CoV2 infection |
talk |
|
Jacob, Aishwarya G |
RNA binding protein multiple splicing (RBPMS) drives a contractile splicing network in human embryonic stem cell derived vascular smooth muscle cells |
poster |
|
Jagannathan, Sujatha |
The myopathic transcription factor DUX4 induces production of truncated RNA-binding proteins in human muscle cells |
talk |
|
Jensen, Madeline K |
Identification and structural basis of a novel cellular inhibitor of the Integrator cleavage module |
poster |
|
Jin, Hong |
Conserved heterodimeric GTPase Drg1/Dfrp1 promotes efficient translation |
talk |
|
Jones, Aarin |
Regulation of splicing events through PARP-1-mediated ADP-ribosylation of U2AF complex |
talk |
|
Jurica, Melissa |
Reconstituting U2 snRNP interactions with the branch point sequence |
talk |
|
Kadijk, Eileigh C |
Nuclear PABP accumulation in influenza A virus infected cells requires concerted action of the viral host shutoff nuclease PA-X and the non-structural protein 1 |
poster |
|
Kainov, Yaroslav A |
A transcriptome-wide antitermination mechanism sustaining identity of embryonic stem cells |
talk |
|
Kalsotra, Auinash |
Splicing factor SRSF1 deficiency in the liver triggers NASH-like pathology via R-loop induced DNA damage and cell death |
poster |
|
Kawachi, Toshihiko |
The essential role of SRSF3 in the constitutive splicing of large exons, which encode intrinsically disordered regions of transcription factors in vertebrates |
poster |
|
Ke, Shengdong |
Deep learning modeling m6A deposition reveals the importance of downstream cis-element sequences |
talk |
|
Khokhar, Eraj S |
Noise to signal—Exploring the landscape of noisy splicing |
poster |
|
Kim, Young Jin |
Gene-specific evasion of nonsense-mediated mRNA for cystic fibrosis therapy |
talk |
|
Kinney, Justin B |
Unraveling the quantitative influences of splice site strength, gene context, and therapeutics on alternative mRNA splicing using massively parallel splicing assays |
poster |
|
Kulinski, Tomasz |
Oncogenic mechanisms of DIS3 mutations in multiple myeloma |
talk |
|
Lai, Eric |
Recursive splice sites—Agents of chaos and order |
talk |
|
Lareau, Liana |
Identifying cell-state associated alternative splicing events and their co-regulation |
talk |
|
Leclair, Nathan K |
SR protein expression is regulated by ultraconserved poison exons during development and in human cancer |
poster |
|
Lee, Yeon J |
Deciphering the role of a disease-associated hnRNP A1 mutation in amyotrophic lateral sclerosis |
talk |
|
Li, Wei |
An atlas of alternative polyadenylation quantitative trait loci contributing to complex trait and disease heritability |
poster |
|
Li, Xin |
Unrecycled 40S-initiated mRNA decay couples translation and piRNA production |
talk |
|
Liao, Susan E |
Splicing at the phase-separated nuclear speckle interface—A model |
poster |
|
Lim, Han Young |
Selective export of mRNAs encoding transcription factors by NXF1 |
poster |
|
Lima, Christopher D |
Targeting RNA for destruction |
talk |
|
Lin, Min-Han |
Novel mechanisms of regulating Integrator function |
talk |
|
Liu, Haibin |
The long noncoding RNA lnc-FANCI-2 in HPV-infected cervical cancer cells plays an important role in RAS signaling through MCAM |
poster |
|
Liu, Liang |
Mechanistic dissection of the anti-cancer compound JTE-607-mediated inhibition of mRNA 3’ processing |
talk |
|
Lopez, Jessie M |
KIN17 and PRCC have roles in maintaining both 5' and 3' splice site identity |
talk |
|
Love, Sierra L |
A high throughput screening platform utilizing fluorescent reporters for splicing inhibitor discovery |
poster |
|
Luzak, Vanessa |
An mRNA processing hotspot orchestrates immune evasion of African Trypanosomes |
talk |
|
Madhani, Hiten |
Base editing the human spliceosome in haploid cells reveals a role for SUGP1 in drug resistance |
talk |
|
Mandler, Mariana |
Elucidating the modification status of tRNAs in response to environmental and metabolic stress |
poster |
|
Marasco, Luciano E |
Epigenetics in SMN2 alternative splicing—Towards a combined therapy of spinal muscular atrophy |
talk |
|
Martin, Charlotte |
Investigating the function of tissue-specific alternative splicing in C. elegans |
poster |
|
Martinez, Nicole M |
Pseudouridine synthases modify human pre-mRNA co-transcriptionally and affect pre-mRNA processing |
poster |
|
Mauer, Chris |
Multiple circular RNAs are generated from backsplicing of the HIV-1 primary transcript |
poster |
|
Mayer, Andreas |
A BRD4-mediated elongation control point primes transcribing RNA polymerase II for 3’-RNA processing |
talk |
|
Mimoso, Claudia A |
Defining the crosstalk between transcription and the splicing machinery |
talk |
|
Miura, Pedro |
Coordinated alternative polyadenylation and alternative splicing during Drosophila development |
talk |
|
Montibus, Bertille |
A gene within a gene—How overlapping transcription influences alternative polyadenylation |
poster |
|
Mukherjee, Srimoyee |
Cleavage/polyadenylation factor CstF64 shapes alternative polyadenylation in differentiating monocytes and promotes their transition to macrophages |
talk |
|
Mullari, Meeli |
Global analysis of RNA-binding proteins in the brain tissue of a Huntington’s disease mouse model using quantitative mass spectrometry |
poster |
|
Muller-McNicoll, Michaela |
Exploring cancer-specific Split-ORF expression as neoantigens |
talk |
|
Mulligan, Dennis R |
MESA—A tool for fast and comprehensive quantification of alternative splicing |
poster |
|
Musaev, Damir |
The role of ORF length and translation in mRNA decay |
poster |
|
Nachtergaele, Sigrid |
The METTL5-TRMT112 N6-methyladenosine methyltransferase complex regulates metabolism and development via translation |
talk |
|
Nazim, Mohammad |
Alternative splicing of a chromatin modifier alters the transcriptional regulatory programs of neuronal development |
talk |
|
Neeb, Zachary T |
Comparative transcriptomic analysis of post-transcriptional gene regulation during SARS-CoV-2 infection |
poster |
|
Niederer, Rachel O |
Translational control by C-rich elements within regulated 5’UTR isoforms |
poster |
|
Nino, Carlos A |
Molecular basis of myosin VI aberrant alternative splicing in ovarian cancer |
poster |
|
Noble, Jerald D |
Alternative mRNA splicing in apoptosis and c-Myc signaling pathways as novel mechanisms of resistance in relapsed and refractory diffuse large B-cell lymphoma (R/R DLBCL) patients receiving CAR-T therapy |
poster |
|
Ntini, Evgenia |
Distinctive features of long non-coding RNA chromatin (dis)-association |
poster |
|
Parsley, Julia V |
Remarkable alternative splicing generates multiple isoforms of polyadenylation factors FIP1L1 and CPSF4 that vary during hESC differentiation |
talk |
|
Patop, Ines L |
The splicing factor MBL forms a self-regulatory circuit by modulating back splicing in a cell type and isoform specific mechanism |
talk |
|
Pawallek, Andrea |
Modulation of RNA processing pathways by the DDD40800 family of small molecules |
talk |
|
Peart, Natoya J |
RBM46—A germ cell specific RNA binding protein required for mammalian spermatogenesis |
talk |
|
Pilaka-Akella, Pallavi P |
Investigation of neural-specific repression of alternative splicing by a CELF protein in Caenorhabditis elegans |
talk |
|
Powell, Geralle N |
Gene regulatory role and polyA track mutations of the minor spliceosomal protein ZCRB1 |
poster |
|
Rajkumar, Sandy M |
Spliceosome profiling using mice harboring endogenously tagged PRPF19 reveals RNA processing reactions in vivo across tissues |
poster |
|
Rastogi, Mohit |
Multi-omics approach in Down syndrome resolves new regulators in two regions of the human brain. |
poster |
|
Regev, Oded |
Using machine learning to decipher the determinants of exon inclusion |
talk |
|
Richard, Hugues |
Assessing conservation of alternative splicing with evolutionary splicing graphs |
poster |
|
Rissland, Olivia S |
Codon optimality—A potent mechanism for post-transcriptional regulation |
talk |
|
Roberts, Justin |
Hypoxic induced depletion of m6A modulates alternative splicing to promote breast cancer progression |
poster |
|
Rodriguez-Molina, Juan B |
Mpe1 senses the polyadenylation signal in pre-mRNA to promote efficient cleavage and control polyadenylation |
talk |
|
Sanford, Jeremy R |
Isoform-specific translational control is evolutionarily conserved in primates |
poster |
|
Sarka, Kenna |
Investigating the role of Snu66 in 5' and 3' splice site choice |
poster |
|
Sarkan, Kristianna |
The mRNA 3’ processing factor CFIm directly participates in 3’ splice site recognition and regulates alternative splicing |
talk |
|
Senn, Katherine |
Monitoring dynamics of Mer1-regulated splicing with single molecule microscopy |
poster |
|
Shah, Sneha |
Can alternative splicing defects explain the pathophysiology of fragile X syndrome? |
poster |
|
Sharma, Shalini |
Distinct interactions of the U1 snRNA stem-loops 3 and 4 during early spliceosome formation |
talk |
|
Singh, Smriti |
Delineating the mechanistic role of human RNA polymerase II transcription and RNA processing events in triple negative breast cancer cells |
poster |
|
Sleeman, Judith |
Phase-separated stress granules and processing bodies are compromised in myotonic dystrophy type 1 |
poster |
|
Sousa-Luis, Rui |
Polymerase-associated intact nascent transcripts reveal different kinetic classes of co-transcriptional splicing |
talk |
|
Stanek, David |
The SMN complex drives structural changes in snRNAs to enable snRNP assembly |
talk |
|
Steidle, Elizabeth A |
Inositol polyphosphate isoforms modulate splicing |
talk |
|
Stigliano, Jose |
Chromatin effects of splicing-correcting antisense oligonucleotide therapy in spinal muscular atrophy |
poster |
|
Swale, Christopher |
A plant-like mechanism coupling m6A reading to polyadenylation safeguards transcriptome integrity in Toxoplasma |
talk |
|
Tang, Alison |
Detecting allele-specific isoform variation in long reads |
poster |
|
Tellier, Michael |
CDK9 and PP2A regulate coupling of RNA polymerase II transcription termination with RNA maturation |
talk |
|
Thomas, James D |
Pharmacologic modulation of RNA splicing enhances anti-tumor immunity |
poster |
|
Thomas, James D |
RNA isoform screens uncover the essentiality and tumor-suppressor activity of ultraconserved poison exons |
poster |
|
Tilgner, Hagen U |
Brain isoforms in single-cell, (developmental time) and space |
poster |
|
Torabi, Seyed |
Importance of conserved elements in the formation of RNA stabilizing triplex-forming motifs |
talk |
|
Torres Ulloa, Leslie |
Estimating the kinetics of mRNA 3’ end cleavage |
talk |
|
Tse, Victor |
Discovery of splicing-sensitive, disease causing mutations during the course of a Curricular Undergraduate Research Experiences (CUREs) project |
poster |
|
Tseng, Cynthia |
Opposing functions for CFIm59 and -68 in mRNA alternative polyadenylation of Pten and the PI3K/Akt signalling cascade |
poster |
|
Tudek, Agnieszka |
Global view on the metabolism of RNA poly(A) tails in yeast Saccharomyces cerevisiae |
talk |
|
Vanacova, Stepanka |
The comprehensive interactomes of human adenosine RNA methyltransferases and demethylases reveal distinct functional and regulatory features |
talk |
|
Vidya, Elva |
Phosphorylation of intrinsically disordered region in mRNA decapping enzyme DCAP-2 reorganizes mRNP interactions in C. elegans embryo |
talk |
|
Vilardell, Josep |
Exon definition by the yeast spliceosome |
poster |
|
Voigts, Lukas |
Understanding the molecular mechanism of Saccharomyces cerevisiae splicing factor Spp381 during spliceosome activation |
poster |
|
Wan, Ledong |
Loss of compensatory feedback mechanism involving splicing factor SRSF1 triggers KrasG12D-mediated pancreatic cancer initiation |
talk |
|
Wiedner, Hannah J |
Two evolutionarily conserved isoforms of eyes absent homolog 3 (Eya3) influence myogenesis and become dysregulated in striated muscle diseases |
poster |
|
Wilusz, Jeremy E |
Modulation of PP2A recruitment by IntS6 enables Integrator complex activity to be tuned in a gene-specific manner |
poster |
|
Wu, Mingkun |
Systematic mapping of nuclear domain-associated transcripts reveals speckles and lamina as hubs of functionally distinct populations of retained introns |
talk |
|
Yang, Yi |
RBPMS-A regulates alternative splicing decision by modulating prespliceosomal assembly pathways |
talk |
|
Zamudio, Jesse R |
Nuclear Argonaute functions in RNA quality control |
poster |
|
Zeng, Yi |
Profiling of nascent lariat intermediates reveals key genetic determinants of human co-transcriptional splicing |
talk |
|
Zenklusen, Daniel |
Single-molecule imaging suggests compact and spliceosome dependent organization of long introns |
talk |
|
Zhang, Bo |
Post-transcriptional silencing of the nuclear poly(A) binding protein is critical for postnatal maturation and function of the heart |
poster |
|
Zhang, Qian |
Antisense therapy for H3.3 K27M diffuse midline gliomas |
talk |
|
Zhang, Tianyi |
RNA binding protein nocte plays important roles in Drosophila development by regulating the translation of CDSs and upstream ORFs |
poster |
|
Zhang, Wenyu |
Structural and functional study of the human exon definition complex |
talk |
|
Zhang, Zhenwei |
Structural insights into the mechanism whereby Prp5 proofreads the pre-mRNA branch site |
talk |
|
Zheng, Sika |
Alternative splicing and nonsense-mediated mRNA decay enable neuronal longevity |
talk |
|
Zuniga, Gabrielle |
Tau-induced deficits in nonsense-mediated RNA decay contribute to neurodegeneration |
talk |