Retroviruses
May 23 - 28, 2022

You must register for the meeting in order to submit abstracts.
After registering you will be sent a web link for abstract submission by email.
You may copy and paste your abstract from Word, Google Docs, or Notepad; abstracts are limited to ~2900 characters.

Program information: An electronic version of the program abstract book will be sent three working days prior to the first day of the meeting, and hard copies will be available for collection upon your arrival at Cold Spring Harbor Laboratory. First night and keynote speakers are informed of their session date and time, otherwise program information is only available upon release of the electronic version of the abstract book. The reason we do this is to try and maximize interactions by encouraging participants to stay for the duration of the meeting.

Please check your email for talk length, in-person and virtual poster instructions, and how to have your poster printed at CSHL for collection upon arrival

Abstract Status

Presenting Author

Abstract Title

Presentation

Abajorga, Milky

Development of “innate” and “adaptive” piRNA responses protecting the germline from retroviruses

poster

Abdul Khader, Thanumol

Role of a newly identified cis-acting element in the transcriptional regulation of MMTV independent of Rem

virtual poster

Acors, Sam

Using induced pluripotent stem cell variation to define HIV-1 regulatory networks

poster

Aiken, Chris

The HIV-1 capsid serves as a nanoscale reaction vessel to ensure the completion of reverse transcription

poster

Akiyama, Hisashi

HIV-2/SIVmac Vpr suppresses integration-induced innate immune activation in myeloid cells

talk

Almeida dos Santos, Nathalia

Identifying HIV-1 regulatory networks using macrophages derived from induced pluripotent stem cells (iPSCs)

poster

Ananias, Catarina

Role of N6-methyladenosine on HIV-1 replication and immune activation in microglia and macrophages

virtual poster

Atindaana, Edmond

Bimodal expression patterns, and not viral burst sizes, predict the effects of Vpr on HIV-1 Jurkat cell proviral populations

talk

Auerbach, Ashley

Primate-specific determinants of APOBEC3B subcellular localization and virus restriction

poster

Baby, Jasmin

Cellular miR-acles—Host miR-17-92 cluster negatively regulates MMTV replication

virtual poster

Badieyan, Somaye

A direct interaction between HIV-1 capsid and dynein is required for HIV-1 retrograde microtubule trafficking

talk

Balasubramaniam, Muthukumar

The integration of HIV-1 capsid mutant that escapes the HLA-B27-restricted cytotoxic T-lymphocyte antiviral response is impaired in Cyclophilin A-expressing target cells

virtual poster

Bandini, Madison

HIV-1 Vif blocks metaphase and causes defects to chromosome segregation

poster

Basukala, Binita

Virally suppressed people living with HIV with opioid use disorder show a block in latency reversal

poster

Becker, Jordan T

Mammalian ZAP and KHNYN are restriction factors of high CpG avian viruses

talk

Beckwith, Sean

The yeast Ty1 retrotransposon contains a prion-like domain essential for transposition

talk

Benichou, Serge

HIV-1 cell-to-cell spread overcomes the virus entry block of non-macrophage-tropic strains in macrophages

talk

Berlioz-Torrent, Clarisse

ATG5 drives an LC3-associated pathway to counter BST2/Tetherin antiviral functions

poster

Bertelli, Cinzia

A conserved phenylalanine within HIV-1 Nef core domain functionally separates SERINC5 and CD4 antagonism

poster

Bertelli, Cinzia

HIV-1 cell-to-cell spreading is not restricted by SERINC5

talk

Betancor, Gilberto

MX2 viral substrate breadth and inhibitory activity are regulated by protein phosphorylation

talk

Bhat, Anayat

Expansion microscopy allows high-resolution single-cell analysis of epigenetic readers

poster

Bhat, Anayat

Single virus imaging of HIV-1 nuclear import

talk

Bibollet-Ruche, Frederic

A germline-targeting chimpanzee SIV envelope glycoprotein elicits V2-apex directed antibodies that cross-neutralize HIV-1

talk

Bieniasz, Paul

Delineation of optimal RNA targets for zinc finger antiviral protein enables conditionally attenuated virus vaccine design

talk

Biswas, Banhi

Inositol hexakisphosphate (IP6) promotes endogenous reverse transcription in Mo-MLV

talk

Boris-Lawrie, Kathleen

HIV-1 cap-hypermethylation segregates viral transcripts by form and function

talk

Boso, Guney

Cross-species transmission of an ancient endogenous retrovirus and convergent co-option of its envelope gene in two mammalian orders

talk

Bosque, Alberto

The sphingosine kinase/sphingosine-1-phosphate receptor axis modulates the restriction factor activity of SAMHD1 in primary CD4 T cells

talk

Bouaziz, Serge

Structures and interactions of primate lentiviral accessory proteins Vpr, Vpx and p6

poster

Boutin, Marianne

Temsavir treatment of HIV-1-infected cells decreases envelope glycoproteins recognition by broadly-neutralizing antibodies

talk

Brancato, Savannah

Structural details of HIV maturation inhibitor binding determined by cryo-EM

talk

Burdick, Ryan C

Reverse transcription of long viral DNA is required to trigger efficient HIV-1 uncoating

talk

Burgess, Ailidh

Structural and functional studies of assembly-directed HIV-1 CA-DARPin interactions

poster

Burgos, Samuel D

The chromatin insulator CTCF inhibits HIV gene expression

poster

Burn, Aidan H

LTR-driven expression of HML-2 proviruses in human tissue

virtual poster

Butta, Giacomo

Characterization of the humoral and cellular immune response elicited by COVID-19 mRNA-1273 MODERNA vaccine in people with HIV (PWH)

poster

Candor, Kathleen

Role of the CLIC/GEEC pathway in formation of the virus-containing compartment in HIV-infected macrophages

poster

Cardoso, Ricardo S

Phosphatidylinositol-(4,5)-bisphosphate is a key determinant for incorporation of CD43, PSGL-1, and CD44 into HIV-1 particles

poster

Carlon-Andres, Irene

Quantitative characterization of HIV-1 viruses using fluorescence lifetime correlation spectroscopy—Lifetime-based virometry

poster

Caroe, Eve R

Investigating how reverse transcription affects uncoating of HIV-1 cores

poster

Carter, Carol

Nedd4 HECT-Tsg101 UEV interactions promote productive HIV-1 assembly

keynote

Chande, Ajit

A competing endogenous host circular RNA relieves HIV-1 transcriptional block

talk

Chang, Jordan

Mobilization of HIV-1 Gag into euchromatin with latency reversal

poster

Chen, Chaoping

Involvement of regulated precursor autoproteolysis in indinavir resistance of an HIV protease double mutant

talk

Chen, Hong-Ru

Optimized CRISPR/Cas9 genome editing in primary human hematopoietic stem cells allows unprecedented functional studies into HIV biology

poster

Cheng, Zetao

Elements in the 5’ untranslated region of viral RNA important for Gag recognition

talk

Cilento, Maria

Drug resistance and hypersensitivity of various HIV-1 subtypes to Islatravir

virtual talk

Cimarelli, Andrea

A genetic screen in macrophage-like cells identifies a member of the Trim family as a novel regulator of microtubule dynamics that interferes with HIV-1 reverse transcription and acts as a pantropic viral inhibitor

talk

Cisneros, William L

Transcriptional elongation complexes in HIV-1 infection

poster

Collora, Jack A

Single-cell multiomics reveals that HIV-1 persists by residing in large and stable cytotoxic CD4+ T cell clones

poster

Collora, Jack A

HIV-1 interacts with host chromatin, alters chromatin accessibility, and disrupts enhancer-promoter interactions

talk

Cook, Matthew

Generating discrete, soluble tubulin assemblies to investigate intracellular trafficking of HIV-1 cores

poster

Cornish, Daphne

CPSF6 modulates the innate immune response to HIV-1 infection

poster

Corte-Real, Joao V

Humanized rabbit entry receptor complex supports HIV-1 entry

virtual poster

Cox, Daniel

Investigating infectivity of HIV-1 Env lentiviral vectors

poster

Dafonte Imedio, Alvaro

The cytoplasmic tail of gammaretrovirus Env is a tetherin antagonist

poster

Dasgupta, Anindita

Identification of a cellular microRNA involved in regulation of HIV-1 infectivity

virtual poster

Davids, Benem

Characterization of ARC particle production and release

poster

Dharan, Adarsh

Mapping the nuclear pore constituents mediating HIV-1 nuclear entry and integration into transcriptionally active regions of the chromatin

talk

Di Nunzio, Francesca

Characterization of the liquid-liquid phase separation properties of CPSF6 induced by HIV infection

talk

Diaz-Griffero, Felipe

GS-CA1 and Lenacapavir induce a conformational change that stabilizes the HIV-1 core and blocks viral uncoating

virtual poster

Dibsy, Rayane

Role of Arp2/3 mediated branched actin in HIV-1 assembly and release in infected CD4 T lymphocytes.

talk

Ding, Shilei

A new family of small-molecule CD4-mimetic compounds contact the highly conserved aspartic acid 368 and expose vulnerable HIV-1 Env epitopes

poster

Disbennett, Walla Miguel

KRAB zinc-finger mediated transcriptional suppression of HIV-1

talk

Dudley, Jaquelin P

MMTV proviral mutations in infected AID- and Apobec3-knockout mice

talk

Ebrahimi, Diako

APOBEC3G mRNA splicing defect across nonhuman primates and its roles in differential hypermutation of SIV sequences

virtual poster

Eltalkhawy, Youssef M

A novel macrophage model to study interaction with HIV-1

virtual poster

Emery, Ann

Repurposing single cell RNA seq data to quantify HIV splicing during latency reversal

virtual talk

Eschbach, Jenna

Investigating the role of capsid stability in innate immune sensing of HIV-1 cores

poster

Espada, Constanza

SAMHD1 negatively regulates IRF7-mediated type I interferon induction

poster

Fabryova, Helena

HIV-1 Vpr induces degradation of gelsolin, a myeloid cell-specific host factor that reduces viral infectivity by inhibiting expression and packaging of the HIV-1 Env glycoprotein

talk

Feathers, Ryan J

IP6 promotes human endogenous retrovirus type K (HERV-K) immature and mature lattice assembly

poster

Figueroa Acosta, Dania M

Endocytic recycling contributes to the evasion of bNAbs by cell-cell infection over cell-free infection by altering Env structure

poster

Francis, Ashwanth C

Capsid remodeling during nuclear import enables host factor interactions with the HIV-1 nucleoprotein complex

poster

Furler O'Brien, Robert L

Ultrastructural analysis of migrating human CD4+ T cells before and after HIV-1 infection

poster

Gallardo, Christian M

Simultaneous sequencing of full-length host cell and HIV-1 transcripts without PCR amplification

talk

Gallois-Montbrun, Sarah

Exploring the role of Tat as a regulator of HIV-1 RNA landscape

poster

Gallucci, Lara

Tissue-like 3D environments shape functional interactions of HIV-1 with immature dendritic cells

talk

Gapp, Madeleine

CD32 drives autoantibody-enhanced trogocytosis to facilitate HIV-1 infection of resting CD4 T cells

poster

Geis, Franziska

Two lymphoid cell lines potently silence unintegrated HIV-1 DNAs

poster

Gleason, Charles R

Transcription, splicing and HERV-K protein identification

talk

Gong, Shang Yu

Mode of interaction of CD4-CD4i antibody hybrids to HIV-1 envelope glycoproteins

poster

Gottlinger, Heinrich

Rescue of Nef-deficient HIV-1 by short BST2

talk

Gramberg, Thomas

The common human TRIM5α variant H43Y efficiently restricts LINE-1 retroelements but not exogenous retroviruses

virtual poster

Grandi, Nicole

Human endogenous retroviruses (HERVs) transcriptome is specifically modulated during SARS-CoV-2 infection and allows to discriminate COVID19 clinical stages

virtual poster

Grover, Jonathan

Phosphatidylserine exposure by SERINC5 destabilizes the state 1 conformation of HIV-1 Env and correlates with reduced infectivity

poster

Grunst, Michael W

Antibody-dependent cellular cytotoxicity of rhesus macaque antibodies to the SIV envelope glycoprotein

talk

Guedan, Anabel

Characterising CPSF6 relocalisation to nuclear speckles during HIV-1 infection

poster

Guerrero, Jorge

Single-cell delineation of strain-specific HIV-1 gene activities using multicolor biosensors and live cell imaging

poster

Gull, Bushra

MMTV interacts with effectors of the RNAi machinery

virtual poster

Gupta, Kushol

Structure of a HIV-1 IN-allosteric inhibitor complex at 2.93 Å resolution—Routes to inhibitor optimization

talk

Hannon-Hatfield, Adam

Domestication of a Ty1 retrotransposon self-encoded restriction factor in Saccharomyces cerevisiae

talk

Hanson, Heather

Transcriptomic analysis of HTLV-1 infection in T-cells reveals novel insights into virus-host cell interactions important for virus assembly and infectious spread

virtual poster

Herrmann, Dominik

Molecular determinants of HTLV-1 Gag targeting to the plasma membrane for assembly

poster

Herschhorn, Alon

In-vivo evolution of a transmitted/founder HIV-1 strain that is highly resistant to broadly neutralizing antibodies

talk

Highland, Carolyn M

High resolution structure determination of the mature HIV capsid lattice using cryo-ET and cryo-EM

talk

Hikichi, Yuta

Mutations in the envelope glycoprotein reduce the susceptibility of HIV-1 to antiretrovirals

poster

Hogan, Victoria A

Mutagenesis and functional characterization of the highly conserved immunosuppressive domain of gammaretrovirus Envs

poster

Hooy, Rick

Cryo electron tomographic structure of a virally hijacked vesicle coat

talk

Hope, Joshua A

Optimization of affinity reagents for purification and detection of HIV-1 pre-integration complexes

poster

Hope, Thomas

A wannabe photographer's 30 year journey to image HIV

keynote

Howard, Jacqueline N

Pharmacological enhancement of IL-15 signaling to improve “Shock-and-kill” strategies

talk

Hu, Yingxia

Structural basis of host CypA and E3 ubiquitin ligase recruitment by the maedi–visna virus Vif

talk

Hwang, Eung Soo

Characterization of insertion of chromosomal sequences into PERV in miniature pig

poster

Itell, Hannah

Defining the cell-intrinsic effectors of the antiviral interferon response against HIV in CD4+ T cells

poster

Iwamoto, Yuichiro

Visualizing interactions between HIV Nef and the clathrin adaptors AP1 and AP2 in cells

poster

Jalloh, Sallieu

De-novo expression of HIV-1 icRNA induces NLRP3 inflammasome activation in myeloid cells

poster

Jansen, Jade

Elimination of the HIV-1 viral reservoir using DDX3 inhibitors

talk

Johansson, Emil

Hierachical clustering and trajectory analyses reveal B-cell activation and exhaustion in HIV-2 infection independent of viremia

talk

Joseph, Sarah B

Temporal dynamics of reservoir formation are not strongly influenced by expression potential or cellular tropism of HIV-1 proviruses

talk

Jurczyszak, Denise

ISG15 deficiency restricts HIV-1 infection

talk

Kaddis Maldonado, Rebecca

Co-transcriptional interactions of RSV Gag with host factors and unspliced viral RNA

poster

Kalpana, Ganjam

INI1 Rpt1 derived stapled peptides target both IN-INI1 and IN-TAR RNA interactions, impair particle morphogenesis and inhibit HIV-1 replication

virtual poster

Kane, Melissa

Determinants for Mx2-mediated inhibition of specific nuclear import pathways

poster

Kane, Melissa

Precise manipulation of nuclear pore complexes to validate the function of individual Nups in HIV-1 infection and Mx2 activity

talk

Kazmierski, Julia

A novel role for ISG15 in HIV-1 persistence

virtual poster

Kiik, Helen

Time-course of host cell transcription during the HTLV-1 transcriptional burst

talk

Kilroy, Jonathan M

Evaluating the impact of defective viruses on immune cell function

poster

Kim, Eunhye Grace

Identification of host factors modulating HIV latency establishment in human CD4+ T memory stem cells

talk

Kirchhoff, Frank

BLM cooperates with EXO I and DNA2 to restrict HIV-1 integration

talk

Kirmaier, Andrea

Horizontal gene transfer and exaptation of a gammaretroviral gene cluster in an alphaherpesvirus

poster

Kisaka, Javan

A cellular model of HIV latency in macrophages show unusual importance of the bromodomain axis

poster

Kitamura, Haruki

DNA-repair factor complex contributes to maintenance of HIV-1 latency

virtual poster

Kleinpeter, Alex B

Manipulation of the central pore in capsomers reveals key insights into the role of IP6 in capsid function.

talk

Klinnert, Sarah

Novel “shock & kill” gene therapy approach against HIV-1 combining CRISPR activation, suicide gene tBid and retargeted adenovirus delivery

talk

Kmiec, Dorota

HIV-2 is less sensitive to ZAP restriction than SIVSMM despite higher genomic CpG content

poster

Kolbeck, Pauline J

HIV-1 integrase compacts viral DNA into multiphase condensates

talk

Krebs, Anna-Sophia

Structure of HERV-K immature Gag at near-atomic resolution reveals insights into ancestral retroviruses

talk

Kumari, Namita

Sickle cell hemoglobin induces antiviral response in sickle cell disease

virtual poster

Kumari, Sushila

A bipartite NUP153 motif plays a critical role in nuclear import of HIV-1 cores

poster

Kutluay, Sebla B

Emergence of compensatory mutations reveal the importance of electrostatic interactions between HIV-1 integrase and genomic RNA

talk

Kvaratskhelia, Mamuka

Lenacapavir potently impairs HIV-1 integration inside the nucleus without displacing CPSF6 from viral capsid

talk

Lagadec, Floriane

Timely chromatin invasion during mitosis dictates PFV integration site selection

talk

Lai, Kin Kui

SERINC5 induces phosphatidylserine exposure on MLV

talk

Lambert, Gregory S

RSV Gag forms biomolecular condensates with viral RNA

talk

Lange, Camille M

Immune reconstitution inflammatory syndrome drives emergence of HIV drug-resistance from multiple anatomic compartments

talk

Langley, Caroline A

A deep mutational scan of HIV-1 Vif

poster

LASSERRE, Angelique

Restriction of HIV proviral expression by the MORC2 chromatin remodeling protein

talk

Lau, Chuen-Yen

Immune correlates of cell-associated HIV RNA levels in infected individuals undergoing long-term antiretroviral therapy

talk

Laumaea, Annemarie

Exposing vulnerable Env epitopes at the surface of HIV-1-infected macrophages

talk

Lee, KyeongEun

DDX3 and eIF4G1 regulate the kinetics of HIV-1 trafficking to nuclear speckles

virtual talk

Lesko, Sydney L

Imaging-based analysis of HIV-1 RNA translation and dimerization

poster

Levin, Henry

The role of LTR-LTR recombination in regulating stress response

poster

Levinger, Callie

An ultrasensitive planar array p24 ELISA to detect HIV in diverse biological matrixes

poster

Lewis, Cat

Vpr synergizes with Vorinostat to prevent HIV-1 latency establishment

poster

Li, Feng

Identification of an integrase-independent pathway of retrotransposition

talk

Li, Shunji

Antagonism of the HIV nuclear entry by an FxFG motif in nucleoporin 153

poster

Li, Wenwei

Direct visualization of HIV-1 envelope glycoprotein - receptor CD4 interaction on native membranes by cryo electron tomography

talk

Lichon, Drew M

Discerning the role of microtubule acetylation during HIV-1 infection

poster

Lista, Maria Jose

A nuclear export signal in KHNYN required for its antiviral activity evolved as ZAP emerged in tetrapods

talk

Liu, Shan-Lu

Cell-to-cell transmission vs. cell-cell fusion—Studies of SARS-CoV-2, HIV and EBOV

talk

LIU, Xingliang

Long terminal repeats LTR12C expression stratifies decitabine response in p53 mutant acute myeloid leukemia patients

virtual poster

Lodge, Robert

Vpu-mediated micro-RNA-25 and 93 upregulation counteracts MARCH-1-mediated restriction on HIV-1 infectivity during macrophage infection

poster

Lyumkis, Dmitry

Efforts toward deciphering mechanisms of resistance to integrase strand transfer inhibitors

talk

Mallorson, Rosa G

The myeloid-specific transcription factor PU.1 regulates expression of mannose receptor 1 in macrophages by binding to two target sites in the MRC1 promoter

poster

Mamede, João I

Fluorescent labeled CA incorporated into the capsid lattice correlates progressive uncoating from the cytoplasm to the nucleus to productive HIV infection

talk

Man, Shirley

Transcriptomic profiling of transcriptionally latent and active HIV-infected CD4 T cells isolated with a novel flow-FISH detection method

poster

Manganaro, Lara

Distinct latency establishment in human CD4+ T cell subsets stimulated with IL-15

talk

Manickam, Ashokkumar

An integrated single-cell multi-omics landscape of HIV latency reversal

poster

Marchitto, Lorie

HIV-1 downregulates SLAMs ligands to evade NK cell responses

talk

Margolis, David M

Combined non-canonical NF-κB agonism and targeted BET bromodomain inhibition reverses HIV latency ex vivo

talk

Marin, Mariana

HIV-1 restriction by SERINC5 involves conformational changes in glycoprotein envelope that lead to loss of its function

virtual talk

Melikian, Gregory

Real-time imaging of HIV-1 protease activation in single newly assembled virions

virtual talk

Menager, Mickael M

Network inference to decipher molecular mechanisms at play during innate sensing of HIV-1—A tale of CLOCK and Actin

talk

Mignanelli, Marianna

HIV-1 Gag-based virus-like particles—Towards a new tool to unmask local RNA pools in neurons

poster

Min, Alice K

Inflammatory modulators purinergic P2X1 receptor and cannabinoid CB2 receptor are up-regulated in ART-suppressed and HIV-associated encephalitic brains

poster

Miyagi, Eri

The myeloid-specific transcription factor PU.1 upregulates mannose receptor expression but represses basal activity of the HIV-LTR promoter

poster

Monette, Anne

Nucleation of the HIV-1 biomolecular condensate by scaffolding protein nucleocapsid

poster

Moran, Eileen

IFI207 controls MLV infection by stabilizing STING

poster

Mudgal, Rajat

Preferential and MA highly basic region-dependent binding of specific tRNAs to HIV-1 Gag in cells

poster

Murakami, Tomoyuki

Macropinocytosis promotes HIV-1 entry into primary CD4+ T cells

talk

Nand, Elizabeth P

HIV-1 envelope glycoprotein - CD4 receptor interactions in native membranes investigated by cryo-ET and a functional fusion assay

poster

Neil, Stuart

Degradation of βTrCP1 and the stabilization of phosphorylated p105/NFκB1 and p100/NFκB2 account for potent suppression of classical and alternative NFκB activity by HIV-1 Vpu

poster

Newhall, Rachael M

Developing mRNA-based HIV-1 vaccines

poster

Nguyen, Don

Enhanced HIV-induced lineage tracing using a replication competent Cre-Lox-mediated Infection reporter system reveals rapid post-infection latent phenotypes with low proviral copy number

poster

Nguyen, Thuy

Characterization of HIV intact and near-full length defective proviral populations during long-term suppression on antiretroviral therapy

virtual poster

Nisson, Karly A

Evolutionary analysis of the nucleolar protein CCDC137 indicates a long-standing conflict with HIV/SIV Vpr

poster

Nyalile, Thomas

Engineering an endogenously expressed HIV-1 restriction factor

poster

Nyenhuis, David

Characterization of Tsg101 UEV domain in complex with Nedd4 HECT domain

virtual poster

Padilla-Parra, Sergi

Imaging virus induced cell-cell fusion with time-resolved fluorescence microscopy

talk

Padron, Adrian

Cyclophilin A promotes HIV-1 pre-integration complex (PIC) function

talk

Paillart, Jean-Christophe

A conserved uORF regulates APOBEC3G translation and is targeted by the HIV-1 Vif protein to repress the antiviral activity

poster

Pal, Virender K

Hydrogen sulfide blocks HIV rebound by maintaining mitochondrial bioenergetics and redox homeostasis

virtual poster

Pandey, Krishan K

Mechanisms of RSV intasome assembly in concerted integration pathway

virtual poster

Panicker, Neena G

Characterization of the potential of MMTV to disrupt mammary epithelial cell differentiation and its consequences for host gene expression

virtual poster

Pathak, Rakesh

The role of LEDGF in gene expression and in integration specificity of HIV-1

poster

Pathirage, Chathuri

Phosphomimetic S207D lysyl-tRNA synthetase binds the tRNA-like element and packaging signal of dimeric HIV-1 genomic RNA for proper primer placement

poster

Pellaers, Eline

Branched DNA imaging to study the role of BRD4 in HIV-1 transcription

talk

Peterson, Jackson J

A histone deacetylase network regulates epigenetic reprogramming and viral silencing in HIV infected T cells

talk

Phillips, Stacia

N6-methyladenosine modifications of HIV-1 RNA suppress type-I interferon induction in macrophages

virtual poster

Pornillos, Owen

Biochemical reconstitution of HIV-1 restriction by TRIM5α

poster

Pornillos, Owen

GS-CA1 binding to the NTD-CTD interface of the HIV-1 CA pentamer

poster

Pornillos, Owen

Biochemical reconstitution of HIV-1 nuclear import

talk

Prakash, Prem

The kinetic mechanisms that allow TREX-1 to preferentially degrade unprocessed HIV-1 DNA

poster

Rahman, Kazi M

Cholesterol interacts with the amphipathic helix of IFITM3 and regulates its antiviral activity

poster

Ramaswamy, Sita

IRF5 mediates persistent inflammatory response in HIV-1 infected macrophages

poster

Ricana, Clifton L

Sub-5Å structure determination of the mature HTLV-1 CA lattice from in vitro-assembled and cell-derived VLPs reveals contacts not described for HIV or RSV

poster

Richard, Jonathan

Productively-infected CD4 T cells are resistant to non-neutralizing antibodies

poster

Richard, Jonathan

Temsavir blocks the immunomodulatory activities of gp120

poster

Rink, Constance

Kinetic measurements of interactions of HIV-1 Gag with RNAs

virtual poster

Rist, Michael

Identification of proviral integrations within HIV associated B cell lymphomas

talk

Roesmann, Fabian

Balanced levels of the interferon regulated host factor hnRNP A0 are crucial for efficient HIV-1 replication

talk

Rohlfes, Nicholas

Nuclear pore heterogeneity—HIV-1's utilization of specific nuclear import pathways

poster

Romerio, Fabio

Elucidating the role of the HIV-1 antisense gene asp in viral latency and replication

virtual poster

Roth, Monica

Interaction of the gammaretroviral Envs A5 and A9a with the SLC35F2 host receptor protein

talk

Rouzina, Ioulia F

HIV-1 nucleocapsid protein regulates double-stranded DNA compaction and capsid uncoating during reverse transcription

talk

Ruhle, Adrian

Rapid and efficient gene editing of primary human resting CD4 T cells and monocyte-derived macrophages allows unprecedented functional analyses

poster

Saffarian, Saveez

Gag-Gag interactions are insufficient to fully stabilize and order the immature HIV Gag lattice

poster

Saito, Akatsuki

A zinc-finger-containing protein ZCCHC3 is a novel antiretroviral host factor

talk

Saito, Hideki

Human mannose receptor 1 attenuates HIV-1 infectivity in a virus isolate-specific manner

poster

Salas-Briceno, Karen

APOBEC3G contributes to escape mutations and drug resistance

poster

Sapp, Nicklas

Trimethylated nucleosomes are the preferred substrate for HIV-1 PIC-mediated integration

virtual poster

Sauter, Daniel

HIV-1 infection activates an endogenous retroviral promoter regulating p53 signaling

virtual talk

Schelle, Luca

Cross-species conservation of the antiretroviral activity of guanylate binding proteins (GBP)

virtual poster

Schirra, Randall

A molecular switch controls assembly, host factor binding, and pharmacological inhibition of the HIV-1 capsid

talk

Schur, Florian

Structures of immature HTLV-1 assemblies reveal a novel CA arrangement in deltaretrovirus particles

talk

Schüssler, Mority

SAMHD1 has no major effect on CRISPR/Cas9 KI and KO efficiency

virtual poster

Sealey, Leanna

Molecular characterization of PSGL-1 for its anti-HIV activity

virtual poster

Shanmugapriya, Shanmugapriya

Dynactin 1 negatively regulates HIV-1 infection by sequestering the host cofactor CLIP170

poster

Sharma, Manish

Elucidating the sites of single HIV-1 entry into cells

virtual poster

Shen, Qi

Modeling HIV-1 nuclear entry with a programmable artificial nuclear pore complex platform

poster

Sherer, Nathan M

Targeting host factors to achieve “block-and-lock” inactivation of HIV-1 gene expression

talk

Shmakova, Anna

The role of HIV-1 Tat in HLA-DR expression regulation in B cells

virtual poster

Sid Ahmed, Samy

Mechanisms of environmental restriction to HIV-1 infectivity

poster

Signell, Adrian

Using single-cell RNA-seq to study intercellular variability in response to HIV-1 infection in CD4+ T-cells

poster

Smith, Steven

Understanding the resistance profile of the second-generation INSTIs

talk

Smyth, Redmond

Long read DMS-Map-seq on nanopores resolves the structures of HIV-1 spliced transcript isoforms

talk

Sondgeroth, Amy L

Modifying the rate of cleavage at specific Gag cleavage sites differentially impacts infectivity

talk

Spearman, Paul

Trafficking to the EHD1/MICAL-L1 tubular recycling endosome regulates HIV-1 envelope protein incorporation in a cell type-specific manner

talk

Stover, Carissa

Evaluating the effects of biological sex, age, and sex hormones in the immunostimulatory activity of the latency reversing agents GS-9620 and IL-15

poster

Suder, Agnieszka

Characterization of the role of MATR3 in HIV latency and reactivation

virtual poster

Sultana, Tahmina

Single mutations in capsid protein of HIV-1 resulting similar phenotypic outcome show distinct intracellular trafficking

poster

Sultana, Tahmina

Escape from IFN-induced human TRIM5α inhibition of HIV occurs through multiple independent capsid mutations that are independent of CypA binding

talk

Symeonides, Menelaos

Probing the physiology and testing the function of HIV-induced syncytia isolated by magnetic cell sorting

talk

Syu, Yu-Ci

HTLV-1 Gag purification, cellular interactome, and in vitro chaperone activity

talk

Taga, Kei

HIV-1 replication and latency is modulated by host Solute Carrier Protein (SCP) expression levels in human cells

virtual poster

Taube, Ran

Role of long non-coding RNAs (lncRNAs) in HIV latency

talk

Taylor, Harry

Physiologic hypoxia uncovers the metabolic restriction of HIV-1 latency reversal

talk

Tenthorey, Jeannette

Permissive evolutionary landscapes favor TRIM5’s adaptation against retroviruses

talk

Toccafondi, Elenia

Different zoonotic transmission events led to mechanistic distinct paths to ensure integration in HIV-1 isolates of groups M and O

virtual talk

Twizerimana, Augustin Penda

Rare HIV-1 N, O, P and HIV-2 are restricted by human TRIM5α

virtual poster

Valeri, Erika

Retroviral cores trigger TBK1-mediated antiviral immunity through a cryptic sensor in human hematopoietic stem cells and primary macrophages

talk

Vamva, Eirini

A novel role for Gag as a cis-acting element regulating RNA structure, dimerization and packaging in HIV-1 lentiviral vectors

poster

van Pul, Lisa

Differences in the gene expression profile of HIV- and CMV-specific CD8 T cells in HIV infection

poster

Vanderlinden, Willem

Conformational landscape of integration cofactor LEDGF/p75 and LEDGF/p75-nucleosome complexes

talk

Vanzo, Teresa

The SERINC protein family—Hints from S. cerevisiae

poster

Virgilio, Maria C

The impact of HIV-1 Vpr on host transcription in macrophages

poster

Waheed, Abdul A

Inhibition of neutral sphingomyelinase 2 blocks HIV-1 maturation

talk

Wang, Tian

Gammaretrovirus-related ERVs in the Indian glassy fish genome

poster

Wei, Guochao

Prion-like low complexity regions enable avid virus-host interactions during HIV-1 infection

talk

Weinberger, Leor S

Discovery and engineering of an HIV-1 therapeutic interfering particle (TIP)

virtual poster

Williams, Zachary H

Tracing the evolutionary transition of a retrovirus from using an HIV Rev/RRE-like RNA export system to a CTE-like mechanism

talk

Winstone, Helena G

Determinants of interferon and IFITM sensitivity in the HIV-1 envelope glycoprotein

poster

Yang, Hua

SAMHD1 suppresses IKKα/β-mediated NF-κB activation in monocytic cells

poster

Yang, Huixin

Novel residues in HIV-2 capsid are important for Gag-Gag interactions

talk

Yang, Vivian

Identification and characterization of novel latency reversing agents

poster

Yang, Ziwei

Human HIV-1 restriction factor SERINC functions as a lipid transporter

talk

Ye, Liqing

A conformational switch in the HIV-1 5’UTR regulates genome dimerization and packaging

virtual poster

Yoh, Sunnie M

Structural determinants of innate immune surveillance against HIV-1 infection

talk

Yoo, Seung Wan

Neutral sphingomyelinase-2 regulates HIV biogenesis

poster

Yoshida, Takeshi

Vpu from an SIV may antagonize human and monkey BST2 by different mechanisms

virtual poster

Youle, Rebecca L

Structural and functional studies of ZAP-associated factor KHNYN

poster

Yurkovetskiy, Leonid

Identification of host factors involved retroviral replication

talk

Zhang, Robert Z

Retroviral determinants for antiviral antibody responses

poster

Zheng, Yong-Hui

CRL3KLHL20 E3 ubiquitin ligase determines SERINC5 anti-HIV-1 activity and Nef antagonism of SERINC5

talk

Zucko, Dora

Circular RNA profiles in viremia and ART suppression predict competing circRNA-miRNA-mRNA networks exclusive to HIV-1 viremic patients

poster