Cell Death        
August 15 - 19, 2017

You must register for the meeting in order to submit abstracts.
After registering you will be sent a web link for abstract submission by email.

Program information: An electronic version of the program abstract book will be sent three working days prior to the first day of the meeting, and hard copies will be available for collection upon your arrival at Cold Spring Harbor Laboratory. First night and keynote speakers are informed of their session date and time, otherwise program information is only available upon release of the electronic version of the abstract book. The reason we do this is to try and maximize interactions by encouraging participants to stay for the duration of the meeting.

Please check your email for talk length, poster instructions, and how to have your poster printed at CSHL for collection upon arrival. 

Abstract Status

Presenting Author





Abstract Title

Talk/Poster

Ali, Aus AT





The effect of green tea on cellular fat accumulation, triglycerides concentrations and alkaline phosphatase activity

poster

Andersen, Courtney L





AZ’5576, a potent and selective Cdk9 inhibitor, displays broad anti-tumor activity in preclinical hematological models

talk

Andrews, David





Investigating how subcellular localization of BIK impacts its BCL-2 family interacting partners

poster

Ark, Mustafa





Possible involvement of Rho kinase on the secretory activity of drug-induced senescent cells

poster

Bhatt, Shruti





Harnessing the power of mitochondria to guide personalized therapy for acute myeloid leukemia

talk

Bhola, Patrick





High throughput identification of apoptosis sensitizing chemicals using freshly isolated tumor cells

talk

Bozkurt, Emir





Yet another way to die—TRAIL induces caspase-8-dependent cell-in-cell death

talk

Campisi, Judith





Cellular senescence, cell death resistance and aging

talk

Cao, Jennifer Yinuo





Inducing ferroptosis to selectively eliminate multidrug resistant cancer cells

poster

Cetin, Bulent





Death in mitosis—Targeting Plk4 and Bcl-2 as a novel therapy for lymphoma

poster

Chen, Fei-Yun





Regulation of BIK ubiquitination by Cul5ASB11 to control life-death cell fate and tumor killing effect

poster

Chen, Ruoyao





Entosis is induced by UV radiation

talk

Cheng, Emily H.-Y.





ΔNp63 inhibits oxidative stress-induced cell death including ferroptosis and cooperates with the BCL-2 family to promote clonogenic survival

talk

Cheng, Ho Wa (Jacky)





Uncovering and overcoming resistance of triple-negative breast cancer to chemotherapy

poster

Chipuk, Jerry





BH3 mimetics target multiple conformations of BAK and BAX to differentially modulate chemotherapy-induced apoptosis

talk

Chung, Alexander





Tumor-specific cell death induced by CIB1-based combination therapies in triple-negative breast cancer

poster

Conlon, Megan M





Uncovering a role for mTOR signaling in ferroptosis

talk

Crowder, Roslyn N





Alpinia zerumbet essential oil induces apoptosis in human leukemia cancer cells

poster

Daniels, Veerle





Identification of metabolic regulators of mitochondrial apoptotic priming to reveal previously unrecognized vulnerabilities of triple negative breast cancer

poster

Darding, Maurice





Deficiency in different LUBAC components—A surprise in three acts

poster

Delgado, Magdalena R





Interphase microtubules are essential for the survival of primary acute lymphoblastic leukemia cells

poster

Deng, Shuo





Gelsolin regulates autophagy to modulate the cell death resistance to 5-Fluorouracil in colorectal cancer cells

poster

Dixon, Scott J





Systematic quantification of population cell death kinetics

talk

Dovey, Cole M





The killer’s accomplice—MLKL requires inositol phosphates to execute necroptosis

talk

Escudero, Silvia





Regulation of fatty acid oxidation by the mitochondrial matrix isoform of MCL-1

talk

Feng, Zhaoqianqi





Enzymatic formation nano-arcs of guanidinium-containing D,L-peptides potently inhibits cancer cells via multi-targeting

poster

Flemmer, Robert T





Identifying the apoptotic and differentiative roles of the Bcl-2 family in the developing mammalian nervous system

poster

Fulda, Simone





Discovery of a synergistic combination of Smac mimetic and Bortezomib to trigger necroptosis in malignant lymphoma cells in the absence of pharmacological caspase inhibition

talk

Garcia-Saez, Ana





Apoptosis control by the Bcl-2 network at the single molecule level

talk

Gavathiotis, Evris





Direct targeting of pro-apoptotic BAX as a novel strategy for cancer therapy

talk

Gelles, Jesse





The sphingosine-1-phosphate lyase regulates BAX-mediated apoptosis

poster

Ghose, Piya





Novel compartment-specific killing and clearance programs in a morphologically complex cell

talk

Gilmore, Andrew





Differential retrotranslocation of Bcl-2 proteins predicts single cell heterogeneity in apoptotic priming

talk

Greaves, Georgia J





Investigating the roles and mechanisms of MCL-1 in apoptosis and beyond

poster

Gross, Atan





Mitochondrial MTCH2 at the interface between homeostasis and apoptosis

talk

Guerra, Rachel





Reactivating apoptosis in BFL-1/A1 driven cancer with cysteine-reactive stapled peptide inhibitors

poster

Guha Mazumder, Arpan





Metamolomics corroborated multimodal quantitative imaging biomarkers for neuroretinal degeneration in diabetic retinopathy

poster

Gulculer, Gulce S





A biophysical approach towards understanding the CD95 receptor triggering—Life or death?

poster

Gupta, Vikas A





B-cell markers predict response to venetoclax in multiple myeloma

poster

Gutierrez, Alejandro





Polycomb repressive complex 2 inactivation induces primary chemotherapy resistance in T-cell acute lymphoblastic leukemia by upregulating the TRAP1 mitochondrial chaperone

poster

Hamacher-Brady, Anne





Switch-like, ubiquitin-regulated endosomal targeting of mitochondria is integral to mitochondrial outer membrane permeabilization

talk

Hamann, Jens





Entosis is induced by glucose starvation

talk

Hartwig, Torsten B





The TRAIL-induced cancer secretome promotes a tumor-supportive immune-microenvironment via CCR2

poster

Iborra, Francisco





Mitochondrial content in individual cell determine cell-to-cell variability in apoptosis through global modulation of gene expression

poster

Inoue-Yamauchi, Akane





Targeting the differential addiction to anti-apoptotic BCL-2 family for cancer therapy

poster

Jiang, Xiaoshan





G protein-coupled receptor kinase 4-induced cellular senescence and its senescence-associated gene expression profiling

poster

Juin, Philippe





Cell survival zipped—C-terminal ends of BCL-2 family members strengthen BH3-dependent oligomers

talk

Kale, Justin





Phosphorylation switches Bax from promoting to inhibiting apoptosis thereby increasing drug resistance

talk

Kanakaveti, Vishnupriya





Systematic computational analysis of chemical space of protein-protein interactions of Bcl-2 family proteins—Applications to prediction

poster

Katz, Samuel G





Mitochondrial associated membrane (MAM)-calcium transfer sites are regulated by Bok

talk

Kluck, Ruth





Regulating Bak and Bax activation and oligomerisation

poster

Ko, Pin-Joe





The small molecule CIL56 disrupts endomembrane trafficking and induces non-apoptotic cell death

poster

Koo, Namjin





Inter-kingdom comparative analysis of translationally controlled tumor protein (TCTP) provides insights into lineage-specific evolution and co-evolution of counterpart genes

poster

Kutscher, Lena M





Competitive phagocytosis—A novel mechanism for clearance of the non-apoptotically dying linker cell in C. elegans

poster

Kuwana, Tomomi





Bax helix 9 affects MOMP

poster

Lee, Alan Yueh-Luen





Mitochondrial Lon restrains apoptosis via sequestering p53 in the matrix under oxidative stress

poster

Li, David





SUMO1-conjugated RanGAP1 regulates the p53-PUMA pathway to control apoptosis of lens epithelial cells

poster

Li, Xiang (Mark)





Bak α6 permits activation by bh3-only proteins and homo-oligomerization via the canonical hydrophobic groove

poster

Li, Yi





The apoptosis anticancer barrier in breast cancer initiation

talk

Li, Yini





The mechanistic insights into caspase-9 activation by the structure of the apoptosome holoenzyme

poster

Li, Zehui





Mechanisms of methuosis defined through the use of indolyl chalcone analogs in glioblastoma cells

poster

Lin, Jialing





tBid activates Bax via two allosterically coupled interactions to initiate apoptotic mitochondrial membrane permeabilization

talk

Lincoln, Franklin A





The triad of procaspase-8, procaspase-3 and Bid expression determines responsiveness to the combination of TRAIL and IAP antagonist TL32711 in glioblastoma

poster

Longley, Daniel B





Development and pre-clinical assessment of a first-in-class small molecule inhibitor of FLIP

poster

Lu, Xin





Regulation of p53—The cancer-causing pathogens connection

talk

Lucantoni, Federico





Bcl2 and Bcl(x)L regulate bioenergetics efficiency of breast cancer cells

poster

Luna-Vargas, Mark PA





BH3 mimetics target multiple conformations of Bak and Bax to differentially modulate chemotherapy-induced apoptosis

poster

Martin, Seamus J





Counterintuitive functions of 'death receptors' that promote cell survival

talk

Mattoo, Abid R





MCL-1 depletion in cancer cells suppresses homologous recombination repair and increases DNA damage in response to S-phase specific drugs and ionizing radiation

poster

McDade, Simon





Transcriptional upregulation of FLIPL by p53 in response to Nutlin-3A is dependent on class I HDACs and determines cell fate

poster

Means, Robert





Regulation of antiviral responses by the BCL-2 family member BOK

poster

Mergenthaler, Philipp





Investigating neuroprotective small molecule inhibitiors of pro-apoptotic Bax and Bak using segmentation-free large scale automated 3d microscopy

poster

Milani, Mateus





Endoplasmic reticulum structural integrity is crucial for mitochondrial outer membrane permeabilization and apoptosis

poster

Mohammed, Jarvier N





Dual suppression of inner and outer mitochondrial membrane functions augments pro-apoptotic responses to oncogenic MAPK signaling inhibition

poster

Moldoveanu, Tudor





BOK is a metastable effector of MOMP

poster

Mondragon, Albert A





Lysosome machinery is utilized by cells to induce cell death non-autonomously

talk

Montero, Joan





Rational combination of targeted agents and BH3 mimetics to improve cancer treatment

poster

Moravcikova, Erika





The Bcl-2 family member BOK has potential tumor suppressor activity in non-small cell lung carcinoma

poster

Morgan, Ann M





Reactivation of p53-mediated apoptosis in pediatric cancers by a stapled peptide inhibitor of HDM2 and HDMX

poster

Newmeyer, Don





Phenotypic selection of intracellularly expressed scFv antibodies reveals a cytoprotective function of PKM2 that opposes the core Bax/Bak-mediated mitochondrial membrane permeabiliation event, via Mitofusin 1 upreguation

poster

Newton, Kim





RIPK1 and caspase-8—Putting the brakes on cell death

talk

Nguyen, Dang





Identification of a non-BH3 Bax activation sequence in Bim

poster

Oh, Sangho





Identifying functional site of human TCTP protein associated with anti-apoptosis process in cancer

poster

Opferman, Joseph T





Targeting anti-apoptotic MCL-1 translation by anti-malarial dihydroartemsinin (DHA) in poor prognosis BCR-ABL+ B-lineage acute lymphoblastic leukemia

talk

Ortega, Oscar O





A mechanistic analysis of cell-to-cell variability in apoptosis execution

poster

Pearce, Martin C





Targeting therapy resistant cancer through Bcl-2 functional conversion

poster

Pemberton, James M





Quantitative comparison of recombinant pro-apoptotic BH3-proteins suggests that the primary function of PUMA is inhibition of Bcl-2 and Bcl-XL

poster

Phillips, Darren C





ABBV-621—A best-in-class TRAIL-receptor agonist fusion protein that optimizes death receptor clustering for the treatment of solid and hematologic tumors

talk

Pogmore, Justin P





The membrane binding domain of BCL-XL contributes to the inhibition of BID and BIM

poster

Ponder, Katelyn





The role of the prodomain of caspase-3 in apoptotic activity

poster

Pritz, Jonathan





An NMR fragment screen identifies an allosteric sensitizer of BAX activation

poster

Rajanala, Harisha





Methionine restriction induces ATF4 and Sestrin2 by a GCN2-dependent mechanism to attenuate cell death in response to methionine depletion

poster

Ramsey, Haley E





Rational targeting of MCL-1 in a BH3-dependent fashion in AML

poster

Rehm, Markus





Simulating and predicting cellular and in vivo responses of colon cancer to combined treatment with chemotherapy and IAP antagonist Birinapant/TL32711

talk

Reljic, Boris





A non-BCL-2-like protein regulates the stability of the BAK/VDAC2 complex to influence apoptosis/BAK apoptotic function

poster

Riegman, Michelle M





Ferroptotic cells undergo death in a wave-like manner

poster

Roberts, Andrew





Clinical progress with BCL2 inhibition in hematological malignancies—Update August 2017

talk

Rodriguez-Enriquez, Ricardo J





Computerized image analysis for unbiased quantification of mitochondrial morphology

poster

Sai, Kazuhito





Host defense against Listeria monocytogenes through RIPK3-MLKL signaling in non-immune cells

poster

Salvucci, Manuela





Systems modelling aids in the decoding and targeting of metabolic reprogramming in cancer

talk

Sarosiek, Kristopher A





Broad resistance to cancer therapies is induced by suppression of apoptosis by lineage programs and oncogene activation

talk

Schafer, Zachary T





RIPK1-mediated induction of mitophagy compromises the viability of extracellular matrix-detached cells

talk

Schulman, Jacqualyn J





The Bok-IP3R interaction protects Bok from proteasomal degradation

talk

Schwarzer, Robin





Epithelial cell death in intestinal inflammation

poster

Shao, Feng





Pyroptosis—From innate immunity to cancer

talk

Stein, Reuven





The effect of Bax on LINC complex proteins following stress

poster

Stoehr, Daniela





Spatiotemporally developing layers of TRAIL-resistant cells shield TRAIL-hypersensitive cells within multicellular tumor spheroids

talk

Strasser, Andreas





Towards targeting MCL-1 for cancer therapy

talk

Syed, Farooq





Circulating preproinsulin (PPI) mRNA as a potential biomarker of β-cell stress

poster

Tessier-Lavigne, Marc





Axon degeneration gated by retrograde activation of somatic pro-apoptotic signaling

talk

Thompson, Craig





Manipulating cell death—The discovery and preclinical development of Bcl-2 inhibitors

talk

Trotta, Andrew P





Disruption of mitochondrial electron transport chain function potentiates the pro-apoptotic effects of MAPK inhibition.

poster

Tsegaye, Matyas Abel





Cancer cell apoptosis is induced by soluble factors secreted from normal mammary fibroblasts

poster

van Delft, Mark





VDAC2 is essential for BAX to efficiently mediate apoptosis

poster

Vanderluit, Jacqueline L





The roles of Mcl-1 and Bcl-xL in survival signaling during developmental mammalian neurogenesis

poster

Varadarajan, Shankar





Modulation of glutamine metabolism can overcome chemoresistance to BH3 mimetics in haematological malignancies

poster

Venkataramani, Vivek





Amyloid precursor protein (APP) protects cancer cells from oxidative stress and p38MAPK-dependent DNA damage

talk

Villunger, Andreas





Checkpoint kinase 1 (CHK1) controls normal B cell development, lymphomagenesis and cancer cell survival

talk

Vucic, Domagoj





Regulation of inflammatory cell death signaling by RIP kinases

talk

Walensky, Loren D.





Noncanonical strategies for modulating the BCL-2 family regulators of apoptosis

talk

Wang, Huaimin





In-situ assembling cholesterols for selective cell death

poster

Wang, Xiaodong





Necroptosis promotes the aging of the male reproductive system

talk

Wang, Yingfei





A novel nuclease MIF mediates cell death induced by DNA damage and poly(ADP-ribose) polymerase-1

talk

Wang, Zhigao





Identification and characterization of natural product inhibitors of necroptosis from Chinese traditional herbs

poster

White, Eileen





Autophagy, metabolism and cancer

talk

Wilson, Blake A





A molecular simulation study of the effects of cardiolipin on the physical properties of mitochondrial outer membrane-like lipid bilayers

poster

Wong, W. Wei-Lynn





XIAP inhibits TNFR2-induced cell death and inflammation

poster

Yu, Victor C





MOAP-1 mediates Fas-induced apoptosis in liver by facilitating recruitment of tBid to mitochondria

poster

Zhang, Jieqiong





cIAPs inhibit RIPK3 and caspase 8 mediated cell death in adult mice

poster

Zhou, Daohong





Identification of the Achilles' heel of senescent cells for developing senolytic drugs

talk

Zinkel, Sandra





Bid maintains mitochondrial cristae structure and function—Evidence for a protective role in human cardiac disease through an integrative genomics approach

talk