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Presenting Author |
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Abstract Title |
Talk/Poster |
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Ali, Aus AT |
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The effect of green tea on cellular fat accumulation, triglycerides concentrations and alkaline phosphatase activity |
poster |
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Andersen, Courtney L |
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AZ’5576, a potent and selective Cdk9 inhibitor, displays broad anti-tumor activity in preclinical hematological models |
talk |
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Andrews, David |
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Investigating how subcellular localization of BIK impacts its BCL-2 family interacting partners |
poster |
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Ark, Mustafa |
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Possible involvement of Rho kinase on the secretory activity of drug-induced senescent cells |
poster |
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Bhatt, Shruti |
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Harnessing the power of mitochondria to guide personalized therapy for acute myeloid leukemia |
talk |
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Bhola, Patrick |
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High throughput identification of apoptosis sensitizing chemicals using freshly isolated tumor cells |
talk |
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Bozkurt, Emir |
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Yet another way to die—TRAIL induces caspase-8-dependent cell-in-cell death |
talk |
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Campisi, Judith |
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Cellular senescence, cell death resistance and aging |
talk |
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Cao, Jennifer Yinuo |
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Inducing ferroptosis to selectively eliminate multidrug resistant cancer cells |
poster |
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Cetin, Bulent |
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Death in mitosis—Targeting Plk4 and Bcl-2 as a novel therapy for lymphoma |
poster |
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Chen, Fei-Yun |
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Regulation of BIK ubiquitination by Cul5ASB11 to control life-death cell fate and tumor killing effect |
poster |
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Chen, Ruoyao |
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Entosis is induced by UV radiation |
talk |
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Cheng, Emily H.-Y. |
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ΔNp63 inhibits oxidative stress-induced cell death including ferroptosis and cooperates with the BCL-2 family to promote clonogenic survival |
talk |
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Cheng, Ho Wa (Jacky) |
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Uncovering and overcoming resistance of triple-negative breast cancer to chemotherapy |
poster |
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Chipuk, Jerry |
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BH3 mimetics target multiple conformations of BAK and BAX to differentially modulate chemotherapy-induced apoptosis |
talk |
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Chung, Alexander |
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Tumor-specific cell death induced by CIB1-based combination therapies in triple-negative breast cancer |
poster |
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Conlon, Megan M |
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Uncovering a role for mTOR signaling in ferroptosis |
talk |
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Crowder, Roslyn N |
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Alpinia zerumbet essential oil induces apoptosis in human leukemia cancer cells |
poster |
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Daniels, Veerle |
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Identification of metabolic regulators of mitochondrial apoptotic priming to reveal previously unrecognized vulnerabilities of triple negative breast cancer |
poster |
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Darding, Maurice |
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Deficiency in different LUBAC components—A surprise in three acts |
poster |
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Delgado, Magdalena R |
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Interphase microtubules are essential for the survival of primary acute lymphoblastic leukemia cells |
poster |
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Deng, Shuo |
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Gelsolin regulates autophagy to modulate the cell death resistance to 5-Fluorouracil in colorectal cancer cells |
poster |
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Dixon, Scott J |
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Systematic quantification of population cell death kinetics |
talk |
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Dovey, Cole M |
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The killer’s accomplice—MLKL requires inositol phosphates to execute necroptosis |
talk |
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Escudero, Silvia |
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Regulation of fatty acid oxidation by the mitochondrial matrix isoform of MCL-1 |
talk |
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Feng, Zhaoqianqi |
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Enzymatic formation nano-arcs of guanidinium-containing D,L-peptides potently inhibits cancer cells via multi-targeting |
poster |
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Flemmer, Robert T |
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Identifying the apoptotic and differentiative roles of the Bcl-2 family in the developing mammalian nervous system |
poster |
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Fulda, Simone |
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Discovery of a synergistic combination of Smac mimetic and Bortezomib to trigger necroptosis in malignant lymphoma cells in the absence of pharmacological caspase inhibition |
talk |
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Garcia-Saez, Ana |
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Apoptosis control by the Bcl-2 network at the single molecule level |
talk |
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Gavathiotis, Evris |
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Direct targeting of pro-apoptotic BAX as a novel strategy for cancer therapy |
talk |
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Gelles, Jesse |
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The sphingosine-1-phosphate lyase regulates BAX-mediated apoptosis |
poster |
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Ghose, Piya |
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Novel compartment-specific killing and clearance programs in a morphologically complex cell |
talk |
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Gilmore, Andrew |
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Differential retrotranslocation of Bcl-2 proteins predicts single cell heterogeneity in apoptotic priming |
talk |
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Greaves, Georgia J |
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Investigating the roles and mechanisms of MCL-1 in apoptosis and beyond |
poster |
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Gross, Atan |
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Mitochondrial MTCH2 at the interface between homeostasis and apoptosis |
talk |
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Guerra, Rachel |
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Reactivating apoptosis in BFL-1/A1 driven cancer with cysteine-reactive stapled peptide inhibitors |
poster |
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Guha Mazumder, Arpan |
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Metamolomics corroborated multimodal quantitative imaging biomarkers for neuroretinal degeneration in diabetic retinopathy |
poster |
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Gulculer, Gulce S |
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A biophysical approach towards understanding the CD95 receptor triggering—Life or death? |
poster |
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Gupta, Vikas A |
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B-cell markers predict response to venetoclax in multiple myeloma |
poster |
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Gutierrez, Alejandro |
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Polycomb repressive complex 2 inactivation induces primary chemotherapy resistance in T-cell acute lymphoblastic leukemia by upregulating the TRAP1 mitochondrial chaperone |
poster |
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Hamacher-Brady, Anne |
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Switch-like, ubiquitin-regulated endosomal targeting of mitochondria is integral to mitochondrial outer membrane permeabilization |
talk |
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Hamann, Jens |
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Entosis is induced by glucose starvation |
talk |
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Hartwig, Torsten B |
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The TRAIL-induced cancer secretome promotes a tumor-supportive immune-microenvironment via CCR2 |
poster |
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Iborra, Francisco |
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Mitochondrial content in individual cell determine cell-to-cell variability in apoptosis through global modulation of gene expression |
poster |
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Inoue-Yamauchi, Akane |
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Targeting the differential addiction to anti-apoptotic BCL-2 family for cancer therapy |
poster |
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Jiang, Xiaoshan |
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G protein-coupled receptor kinase 4-induced cellular senescence and its senescence-associated gene expression profiling |
poster |
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Juin, Philippe |
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Cell survival zipped—C-terminal ends of BCL-2 family members strengthen BH3-dependent oligomers |
talk |
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Kale, Justin |
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Phosphorylation switches Bax from promoting to inhibiting apoptosis thereby increasing drug resistance |
talk |
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Kanakaveti, Vishnupriya |
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Systematic computational analysis of chemical space of protein-protein interactions of Bcl-2 family proteins—Applications to prediction |
poster |
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Katz, Samuel G |
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Mitochondrial associated membrane (MAM)-calcium transfer sites are regulated by Bok |
talk |
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Kluck, Ruth |
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Regulating Bak and Bax activation and oligomerisation |
poster |
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Ko, Pin-Joe |
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The small molecule CIL56 disrupts endomembrane trafficking and induces non-apoptotic cell death |
poster |
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Koo, Namjin |
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Inter-kingdom comparative analysis of translationally controlled tumor protein (TCTP) provides insights into lineage-specific evolution and co-evolution of counterpart genes |
poster |
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Kutscher, Lena M |
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Competitive phagocytosis—A novel mechanism for clearance of the non-apoptotically dying linker cell in C. elegans |
poster |
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Kuwana, Tomomi |
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Bax helix 9 affects MOMP |
poster |
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Lee, Alan Yueh-Luen |
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Mitochondrial Lon restrains apoptosis via sequestering p53 in the matrix under oxidative stress |
poster |
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Li, David |
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SUMO1-conjugated RanGAP1 regulates the p53-PUMA pathway to control apoptosis of lens epithelial cells |
poster |
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Li, Xiang (Mark) |
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Bak α6 permits activation by bh3-only proteins and homo-oligomerization via the canonical hydrophobic groove |
poster |
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Li, Yi |
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The apoptosis anticancer barrier in breast cancer initiation |
talk |
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Li, Yini |
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The mechanistic insights into caspase-9 activation by the structure of the apoptosome holoenzyme |
poster |
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Li, Zehui |
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Mechanisms of methuosis defined through the use of indolyl chalcone analogs in glioblastoma cells |
poster |
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Lin, Jialing |
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tBid activates Bax via two allosterically coupled interactions to initiate apoptotic mitochondrial membrane permeabilization |
talk |
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Lincoln, Franklin A |
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The triad of procaspase-8, procaspase-3 and Bid expression determines responsiveness to the combination of TRAIL and IAP antagonist TL32711 in glioblastoma |
poster |
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Longley, Daniel B |
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Development and pre-clinical assessment of a first-in-class small molecule inhibitor of FLIP |
poster |
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Lu, Xin |
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Regulation of p53—The cancer-causing pathogens connection |
talk |
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Lucantoni, Federico |
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Bcl2 and Bcl(x)L regulate bioenergetics efficiency of breast cancer cells |
poster |
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Luna-Vargas, Mark PA |
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BH3 mimetics target multiple conformations of Bak and Bax to differentially modulate chemotherapy-induced apoptosis |
poster |
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Martin, Seamus J |
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Counterintuitive functions of 'death receptors' that promote cell survival |
talk |
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Mattoo, Abid R |
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MCL-1 depletion in cancer cells suppresses homologous recombination repair and increases DNA damage in response to S-phase specific drugs and ionizing radiation |
poster |
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McDade, Simon |
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Transcriptional upregulation of FLIPL by p53 in response to Nutlin-3A is dependent on class I HDACs and determines cell fate |
poster |
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Means, Robert |
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Regulation of antiviral responses by the BCL-2 family member BOK |
poster |
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Mergenthaler, Philipp |
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Investigating neuroprotective small molecule inhibitiors of pro-apoptotic Bax and Bak using segmentation-free large scale automated 3d microscopy |
poster |
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Milani, Mateus |
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Endoplasmic reticulum structural integrity is crucial for mitochondrial outer membrane permeabilization and apoptosis |
poster |
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Mohammed, Jarvier N |
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Dual suppression of inner and outer mitochondrial membrane functions augments pro-apoptotic responses to oncogenic MAPK signaling inhibition |
poster |
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Moldoveanu, Tudor |
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BOK is a metastable effector of MOMP |
poster |
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Mondragon, Albert A |
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Lysosome machinery is utilized by cells to induce cell death non-autonomously |
talk |
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Montero, Joan |
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Rational combination of targeted agents and BH3 mimetics to improve cancer treatment |
poster |
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Moravcikova, Erika |
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The Bcl-2 family member BOK has potential tumor suppressor activity in non-small cell lung carcinoma |
poster |
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Morgan, Ann M |
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Reactivation of p53-mediated apoptosis in pediatric cancers by a stapled peptide inhibitor of HDM2 and HDMX |
poster |
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Newmeyer, Don |
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Phenotypic selection of intracellularly expressed scFv antibodies reveals a cytoprotective function of PKM2 that opposes the core Bax/Bak-mediated mitochondrial membrane permeabiliation event, via Mitofusin 1 upreguation |
poster |
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Newton, Kim |
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RIPK1 and caspase-8—Putting the brakes on cell death |
talk |
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Nguyen, Dang |
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Identification of a non-BH3 Bax activation sequence in Bim |
poster |
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Oh, Sangho |
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Identifying functional site of human TCTP protein associated with anti-apoptosis process in cancer |
poster |
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Opferman, Joseph T |
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Targeting anti-apoptotic MCL-1 translation by anti-malarial dihydroartemsinin (DHA) in poor prognosis BCR-ABL+ B-lineage acute lymphoblastic leukemia |
talk |
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Ortega, Oscar O |
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A mechanistic analysis of cell-to-cell variability in apoptosis execution |
poster |
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Pearce, Martin C |
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Targeting therapy resistant cancer through Bcl-2 functional conversion |
poster |
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Pemberton, James M |
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Quantitative comparison of recombinant pro-apoptotic BH3-proteins suggests that the primary function of PUMA is inhibition of Bcl-2 and Bcl-XL |
poster |
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Phillips, Darren C |
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ABBV-621—A best-in-class TRAIL-receptor agonist fusion protein that optimizes death receptor clustering for the treatment of solid and hematologic tumors |
talk |
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Pogmore, Justin P |
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The membrane binding domain of BCL-XL contributes to the inhibition of BID and BIM |
poster |
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Ponder, Katelyn |
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The role of the prodomain of caspase-3 in apoptotic activity |
poster |
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Pritz, Jonathan |
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An NMR fragment screen identifies an allosteric sensitizer of BAX activation |
poster |
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Rajanala, Harisha |
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Methionine restriction induces ATF4 and Sestrin2 by a GCN2-dependent mechanism to attenuate cell death in response to methionine depletion |
poster |
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Ramsey, Haley E |
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Rational targeting of MCL-1 in a BH3-dependent fashion in AML |
poster |
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Rehm, Markus |
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Simulating and predicting cellular and in vivo responses of colon cancer to combined treatment with chemotherapy and IAP antagonist Birinapant/TL32711 |
talk |
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Reljic, Boris |
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A non-BCL-2-like protein regulates the stability of the BAK/VDAC2 complex to influence apoptosis/BAK apoptotic function |
poster |
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Riegman, Michelle M |
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Ferroptotic cells undergo death in a wave-like manner |
poster |
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Roberts, Andrew |
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Clinical progress with BCL2 inhibition in hematological malignancies—Update August 2017 |
talk |
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Rodriguez-Enriquez, Ricardo J |
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Computerized image analysis for unbiased quantification of mitochondrial morphology |
poster |
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Sai, Kazuhito |
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Host defense against Listeria monocytogenes through RIPK3-MLKL signaling in non-immune cells |
poster |
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Salvucci, Manuela |
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Systems modelling aids in the decoding and targeting of metabolic reprogramming in cancer |
talk |
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Sarosiek, Kristopher A |
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Broad resistance to cancer therapies is induced by suppression of apoptosis by lineage programs and oncogene activation |
talk |
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Schafer, Zachary T |
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RIPK1-mediated induction of mitophagy compromises the viability of extracellular matrix-detached cells |
talk |
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Schulman, Jacqualyn J |
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The Bok-IP3R interaction protects Bok from proteasomal degradation |
talk |
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Schwarzer, Robin |
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Epithelial cell death in intestinal inflammation |
poster |
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Shao, Feng |
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Pyroptosis—From innate immunity to cancer |
talk |
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Stein, Reuven |
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The effect of Bax on LINC complex proteins following stress |
poster |
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Stoehr, Daniela |
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Spatiotemporally developing layers of TRAIL-resistant cells shield TRAIL-hypersensitive cells within multicellular tumor spheroids |
talk |
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Strasser, Andreas |
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Towards targeting MCL-1 for cancer therapy |
talk |
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Syed, Farooq |
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Circulating preproinsulin (PPI) mRNA as a potential biomarker of β-cell stress |
poster |
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Tessier-Lavigne, Marc |
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Axon degeneration gated by retrograde activation of somatic pro-apoptotic signaling |
talk |
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Thompson, Craig |
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Manipulating cell death—The discovery and preclinical development of Bcl-2 inhibitors |
talk |
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Trotta, Andrew P |
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Disruption of mitochondrial electron transport chain function potentiates the pro-apoptotic effects of MAPK inhibition. |
poster |
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Tsegaye, Matyas Abel |
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Cancer cell apoptosis is induced by soluble factors secreted from normal mammary fibroblasts |
poster |
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van Delft, Mark |
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VDAC2 is essential for BAX to efficiently mediate apoptosis |
poster |
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Vanderluit, Jacqueline L |
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The roles of Mcl-1 and Bcl-xL in survival signaling during developmental mammalian neurogenesis |
poster |
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Varadarajan, Shankar |
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Modulation of glutamine metabolism can overcome chemoresistance to BH3 mimetics in haematological malignancies |
poster |
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Venkataramani, Vivek |
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Amyloid precursor protein (APP) protects cancer cells from oxidative stress and p38MAPK-dependent DNA damage |
talk |
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Villunger, Andreas |
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Checkpoint kinase 1 (CHK1) controls normal B cell development, lymphomagenesis and cancer cell survival |
talk |
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Vucic, Domagoj |
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Regulation of inflammatory cell death signaling by RIP kinases |
talk |
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Walensky, Loren D. |
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Noncanonical strategies for modulating the BCL-2 family regulators of apoptosis |
talk |
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Wang, Huaimin |
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In-situ assembling cholesterols for selective cell death |
poster |
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Wang, Xiaodong |
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Necroptosis promotes the aging of the male reproductive system |
talk |
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Wang, Yingfei |
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A novel nuclease MIF mediates cell death induced by DNA damage and poly(ADP-ribose) polymerase-1 |
talk |
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Wang, Zhigao |
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Identification and characterization of natural product inhibitors of necroptosis from Chinese traditional herbs |
poster |
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White, Eileen |
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Autophagy, metabolism and cancer |
talk |
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Wilson, Blake A |
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A molecular simulation study of the effects of cardiolipin on the physical properties of mitochondrial outer membrane-like lipid bilayers |
poster |
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Wong, W. Wei-Lynn |
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XIAP inhibits TNFR2-induced cell death and inflammation |
poster |
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Yu, Victor C |
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MOAP-1 mediates Fas-induced apoptosis in liver by facilitating recruitment of tBid to mitochondria |
poster |
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Zhang, Jieqiong |
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cIAPs inhibit RIPK3 and caspase 8 mediated cell death in adult mice |
poster |
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Zhou, Daohong |
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Identification of the Achilles' heel of senescent cells for developing senolytic drugs |
talk |
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Zinkel, Sandra |
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Bid maintains mitochondrial cristae structure and function—Evidence for a protective role in human cardiac disease through an integrative genomics approach |
talk |