Network Biology
March 11 - 15, 2025

You must register for the meeting in order to submit abstracts.
After registering you will be sent a web link for abstract submission by email.
You may copy and paste your abstract from Word, Google Docs, or Notepad; abstracts are limited to ~2900 characters.

Program information: An electronic version of the program abstract book will be sent three working days prior to the first day of the meeting, and hard copies will be available for collection upon your arrival at Cold Spring Harbor Laboratory. First night and keynote speakers are informed of their session date and time, otherwise program information is only available upon release of the electronic version of the abstract book. The reason we do this is to try and maximize interactions by encouraging participants to stay for the duration of the meeting.

Please check your email for talk length, poster instructions, and how to have your poster printed at CSHL for collection upon arrival. 

Abstract Status

Presenting Author

Abstract Title

Talk/Poster

Alvarez, Jose M

Opposite forces—Transcriptional networks that integrate stress and nutritional signals in plants.

poster

Aregger, Michael

Combinatorial CRISPR screening uncovers genetic interaction networks underlying metabolic plasticity in cancer cells

talk

Bader, Gary D

Mapping the multiscale human

talk

Bennett, Kate

Hypergraph approach to identify serum biomarkers of glucocorticoid downstream action in adipose tissue

poster

Beyer, Andreas

One size fits all – using a general purpose transcriptome network to understand human biology

talk

Braynen, Janeen C

Genomic strategies to improve nitrogen use efficiency and reduce nitrate levels in sorghum forage lines

poster

Braynen, Janeen C

Understanding iron response mechanisms and carbon partitioning strategies in sorghum under Fe stress

poster

Brun, Christine G

Predictions of human micropeptide functions from an interactome study

poster

Bruns, Imke

Translational systems toxicology models bridging in vitro renal test systems to human renal pathologies

poster

Callegaro, Giulia

The TXG-MAPr—An unprecedented transcriptomics database and network model of toxicological test systems

poster

Carpenter, Anne E

Learning about gene functions and gene relationships from cell images

talk

Carvunis, Anne-Ruxandra

Network biology of the dark proteome

talk

Cetin, Ronay

Towards sequential genetic dependencies—Technical and experimental considerations

poster

Chakrabarty, Souparna

Introducing dysfunctional protein-protein interactome (dfPPI)—A platform for systems-level protein-protein interaction (PPI) network dysfunction investigation in disease

talk

Clark, Amanda M

Characterization of tertiary lymphoid structures in inflammatory bowel disease

poster

Creeggan, Finn

A multi-omic network analysis defines a novel reactive ependymal cell state in multiple sclerosis

poster

Daakour, Sarah

Integrative genome-wide interactome mapping of a high-light-adapted Cyanobacterium species using CrY2H-seq and generative AI

talk

Das, Jishnu

An interpretable multi-scale network approach to uncover novel drivers of T follicular helper cell differentiation

poster

Das, Jishnu

Sliding Window INteraction Grammar (SWING)—A generalized interaction language model for peptide and protein interactions

talk

Das, Jishnu

Uncovering novel cellular programs and regulatory circuits underlying primary human B Cell states

poster

Daura, Xavier

Identification of COPD comorbidity biomarkers using network biology and deep learning, validated with real-world data

poster

DeGroat, William B

Reconstructing cell type-specific enhancer-promoter interaction regulatory networks with massively parallel reporter assays

talk

Diss, Guillaume

Deep mutational scanning of entire human protein interaction domain families

talk

Falter-Braun, Pascal

Network organization of human genetic variation—Modules and core genes

talk

Fernandez Macgregor, Jaime M

Gut microbiome Pseudomonadota—Quantifying the molecular dialogue

poster

Fischbach, Mathew

Genetic interaction-based machine learning models for disease risk prediction

poster

Fisher, Jasmin

Cancer digital twins

talk

Fu, TingTing

Epigenetic regulatory network in microglia reveals context-dependent trans-regulatory programs in brain disease

poster

Fuxman Bass, Juan I

Widespread variation in molecular interactions and regulatory properties among transcription factor isoforms

talk

Georgakopoulos-Soares, Ilias

Identification of the shortest species-specific oligonucleotide sequences

poster

Gladman, Nicholas P

Pan-transcriptome of developing sorghum meristems reveal putative regulatory targets for mature seed traits

poster

Guan, Yue

High-throughput and high-resolution mapping of MDM2 interactions screened against cancer relevant proteins

poster

Hammell, Christopher

LIN-42/Period coordinates a network of transcription factors to program sequential cell fates during C. elegans larval development

poster

Hart, Traver

Network-guided IN4MER interaction screens of 350 genes in 12 cell lines show dense genetic interaction networks in RTK signaling and DNA damage response

talk

Hassan, Arshia Zernab

Integrating chemical-genetic interactions and gene-expression profiles to predict tumor drug sensitivity

talk

Hayes, Wayne B

Graphlet-based magic tricks for community detection, link prediction, and local network alignment

poster

Houghton, Carly L

Subcellular localization and expression of de novo emerged proteins

poster

Jaaks-Kraatz, Sebastian

The genetic architecture of the human SH3 domain interaction network

poster

Jakobson, Chris

A genome-to-proteome atlas charts natural variants controlling proteome diversity and forecasts their fitness effects

talk

Jensen, Lars Juhl

Disease protein prioritization from omics data and STRING network embeddings

talk

Jo, Kyeong Beom

Gene perturbation profile similarity network using a novel overexpression screening platform for chemotherapeutic resistance

talk

Karamveer, Karamveer

An unbiased evaluation of single-cell multi-omic GRN inference methods

poster

Kaulich, Manuel

Time-resolved combinatorial perturbations identify iterative druggable relationships.

talk

Khetan, Shubham

Transcription factor genomic occupancy is determined by multiple, overlapping DNA binding sites.

talk

Kong, JungHo

A foundation model of the tumor mutation reveals biomarkers of drug response

talk

Kosciuszko, Martyna

Hypergraph analysis of single cell transcriptomic data implicates placental genes associated with birthweight in healthy pregnancies that display distinct later-life risk phenotypes

poster

Krishnan, Arjun

Joint representation of multispecies networks for classifying genes and phenotypes within and across species

poster

Krishnaswamy, Smita

Dynamics-based network-inference using neural and graph ODEs

talk

Lambourne, Luke

Comprehensive empirical assessment of interactome computability

poster

Land, Max

Investigating the cellular response to mtDNA deletion heteroplasmy using optimized mtDOGMA-seq

poster

Leger, Brittany S

Getting the run around—Is the locomotor response to a novel environment a model of human externalizing behavior?

poster

Levy, Orr

Gene regulatory interactions limit the gene expression diversity

poster

Licata, Luana

The IMEx binding domain dataset—A useful tool to analyse and predict interaction interfaces and variant effects

poster

Louloudis, Ioannis

Data driven drug repurposing using electronic health records

poster

Luck, Katja

From networks to mechanisms in health and disease

talk

Madenidou, Anastasia

Utilising hypergragh multi-omic intergration to compare two mass spectrometry proteomic methods—MagNet and S-TRAP

poster

Malek, Joel A

A tiled synthetic fragment protein-interaction map of all Helicobacter pylori genes using short-read sequencing

poster

Martirosian, Evgenii

Hypergraph approach reveals distorted cis-interacting DNA methylome in Kabuki syndrome Type 1

poster

McDonald, Eli F

Proteostasis landscapes of cystic fibrosis variants reveals drug response vulnerability

poster

McKim, Alexander P

A modular network-based approach improves post-omics and post-GWAS hypothesis generation about disease genes and mechanisms

poster

Moeller, Eric S

Inferring gene regulatory networks from single-cell multiomic data—A novel framework for cell-level analysis

poster

Monsellier, Elodie

The holdup assay—Towards system-wide affinity mapping of interactomes

talk

Nakatsuka, Nathan J

A reproducibility focused meta-analysis method for single-cell transcriptomic case-control studies uncovers robust differentially expressed genes and networks

poster

Narayanan, Manikandan

NLCD—A method to discover nonlinear causal relations among genes

poster

Nersisyan, Stepan

Adjusting for hidden confounders in transcriptomic correlation networks with CorrAdjust

poster

Ocitti, Faith Abiria

Decoding the functional interactome of non-model organisms with PHILHARMONIC

poster

Oliva, Baldo

SNPeBoT—A method for predicting transcription factor allele specific binding

poster

Palenikova, Petra

Building cell-type-specific protein-protein interaction networks of transcription factors and general cofactors to study the combinatorial logic of gene regulation programs

poster

Parwana, Diksha

From local perturbations to global dynamics—ENMs for allosteric site prediction

poster

Penny, Eleanor

Modelling gene regulatory networks underlying wheat inflorescence architecture

poster

Perfetto, Livia

PatientProfiler, a network-based approach to support personalized medicine

talk

Petsalaki, Evangelia

Integrative network analysis to uncover mechanisms of melanoma drug resistance

talk

Pinheiro-de-Sousa, Iguaracy

From networks to improve cardiac organoid design

poster

Rele, Chinmay P

Network topology is correlated with evolutionary rates of genes and their regulatory regions in Drosophila

poster

Rogers, Julia

Quantitative models of signaling networks enabled by machine learning

talk

Rohde, Thomas

BaCoN (Balanced Correlation Network) improves prediction of gene buffering

poster

Saez-Rodriguez, Julio

Combining prior knowledge networks and multi-omics data to extract disease mechanisms

talk

Serohijos, Adrian

Genetic landscape of an in vivo protein interactome—Development of protein-interaction QTL (piQTL) mapping

talk

Sidhu, Gurpinder Singh

From Arabidopsis to Brassica napus—Determining the regulatory control of flowering time

poster

Simhal, Anish K

The blessings of dimensionality—Unsupervised network-based learning on omic data using Ollivier-Ricci curvature

poster

Skinnider, Michael

Harmonizing interaction proteomic datasets at the repository scale

talk

Sledzieski, Samuel

Decoding the functional interactome of non-model organisms with PHILHARMONIC

poster

Sontakke, Neha

Bayesian inference for metabolic gap filling in microbiomes

poster

Springer, Michael

The galactokinase enzyme of yeast senses metabolic flux to stabilize galactose pathway regulation

talk

Szymborski, Joseph

A serious flaw in the design of pLLM-based protein-protein interaction models

poster

Taipale, Mikko

Protein (mis)localization in human genetic disorders

talk

Terai, Kiriko

Protein fluctuations produce non-Arrhenius electron transport in Geobacter OmcS nanowires

poster

Terao, Chikashi

Deciphering human complex traits using population-specific germline and somatic genetic variations combined with gene expression regulation

poster

Trave, Gilles

Systemwide mapping of binding free energies of living organisms—What for?

poster

Uzun, Yasin

Building cell-specific gene regulatory networks with single-cell multi-omics

poster

Valensi, Hannah

A comprehensive single-cell multi-omic repository for robust gene regulatory network construction and validation

poster

Vasciaveo, Alessandro

Reversing lineage plasticity and drug resistance in lethal prostate cancer

poster

Vera Guapi, Loren Antonella

Time-separated combinatorial screens uncover directional dependencies among cancer druggables

poster

Waaben, Jens

Exploring the sub-diagnosis level effects of different active components in hormonal contraception

poster

Walhout, Marian

Genome-scale models of metabolic wiring and rewiring

talk

Wang, Emily

Simulating electron bifurcation hopping networks in bacterial [FeFe]-hydrogenase

poster

Wang, Wen

Evidence for genetic interactions as shared genetic risk factors for Parkinson’s and Alzheimer’s disease

poster

Wang, Yijie

Leveraging transcription factor physical proximity for enhancing gene regulation inference

poster

Wang, Zijian

Exploration of cascade behavior in higher-order networks

poster

Wanker, Erich E

The genotype-phenotype nexus—Uncovering causal mechanisms in neurodegenerative disease with experimental and theoretical approaches

talk

White, William L

Proofreading and single-molecule sensitivity in T-cell receptor signaling by condensate nucleation

poster

Wright, Lily

Single cell transcriptome hypergraph modelling of the fallopian tube epithelium identifies cellular specialisation and gene network associations with ectopic pregnancy

poster

Xi, Emma H

Crystal structure of the Orsay virus fiber knob reveals mechanisms for host receptor interaction

poster

Yi, Stephen

Systems-scale, population-level disease stratification and precision medicine prediction by transfer learning and functional variomics

talk

Yiasoumi, Georgia N

A Bayesian approach to building co-expression networks from multiple datasets

poster

Yuan, Hao

ICePop—Identifying disease-affected cell types through network-based analysis of gene module overexpression in single-cell data

poster

Zeng, Xin

Gene2role—A role-based gene embedding method for comparative analysis of signed gene regulatory networks

poster

Zhang, Lifang

Characterization of key regulators in microRNA-mediated responses to phosphate deficiency during Arabidopsis root development

poster

Zhang, Xiang

A deep learning approach for predicting genetic interactions in human cells

poster

Zhao, Yunwei

A bayesian framework for single-cell gene regulatory network discovery with contrastive learning

poster

Zitnik, Marinka

ProCyon—A multimodal foundation model for protein phenotypes

talk

Zubair, Ghania

Bioinformatics approaches to distinguish ipsilateral and contralateral retinal ganglion cell populations—Molecular signatures and computational strategies

poster