Gene Expression & Signaling in the Immune System
April 16 - 20, 2024

You must register for the meeting in order to submit abstracts.
After registering you will be sent a web link for abstract submission by email.
You may copy and paste your abstract from Word, Google Docs, or Notepad; abstracts are limited to ~2900 characters.

Program information: An electronic version of the program abstract book will be sent three working days prior to the first day of the meeting, and hard copies will be available for collection upon your arrival at Cold Spring Harbor Laboratory. First night and keynote speakers are informed of their session date and time, otherwise program information is only available upon release of the electronic version of the abstract book. The reason we do this is to try and maximize interactions by encouraging participants to stay for the duration of the meeting.

Please check your email for talk length, poster instructions, and how to have your poster printed at CSHL for collection upon arrival. 

Abstract Status

Presenting Author

Abstract Title

Talk/Poster

Alici, Aybuke

Epithelial YAP modulates intestinal immune surveillance through immune-stem crosstalk

poster

Alippe, Yael

Fetal MAVS and type I IFN signaling pathways control ZIKV infection in the placenta and viral persistence in the mother

poster

Alt, Frederick

Molecular basis for differential igκ versus Igh V(D)J joining mechanisms

talk

Anderson, Hope D

Eomes expression identifies the early bone marrow precursor to classical NK cells

talk

Arce, Maya

CD4+ T cell rest and activation is enabled by centralized control of state specific regulatory genes

talk

Ayres, Janelle S

Host-pathogen interactions—Harnessing co-evolution to treat disease

talk

Azad, Adiba I

IL-17C mediated crosstalk between cholangiocytes and MAIT cells in primary sclerosing cholangitis

poster

Bai, Lu

Ascorbate-TET axis regulates conventional T cell intrinsic self-tolerance

poster

Banerjee, Amitava

BATMAN—Improved T cell receptor cross-reactivity prediction benchmarked on a comprehensive mutational scan database

poster

Becker, Samuel H

CD4+ T cells recruit lung macrophages that restrict Mycobacterium tuberculosis in an MHCII-dependent manner

poster

Bernheim, Jacob M

BHLHE40 primes the chromatin landscape for ectopic gene expression to promote immune tolerance

poster

Beyaz, Semir

A metabolic switch that boosts immune cell fitness against cancer

talk

Bhargava, Hersh K

Synthetic rewiring of IL-2 signaling reveals design principles of the decision threshold for T cell responses.

talk

Bianchini, Filippo

Human monoclonal antibodies to the spike subdomain 1 neutralize SARS-CoV-2 and its variants of concern

poster

Boehm, Thomas

The evolutionary trajectory of vertebrate adaptive immune systems

talk

Borbet, Timothy C

A role for microRNA-29 regulation of B cell class switching and the development of atopic dermatitis

poster

Brambach, Max

Towards a dynamic understanding of regulatory niche formation

poster

Brito, Ilana

Gut bacteria elicit conserved transcriptomic states in macrophages across individuals

poster

Brodin, Petter

Immune system adaptation during gender-affirming testosterone treatment

poster

Brown, Chrysothemis

Regulation of oral tolerance by intestinal antigen-presenting cells

talk

Bunk, Paul

PPARδ promotes intratumoral Treg plasticity through fatty acid oxidation

poster

Cao, Anh

Long acyl chains as a primal molecular cue for identifying potential threats

talk

Carpenter, Stephen M

TCR clonotype analysis distinguishes antigen-specific human memory CD4+ T cells linked to recognition of macrophages infected with Mycobacterium tuberculosis

poster

Challman, Matthew F

Signaling control of microglia-mediated beta-amyloid uptake by cytosolic version of the  Polycomb Repressive Complex 2

poster

Chen, Erin

Engineering commensal-directed immunity for T cell vaccination

talk

Chen, Zeyu

Dissecting transcriptional circuit via single-base tuning on immune-related cis-regulatory elements

poster

Chisolm, Danielle A

The role of Paxbp1 in CD4+ T helper differentiation potential

talk

Chiu, Isaac

Nociceptor neuron regulation of barrier tissue immunity

talk

Chobirko, Jason D

Cis-regulatory activity of transposable elements in T cell development

poster

Choi, Joon H

Hyperactive dendritic cells and the control of virus infection

poster

Chu, Jiangbangrui

Understanding roles of fucoxanthin in treating Alzheimer‘s disease by both traditional 2D cell culture and 3D organoid culture using 3D bioprinting

poster

Chung, Charlie

A microbiome - MHC-II antigen presentation axis restricts metastatic colorectal cancer

poster

Colson, Tyler

Control of established autoimmunity by regulatory T cells epigenetically reprogrammed from autoreactive effector T cells

poster

Cortez, Victor S

ILC2 orchestrate gut tissue memory in response to type 2 inflammation

talk

Courvan, Edward

Hypoxia triggers widespread RNA decay in macrophages leading to modified inflammatory output

talk

Dash, Barsha

Regulation of CD8 T cell effector function by NFKBID

poster

DeKoter, Rodney

Role of transcription factor ETV5 in B cell differentiation and leukemia

poster

Du, Jasper

Structural insights reveal interplay between LAG-3 homodimerization, ligand binding, and function

poster

Dustin, Michael

Bispecific T cell engagers mind the gap and more

talk

Egawa, Takeshi

Terminally exhausted CD8+ T cells represent an independent lineage of CD8 T cells

talk

Farrar, Michael

Acute lymphoblastic leukemia coopts a stem cell surveillance program to elicit suppressive Tr1-like CD4 T cell responses that can be circumvented with PDL1-blockade

poster

Feldstein, Sam

Elucidating mechanisms of quorum-sensing-mediated immunosuppression by Streptococcus pyogenes

talk

Feng, Chuhan

Dual targeting PTPN1 and PTPN2 to augment human natural killer cells' anti-tumor cytolytic functions

poster

Fernandez-Saiz, Vanesa

OTUD4 is a novel target to regulate B-cell receptor and NF-kappaB signaling in immuno-oncology

poster

Gamble, Noah

Medullary thymic epithelial cells destabilize the chromatin landscape to promote promiscuous gene expression and impose immunological tolerance

poster

Ganapathi Sankaran, Divya

Swift or steady—Gene regulatory programs involved in age-related differences during thymocyte development

talk

Gao, Lei

Altered T cell profile in mice with Ezh2-deficient DCs modulates the CNS astrocyte and microglia

poster

Garcia, Christopher

Tuning immune receptor signaling

talk

Gottschalk, Rachel A

Systematic prediction and perturbation of phosphosites directing cytokine specificity

talk

Graziani, Andrea

Diacylglycerol Kinase alpha (DGKα) couples antigen-induced T cell activation to the negative feedback mechanism leading to TCR and CAR ubiquitination and lysosomal degradation

poster

Griffiths, Gillian

Curiouser and curiouser—Mapping events leading to CTL-mediated killing

talk

Guillemin, Karen

A microbiome-derived immunomodulatory protein counteracts host nutritional immunity

poster

Gumina, Megan

Investigating the role of S. aureus in cutaneous T cell lymphoma

poster

Guo, Xiaolu

Modeling the heterogenous NFκB dynamics of single immune cells

poster

Han, Ji Hye

Blockade of cannabinoid 1 receptor mitigates oxazolone-induced contact hypersensitivity in mice

poster

Hawley, Katrina

Transcriptional and epigenetic circuitries defining CD8 T cell stemness in the context of chronic antigen encounter

poster

Hegner, Courtney L

Mapping CAR transcriptional networks in CD4+ T cells

poster

Hilligan, Kerry L

Identification of two distinct Th2 effector subsets with unique developmental pathways and functional roles

poster

Ho, Ya-Chi

CD4+ T cell polarization, proliferation, and migration during chronic viral infection

poster

Hoffmann, Alexander

Distinct regulatory logics in PAMP-responsive de novo enhancer formation

talk

Hu, Hongli

Molecular basis for differential Igκ versus Igh V(D)J joining mechanisms

poster

Huang, Luqi

Understanding the cytosolic role of EZH2 and the immune environment evolution in triple-negative breast cancer

poster

Huang, Yuefeng

Recirculation of tissue-resident group 2 innate lymphoid cells

poster

Hullahalli, Karthik

Endogenous retroviruses control inflammatory responses during E. coli bloodstream infection

talk

Huse, Morgan

Single-cell topographical profiling of the immune synapse reveals a biomechanical signature of cytotoxicity

talk

Ichise, Hiroshi

Highly multiplex volumetric imaging Ce3D-IBEX reveals commensal-induced immune clustering along sensory nerves in the lung

talk

Iwasaki, Akiko

Immunology of Long COVID

talk

Jansen, Camden S

Inferring transcriptional mis-regulation in T-LGL leukemia through integration of highly dimensional multi-omic data

poster

Javaid, Azka

Single cell transcriptomics-level cytokine activity prediction and estimation (SCAPE) for human and mouse models

poster

Jiang, Ya

Unraveling the gene regulatory network of human naïve CD8+ T cells

poster

Jones, Joshua

Bacterial commensals elicit heterogeneous transcriptomic states in macrophages across individuals

poster

Jung, Jae

Necroptosis-mediated anti-viral immune response

talk

Kaku, Machika

Heterogeneity of interferon-β induction during Kaposi’s sarcoma-associated herpesvirus infection

poster

Kazzaz, Sarah A

Phosphorylation of aryl hydrocarbon receptor interacting protein by TBK1 negatively regulates IRF7 and the type I interferon response

talk

Kean, Connor

Understanding the gene regulatory mechanisms of bystander activation in CD8+ T cells at single cell resolution

poster

Kedmi, Ranit

Common mechanisms triggering Treg responses to dietary antigens and gut microbes

talk

Khan, Nadeem

Transcriptional programming of  CD8+ tissue resident memory following influenza infection

poster

Kim, Brian

Sensing inflammation in the skin and beyond

talk

Kim, Hosu

Distinct vaccination strategies divulge the shared immunome in the multi-omic integration analyses

poster

Kovaleva, Vasilisa

copepodTCR—Identification of antigen-specific T cell receptors with combinatorial peptide pooling

poster

Krappmann, Daniel

MALT1 paracaspase bifurcates antigenic signaling to coordinate transcriptional and post-transcriptional gene expression in lymphocytes

poster

Kruszelnicki, Sonia M

Microbiota-dependent lung stimuli shape alveolar macrophage signaling-to-transcription networks

poster

Kumar, Naveen

Non-canonical NF-κB signaling promotes intestinal inflammation by restraining the tolerogenic β-catenin-Raldh2 axis in dendritic cells

poster

Lafyatis, Robert

Single nucleotide resolution of transcription factor binding sites implicate USF1/MITF/TFE3/TFEB regulation of profibrotic macrophage gene expression

poster

Lengyel, Miklos

The G-protein coupled receptor OXER1 is a tissue redox sensor essential for the integrity of the intestinal mucosal barrier

talk

Leon Quinonez, Stephanie

OASL as a negative regulator of ADAR1-mediated RNA editing

poster

Leslie, Eric

PGAP3 promotes innate immune and antiviral responses in human bronchial epithelial cells

poster

Lewis, Steven

Infection accelerates Brca1 mammary tumorigenesis through induction of an immune-evasive tumor initiating cell population

poster

Licona-Limon, Paula

TIF1γ regulates stability of T regulatory cells during inflammation

poster

Lin, Bin

Expanded γδ T cells may contribute to inflammation and organ damage in patients with NEMO deleted exon 5 autoinflammatory syndrome

poster

Littman, Dan

Towards a logic for microbiota-directed immune system programming

talk

Longman, Randy

Bhlhe40 in group 3 innate lymphoid cells shapes innate and adaptive gut immunity

poster

Lynch, Adam

Dapl1 expression marks a novel subset of naïve T cells

poster

Lyu, Shuzhen

Activating a collaborative innate-adaptive immune response to enhance anti-tumor activity of hPSC-derived CAR-macrophages

poster

Ma, Claire

Single cell characterization of effector CTL’s response to signal strength

poster

Manakkat Vijay, Godhev K

Temporal dynamics and genomic programming of plasma cell fates

poster

Mangan, Matthew

Cytosolic sodium accumulation is a cellular danger signal triggering en-docytic dysfunction and NLRP3 inflammasome activation

talk

Mathis, Diane

Aire relies on Z-DNA to flag gene targets for thymic T-cell tolerization

poster

Mathur, Ramkumar

Regulation of the Foxp3+ mitochondrial transcription factor A in CD4+ T cell landscapes and immunological aging

poster

Mattoo, Seema

Interplay between AMPylation and bacterial infection

talk

McCarthy, Julia V

Structural correlates of T cell receptor specificity and cross-reactivity

talk

McCourt, Blake

C9orf72 in myeloid cells prevents an inflammatory response to microbial glycogen

poster

Medzhitov, Ruslan

A role of antigenic environment in allergic hypersensitivity

talk

Mehta, Naren U

Regulation of innate Tγδ17 cell plasticity by bZIP transcription factors

poster

Miakicheva, Svetlana

Molecular and spatiotemporal factors determining autoimmune T cell stemness and differentiation in type 1 diabetes

poster

Miao, Max

Investigating divergent T cell exhaustion trajectories driven by varied TCR signal strength

poster

Mitra, Sneha

Role of regulatory T cells in colorectal cancer

poster

Miyazaki, Masaki

The amplifier circuit of the E2A-Notch1 axis orchestrates T-cell lineage commitment and suppresses innate lymphoid cell development during the thymic ontogeny

poster

Momen-Heravi, Fatemeh

Elucidating the role of double negative T Cells in the pathogenesis of oral inflammation

poster

Mostanfar, Mehrpouya

Role of the transcription factor BHLHE40 in modulating inflammatory responses in human T lymphocytes

poster

Mucida, Daniel

Circadian control of duodenal regulatory T cells by enteric neurons and eosinophils

talk

Muljo, Stefan

Unexpected role of MATRIN3 (MATR3) in preventing an innate immune response

poster

Muralidhara, Prerana

Topoisomerase 1 regulates the development of lymphocytes

poster

Murphy, Kenneth M

Cis-dependent activity of sequentially acting enhancer constituents in the IRF8 superenhancer

talk

Murre, Cornelis

Molecular mechanisms that instruct polymorphonuclear cell development

talk

Myers, Samuel A

Post-translational modification-centric base editor screens to assess phosphorylation site functionality in high-throughput

poster

Nalawade, Saisha A

Human dendritic cell hyperactivation using CRN-1001 is an adjuvant strategy that enhances T cell responses

poster

Nowosad, Carla R

Tunable dynamics of B cell selection in gut-draining germinal centers

talk

Ou, Feiya

Optimization of the Irf8 +32 kb enhancer disrupts dendritic cell lineage segregation

poster

Oyler-Yaniv, Alon

The spread of interferon-γ in melanomas is highly spatially confined, driving non-genetic variability in tumor cells

poster

Ozcelik, Elif

Dietary regulation of tumor immune microenvironment

poster

Pal, Sujay

IκBζ is a dual-use coactivator of NF-κB and POU transcription factors

poster

Palm, Noah

A host-microbiota interactome reveals extensive transkingdom connectivity

talk

Park, Tyler

Uncovering the transcriptional and epigenetic landscape of tumor infiltrating lymphocytes in lung cancer through multimodal single-cell analysis

poster

Pasare, Chandrashekhar

Dendritic cells integrate PRR signaling with stress sensing to drive pathogen-specific Th17 responses

talk

Pease, Nicholas A

Dynamic transcription factor networks regulating divergent human B cell fates

poster

Peng, Dingkang

Foxp3 M370I mutation allows the activation of T effector programs in regulatory T cell

poster

Pieters, Jean

Coronin 1-dependent cell density sensing and the regulation of peripheral T cell populations

poster

Poholek, Amanda C

Spatial microniches of IL-2 synergize with IL-10 to drive lung migratory Th2 cells in response to inhaled allergen

poster

Randolph, Gwendalyn J

Tissue folds enriched in lymphatic vessels and lymphoid follicles orchestrate interstitial outflow from the colon

talk

Riesenfeld, Samantha J

Modeling continuous immune cell states and their transcriptional dynamics

poster

Robey, Ellen

T cell fate in the thymus—A multiomics approach

talk

Ron, Eric

Integrating single-cell experiments and stochastic models to understand and predict glucocorticoid receptor transport and DUSP1 mRNA expression dynamics

poster

Roodveldt, Cintia

A new role of MOK signaling kinase by linking microglial inflammatory responses with cellular metabolism and autophagy

poster

Roodveldt, Cintia

Integrated gene expression and signaling pathways reveal functional ADNP protein (activity-dependent neuroprotective protein) roles in microglia—Potential implications in neurodegeneration

poster

Rose, Samuel A

Learning contextual determinants of cytokine gene programs during immunity

poster

Sallusto, Federica

Clonal diversity of human effector and memory T cells—Extending to regulatory T cells

talk

Sanyal, Sulagna

Exploring the YY1-controlled mechanisms influencing B-cell lineage commitment

poster

Sato, Kazuki

Identification of fractalkine/FKN as a novel receptor to promote transendothelial migration of leukocytes

poster

Scharping, Nicole

Protein homeostasis enables T cell differentiation potential and sustains TIL function in cancer

talk

Schernthanner, Marina

Decoding stem cell:niche crosstalk in the intestine during postnatal development

poster

Schietinger, Andrea

Molecular and spatiotemporal factors defining CD8 T cell stemness and differentiation

talk

Scott, Milcah C

Deep residence profiling deconstructs programs associated with memory CD8 T cell migration

poster

Shah, Vyom

Nutritional regulation of intestinal epithelial-immune crosstalk

poster

Sharma, Utkarsh

New ultrasensitive assay to measure host immune profile from feces

poster

Sheridan, Ryan M

Dynamics and determinants of antigen archiving in lymphatic endothelial cells

poster

Shin, Boyoung

Runx factors launch T-cell and innate lymphoid cell programs via direct and gene network-based mechanisms

talk

Shittu, Adenike R

The role of AP-1 in the rapid recall ability of memory T cells

poster

Shukla, Vipul

Arid1a-dependent canonical BAF complex suppresses inflammatory programs to maintain germinal center homeostasis

poster

Sifakis, Joseph J

GATA4-mediated intestinal regionalization shapes Peyer's patch functionality and tissue immunity

poster

Sivasudhan, Enakshi K

Investigation of the epitranscriptomic role of hepatitis B virus X protein-mediated immune evasion mechanisms in liver cancer cell and tumour-associated macrophage in vitro models

poster

Smart-Marshall, Germaine

Characterizing the interactions of ketogenic high fat diet, microbiome, and colon cancer

poster

Srivastava, Tamanna

Ubiquitin specific peptidase 18 (USP18) promotes Severe acute respiratory syndrome coronavirus 2 infection

poster

Su, I-Hsin

The role of Setd3 in regulating B cell receptor signaling

poster

Su, Laura

Long-lasting CD4+ T cell memory after yellow fever virus vaccination

poster

Subramanian, Ayshwarya

Immune checkpoint molecule Tim-3 regulates microglial function and the development of Alzheimer’s disease pathology

poster

Taniuchi, Ichiro

Phosphorylation of Runx proteins controls thymocyte fate

talk

Tashi, Zeinab

Lipid metabolic readouts in humanized models of neuroimmune function

poster

Titelbaum, Moran

The involvement of polycomb group proteins in the regulation of gene expression in T-helper Cells

poster

Tomaskovic, Ines

A crosstalk between unrepaired DPCs and immune signaling

talk

Ucar, Duygu

Distinct baseline immune characteristics associated with responses to conjugated and unconjugated pneumococcal polysaccharide vaccines in older adults

poster

Umhoefer, Jennifer M

Understanding regulatory T-cell identity to inform better regulatory T cell therapies

poster

Upadhyay, Rabi

Harnessing human gut-derived Bacteroides to drive systemic anti-tumor immunity

poster

Vaidehi Narayanan, Haripriya

Direct observation correlates NFκB cRel in B cells with activating and terminating their proliferative program via nonlinear control of cMyc induction

poster

Valenca-Pereira, Felipe

Inactivation of GSK3βby Ser389 phosphorylation prevents thymocyte necroptosis and impacts Tcrβ and Tcrα repertoire diversity

poster

van der Leun, Anne M

The impact of DNA methylation changes on CD8+ T cell fate and function

poster

van Ooijen, Hanna

Molecular pixelation—Dissecting the spatial organization of 80 surface proteins in single immune cells

poster

Vlachou, Evi

Macrophages in bone marrow remodeling—Constructing the gene regulatory networks of cellular crosstalk.

poster

Vyas, Shachi

RNA translation regulation in activated CD4+ T cells

poster

Wang, Xinxin

Onco-circuit addiction and nutrient mTORC1 signaling vulnerability in a model of aggressive T cell malignancy

poster

Wang, Yutao

Unveiling nuclear receptor functions in the immune system—Distinct control of large peritoneal macrophages by RXRα and RARγ

talk

Webb, Carol

ARID3a is expressed in a subset of human chronic lymphocytic leukemia samples and is required for maintenance

poster

Weiss, Felix D

Strain-specific regulation drives NLRP1 hypersensitivity in Nlrp3-/- macrophages

poster

Wilder, Catera

Dynamic control of signaling networks—Uncovering specificity in interferon-mediated cellular responses through coordinated positive feedback loops

poster

Winer, Benjamin Y

Membrane abundance dictates phagocytic capacity and functional crosstalk in myeloid cells

poster

Wolkers, Monika C

Learning the sequence code for protein abundance in human immune cells

poster

Wu, Jinghua

Impaired pathogen-specific CD4+ T cell functionality in patients with CLL

poster

Xie, Xuan

Eos is a critical transcription factor for T regulatory cell (Treg) function

poster

Yablonski, Deborah

Survival and developmental progression of unselected thymocytes in the absence of the T cell adaptor GADS

poster

Yang, Chin-An

The potential role of solute carrier transporters in cold-aggravated juvenile idiopathic arthritis

poster

Yassini, Nima

Memory Th1 cells modulate heterologous diseases through innate function

poster

Ye, Jimmie

Human ERAP2 polymorphisms elicit differentiated antigen processing in response to virus

talk

Yomogida, Kentaro

AIOLOS restrains activation of intraepithelial lymphocytes

poster

Zhanzak, Zhuldyz

Epitope mapping and characterization of indirect CD4+ T cells in transplantation enable the therapeutic potential as tolerizing peptide-immunotherapy

poster

Zhou, Xu

pH-dependent regulation of inflammatory response via transcriptional condensates

poster

Zhu, Xiaoliang

Optimal CXCR5 expression during Tfh maturation involves the Bhlhe40-Pou2af1 zxis

poster

Zhu, Yongchang

The role of the CTCF binding site EACBE in Tcrd V(D)J recombination

poster