Germ Cells
October 4 - 8, 2022

You must register for the meeting in order to submit abstracts.
After registering you will be sent a web link for abstract submission by email.
You may copy and paste your abstract from Word, Google Docs, or Notepad; abstracts are limited to ~2900 characters.

Program information: An electronic version of the program abstract book will be sent three working days prior to the first day of the meeting, and hard copies will be available for collection upon your arrival at Cold Spring Harbor Laboratory. First night and keynote speakers are informed of their session date and time, otherwise program information is only available upon release of the electronic version of the abstract book. The reason we do this is to try and maximize interactions by encouraging participants to stay for the duration of the meeting.

Please check your email for talk length, poster instructions (in-person and virtual), and how to have your poster printed at CSHL for collection upon arrival. 

Abstract Status

Presenting Author

Abstract Title

Presentation

Amoyel, Marc

Metabolic support of germ cell survival by somatic cyst cells in the Drosophila testis

poster

Barton, Lacy J

Old hormones, new tricks—Juvenile hormones ensure germ cells populate the embryonic somatic gonad

poster

Belew, Mezmur D

A novel global chromatin compaction (GCC) pathway silences the genome in maturing Caenorhabditis elegans oocytes

talk

Bhandari, Nirajan

5'-tyrosyl-DNA phosphodiesterase 2 (tdpt-1) is required for meiotic fidelity through suppression of a Topoisomerase 2 (top-2) mutation in C. elegans

poster

Blundon, Joshua

SKP1 proteins promote the assembly of the synaptonemal complex in C. elegans

poster

Bodas, Devavrat

Investigating the connection between P granules and RNAi in C. elegans

poster

Bosco, Giovanni

Germline-neuroendocrine signaling, stem cell proliferation and development in Drosophila

talk

Butsch, Tyler

VCP acts downstream of tTAFs to downregulate mono-ubiquitinated H2A and permit spermatocyte differentiation

poster

Cahoon, Cori

Sexually dimorphic regulation of meiotic recombination by the C. elegans synaptonemal complex proteins

poster

Cassani, Madeline

P-bodies are required for germ cell fate in C. elegans embryos

talk

Chakraborty, Prabuddha

Chromatin remodeler INO80 regulates meiotic sex chromosome inactivation during mouse spermatogenesis

poster

Chatterjee, Pranam

Efficient human oogonial germ cell specification from stem cells via combinatorial expression of transcription factors

talk

Chavan, Ankita

Stonewall links chromatin organization at the nuclear periphery to female germline stem cell fate in Drosophila

talk

Chen, Jingxun

A short-lived killifish model for studying the intersection between aging and reproduction

poster

Chen, Peiwei

Genetic control of a sex-specific piRNA program

talk

Chen, Ruoyu

Structure-function study of germ granule-mediated translational de-repression

poster

Chen, Xin

Breaking symmetry—Asymmetric histone inheritance in Drosophila male germline stem cells

talk

Crittenden, Sarah

C. elegans FBF directly represses gld-1 RNA in germline stem cells and activates gld-1 RNA in their daughters during meiotic entry

poster

Crown, Nicole

Mechanisms of crossover suppression by heterozygous inversion breakpoints

poster

Cummings, Ryan

Investigating CG3548 as a potential physical link between chromocenters and the nuclear envelope in Drosophila

poster

Das, Debabrata

ERK links nutritionally regulated signaling and meiotic progression by regulating HORMA domain protein HTP-1 to control synapsis formation and maintenance

talk

de Cuevas, Margaret

Homothorax is enriched in the adult Drosophila testis hub and is essential for its maintenance.

poster

DiNardo, Acadia

Sexually dimorphic Argonaute protein organization within P-granules affects C. elegans fertility

poster

Draper, Bruce

Single-cell transcriptome of the zebrafish ovary reveals novel insights into ovary development and function

talk

Drummond-Barbosa, Daniela

Warm and cold temperatures have distinct germline stem cell lineage effects during Drosophila oogenesis

talk

Ellis, Ronald

Rewiring TRA-1 regulation and the control of the sperm/oocyte decision during nematode evolution

poster

Ferdous, Ahlan

LST-1 is a bifunctional regulator of C. elegans germline stem cells

talk

Fingerhut, Jaclyn

Co-transcriptional splicing of gigantic introns during Drosophila spermatogenesis

poster

Flynn, Jullien M

The role of Bloom helicase in satellite DNA instability across aging and multiple generations in Drosophila melanogaster

poster

Fontan, Adrienne

Intronic satellite DNA expression and role in Drosophila hybrid sterility

poster

Gao, Ming

A mutational approach to analyze RNA helicase Me31B’s in vivo working mechanism in Drosophila fertility and germline development

poster

Gassler, Johanna

Orphan nuclear receptors are required for major zygotic genome activation in murine embryos

talk

Gavis, Elizabeth

Assembly and plasticity of Drosophila germ granules

talk

Gillen, Matthew J

Role of microtubule motor adaptor proteins in controlling mitochondrial inheritance and quality

poster

Gleason, Ryan J

Developmentally programmed epigenome regulates cellular plasticity at the parental-to-early embryo transition

talk

Greenblatt, Ethan

The loss of translation of long-lived mRNAs during oocyte storage represents an Achilles' heel of meiotic spindle integrity and oocyte viability

talk

Grill, Sherilyn A

Uncovering the mechanisms that protect and maintain germ cell totipotency

poster

Grobicki, Katarina

The evolution of ribosomal protein paralogues and their contribution to translational regulation during germline development

poster

Gupta, Nilay

Morphological changes in an aging germline stem cell niche

poster

Hakim, Bilal A

Investigating the role of Nemp1 in maintaining the ovarian reserve and oocyte competence

poster

Hamazaki, Nobuhiko

Reconstitution of the oocyte transcriptional network with transcription factors

poster

Harbin, Jonathan

Manipulating sex determination in Caenorhabditis tetraploids to evaluate Haldane’s rule

poster

Hatkevich, Talia

The RNA-binding protein DND1 may ensure proper germ cell development through the translational regulation of nuclear protein NuMA1

talk

Hayashi, Katsuhiko

Reconstitution of gametogenesis using pluripotent stem cells

talk

Hayashi, Masafumi

Robust induction of primordial germ cells of white rhinoceros on the brink of extinction.

talk

Heemskerk, Idse

Efficient differentiation of human primordial germ cell like cells in micropatterned stem cell colonies reveals a key role for Nodal signaling

talk

Hobbs, Robin M

Molecular controls of male germline maintenance and regeneration

talk

Holthenrich, Anna

Cortical plasticity during zebrafish egg activation

talk

Hsu, Hweijan

Excess sugar impairs stem cell function

virtual poster

Hurd, Thomas R

Mitochondrial DNA quality control in the female germline requires a unique programmed mitophagy

talk

Ikami, Kanako

Oocytes from juvenile mice have high levels of chromosome segregation errors due to excess cohesin

poster

Ikeda, Tatsuro

Clonal dynamics in the murine male germline—From primordial germ cells to spermatogonial stem cells, and the next generation

talk

Imai, Atsuki

Embryonal carcinoma cells arise by conversion of PGCs to pre/early-gastrulation-stage epiblast in Dnd1-cKO embryos

virtual poster

Ishiguro, Kei-ichiro

The sexually different mechanism of initiation of meiosis in mouse germ cells

talk

Issigonis, Melanie

A non-ribosomal peptide triggers sexual development in the planarian Schmidtea mediterranea

poster

Jansen, Gloria

DNA damage control in Drosophila germline development

talk

Kao, Jonchee

Exploring the roles of germ cell-less in germ line development of the milkweed bug Oncopeltus fasciatus

poster

Keiper, Brett

Germ cell mRNAs are regulated by translation factors and Vasa/GLH-1 mRNP complexes in P granules

poster

Kennedy, Scott

poly(UG)-tailed RNAs in genome protection and epigenetic inheritance

talk

Kern, Beth

Investigating F-actin destabilization at RCs during tumorigenesis in the Drosophila male germline

poster

Ketting, Rene

The nuclease complex PUCH processes piRNA 5’ ends in C. elegans

talk

Kharel, Kabita

Building the large solitary germ granule in the embryos of the wasp Nasonia vitripennis

talk

Kim, Jongmin

Cell type-specific role of CBX2-cPRC1 at the onset of spermatogonial differentiation

poster

Kitajima, Tomoya S

Roles of the two-pronuclear state in zygotes

talk

Koornneef, Lieke

Multi-color dSTORM microscopy in Hormad1-/- spermatocytes reveals alterations in meiotic recombination intermediates and synaptonemal complex structure

poster

Kosinski, Kaitlin E

Autophagy in meiotic fidelity and genome integrity

virtual poster

Kotb, Noor

Ribosome biogenesis promotes heterochromatin maintenance to regulate germ cell to oocyte transition

talk

Kumon, Tomohiro

Ribosomal DNA instability as a potential cause of karyotype evolution

poster

Kurlovich, Julia

Primordial germ cell differentiation from marmoset induced pluripotent stem cells

poster

Kwah, Ji Kent

Understanding the roles of sperm supplied SPE-11 and its novel oocyte partner, OOPS-1, in C. elegans egg activation

poster

Laird, Diana J

Linking heterogeneity in fetal development to oocyte fate

talk

Lee, Heng-Chi

CGH-1 RNA helicase regulates the phase separation and organization of germ granules to promote the transgenerational inheritance of gene silencing in C. elegans

poster

Lei, Lei

Branched germline cysts and female-specific cyst fragmentation patterns facilitate oocyte fate determination in mouse germline cysts

talk

Llewellyn, Darren R

Perturbing germ cell population size to investigate the conversation between germ cells and somatic cells

poster

Ma, Binbin

Histone inheritance patterns in asymmetrically dividing mouse spermatogonial stem cells

poster

Mahadevaraju, Sharvani

Non-autonomous somatic cues are necessary for the XY germ cell to undergo spermatogenesis

poster

Maine, Eleanor

Complex roles for poly(U) polymerases in regulating RNA abundance and germline and embryonic development in C. elegans

poster

Maniataki, Elisavet

Complicity of piRNA loci and/or precursors in nuclear coherence—Guilty by imagination?

virtual poster

Manske, Gabriel

Sex-specific differences in germline centromere strength are equalized via asymmetric CENP-A deposition in the early embryo

talk

Marlow, Florence L

Prefollicle cell sentinels trigger macrophage activation and sex-reversal in zebrafish

talk

Mathieu, Juliette

Regulation of abscission in Drosophila germline cells

poster

McHugh, Leah

Investigating the role of the subcortical maternal complex in DNA methylation patterning in the oocyte and cleavage-stage embryo

poster

McNeill, Helen

Nuclear envelope membrane protein 1 (NEMP1) is required for mammalian oocyte nuclear envelope organization, chromatin compaction and developmental competence

talk

Melendez, Alicia

Distinct heparan sulfate modification patterns control proliferation and differentiation of germline stem cells in Caenorhabditis elegans

talk

Meng, Xuefeng

Investigate the role of satellite DNA in Drosophila speciation

poster

Mercer, Marianne

Bourbon interacts with Otu and promotes the expression of Sxl in the Drosophila female germline

poster

Mikhalchenko, Aleksei

Toward the generation of haploid oocytes by somatic cell nuclear transfer: a road less traveled by

poster

Min, Hyemin

The conserved role of BYN-1/Bystin in cellular uptake and clearance in the C. elegans germline

poster

Monteiro, Vernon L

Ataxin-2 regulates meiotic entry and progression in female Drosophila germ cells

poster

Mueller, Jacob L

The sequence and evolution of a t-haplotype, a selfish mouse chromosome

poster

Munakata, Yasuhisa N

The chromatin remodeler CHD4 is required to maintain the ovarian reserve in postnatal mice

virtual poster

Naitou, Yuki

Dual role of Ovol2 in PGC specification during embryogenesis

poster

Navarro-Costa, Paulo

The conserved genetic program of male germ cells uncovers ancient origins of human infertility

virtual poster

Nelson, Jonathan O

The retrotransposon R2 maintains ribosomal DNA in the Drosophila male germline

talk

Newmark, Phillip

A non-ribosomal peptide triggers sexual development in the planarian Schmidtea mediterranea

talk

Niepielko, Matthew G

Germ granule analysis reveals conserved and diverse features among Drosophila species

poster

Niu, Wanbao

Mouse oocytes develop in cysts with the help of nurse cells

talk

N'tumba-byn, Thierry

High-throughput screening of meiotic gene mutants through germ line stem cell transplantation

poster

O'Carroll, Donal

piRNA-directed transposon DNA methylation during mammalian germline development

talk

Ortega, Jacob M

C. elegans PIWI regulates meiotic pairing and DNA double-strand break formation during spermatogenesis to control fertility

talk

Oulhen, Nathalie

Evolution of germline gene regulations in echinoderms

poster

Ozpolat, Duygu

Germ cell regeneration in Annelids

poster

Pamula, Melissa C

Identifying regulators of mitochondrial segregation during primordial germ cell formation

poster

Park, Jun

Modulo/nucleolin functions to repress Y-linked protamine-like genes to prevent meiotic drive in D. melanogaster

talk

Patel, Bhumil

Understanding meiotic crossover control via PCH-2

poster

Pathak, Madhulika

Fusome-like structure during mouse germline cyst development

poster

Pauli, Andrea

Regulatory mechanisms of dormancy during the egg-to-embryo transition

talk

Payer, Bernhard

Controlled X-chromosome dynamics defines meiotic potential of female mouse in vitro germ cells

poster

Peters, Antoine

Histone demethylases KDM2A/2B safeguard the oocyte methylome and embryonic development

talk

Petrella, Lisa N

Investigating the role of germ granules across the Caenorhabditis phyla in thermal limits of fertility

poster

Phillips, Carolyn M

Regulation of gene expression by small RNAs

talk

Pozmanter, Caitlin

Tudor5-like promotes germline differentiation through post-transcriptional gene regulation and maternal RNA regulation

talk

Price, Kari L

Evolutionarily conserved midbody reorganization precedes ring canal formation during gametogenesis

talk

Puchkina, Arina

Retrospective gene expression analysis during mouse embryonic development for optimization of in vitro Sertoli cell differentiation

poster

Raz, Amelie

Asymmetric transcript abundance in germline stem cell division

poster

Raz, Erez

Control of cell fate by Dnd1-dependent mRNA localization within phaseseparated condensates

virtual talk

Reis Matias, Neuza

Preventing a promiscuous transcription factor from activating cryptic promoters during spermatocyte differentiation

talk

Roach, Tiffany V

Investigating stem cell coordination in the Drosophila testis niche

poster

Sadanandappa, Madhumala

Parasitoid stress signaling regulates Drosophila germline development

poster

Saga, Yumiko

How NANOS2 represses cell cycle in mouse male germ cells

talk

Saiduddin, Mariyah

Germ cell formation is suppressed by RalA, a Ras effector

poster

Salz, Helen

Germ cell sex and H3K9me3-mediated gene silencing

poster

Sarkar, Kahini

A feedback loop between heterochromatin and the nucleopore complex controls germ-cell to oocyte transition during Drosophila oogenesis

poster

Schisa, Jennifer

The roles of phosphorylation and protein folding in regulating RNP granule condensates during oogenesis

poster

Scholl, Alyshia

A TRIM32-like E3 ubiquitin ligase is required in parallel to Nanos to specify PGCs in C. elegans

talk

Schreier, Jan

PEI granules mediate paternal epigenetic inheritance in Caenorhabditis elegans

talk

Schwartz, Aaron Z

Independent regulation of mtDNA quantity and quality resets the mitochondrial genome in C. elegans primordial germ cells

talk

Sharma, Manju

GFRA1-GDNF signaling is mediated by HS/HSPGs in spermatogonial stem cells

talk

Shimada, Ryuki

The sexually different mechanism of initiation of meiosis in mouse germ cells

poster

Siegfried, Kellee R

Regulation of germ line stem cell function by the RNA binding protein Adad1 in zebrafish

talk

Simmons, William R

Proteomics of P granules reveals a link to translational repressors including the microRNA RISC complex

poster

Skrutl, Lena

Pericentromeric satellite DNA repeats promote non-homologous centromere clustering in Drosophila

poster

Soyalan, Olcay

Regulation of RNA polymerase II elongation during the mammalian oocyte-to-embryo transition

poster

Spaulding, Emily L

The C. elegans homologs of Nucleolin and GAR1 contribute to sub-nucleolar phase separation in germ cells through their intrinsically disordered RG/RGG repeat domains

poster

Sposato, Andrea L

​Zebrafish spermatogonial stem cells cycle between active and silent states during sperm production

talk

Strome, Susan

Inherited chromatin states shape transcription patterns in offspring and grandoffspring

talk

Subramaniam, Kuppuswamy

Nutritional signalling and Nanos regulate translational activation in C. elegans PGCs 

poster

Subrini, Jeremie

Dissection of Y-gene functions in mouse spermatogenesis

talk

Suzuki, Atsushi

Loss of Dead end1 induces testicular teratomas from primordial germ cells that fail to undergo sexual differentiation in embryonic testes

virtual poster

Szabo, Piroska E

Transcription across the H19/Igf2 imprinting control region initiates paternally methylated imprinting in mouse prospermatogonia

poster

Tang, Shaogeng

Human sperm TMEM95 binds eggs and facilitates membrane fusion

talk

Tezak, Boris M

Germ cell number may explain adaptive significance of temperature dependent sex determination

talk

Thomalla, Jonathon

Calcium-mediated phosphoproteome regulation during egg activation in mice and flies

poster

Tolkin, Theadora

A passive “hitch and tow” mechanism for cell shape change in the adult C. elegans germline stem cell niche

poster

Trimmer, Kenneth

TOR and insulin signaling regulate a nutritional G2/M checkpoint in the C. elegans adult hermaphroditic germline progenitor zone cells

poster

Tzur, Yonatan B

lincRNA promote germline stem cells differentiation via sequestering of PUF proteins

poster

Uebel, Celja J

COSA-2—A newly identified protein required for crossover formation during Caenorhabditis elegans meiosis

poster

Updike, Dustin L

GLH-1/Vasa represses neuropeptide expression and drives spermiogenesis in the C. elegans germline

poster

Venkat, Shruti

Nicknack facilitates germ-cell to oocyte transition in female Drosophila

poster

Vida, Gabriela S

Identifying factors that maintain a stem cell niche

poster

Villeneuve, Anne

Promoting and ensuring crossover recombination during C. elegans meiosis

talk

Wallis, Dylan C

Regulation of C. elegans Argonaute proteins by arginine dimethylation

poster

Warder, Bailey N

The cytoskeletal mechanics that shape a stem cell niche

poster

Watase, George

Mechanism of rDNA copy number maintenance by rDNA binding protein Indra in Drosophila male germline

poster

Whelan, Eoin C

Comparison of fertile and infertile mouse testes by single-cell RNA-sequencing reveals interactions between somatic and germ cells

poster

Whelan, Eoin C

Single-cell multiomic analysis of rat spermatogenesis reveals novel regulatory mechanisms

talk

Yang, Guanghui

eIF4E1b regulates maternal RNA translation to ensure zygotic genome activation

poster

Yin, Qi

Theca cells from wave 1 follicles likely contribute to the onset of puberty

poster

Zhao, Jenny

Loss of piRNA binding alters PRG-1 function, expression, and localization in C. elegans

poster