|
Presenting Author |
Abstract Title |
Talk/Poster |
|
Ajit, Deepa |
A conformationally distinct tau mutant alleviates toxicity in mice |
poster |
|
An, Disi |
Stem cell-derived cranial and spinal motor neurons reveal proteostatic differences between ALS resistant and sensitive motor neurons |
poster |
|
Ansari, Aseem Z. |
Designing a new class of SynTF-based therapeutics for neurodegenerative diseases |
poster |
|
Apicco, Daniel |
Activity-dependent secretion of α-synuclein protects against neuropathology in primary neurons |
poster |
|
Baekelandt, Veerle |
In vivo characterization of distinct patient-derived α-synuclein assemblies/strains |
poster |
|
Balasundaram, Padmanabhan |
Discovery of the oxidation inhibitors of human superoxide dismutase I (hSOD1) by rational approach—A potential therapeutic target for ALS |
poster |
|
Bennett, Frank |
Antisense oligonucleotide based therapies for neurological diseases |
talk |
|
Boland, Sebastian |
Progranulin deficiency results in cellular accumulation of acidic glycosphingolipids |
talk |
|
Borbolla Jimenez, Fabiola V |
Design and characterization of rapamycin-loaded-PLGA nanoparticles for potential treatment of spinocerebellar ataxia type 7 |
poster |
|
Borchelt, David |
Prion-like characteristics of ALS caused by mutations in superoxide dismutase 1 |
talk |
|
Brennan, Melanie S |
APOE4-dependent cellular phenotypes in hIPSC-derived astrocytes |
poster |
|
Cahn-Hidalgo, Diego |
Comparison of the Cognivue® quantitative assessment tool and SLUMS to classify the risk of cognitive impairment |
poster |
|
Cahn-Hidalgo, Diego |
Validity, reliability, and psychometric properties of Cognivue®, a quantitative assessment of cognitive impairment |
poster |
|
Cai, Yifei |
Decoding competing endogenous RNA regulations in Alzheimer’s disease |
poster |
|
Chang, Yung-Heng |
Glial retrotransposon activation contributes to non-cell autonomous neurodegeneration in a Drosophila TDP-43 model of ALS |
poster |
|
Chen, Ping-Chung |
Neuronal expression of Alzheimer’s disease-associated U1-70K cleavage product causes splicing dysfunction and cognitive impairment in mice |
poster |
|
Cho, Yoonsuk |
Characterization of TG as a BACE1 inhibitor in Alzheimer’s disease |
poster |
|
D'Abramo, Cristina |
AAV-mediated peripheral administration of recombinant scFv anti-tau antibody MC1 reduces insoluble tau phosphorylation in a transgenic model of tauopathy |
poster |
|
Daniel, Dianne |
Effects of Pur-alpha and a Pur-based peptide upon G-quadruplex structure in expanded polynucleotide repeats of a neurological disease spectrum, ALS/FTD |
poster |
|
Das, Arupratan |
Human RGCs and their precursor stem cells differ in how they degrade their mitochondria using proteasomal and the lysosomal pathways |
poster |
|
Das, Sromona |
Bromelain derived peptides—A novel agent in amyloidal fibril destabilization |
poster |
|
Dawson, Ted M. |
Poly (ADP-ribose) (PAR) drives the pathogenesis of PD |
talk |
|
Deb, Bipan K |
Septin modulate neuronal Ca2+ homeostasis |
poster |
|
Dieriks, Victor B |
α-synuclein transmission by non-neuronal cells in the human Parkinson’s disease brain |
poster |
|
Duff, Karen |
Accumulation and propagation of tauopathy—-Mechanisms and therapeutic opportunities |
talk |
|
El gaamouch, Farida |
VGF and its C-terminal peptide TLQP-21 modulate Alzheimer's disease phenotype via C3aR1 activation in the 5XFAD mouse |
poster |
|
Eliasova, Barbora |
Pin1 regulates stability and solubility of CDK5 phosphorylated CRMP2A |
poster |
|
Fares, Mohamed Bilal |
Assessment of potential neuroprotective effects of nicotine in a human dopaminergic in vitro model of Parkinson’s disease |
poster |
|
Farsi, Zohreh |
Functional mapping of spontaneous and evoked neurotransmission reveals intersynaptic heterogeneity |
poster |
|
Ferguson, Shawn M |
Pleiotropic requirements for human TDP-43 in the regulation of organelle homeostasis |
poster |
|
Fernandes, Alinda |
Identifying targets for enhancing TDP-43 clearance in ALS and FTD |
poster |
|
Fernandez, Uxoa |
Insights into ALS from the silencing of TDP43, FUS and SOD1 |
poster |
|
Fernandopulle, Michael S |
Annexin A11 mediates axonal trafficking of RNP granules via endolysosomal hitchhiking |
talk |
|
Fishilevich, Elane |
Intrathecally-delivered siRNA conjugates lead to robust and durable silencing in the central nervous system |
poster |
|
Foley, Kate E |
Preventing cerebrovascular decline in humanized APOEε4 mice |
poster |
|
Fowler, Stephanie L |
Investigating regional and disease-specific tau strains in human AD and CBD post-mortem brain tissue |
poster |
|
Friedman, Brad |
The transcriptional landscape of brain myeloid cells reveals gene expression responses associated with diverse myeloid cell types and cellular states |
talk |
|
Gale Hammell, Molly |
Awakening old foes—Transposon de-silencing in ALS patient tissues |
talk |
|
Gilch, Sabine |
Prion-induced membrane cholesterol accumulation and impaired endocytic vesicle trafficking—New targets for treatment of prion disease |
poster |
|
Gitler, Aaron |
RPS25 regulates RAN translation of C9orf72 repeat expansions |
talk |
|
Grima, Jonathan C |
Specific components of nucleocytoplasmic transport are disrupted in C9orf72-ALS/FTD and can be rescued with antisense therapy |
poster |
|
Grubman, Alexandra |
Distinct microglial subtypes in Alzheimer’s disease are controlled by plaque phagocytosis |
poster |
|
Guzman-Ramos, Kioko R |
Serum levels of glial fibrillary acidic protein in elderly patients with cognitive decline |
poster |
|
Haure-Mirande, Jean-Vianney |
Integrative approach to sporadic Alzheimer’s disease—Deficiency of driver Tyrobp in cerebral Aβ amyloidosis and tauopathy mouse models normalizes clinical phenotype and complement subnetwork molecular pathology despite a paradoxical evolution |
poster |
|
Havrda, Matthew C |
Clinical manifestations of inflammasome activity in Parkinson’s disease |
talk |
|
Heneka, Michael T |
NLRP3 mediated innate immune mechanism in neurodegenerative disease |
talk |
|
Hopkins, Paul |
The TMCC2/Dementin protein family—A potential route to a better understanding of the contribution of apolipoprotein E to Alzheimer’s disease |
poster |
|
Hu, Fenghua |
The role of C9orf72 complex in AKT/MTORC1 signaling, lysosome biogenesis and tissue homeostasis |
talk |
|
Huang, Shih-Ling |
Distinct ALS-TDP pathogenesis in knock-in mouse models with different ALS-associated TDP-43 mutations |
poster |
|
Ibrahim, Fadia F |
Ribothrypsis—Unveiling a novel RNA decay process and implications for gene expression profiling |
poster |
|
Jiang, Ke |
Mitochondria defects represent an early step in retinal degeneration |
poster |
|
Joachimiak, Lukasz A |
Native tau structure is disrupted by disease-associated mutations that promote aggregation |
poster |
|
Johansson, Jan |
Bri2 BRICHOS passes the blood brain barrier and efficiently reduces Aβ42 neurotoxicity |
poster |
|
Kampmann, Martin |
Elucidating cellular mechanisms controlling tau aggregation and spreading using CRISPRi and CRISPRa functional genomics in human iPSC-derived neurons |
talk |
|
Kashikar, Nachiket D |
Screening of synaptic modulators with a novel high-throughput imaging platform |
poster |
|
Kastanenka, Ksenia V |
Aberrant circuit dynamics in an Alzheimer’s animal model |
talk |
|
Klenerman, David |
The role of Prion-like spreading in Alzheimer’s and Parkinson’s disease |
poster |
|
Kocovski, Pece |
Platelet targeting alleviates anxiety-like-behavior in the experimental autoimmune encephalomyelitis model of multiple sclerosis |
poster |
|
Kour, Sukhleen |
MicroRNA processing factor Drosha modulates FUS-mediated neurodegeneration via GSK3beta |
poster |
|
Kraus, Allison |
Seeding selectivity and ultrasensitive detection of tau aggregate conformers of Alzheimer’s disease |
talk |
|
Kuo, Szu-Yu |
Novel cellular model for the characterization of mechanisms regulating free tau homeostasis |
poster |
|
Kwon, Sunkuk |
Imaging CSF outflow into the lymphatic system in mice and swine |
poster |
|
La Spada, Albert |
Nicotinamide pathway dependent Sirt1 inactivation underlies neurodegeneration in spinocerebellar ataxia type 7 |
talk |
|
Lapierre, Louis |
Give me a SINE—How Selective Inhibitors of Nuclear Export modulate autophagy and aging |
poster |
|
Lee, Virginia |
Transmission of misfolded proteins in neurodegenerative disorders—A common mechanism of disease progression |
talk |
|
Li, Emmy |
Elucidating Alzheimer’s disease progression by examining cell-type specific transcriptional changes at single-cell resolution |
poster |
|
Li, Jixi |
Structural basis of cell necrosis and implications in neurodegenerative diseases |
poster |
|
Lie, Pearl |
Restriction of functionally active lysosomes from anterograde axonal transport limits clearance capability of axons and may underlie their susceptibility to neuritic dystrophy |
poster |
|
Liu, Yuanjing |
The investigational stereopure antisense oligonucleotide WVE-3972-01 preferentially reduces G4C2 repeat-containing C9ORF72 transcripts—A potential therapeutic approach for the treatment of frontotemporal dementia |
poster |
|
Luo, Wenjie |
A dual effect of the retromer chemical chaperone R33 in promoting Aβ degradation and attenuating inflammasome activation in microglia |
poster |
|
Ma, Chao |
Tauopathies reveal uncoupling of arginine sensing pathways and mTORC1 activation |
poster |
|
Ma, Dongrui |
Generation of isogenic human TMEM230 Parkinson’s disease model |
poster |
|
Ma, Keran |
Enhancing inhibitory interneuron function improves EEG abnormalities, brain pathology and cognitive function in mouse models of Alzheimer’s disease |
poster |
|
Mallucci, Giovanna |
UPR activation in astrocytes induces non-cell autonomous neurotoxicity in neurodegenerative disease |
talk |
|
Marcogliese, Paul C |
Loss-of-function variants in IRF2BPL are associated with neurological phenotypes |
poster |
|
Marcora, Edoardo |
Genome-wide integration of Alzheimer’s disease genetics and myeloid cell genomics identifies novel risk genes expressed in microglia |
poster |
|
Marcus, Jacob |
Administration of intracranial alpha-synuclein fibrils into an A30P synuclein transgenic mouse |
poster |
|
Margolin, Richard A |
Therapeutics for tauopathies—Linking molecular hypotheses and clinical benefit |
poster |
|
Marques, Rita |
Identification of potential disease-driving molecules in mouse models of amyotrophic lateral sclerosis caused by mutant TDP-43 |
poster |
|
Mordes, Daniel A |
A chemical screen in human neurons identifies potential targets for C9ORF72-ALS/FTD |
poster |
|
Mourelatos, Zissimos |
Ribothrypsis—Implications for gene expression regulation and analysis |
talk |
|
Munoz, Mikel |
Rearrangements in the ATAD3 gene cluster cause neurodevelopmental disorders owing to perturbed mitochondrial and cholesterol metabolism |
poster |
|
Myeku, Natura |
Receptor-mediated clearance of synaptic tau as a therapeutic strategy to attenuate trans-synaptic propagation of tauopathy |
poster |
|
Naito, Yusuke |
Role of synaptic organizer Neurexin on amyloid β-induced synaptic pathology |
poster |
|
Nathanson, Pierce |
TDP-43 is a genome-wide DNA-binding protein and regulator of snRNA expression |
poster |
|
Nezich, Catherine L |
Investigation of how TFEB upregulation affects Parkinson’s disease-associated genes |
poster |
|
Nguyen, Lien |
Antibody therapy targeting RAN proteins rescues ALS/FTD in C9orf72 mouse model |
poster |
|
Nilsson, Per |
Somatostatin receptor 1 and 4 redundantly regulate the major amyloid β-degrading enzyme neprilysin |
poster |
|
Nuriel, Tal |
Utilizing systems biology approaches to elucidate the effects of APOE4 expression in an AD-vulnerable brain region |
poster |
|
Oddo, Salvatore |
Necroptosis activation in Alzheimer's disease |
poster |
|
Onos, Kristen D |
Genetically distinct mouse strains exhibit differences in amyloid-induced neuroinflammation and cerebral amyloid angiopathy |
poster |
|
Palop, Jorge |
Network abnormalities and interneuron dysfunction in Alzheimer’s disease |
talk |
|
Park, Jin Su |
XHC restores cognition of Alzheimer’s disease mice and reduces amyloid-beta burden via repressing BACE1 promoter activity |
poster |
|
Pehar, Mariana |
RAGE signaling as a pharmacological target in ALS models |
poster |
|
Pensalfini, Anna |
Over-activating neuronal Rab5 in mice by itself causes AD-related endosomal, synaptic, cholinergic, and cognitive deficits and, in APP-models of AD, accelerates disease |
poster |
|
Porta, Sílvia |
Intracerebral injection of pathological TDP-43 extracted from frontotemporal lobar degeneration human brains induces seeding and spreading of TDP-43 pathology in vivo |
talk |
|
Pourshafie, Naemeh |
RNA-seq of human iPSC derived motor neurons implicates mitochondrial dysfunction in spinal and bulbar muscular atrophy |
poster |
|
Ramalingam, Nagendran |
The strong neurotoxicity of membrane-associated monomeric αS variants is accompanied, but not mediated by S129 hyperphosphorylation |
poster |
|
Ramesh, Nandini |
The RRM domain of Matrin 3 mediates neuromuscular degeneration in ALS models |
poster |
|
Reed, Robin |
The neurodegenerative diseases ALS and SMA are linked at the molecular level via the ASC-1 complex |
poster |
|
Reed, Robin |
The RNAP II/U1 snRNP machinery is a central hub for multiple ALS and SMA-causative proteins |
poster |
|
Russell, Kristi L |
TP73 functions in amyotrophic lateral sclerosis pathology |
poster |
|
Shalem, Ophir H |
Unbiased mapping of the regulatory network that controls alpha synuclein levels in human cells |
poster |
|
Shaw, Timothy I |
A case study of RNA sequencing protocols and their ability to detect splice junctions and intron retention events in Alzheimer disease |
poster |
|
Shorter, James |
Therapeutic dissolution of aberrant phases by nuclear-import receptors |
talk |
|
Siew, Jian Jing |
The pro-inflammatory role of Galectin-3 in Huntington’s disease |
poster |
|
Small, Scott A |
Endosomal traffic jams represent a pathogenic hub and therapeutic target in Alzheimer’s disease |
talk |
|
Sohre, Selina |
Excitatory insufficiency as origin of Alzheimer's disease |
poster |
|
Stanaszek, Luiza |
Global glia replacement as a strategy for treatment of demyelinating and neurodegenerative diseases |
poster |
|
Taylor, Paul |
Disturbance of phase transitions in neurological disease |
talk |
|
Trojanowski, John |
Tau strains may account for heterogeneity of Alzheimer’s disease (AD), progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) |
talk |
|
Trzeciakiewicz, Hanna |
The deacetylase HDAC6 modulates tau mediated neurodegeneration |
poster |
|
Valdez Vargas, Claudia |
Circulating miRNAs as potential biomarkers for spinocerebellar ataxia type 7 (SCA7) |
poster |
|
van der Kant, Rik |
Phenotypic screening in iPSC-Alzheimer’s disease neurons identifies a druggable CYP46A1-cholesteryl metabolic-Tau axis |
poster |
|
Varela, Juan A |
Optical structural characterisation of individual protein aggregates |
poster |
|
Volpicelli-Daley, Laura A |
Membrane trafficking of α-synuclein in the pathogenesis of Parkinson's Disease and Lewy Body Dementias |
talk |
|
von Herrmann, Katharine M |
Characterizing neuroinflammation resulting from expression of constitutively activated NLRP3 under the control of the dopamine transporter |
poster |
|
Warren, Lee |
Development of a high throughput assay to detect tau aggregation in human iPSC-derived neurons to model neurodegenerative diseases |
poster |
|
Wu, Haifan |
A 31-residue fragment of tau shows prion-like behavior in cells |
poster |
|
Xu, Xiao |
Cell-type specific profiling of human brain for novel therapeutic development |
poster |
|
Yamanaka, Tomoyuki |
Biochemical characterization of pathological ER domain isolated from cultured cells |
poster |
|
Yousef, Hanadie |
Aged blood activates microglia and inhibits adult hippocampal neural precursor cells through brain endothelial VCAM1 |
talk |
|
Zariwala, Hatim |
Evaluation of progressive neurodegeneration and pharmacological effects in preclinical models of amyotrophic lateral sclerosis (ALS) |
poster |