Presenting Author

Abstract Title

Talk/Poster

Abdusselamoglu, Merve Deniz

Deciphering the role of pioneer factors in regulating tumor progression and heterogeneity

poster

Aceto, Giulio

Exploiting calcium flux vulnerability of SMARCA4/2-deficient cancers

poster

Adler, Keren M

Cancer cell autonomous regulation of immunogenicity—Revisiting the immunoediting hypothesis

poster

Ahad, Abdul

Abrogation of myeloid TGF-β signaling orchestrates distinct immune niches to induce tumor dormancy

talk

Ahmed, Nusaiba N

GATAD2B O-GlcNAcylation regulates breast cancer stem-like potential

poster

Aitken, Sarah J

Strand-resolved mutagenicity of DNA damage and repair

talk

Alici, Aybuke

Epithelial-intrinsic epigenetic regulation of intestinal immune surveillance

poster

Altman, Brian J

MYC disrupts the circadian clock to drive loss of lung epithelial cell identity in early lung adenocarcinoma

poster

Andohkow, Tiffany A

Inactivation of neurofibromin type 1 (NF1) increases LAG3+ mediated immune suppression via JAK/STAT pathway in breast cancer metastasis

poster

Andreani, Cristina

Ferroptosis suppression drives therapy resistance in mutant KRAS lung cancer

talk

Aouad, Patrick

Leveraging the mouse intraductal model to study persistent cells post-endocrine therapy in ER+ breast cancer

poster

Aqeilan, Rami

Mapping the breakome of cancer cells—What lessons have we learned?

poster

Arbajian, Elsa

Multiomics assessment of lung adenocarcinoma subtypes defined through tumor purity-adjusted DNA methylation

poster

Arnold, Frank

Exploring stromal evolutionary routes in primary versus metastatic microenvironments of pancreatic ductal adenocarcinoma

poster

Attardi, Laura

p53 promotes lung adenocarcinoma regression through a TFEB-driven lysosomal program

talk

Bagchi, Anindya

Why are MYC-driven cancers so lethal? New insights and therapeutic opportunities

talk

Bahia, Ravinder

Loss of tumor suppressor gene, EPB4.1L3, promotes PRMT3-driven epigenetic regulations in brain tumor stem cells

poster

Bargonetti, Jill

A cancer persistent DNA repair circuit driven by MDM2, MDM4 (MDMX), and mutant p53 for recruitment of MDC1 and 53BP1 on chromatin

poster

Bartolacci, Caterina

In vivo deuterated water labeling combined with HPLC-MS/MS and MALDI-MSI imaging to measure/visualize the flux of single lipids in Mutant KRAS lung cancer

poster

Barua, Amrita

Identifying resistance mechanisms to direct-KRAS inhibitors in NSCLC

poster

Baslan, Timour

Discrete phases of cancer genome evolution underlie sarcomagenesis

poster

Bernstein, Emily

Histone variant regulation of the melanoma tumor microenvironment

talk

Bhardwaj, Abhishek

Identification of a unique hypoxia-induced inflammatory cell death pathway

poster

Bhosale, Mrinalini R

p53 genetic sensor system to identify novel mutant p53 reactivators

poster

Bisht, Deepa

Exploring the feasibility and challenges of DNA methylation-based ARMS-PCR and methylight assay for early detection of epithelial ovarian cancer

poster

Bu, Wen

Creating immunocompetent rat models for estrogen receptor-positive breast cancer through somatic genome editing

poster

Bunk, Paul

PPARδ-induced fatty acid oxidation in Tregs promotes anti-tumor immunity

talk

Chaikovsky, Andrea C

Investigating the cellular and molecular determinants of malignant transformation

poster

Chala, Raafat

Sphingolipid metabolic plasticity enhances cancer cell evolvability in adapting to acidic tumor microenvironments

poster

Chan, Jason

NF-κB drives an essential high-plasticity cell state in lung cancer

talk

Chan, Lok Hei

The development of protein degraders targeting KDM5 histone demethylases

poster

Chandra, Vidhi

Functional interrogation of the pancreatic intratumoral microbial niche reveals tumor modulation and reshaping of the microenvironment

talk

Chen, Chong

Acquired resistance to immunotherapy by cancer cells’ self-built physical barriers

poster

Chen, Jing

Circulating nutrients and anti-tumor immunity

talk

Childress, Avery R

Using EZH2 inhibition to modulate immune cells in non-small cell lung cancer

poster

Chung, Charlie

Autologous patient-derived organoid-immune cell co-culture platform for therapeutics discovery in high-grade endometrial cancer

poster

Citron, Francesca

WRAD core is required for DNA replication fidelity and coordinated G2/M transition in pancreatic cancer

talk

Coutinho de Miranda, Marcelo

Novel humanized TROP2 mouse model reveals TROP2hi luminal population as potential pre-cancer stem cell that can be targeted to inhibit breast cancer progression

poster

Cozzens, Lauren M

Investigating semaphorin7a and SOX2 crosstalk in mammary gland involution and postpartum breast tumorigenesis.

poster

Cunniff, Patrick J

Aberrantly expressed Krüppel-like factor 5 (KLF5) co-opts RUVBL1/2 to drive PDAC proliferation

poster

Dai, Yutong

Defining metabolic liabilities in oncogene-driven lung cancer

poster

Das, Subhadeep

Understanding the molecular mechanism of Supinoxin (RX-5902) on Small cell Lung Cancer Therapy

poster

Datta, Amrita

The role of fat cadherins in metastatic breast cancer

poster

Dias, Matheus Henrique

Behave or die—Overactivation of oncogenic signaling steers cancer cells toward less malignant phenotypes

talk

Dive, Caroline

Functional plasticity in small cell lung cancer

talk

Do Carmo, Mariana

Genetic determinants of EGFR-mutant lung adenocarcinoma progression and osimertinib sensitivity

talk

Doerig, Katherine

Paradoxical effects of //Setd2// inactivation in EGFR- and KRAS-driven lung adenocarcinoma

poster

Doherty, Mary R

Role of adrenergic nerves in lethal metastatic prostate cancer

poster

Dongre, Anushka

Sensitizing quasi-mesenchymal breast tumors to anti-CTLA4 immune checkpoint blockade therapy by targeting CD73

talk

Dow, Lukas E

Genetic and non-genetic mechanisms of resistance to KRAS inhibition

talk

Dziadowicz, Sebastian

Molecular xignatures of CB-6644 inhibition of the RUVBL1/2 2 complex in multiple myeloma

poster

Eichner, Lillian J

Transcriptional repression by HDAC3 mediates T-cell exclusion from Kras mutant lung tumors

talk

Eisfeld, Ann-Kathrin

Genomic profiles and associated survival prognosticators in ancestry-diverse patients with AML—Refining the genetic landscape and new biologic insights

talk

Espinosa, Santiago

Dual and opposing functions of CUL3 ubiquitin ligase in lung cancer

poster

Essel Dadzie, Headtlove

The role of HNF4α in lineage plasticity and tumor progression in invasive mucinous adenocarcinoma of the lung

talk

Fall, William

Enhancer reprogramming in pancreatic injury and tumorigenesis

poster

Falvo, David J

Differential effects of KRAS mutations on epigenetic reprogramming and lineage reversion in pancreatic tumorigenesis

talk

Farias, Eduardo F

Modeling mechanisms of drug resistance with biologically informed deep learning

poster

Fearon, Douglas T.

Immunotherapy of mouse pancreatic cancer with anti-human CXCR4 antibody

talk

Fendt, Sarah-Maria

Metabolic rewiring driving metastasis formation

talk

Fonseca, Frank

Applications of WNTinib in Colorectal Cancer

poster

Frederickson, Andrew

Leveraging a novel biomaterial to examine dormancy and therapy resistance in ovarian cancer

poster

Friedlein, Jordan

MYC alone is not enough—How the circRNA derived protein firefox enhances MYC expression in cancer

poster

Fry, Josh

Analysis of super-enhancer-associated lncRNA landscape identifies IGF1R-AS1 which trans-regulates MYC long-range enhancer-promoter interactions and promotes prostate cancer progression

poster

Gaikwad, Snehal M

Metabolomics, transcriptomics, and RNAi identify molecular modifiers contributing to proteasome inhibitor resistance in multiple myeloma

poster

Gao, Shuai

Histone lactylation directs distinct enhancer landscape to drive prostate cancer progression

poster

Gardner, Eric E

How does a transformed secretory cell shape its pulmonary niche?

poster

Gargiulo, Domenic

Inhibition of purine biosynthetic enzyme ATIC impedes prostate cancer progression by activating AMPKα

talk

Ghosh, Promita

METΔex14 mimics KRAS phenotype with FOSL1 as a central player in tumor progression

talk

Girnius, Nomeda

The spatial distribution of antioxidants in a mouse model of triple negative breast cancer

talk

Gladstein, Amy C

The oncohistone H3%K36M% is a tumor suppressor in lung adenocarcinoma

talk

Goffe, Raaven

A genetic engineering approach to interrogate Myosin 10 as a driver of non-small cell lung cancer metastasis

poster

Gritti, Ilaria

DNAJB1-PRKACA fusion drives fibrolamellar liver cancer through impaired SIK signaling

poster

Guccione, Ernesto

Oncofetal reprogramming fuels phenotypic plasticity in WNT-driven colorectal cancer and CRTC2/p300-mediated transcriptional reprogramming

poster

Guerriero, Jennifer L

The complexities of tumor associated macrophages and the key to effective targeting for anti-cancer therapy

talk

Han, Xiao

A panel of D2.0R-derived mammary carcinoma cell lines as a model system to study the diverse mechanisms of cancer recurrence

poster

Han, Yiping

Annexin A1 stimulates neoplastic progression from precancer through metastasis via activation of β-catenin

poster

Hanna, Jason A

EndMT plasticity in epithelioid hemangioendothelioma

poster

Hargreaves, Diana

Loss of the tumor suppressor ARID1A activates a STING-type I interferon signaling axis that promotes anti-tumor immunity

talk

Harkins, Shannon K

The role of //EP400// in the endometrial epithelium

poster

Hayashi, Makiko

Overcoming KRAS inhibitor resistance in genetic subsets of lung adenocarcinoma

poster

Heard, Kelly

NOTCH1 activation mediates tumor cytotoxicity and immunogenicity following LSD1 inhibition in small cell lung cancer

talk

Hebert, Jess

Diverse and complex lung adenocarcinoma genotypes promote metastatic ability

talk

Herve, Solene

Nuclear mechanotransduction and cell state regulation in colorectal cancer

poster

Hilgendorf, Keren I

Lean adipocyte-secreted oxylipin triggers ferroptosis and protects against obesity-accelerated breast cancer

talk

Hinterleitner, Clemens

Targeting senescent cells with precision—A nanoparticle approach to combat fibrosis, cancer, and metastasis

talk

Holderfield, Matthew

Mechanism of RAS inhibition and activity across multiple RAS addicted genotypes for the RAS(ON) multi-selective inhibitor, RMC-7977

talk

Hosein, Hannah

DICER1-associated central nervous system sarcoma is sensitive to cyclin-dependent kinase 4/6- and MEK- inhibition

poster

Hsu, Hsin-Ling

Immunotherapeutic IL-6R and targeting the MCT-1/IL-6/CXCL7/PD-L1 circuit prevent stemness, relapse and metastasis of triple-negative breast cancer

poster

Hua, Fanghui

The translation initiation factor eIF5B drives PD-L1 translation and a tumor promoting translation program in lung cancer

poster

Huang, Mohan

HIF1A-mediated pathways under hypoxic conditions, potential mechanisms and clinical implications in hepatocellular carcinoma

poster

Huang, Sidong

SMARCA4-loss increases RNA polymerase II pausing resulting in R-loop-mediated impediment to BRCA1 repair in small cell ovarian carcinoma

poster

Hunt, Brian G

Productive T-cell-mediated immunoediting of developing sarcomas by distinct mechanisms

talk

Hunter, Miranda

Physical confinement governs phenotypic plasticity in melanoma

talk

Hwang, Chang-il

Engrailed-1 promotes pancreatic cancer metastasis

poster

Jackstadt, Rene

Deciphering and targeting fetal-like stem cells in advanced colorectal cancer

talk

Janson, Nimod D

The mitotic kinase polo-like kinase I (PLK1) as a therapeutic target in angiosarcoma

poster

Jiang, Lingyan

Discovery and preclinical characterization of RMC-9805, a RAS(ON) G12D-selective, covalent tri-complex inhibitor

poster

Jones, Matthew

Mechanisms and consequences of extrachromosomal DNA co-inheritance in cancers

poster

Kalli, Maria

Mechanical stress promotes autophagy activation to impair the efficacy of chemotherapy in pancreatic cancer

poster

Karreth, Florian

The transcription factor MAFG is a melanoma driver and vulnerability

talk

Kechejian, Vahag

Comprehensive SOX HMG domain-swaps reveal unique properties of SOX10 in melanoma

poster

Khalil, Athar

Unveiling Egr1 as a novel tumor suppressor in Kras-driven lung cancer—A Tuba-seq exploration

poster

Khatri, Naheel

Predicting the evolutionary trajectory of radiation treated triple negative breast cancer at a single cell resolution

poster

Kim, Dae-Kyum

Exploring drivers of chemotherapeutic resistance through a novel overexpression screening platform

poster

Kim, Sahee

Obesity-induced endotrophin accelerates type 1 endometrial cancer progression via WNT signaling pathway

poster

Kim, Sang Soo

Inhibition of mTOR attenuates the initiation and progression of //BRCA1//-associated mammary tumors

poster

Kim, Seung Tea

Characterization of step-wise progression of prostate cancer using RapidCaP GEMM model

poster

Kim, Yumi

PHGDH supports glutamine levels and promotes PDAC progression

poster

Klingbeil, Olaf

MARK2/MARK3 kinases are catalytic co-dependencies of YAP/TAZ in human cancer

talk

Krause, Klavdija

An //in vivo// genetic screen identifies mechanisms of lung cancer initiation

poster

Kuang, Shan

Single nucleus whole genome sequencing for identification of bottle necks of prostate cancer metastasis

poster

Kurleto, Justyna

Investigating the oncogenic activity of translation initiation factor eIF5B in non-small cell lung cancer

poster

LaBella, Kyle

Models of chromosomal instability and cell competition in gastroesophageal cancer

poster

Lan, Wenjun

Soat1 promotes invasion and metastasis that is blocked by a novel chemo-metabolite in PDAC

talk

Lanzafame, Manuela

Decoding skin cancer—Insights from UV-induced DNA damage repair disorders

poster

Lawrence-Paul, Matthew R

Cancer type-specific convergent evolution between species identifies cardinal genomic drivers of breast cancer

poster

Lee, Alan Yueh-Luen

Mitochondrial chaperone enhances the malignancy via PYCR1 and glutamate/proline metabolism in the inflammatory tumor microenvironment

poster

Lee, Jonathan D

Reverse engineering leukemic cell states with accessible chromatin proteomics

poster

Lee, Terence Kin Wah

Wild-type Kirsten rat sarcoma (KRAS) activation drives evasion of interferon-mediated immunity in hepatocellular carcinoma

poster

Lee, Yu-Ru

UFL1 ablation in T cells suppresses PD-1 UFMylation to enhance anti-tumor immunity

poster

Lentzas, Aristeidis

Upgrading mouse models for drug development—How can human-to-mouse translation of pharmacokinetics predict clinical antitumor efficacy?

poster

Lewis, Steven

Urinary tract infection alters mammary tissue homeostasis and accelerates tumors in Brca1 deficient mice

poster

Li, Yinghui

TWEAKing genome regulation in breast cancer to identify novel drivers of metastasis

poster

Li, Yinghui

Unravelling the role of non-canonical NF-κB signalling in the epigenome landscape of multiple myeloma

poster

Liang, Gaoyang

Rewiring HDAC-controlled epigenetic programs sensitizes pancreatic cancer to DNA damage-inducing therapies

poster

Liang, Nang Kham Hsi

Investigating chemotherapy efficacy within human vascular endothelial cells constituted tumor microenvironment

poster

Lindenberger, Joshua H

Mutant //Trp53// driven breast cancer serves as a model for dormant singlet tumor cell dissemination

poster

Liu, Bodu

A casein kinase 2 interacting LncRNA regulates cellular plasticity of breast cancer by stabilizing c-Myc

poster

Liu, Shiyu

Advanced quantitative analysis of physiological metabolic activities in large-scale networks

poster

Liu, Yu

Identifying //ABCB8// as a tumor suppressor gene on chromosome 7q in leukemia

poster

Lopez Fuentes, Eunice

Epigenetic heterogeneity of osteosarcoma reveals distinct cellular states driven by enhancer regulation

talk

Lu, Billy

//Rb1// loss increases disease penetrance and liver metastasis in novel mouse model of bladder cancer

poster

Luck, Cuyler H

Exploring how choice of partner gene influences fusion oncoprotein function in the context of CIC-rearranged tumors

poster

Ma, Stephanie

Genetically defined, syngeneic mouse organoid platform for understanding heterogeneity and response to therapy in liver cancer

poster

Mackie, Kate

Identifying breast cancer associated risk variants with functional regulatory activity—Validation using a lentivirus based massively parallel reporter assay

poster

Magdy, Ahmed

Mortality of AKT-deficient mice is mediated by intestinal damage and is rescued by either FOXO1 deletion or by mTORC1 hyperactivation

poster

Maher, Timothy J

A metabolic switch that boosts immune cell fitness against immune-evasive cancer

poster

Maldonado, Elias

The role of p66ShcA and PKR in promoting breast cancer malignancy through adaptation to chronic oxidative stress

poster

Mall, Moritz

Suppression of cell fate plasticity by active transcriptional repression safeguards hepatocyte identity and prevents liver tumorigenesis

talk

Malysa, Agnes P

Role of novel R1 complex in regulating DNA replication

poster

Mashati, Pargol

Evaluating the therapeutic potential of a novel ADAM10 modulator in colorectal cancer

poster

McMahon, Martin

Direct pharmacological targeting of RAS signaling as potential therapy for NRAS-driven melanoma

talk

Meng, Yinuo

RAC1 is a critical node in KRAS-driven pancreatic ductal adenocarcinoma maintenance

poster

Miao, Shucheng

Malat1 induces resistance to ICIs by increasing oxidative phosphorylation (OXPHOS) in malignant cells and fostering immunosuppression within the TME of NSCLC

poster

Minden-Birkenmaier, Benjamin A

ZBTB18 restricts tumor cell pliancy, reducing metastasis via immune attack

talk

Morera, Erika

Establishment and scRNA-seq characterization of breast patient-derived organoid cultures

poster

Mosur Swamynathan, Manojit

Pro-oxidant therapy by a vitamin K precursor targets PI 3-Kinase VPS34

poster

Moyer, Sydney M

Th1-mediated immunosurveillance in colorectal cancer initiation

poster

Mulholland, Eoghan J

GREMLIN1 disrupts intestinal epithelial-mesenchymal crosstalk to induce a Wnt-dependent pre-cancer niche via stromal remodelling

poster

Murakami, Shigekazu

Modeling PDAC tumor heterogeneity and link between EMT and metastasis

poster

Nadeau, Christine

The NCI Oncology Models Forum—A research community for modelers of cancer

poster

Nadella, Sandeep

Evaluation of the stromal cell compartment in the pancreas reveals the contribution of Pdgfra+ cells to pathologic fibroblasts

poster

Naseri, Marzieh

Targeting the mRNA 3' end nuclease, CPSF73—A novel approach to impede invasiveness of cancer cells

poster

Neel, Benjamin

New tricks by old friends

talk

Nguyen, Don

Epigenetic regulation of tumor cell clustering and metastasis in lung adenocarcinoma

talk

Nigri, Jeremy

Direct interactions of cancer-associated fibroblasts and neurons in PDAC

poster

Nishitani, Kenta

The MLL3/TP53/PIK3CA cancer driver mutations promote HIF1α-dependent recruitment and differentiation of pro-tumor ICOS%hi%GITR%hi% Blimp-1%+% effector regulatory T cells in breast tumors

poster

Niu, Xiaoteng

The cGAS/STING signaling pathway and p53 function in a reciprocal manner to suppress tumor growth.

poster

Nogueira de Almeida, Larissa M

A genetic screening strategy for revealing the PAX3-FOXO1 transcriptional pathway in rhabdomyosarcoma

poster

Nor Rashid, Nurshamimi

Morindone from //Morinda citrifolia//—A promising agent targeting DNA replication and key mutations in colorectal cancer

poster

Obenauf, Anna

Cancer cells impair monocyte-mediated intratumoral T cell stimulation to evade immunity

talk

Ogunlusi, Olajumoke

Circadian rhythm disruption alters mammary gland morphology and accelerates "cold" aggressive mammary tumorigenesis through a LILRB4-dependent pathway

talk

Oh, Jihoon

Virtual memory T cells are induced by wild-derived microbiota in an IL-15-dependent manner and enhance the response to immune checkpoint inhibitor therapy

poster

Oh, Yerin

RARRES1 function in protein quality control during tumorigenesis

poster

Olive, Kenneth P.

Adaptive heterogeneity enables the survival of residual malignant PDAC cells in response to pan-RAS-GTP inhibition

talk

Olsen, Sarah Naomi

KAT6A/B and Menin-MLL complexes coordinately regulate estrogen receptor-driven gene expression programs in breast cancer

talk

OToole, Kayla T

Characterization of the BRAF interactome reveals BRAF%V600E%-p53 interaction

poster

Ozcelik, Elif

Dietary influences on tumor microenvironment immune cells

poster

Pan, Chun-Hao

Functional interrogation of a high-plasticity cell state in lung adenocarcinoma

poster

Pandey, Medha

Inferring cell type-specific nucleosome positions from cell-free DNA to detect cancer

poster

Perelli, Luigi

Evolutionary fingerprints of EMT in pancreatic cancers

poster

Perry, Laura

Understanding and targeting the prostaglandin E_2_ receptor EP4 for cancer therapy

poster

Pessa, Jenny

Dynamic HSF2 regulation drives breast cancer progression by steering the balance between proliferation and invasion

poster

Petrescu, Isabel

Determining the function of the glycosyltransferase GALNT14 for osteosarcoma tumorigenesis

poster

Phadkar, Janhavi

Development of immortalized breast epithelial cell lines from diverse donors differing in inherited risk alleles

poster

Picech, Florencia

Genetically engineered mouse models that recapitulate treatment naïve and castration-resistant metastatic prostate cancer

talk

Pinto Medici, Natasha

Altered RNA splicing causes pancreatic cancer and exposes a therapeutic vulnerability

talk

Pirtz, Matalin

Dysregulation of cell state dynamics during early stages of serous endometrial carcinogenesis

poster

Piskounova, Elena

tRNA wobble modifications as drivers of stress resistance and the adaptive proteome in melanoma metastasis

poster

Proud, Hailey

Exploring the use of Chi3l1 as a prognostic biomarker and therapeutic target in breast cancer

poster

Pundel, Oscar J

Investigation of Ccne1Amp-driven HGSOC genomic evolution using syngeneic organoid models

poster

Ratner, Nancy

Combining SHP2 inhibition with immune modulation via CX3CR1 inhibition normalizes the pre-cancer microenvironment and shrinks tumors

talk

Ravasz Regan, Erzsebet

Unlocking mitochondrial dysfunction-associated senescence (MiDAS) with NAD%+%—A Boolean model of mitochondrial dynamics and cell cycle control

poster

Ray, Upasana

Analysis of gene regulatory network topology and dynamics uncovers the key transcription factors associated with cancer progression

poster

Rendleman, Justin

Gene regulatory networks involved in dynamic cell state transitions of drug response and resistance in ER+ breast cancer

poster

Reyes, Jose

Catching p53 in the act of tumor suppression

poster

Rivera-Lopez, Yadiel A

Characterization of myeloid-derived suppressor cells in response to restraint stress in preclinical models of ovarian cancer

poster

Roman Moreno, Marta

Targeting the long isoform of Rap1GDS1 to modulate KRAS signaling in lung adenocarcinoma

poster

Romero, Rodrigo

The neuroendocrine transition in prostate cancer is dynamic and dependent on ASCL1

talk

Rose, John C

Mechanisms of excisional ecDNA biogenesis in cancer

poster

Roussel, Martine

Developing new models and therapies for atypical teratoid/rhabdoid tumors

talk

Rueda Gensini, Laura

Revealing key transcriptional regulators of plasticity in glioblastoma through single-cell multi-omics

talk

Ruiz, Christian F

Dietary fats dictate pancreatic cancer fate via phospholipid saturation

poster

Russo, Giancarlo

Multi-transcriptomic profile of 5-FU-resistant colorectal cancer cells in vivo using third generation sequencing

poster

Samma, Muhammad K

LY6G6D in colorectal cancer—Novel biomarker identification and therapeutic implications

poster

Schade, Amy

AKT and EZH2 inhibitors kill TNBCs by hijacking mechanisms of involution

talk

Schulte, Anthony J

Mutations in retinoic acid receptor alpha and c-Kit elucidate heterogeneity in breast cancer tumor biology

poster

Serio, Ryan N

Tracking metastatic spread in prostate cancer using the //EvoCaP// mouse model

poster

Sevgi, Selin

A CRISPR based approach to identifying target genes and causal variants at breast cancer risk loci

poster

Shah, Vyom

Dietary arachidonic acid evokes endometrial stem cell plasticity

poster

Sharma, Padmanee

Immune checkpoint therapy—Identifying mechanisms of resistance that nominate targets for rational combination strategies

talk

Sharma, Swati

SIRT3 mediated metabolic reprogramming enhances anti-tumor immune responses in prostate tumor microenvironment

poster

Singhal, Anupriya

A classical epithelial state drives acute resistance to KRAS inhibition in pancreas cancer

poster

Sivetz, Nicole

Sepsis-induced inflammation alters natural killer cell-mediated surveillance of liver metastasis

talk

Song, Joon-Hyun

Variable tumor microenvironment increases evolvability and selects for generalist cancer cells

poster

Sonnentag, Steffen J

CD44—A novel regulator of colorectal cancer cell plasticity

poster

Soto Vargas, Zulaida M

MafG is an essential transcription factor in melanoma

poster

Srinivasan Boggaram, Sanjana

Constitutive activation of AKT1 protein kinase cooperates with BRAF%V600E% in accelerating lung tumorigenesis

poster

Stevens, Bradley T

Determining the genomic basis of PAX3-FOXO1 mediated transformation in rhabdomyosarcoma

poster

Subhash, Santhilal

Ancestrally diverse single cell atlas of human gynecologic carcinosarcoma

poster

Subhash, Santhilal

Endometrial carcinosarcoma patient-derived organoids from diverse ancestries reveal disease heterogeneity and cancer plasticity

poster

Suzuka, Jun

Analysis of the induction mechanism of breast cancer cell dedifferentiation and its malignant trait using hydrogel

poster

Sweet-Cordero, Alejandro

Unveiling the therapeutic potential of targeting Rap1GDS1 in KRAS-mutant lung adenocarcinoma

talk

Tavartkiladze, Alexandre

An alternative personalized treatment algorithm for metastatic breast cancer resistant to traditional medical treatments

poster

Tavartkiladze, Alexandre

Chronotherapy enhances melatonin secretion and liver enzyme activity, improving therapeutic outcomes in hodgkin’s lymphoma patients

poster

Tavartkiladze, Alexandre

The impact of disrupted melatonin secretion on structural and functional changes in the microbiome and the role of the melatonin-microbiome axis in carcinogenesis initiation

poster

Tavazoie, Sohail

Regulation of breast cancer metastasis by sensory neurons

talk

Tonelli, Claudia

Fgfr2 promotes Kras-driven pancreatic tumorigenesis

poster

Torres Mejia, Elen

SOX2 expression in NSCLC mediates resistance to checkpoint blockade therapy by inducing Treg-dependent CD8 T cell exclusion

talk

Travis, Olivia K

Osteosarcoma primary tumors alter megakaryocyte maturation and subsequent platelet function to promote metastasis

poster

Tuveson, David

Kras dependency and pancreatic cancer

talk

Venkat, Vignesh V

MESAM tracks multi-scale changes in tissue microenvironment across different stages of lung cancer development

poster

Vijay, Vindhya

Altered lipid metabolism in BAP1-mutant cholangiocarcinoma—From Mechanisms to Therapeutic Strategies

talk

Vipparthi, Pratyusha Rama Kavya

BRCA2 deficiency induces common fragile site instability in human mammary epithelial cells

poster

Wajapeyee, Narendra

EHMT2 suppresses NK cell-mediated anti-tumor immunity by AZGP1 repression-mediated stimulation of TGF-beta pathway

poster

Walters, Benjamin

Epigenetic inheritance of cancer risk via the mammalian paternal germ line

poster

Wang, Chenran

A model to study brain metastasis with human cerebral organoids and breast cancer cells

poster

Wang, Guiping

Enhancing transcription replication conflict targets ecDNA positive cancers

talk

Wasylishen, Amanda

The Daxx/Atrx/H3.3 epigenetic regulatory axis in cell state regulation and pancreatic neuroendocrine tumor suppression

talk

Westcott, Peter M

Modeling stepwise clonal evolution of colon cancer

poster

Wu, Bing

Ablation of KDM5 histone demethylase stimulates anti-tumor immunity in triple-negative breast cancer

poster

Wu, Meng-Ju

Mutant IDH1 inhibition stimulates anti-tumor immunity by epigenetically inducing viral mimicry signaling

poster

Xiao, Yujie

Spatial multiomics development of an ecological atlas of breast cancer evolution

poster

Yang, Dian

Spatiotemporal lineage tracing reveals the dynamics and plasticity of lung cancer evolution

talk

Yang, Rachel

Unveiling novel therapeutic target and insight into nuclear expulsion

poster

Yang, Yang

Autophagy dependent regulation of MAT2A enables adaptation to hypoxia in pancreatic cancer

poster

Yeh, Hsiwen

Mitochondrial GSH import by SLC25A39 is essential for metastatic colonization of breast cancer cells

poster

Yeh, Johannes

Synthetic ligands leveraging CUL3%KLHL20% E3 ligases for targeted protein degradation in cancer

poster

Yeung, Joanna

Temporal dynamics of the senescence-associated secretory phenotype—Transcriptomic and chromatin accessibility insights in CDK4/6 inhibitor and doxorubicin-treated liposarcoma

poster

Yoda, Hiroyuki Y

Myeloid-targeting immunotherapy but not genetic depletion overcomes inhibitory barriers in immune-evasive neuroblastoma

poster

Young, Riley G

Role of acetate metabolism in breast cancer brain metastatic cells  

talk

Yuan, Wei-Chien

YIP is a novel target for treating YAP-mediated malignancies

poster

Zhang, Boyao

Gut microbiota carcinogen metabolism causes distal tissue tumours

poster

Zhang, Daniel Xin

Extracellular RNA signature as potential novel biomarker for colorectal cancer

poster

Zhang, Zeda

Developing senolytic CAR T cells for high-grade serous ovarian cancer

poster

Zhen, Yuanli

Modeling tumor-immune communications in FGFR2 fusion-driven cholangiocarcinoma

poster

Zhu, Changyu

Steatosis remodels cancer epigenome to promote liver metastasis

poster

Zhu, Yu

Notch signaling in endothelial cells regulates the functions of cancer-associated fibroblasts to promote tumor immune evasion

poster

Zhuang, Xuenqian

Aging limits stemness and tumorigenesis in the lung by reprogramming iron homeostasis

poster

Zuber, Johannes

Unraveling bottlenecks and adaptations in cancer metabolism through //in vivo// CRISPR screens

talk