Presenting Author

Abstract Title

Presentation

Amberg, Nicole

Meta-analysis of transcriptional and epigenetic profiles of tumors associated with germline mismatch repair disease across brain regions and developmental time

poster

An, Hsiao-Lung

Modeling human primary microcephaly with hiPSC-derived brain organoid carrying the centrosomal CPAP mutant protein

talk

Anderson, Alexander

Cell-specific dysfunction of complex IV underlies neuronal cell death in Mohr-Tranebjaerg syndrome

poster

Andrews, Madeline

LIF signaling regulates differentiation of outer radial glial cells into inhibitory interneurons during human corticogenesis

poster

Anonuevo, Adam

A reliable, efficient, and matrix-free method to generate midbrain organoids from human pluripotent stem cells

poster

Anton-Bolanos, Noelia

Multi-donor brain chimeroids unveil selective individual vulnerability to neurotoxic triggers.

poster

Aragon-Gonzalez, Ana

Blood-brain barrier human-derived in vitro model—A valuable resource for researching neurological disorders dynamics and therapeutics

poster

Arlotta, Paola

The power of different genomes—Understanding inter-individual vulnerability to disease risk

talk

Azizi, Afnan

Heterochronic signalling in dorsoventral patterning of human and mouse telencephalon

poster

Baliaouri, Natella

Modeling the emergence of neural network dysfunction in Rett syndrome with mosaic organoids

poster

Bhaduri, Aparna

Utilizing cortical organoid transplants to study glioblastoma

poster

Bicks, Lucy K

Early convergence in autism spectrum disorder risk genes implicates a shared transcriptional complex regulating neural development and synaptic function

poster

Bogetofte, Helle

Proteomics of guided and unguided early forebrain organoids reveal differences in maturity and metabolic profiles

poster

Bonefina, Antonela

Modeling cortical interneuron migration in brain assembloids from patients presenting CCP1 mutation

poster

Brancati, Giovanna

Dissecting retinal dystrophies in organoid one cell at a time

talk

Brown, Sophie C

A hybrid 3D xenoculture system to study human iPSC-derived microglia

poster

Bubnys, Adele

A multi-cellular integrated brain-on-chip for modeling pathological outcomes of Alzheimer's disease

poster

Budd, Kaitlin M

Investigating the region-specific effects of oncohistone H3 K27M in oligodendrocyte development

poster

Bury, Luke A

Lineage tracing in cortical organoids reveals transcriptional differences between neurons derived from different progenitor subtypes and variability in the proportion of indirect neurogenesis in control and trisomy 21 organoids

talk

Buth, Jessie E

A reduction in the autism associated gene lysine demethylase 6B (KDM6B) alters cortical development

poster

Buurma, Mirle

In vivo paternal UBE3A reactivation in transplanted patient-derived Angelman syndrome neurons using antisense oligonucleotides as a model for therapeutic screening

poster

Carter, Ava C

ZNF transcription factors in activity-dependent neuronal gene regulation and evolution

poster

Castaldi, Davide

Harnessing genetic variability in human neurodevelopment through multiplexed brain organoids

poster

Chan, Wai Kit

Loss of PAX6 disrupts excitatory/inhibitory (E/I) neuron balance in human cerebral organoids

poster

Chang, Xuyao

Epigenetic dysregulation by ZMYND11 mutants leads to aberrant neurodevelopment

talk

Chen, George T

Targeting enhancers of autism risk genes CHD8 and SCN2A using CRISPR-A corrects mutant gene expression and phenotypes in developing brain organoids

talk

Chen, Kaihua

Introduction of circulating factors to the µSiM-BBB for in vitro studies of sepsis-associated brain injury

poster

Chew, Leon H

A human pluripotent stem cell-derived organoid model for recapitulation of central nervous system (CNS) barrier and fluid secretion functions of the choroid plexus

poster

Chinchalongporn, Vorapin

MR spectroscopy assessment of neurochemistry in human-derived cerebral organoids at various stages of maturity

poster

Choi, GiHun

The role of FOS and the BAF complex in regulating activity-dependent gene programs in human neurons

poster

Chua, John Jia En

FEZ1 participates in human embryonic brain development by modulating neuronal progenitor subpopulation specification and migration

poster

Colak, Dilek

Astrocytes derived from ASD individuals alter behavior and destabilize neuronal activity through aberrant Ca²⁺ signaling

poster

Colantuoni, Carlo

Defining conserved molecular dynamics across mammalian neocortical development using the NeMO Analytics integrated multi-omics data exploration environment

poster

Colombo, Elisa

A human forebrain organoid platform to study the role of ADA in neurodevelopment

poster

Corsini, Nina S

CGE derived interneuron progenitors in human brain development and disease

poster

Criscuolo, Lucrezia

Characterization of synapse development in human dorsal forebrain organoids using proteomics and immunofluorescence

poster

Dai, Qi

Spatial and temporal regulation of neural stem cell proliferation and quiescence by PRDM16

poster

Daoutsali, Elena

In  vitro 3D modeling of FOXP1 syndrome using striatal organoids

talk

Das, Debamitra

Investigating the impact of common genetic risk variants for schizophrenia on neuronal function elucidates relationships between cellular phenotypes, clinical status and cognitive performance

poster

de Martin, Xabier

The dynamic landscape of Neurod2 binding sites in mouse corticogenesis

poster

De Serres-Berard, Thiery

Modeling neurodevelopmental defects in congenital myotonic dystrophy type 1 using forebrain organoids

poster

de Vrij, Femke M

3D MICro-brains—A 3D myelination and inflammation cortical network platform

poster

Deb, Bipan K

mTORC1 regulates the development of glial-lineage cells in human brain organoids via STAT3

poster

Demirbas, Didem

Establishing organoid models to study MAPK8IP3-related neurodevelopmental disorder

poster

den Hoed, Joery

Deciphering the roles of CHD3 during early human brain development using cerebral organoids

talk

Dykstra, Werner

Advanced brain organoid modeling of mutant GFAP

poster

Elahi, Lubayna

Altered development in iPSC-derived organoids from a patient with PTEN mutation, autism, and macrocephaly

poster

Elmkvist, Sofie Blomberg

Investigating the molecular effects of matrigel embedding on cerebral organoids using proteomics, phosphoproteomics and imaging

poster

Elvassore, Nicola

Timely developmental morphogenesis in a 3D ECM-rich environment of naïve human iPSCs

poster

Esk, Christopher

Cerebral organoids display dynamic clonal growth with lineage replenishment

poster

Farmer, Sonia L

Understanding human TREM-2 dependent microglial responses to Alzheimer's disease pathology in vivo with chimeric mice

poster

Fattorelli, Nicola

A xenograft model to study human microglia genetics, development and disease

poster

Finan, John D

A 3D human in vitro model of spinal cord injury to isolate gene-trauma interactions

poster

Foliaki, Simote T

Fatal Familial Insomnia in a cerebral organoid model

poster

Fu, Shuai

Autism-specific PTEN p.I135L mutation and an autism genetic background combine to dysregulate cortical neurogenesis

poster

Gage, Fred (Rusty)

Glia-enriched organoids show mature glial functions upon engraftment

talk

Gagliano, Onelia

Nascent pluripotent state shows fully 3D developmental potential

poster

Galimberti, Maura

HD telencephalic organoids reveal neurodevelopmental and cytoarchitectural alterations with impaired GABAergic maturation

poster

Gasque, Gabriel

protocols.io for method development, sharing, and publication

talk

Gherardelli Brooks, Camila

Apoe4 modulates embryonic neurogenesis during the early stages of human brain development

poster

Glass, Madison R

Relating interindividual differences in cerebral organoids to longitudinal infant brain growth

poster

Gosio, Jessica T

Human cerebral organoid allografts of glioblastoma multiforme recapitulate pathologically relevant clinical phenotypes

poster

Gray, Toteona J

 CLCN7-mediated lysosomal hyper-acidification and disordered myelination—Organoid functional modeling

poster

Groveman, Bradley R

Cerebral organoids for studying human prion disease

poster

Guo, Qiuyu

Functional, high throughput dissection of non-coding genetic risk in ASD

poster

Hamann, Catherine A

Synthetic floor plate morphogenesis using engineered cell circuits

poster

Harkin, Jade

A highly reproducible and efficient method for retinal organoid differentiation from human pluripotent stem cells

poster

He, Chenfeng

Brain and organoid manifold alignment (BOMA) reveals cell-type developmental functional genomics across in-vivo brains and in-vitro organoids

poster

Hebisch, Matthias

Recapitulating Alzheimer’s disease neurodegeneration using an inducible 3D human cortical organoid model

poster

Heffel, Matthew G

Epigenomic and chromosomal architectural reconfiguration in the developing human frontal cortex and hippocampus

poster

Jaklic, Daniel C

Characterizing low-frequency oscillations in human pluripotent stem cell derived cortical organoids using multiple electrode arrays

poster

Jansen, Sophie

Inferring and perturbing cell fate regulomes in human brain organoids

poster

Jensen, Pia

Investigation of familial Alzheimer’s disease mutations in human stem cell-derived brain organoids using proteomics and PTMomics

poster

Kalpana, Kriti

Novel methods for the integration and study of iPSC-microglia in oligo-cortical organoid models of neurodegenerative disease

poster

Kao, Jennifer

GAD1+ interneurons facilitate the emergence of organized activity in human cerebral organoids

talk

Kasap, Pelin

A human isogenic in vitro model of the neurovascular unit to explore blood-brain barrier dysfunction in neuroinflammation

poster

Kilpatrick, Savannah A

Investigating early neurodevelopmental abnormalities and neural circuitry in 3D human models of the 15q13.3 microdeletion disorder

talk

Kim, Jonghun

Modeling DEAF1-associated neurodevelopment disorder (DAND) with human brain organoids

poster

Kim, Suel-Kee

Origins of individual variation in the emergence of the neural lineage from human pluripotent stem cells

poster

Kim, Yangsik

Prediction of receptor-drug interaction in neural stem cells

poster

Kiral, Ferdi Ridvan R

Generation of ventralized human thalamic organoids with the thalamic reticular nucleus

poster

Knoblich, Juergen A

Genetic CRISPR/Cas9 screening in cerebral organoids by barcoded single cell transcriptomics

talk

Kundu, Srikanya

Fluorescent biosensor-based functional validation of biofabricated 3D human iPSC-derived neuronal models for drug screening

poster

Lai, Jenny

Uncovering the molecular and cellular mechanisms of RFX3 haploinsufficiency associated autism spectrum disorder

poster

Lakatos, Andras

A novel ALS brain organoid slice model—Pathomechanistic and therapeutic discoveries at single cell resolution

poster

Lancaster, Madeline

Unravelling human-specific mechanisms of neural stem cell fate determination

talk

Laterza, Cecilia

FMR1 silencing and stability during human FXS brain development—From early stage of pluripotency to 3D cortical organoids

talk

Latour, Brooke

Modelling Koolen-de Vries syndrome in cerebral organoids

talk

Lee, Sumin

Label-free three-dimensional imaging and quantitative analysis of live organoids using low-coherent holotomography

poster

Lendemeijer, Bas

Rapid specification of human pluripotent stem cells to functional astrocytes

poster

Leysen, Marlies

Brain organoids as a platform to study subcellular trafficking of recombinant AAV vectors

poster

Li, Chong

Single-cell CRISPR screening in cerebral organoids identifies developmental and cell type-specific defects of autism

poster

Li, Zhuoliang

Label-free functional characterization of human brain organoids at single-cell resolution

poster

Lindhout, Feline W

Modeling species-specific aspects of axon tract development in long-term human and mouse brain organoid cultures

poster

Liu, Daniel

Purification and characterization of human neural stem and progenitor cells

poster

Lloyd-Davies Sanchez, Daniel

Long term in-situ electrical recording of cerebral organoids grown at the air-liquid interface, permitted by novel MEA design

poster

Lu, Xiaoyu

Genetically encoded voltage indicators for deep and sustained voltage imaging in brains

poster

Lunshof, Jeantine E.

The Brainstorm Organoid Project—A collaboration of bioethics and neuroscience to advance brain organoid research

talk

Maletic-Savatic, Mirjana

Why so stressed? Metabolic considerations for brain organoids

poster

Maloney, Zacharie

Dual effects of poly-alanine expansion mutations in ARX during human cortical and interneuron development

poster

Manso Musso, Camila

EIF4A3 regulation of neurogenesis and neuronal maturation in mouse and human development

poster

Marziali, Leandro N

Human iPSC derived myelinating organoids to study Krabbe disease

poster

Massih, Bita

A 3D cell culture system for bioengineering human neuromuscular junctions

poster

Meng, Xiangling

CRISPR screens in assembloids reveal autism spectrum disorder genes that interfere with human interneuron development

poster

Micali, Nicola

Molecular programs of area specification and neural stem cell fate progression in developing macaque cortex

poster

Millen, Kathleen

Surprises from human cerebellar development—We can’t model what we don’t know

talk

Ming, Guo-li

Molecular mechanisms regulating brain development

talk

Morales, Matheo

Aligning single-cell gene expression profiles from human and chimpanzee organoid models and the developing human brain to uncover gene expression signatures of heterochronic neurodevelopment

talk

Moses, Colette

The impact of human-specific NOTCH2NL gene variants on 1q21.1 microdeletion/duplication syndrome

poster

Mummery, Christine L

Vascularized 3D models of the heart derived from human pluripotent stem cells

talk

Murray, Aoife M

A cerebral organoid model of Alzheimer’s disease pathogenesis including naturally secreted soluble oligomeric aggregates

poster

Murtaza, Nadeem

Cell type-specific proteomic screening using brain organoids to study PPP2R5D in neurodevelopmental and neurodegenerative disorders

poster

Nair, Preethika

3D multicellular patient-derived glioblastoma spheroids for personalized therapeutics

poster

Nikolla, Kamela

MECP2 expression and role during early primate corticogenesis

poster

Niu, Wei

Human cortical organoid models of PCDH19 clustering epilepsy

poster

Novitch, Bennett

Distinct patterns of neural oscillation activities and deficits in cortex- and hippocampal-ganglionic eminence fusion organoid models of genetic epilepsy

poster

Öhlenschläger, Marie

Enrichment of synaptosomes from dorsal forebrain organoids

poster

Okano, Hideyuki

Modeling Alzheimer's disease and tauopathy using iPSCs-derived brain organoids

talk

Osenberg, Sivan

16p11.2 deletion affects the transcriptome and the lipidome of human iPSC-derived neurons and brain organoids

poster

Pak, ChangHui

Human brain organoid models of NRXN1 CNVs reveal disease genetic background induced developmental phenotypes associated with schizophrenia

talk

Pal, Atreyo

Resolving the 3D chromatin interactome of human accelerated regions during human and chimpanzee neurodevelopment

poster

Park, JiSoo

Towards engineering an artificial neural tube

poster

Parmar, Malin

Precise and reproducible midbrain patterning in silk-bioengineered human brain organoids

talk

Pasca, Sergiu P

From stem cells to organoids to assembloids and toward buildings human circuits in living systems to study disease

talk

Pavon, Narciso S

Diffusion based morphogen gradient microsystem for the dorsal-ventral patterning of forebrain organoids

poster

Pearson, Caroline A

2-dimensional and 3-dimensional patient-derived stem cell models of STXBP1-associated epilepsy

poster

Pellegrini, Laura

Temporal development and maturation of CSF-producing choroid plexus organoids

poster

Polleux, Franck

SRGAP2C, a human-specific modifier of cortical connectivity and circuit function also regulates synaptic plasticity and microglial cell function in the adult cortex

talk

Popova, Galina

Neuro-immune organoids for modeling prenatal brain infections

poster

Raj, Nisha

A multiomic network approach to identify defects in proteostasis across patient-derived organoid models of FXS and DM1

poster

Rakotomamonjy, Jennifer M

Investigating the cellular mechanisms that underlie the neurological phenotype associated with PCDH12 variants in cerebral organoid cultures

poster

Ramis Bravo, Elena

Identification and characterization of Cajal Retzius-like cells in cerebral organoids

poster

Rezzonico, Mitchell G

The transcriptional and regulatory landscape of NGN2-induced excitatory neurons

poster

Ricchetti, Miria

Cerebral organoids to study the progeroid, neurodegenerative, and clinically heterogeneous Cockayne syndrome

poster

Rittenhouse, Chelsea

Elucidating microglia's roles in proper neurodevelopment

poster

Robertson, Gabriella

Defective mitochondrial and peroxisomal fission disrupts neurogenesis

poster

Romero-Morales, Alejandra I

TCF4 mutations cause dysregulation of the oligodendrocyte lineage in a human model of autism spectrum disorder

poster

Rylaarsdam, Lauren E

A gain-of-function recurrent missense variant leads to a GABAergic/glutamatergic imbalance in a forebrain organoid model of PACS1 syndrome

poster

Salzinger, Andrea

Human stem cell derived neuromuscular assembloid model to study neuromuscular junction degeneration in amyotrophic lateral sclerosis

poster

Sanchis Calleja, Fatima

Decoding morphogen-induced patterning of developing human brain organoids

poster

Sandoval, Soraya O

Establishing methods for quantitative analysis of brain organoids to study neurodevelopmental disorders

poster

Santamaria, Mario

Early neurodevelopment disruption of gene regulatory networks in cortical disorders and neuropsychiatric traits

poster

Sebastian, Rebecca

Mapping out functional effects of schizophrenia-associated NRXN1 deletions in early forebrain development

poster

Sevetson, Jess

Connectoids—Models of local and long-distance network activity

poster

Sharf, Tal

Internally generated sequential firing patterns in human brain organoids

poster

Song, Hongjun

Modeling therapeutic treatment of glioblastoma with a patient-derived organoid model

talk

Song, Janet

Identification and characterization of human-specific deletions in neural progenitors

poster

Sonthalia, Shreyash

Structured joint decomposition identifies reproducible cell states and their developmental progression across human neocortical development

poster

Sozzi, Edoardo

Investigating human dopaminergic—Striatal neuron interactions with bioengineered multi-organoid systems

poster

Stankovic, Isidora

Elucidating the roles of brain endothelial cells in the onset of schizophrenia

poster

Starr, Alexander L

Allele-specific splicing in human/chimpanzee hybrid cortical organoids reveals potential drivers of human evolution

poster

Stokes, Kyle

Modeling STXBP1 loss of function using human pluripotent stem cell derived 2D and 3D models

poster

Sud, Reeteka

Generation and characterisation of neuropsychiatric patients-derived stem cells from a cohort in India

poster

Summers, Rose

Generation of microglia-containing APOE4 cerebral organoids as a model of Down syndrome associated Alzheimer’s disease

poster

Tanaka, Yoshiaki

Identifying disease-associated cells in single-cell transcriptome profiles of patient-derived brains and organoids with deep learning models

poster

Temple, Sally

Improving efficiency and reproducibility of brain organoids for modeling neurodegenerative disease

talk

Trepte, Philipp

Integrated transcriptome and proteome analysis in human brain organoids reveals posttranscriptional regulation of ribosomal genes

poster

Umans, Benjamin

Mapping genetic contributions to individual- and cell type-specific brain oxidative stress responses

poster

Uzbas, Fatma

Dynamic proteome of the centrosome during human cortical development and its disease relevance

poster

Vaccarino, Flora

Epigenomic determinants of excitatory neuron imbalances in ASD

talk

Villa, Emanuele

One by one—Single cell resolution illuminates disease pathogenesis in organoid models of neurodevelopmental disorders

poster

Voitiuk, Kateryna

Optogenetic stimulation of cortical organoids on high-density CMOS microelectrode arrays using a custom open-source hardware platform

poster

Walsh, Ryan

Assessment of schizophrenia associated structural variants in a developing cortical interneuron assembloid model reveals impaired tangential migration linked to mitochondrial function

poster

Waxman, Elisa A

Cross-site reproducibility of iPSC-derived human cortical organoids

poster

Werner, Jonathan

Conservation of co-expression defines the fetal fidelity of human brain organoids

poster

Whitney, Kristen

Increased toxic tau proteoforms in human iPSC-derived midbrain organoids from sporadic progressive supranuclear palsy patients

poster

Whye, Dosh

Dynamic 3D combinatorial generation of hPSC-derived neuromesodermal organoids with diverse regional and cellular identities

poster

Wong, Sakurako

Cerebral organoids model altered activity in tuberous sclerosis

poster

Yang, Woo Sub

Generation of hypothalamic organoid for the study of the developing brain

poster

Yoo, Taesun

Shank3-L68P mutant mice show reduced social communication and cognitive inflexibility and impaired mGluR-LTD

poster

Zenk, Fides

Single cell epigenomic reconstruction of human brain organoid development

poster

Zhang, Jiajing

3D brain region-specific spheroids for modeling neurodegenerative diseases and therapeutic evaluation

poster