Forty Years of mRNA Splicing: From Discovery to Therapeutics        
October 22-25, 2017

You must register for the meeting in order to submit abstracts.
After registering you will be sent a web link for abstract submission by email.

Program information: An electronic version of the program abstract book will be sent three working days prior to the first day of the meeting, and hard copies will be available for collection upon your arrival at Cold Spring Harbor Laboratory. First night and keynote speakers are informed of their session date and time, otherwise program information is only available upon release of the electronic version of the abstract book. The reason we do this is to try and maximize interactions by encouraging participants to stay for the duration of the meeting.

Please check your email for talk length, poster instructions, and how to have your poster printed at CSHL for collection upon arrival. 

Abstract Status

Presenting Author

Abstract Title

Talk/Poster

Abelson  John

Splicing, a field that has succeeded

talk

Bai, Rui

Structure of an intron lariat spliceosome from Saccharomyces cerevisiae

poster

Barbosa-Morais, Nuno

psichomics—A bioinformatics application for the quantification, analysis and visualization of alternative splicing from large transcriptomic datasets

poster

Barbosa-Morais, Nuno

CELF2 at the core of a prognostic alternative splicing signature in colorectal cancer

poster

Beggs  Jean

From gene cloning to splicing, transcription and chromatin

talk

Black  Douglas

Pre-mRNA binding proteins as positive and negative regulators of splicing pattern

talk

Blencowe, Benjamin

Systematic exploration of the regulatory and functional landscapes of alternative splicing

talk

Braun, Joerg

Synergistic assembly of human pre-spliceosomes across introns and exons

poster

Broker  Thomas

Discovery and characterization of alternative RNA splicing, promoter usage and poly-A site selection in mRNAs and their biological implications

poster

Brooks, Angela N

High-throughput and full-length characterization of transcript isoforms to investigate cancer-associated mutations

poster

Calarco, John

CRISPR-mediated genetic interaction profiling identifies RNA binding proteins regulating alternative splicing and metazoan fitness

poster

Capponi, Simona

nSR100 is involved in alternative micro-exon splicing of TAF1 mRNA and linked to X-linked Dystonia-Parkinsonism

poster

Cartegni  Luca

Induction of secreted soluble decoy EGFR variants by splicing interference inhibits signaling and tumor growth In treatment-refractory lung cancer

poster

Catania, Francesco

mRNA-associated processes and the evolution of the eukaryotic gene structure

poster

Chakrama, Fatima

Alternative splicing induced by cisplatin—Effect on mitochondria shape

poster

Chen, Lingling

Genome-wide screening of NEAT1 regulators reveals mito-paraspeckle communications

poster

Chen, Weijun

Transcriptome-wide analysis of the functional intronome using spliceosome profiling

poster

Cheng  Soo-Chen

Studies of protein components and protein complexes of the yeast spliceosome

talk

Cho, Sung Hwan

Association of the miR-604A>G, miR-608C>G, miR-631I/D, miR-938C>T, and miR-1302-3C>T polymorphisms with risk of idiopathic recurrent pregnancy loss in Korean women

poster

Chow  Louise

The EM discovery of split genes and RNA splicing in adenovirus transcripts

talk

Dreyfuss  Gideon

RNA-binding proteins and RNPs in splicing and mRNA regulation

talk

Espinosa, Sara

Structure and function of U1 snRNP

poster

Flaherty, Erin

Cataloging and manipulating NRXN1α transcriptional variants in hiPSC neurons from psychosis patients with heterozygous NRXN1 deletions

poster

Fu  Xiang-Dong

Splicing factors and regulators in biology—More than we could have imagined

talk

Galarza-Munoz, Gaddiel

Epistasis between genetic variants controlling alternative splicing of IL7R increases the risk of multiple sclerosis

poster

Garcia-Blanco  Mariano

Human epistatic interaction controls IL7R splicing and increases multiple sclerosis risk

talk

Gelinas  Richard

Splicing foretold—Abundant adenovirus 2 mRNAs were composed of sequences derived from more than one position on the genome

talk

Glasser, Eliezra

A decade of U2AF65 structures and still more to learn

poster

Gokmen-Polar, Yesim

High ESRP1 induces aggressiveness in ER+ breast cancer independent of EMT

poster

Graveley  Brenton

The incredible world of pre-mRNA splicing

talk

Green  Michael

Identification of alternative splicing factors through large-scale RNA interference screens

talk

Gunderson  Samuel

Impressive potency of anti-KRAS and anti-MYC U1 Adaptor Oligo conjugates to shrink tumors in xenograft mice

poster

Guthrie  Christine

Exploiting the “awesome power” of yeast genetics

talk

Hannigan, Molly M

Ptbp2 controls an alternative splicing network required for cell communication during spermatogenesis

poster

Hayati, Sheida

Identification of alternative splice variants as biomarkers of predisposition to chemotherapy resistance in acute myeloid leukemia

poster

Hernandez  Nouria

The early days of splicing in vitro

talk

Hoskins, Aaron A

Insights into the function of SF3b1 during branchsite recognition

poster

Hosokawa, Motoyasu

Loss of Sfpq impaired long gene expression and caused metabolic myopathy with severe muscle mass reduction

poster

Jansen, Kathrin

Self-antigen splicing in thymic epithelial cells—Insights from population and single-cell transcriptomics

poster

Jurica  Melissa

A flexible region of Prp8 stabilizes U5 snRNA loop I and is functionally linked to 5′ splice site recognition

poster

Ke, Shengdong

m(6)A mRNA modifications are deposited in nascent pre-mRNA and are not required for splicing but do specify cytoplasmic turnover

poster

Kim, Tae-Don

Post-transcriptional regulations of natural killer cells in their differentiation and immunity

poster

Konarska  Magda

Spliceosome complexes—From early manifestations to future challenges

talk

Kornblihtt  Alberto

Transcriptional control of alternative splicing along time—Ideas change, experiments remain

talk

Laaref, Mahdi

Transcription-dependent control of stem cell self-renewal and differentiation by the splicing factor U2AF1

poster

Lapasset Carbones, Laure

Long lasting control of viral rebound with a new drug candidate ABX464

poster

Lee, Gina

Post-transcriptional regulation of de novo lipogenesis by mTORC1-S6K1-SRPK2 signaling

poster

Li, Joshua S

Neuronal cell-type-specific alternative splicing of Drosophila Dscam2 is regulated by muscleblind

poster

Loenen, Wil

The role of S-adenosylmehionine (SAM) in RNA biology

poster

Luco, Reini F

A chromatin signature for alternative splicing

poster

Luehrmann, Reinhard

An intriguing journey from the initial biochemical characterization of snurps to cryo-EM snapshots of the spliceosome

talk

Luteijn, Maartje

Towards understanding the life cycle of toxic repeat RNAs in amyotrophic lateral sclerosis through chemical biology

poster

Lynch  Kristen

Regulation of alternative splicing in T cell activation and viral infection

talk

Maniatis  Thomas

RNA transcription, splicing and stochastic promoter choice in the Protocadherin α gene cluster

talk

Manley  James

Concentration-dependent splicing regulation—A critical mechanism in normal and disease cells

talk

Marasco, Luciano E

Roles for transcription elongation and chromatin modifications on SMN2 E7 alternative splicing

poster

Mayeda  Akila

40 years of mRNA splicing—35 years of my studies

poster

Moore  Melissa

Spliceosome profiling allows for transcriptome-wide analysis of the functional intronome

talk

Mount  Stephen

Nano-exons in Drosophila melanogaster

poster

Nagai  Kiyoshi

CryoEM snapshots of the spliceosome provide insights into the mechanism of pre-mRNA splicing

talk

Neugebauer  Karla

Perfect timing—Splicing and transcription in living cells

talk

Nguyen, Dang H

Myelodysplastic syndrome-associated spliceosome mutations confer
R loop-dependent ATR inhibitor sensitivity

poster

Nik, Sara

Spliceosomal components protect embryonic neurons from R-loop mediated DNA damage and apoptosis

poster

Padgett  Richard

Spliceosomal factor mutations in human diseases

talk

Potts, Kathryn S

The spliceosomal component Sf3b1 is essential for hematopoietic stem cell formation through regulation of the Jak/Stat signaling pathway

poster

Pulvino, Mary

A conserved SF3b1 – Tat-SF1 interaction enforces an ATP-dependent checkpoint in spliceosome assembly

poster

Raghavan, Madhura

Investigating the mechanism by which Prp8 balances splicing fidelity and efficiency using a saturation mutagenesis approach

poster

Ratni, Hasane

Small molecule SMN2 splicing modifier for the treatment of SMA. An insight into a unique mode of action

poster

Roberts, Richard

The discovery of RNA splicing

talk

Roca  Xavier

Noncanonical mechanisms of recognition of 5’ splice sites

poster

Saini, Harleen

Introns in neuronal projections—What role(s) do they play?

poster

Saito, Yuhki

Neuron-specific cTag-CLIP reveals cell-specific diversity of functional RNA regulation in the brain

poster

Schott-Lerner, Geraldine O

Regulation of IL7Rα alternative splicing by DDX39B and PTB

poster

Sharp  Phillip

The journey to RNA splicing

talk

Shi, Yigong

Mechanistic insights into pre-mRNA splicing by the spliceosome

talk

Spector  David

Nuclear speckles, non-coding RNAs, and cancer—Full circle

talk

Sperling  Ruth

The endogenous pre-mRNA processing machine & miRNAs found within it

poster

Srebrow, Anabella

Exploring the connection between SUMO conjugation and the splicing process

poster

Srinivasan, Venkat N

Thirteen ways—Building varying digital narratives from interconnected science archives

poster

Staley  Jon

Proofreading and catalyzing pre-mRNA splicing

talk

Steitz  Joan

RNA-RNA interactions in the spliceosome

talk

Tapial, Javier

VastDB—An atlas of alternative splicing profiles and functional associations in vertebrate tissues and cell types

poster

Tarn  Woan-Yuh

The exon junction factor Y14 modulates p53 splice isoform expression and genomic stability

poster

Ustianenko, Dmytro

LIN28 selectively modulates a subclass of let-7 microRNAs

poster

Vaz-Drago, Rita

The impact of deep-intronic mutations on human disease

poster

Vrbsky, Jan

Differential patterning of alternatively spliced YAP1 gene in adult human heart and during in-vitro cardiac differentiation

poster

Watabe, Eichi

Genome-wide kinetic analysis of pre-mRNA processing in living animals

poster

Widom, Julia

Fluorophore labeling of the U5 snRNA for use in single-molecule studies

poster

Willems, Patrick

SmE-b at the center of plant spliceosomes directing the transcriptome and splicing events

poster

Wilusz, Jeremy

Reducing the efficiency of pre-mRNA processing promotes circular RNA production

poster

Xu, Yong-Zhen

Alternative splicing regulation of doublesex gene in the silkworm Bombyx mori

poster

Yang, Li

Regulation of circRNA biogenesis and function

poster

Yano, Yoshika

An RNA-binding protein, Qki5 is a novel embryonic neural stem cell regulator through pre-mRNA processing in cell adhesion signaling

poster

Zhang, Chaolin

Rbfox splicing factors promote neuronal maturation and axon initial segment assembly

poster

Zhang, Xiaofeng

An atomic structure of the human spliceosome

poster

Zipursky  Larry

Alternative splicing of Dscam1 generates a vast number of isoforms essential for neural circuit assembly

talk