Brain Barriers
April 8 - 12, 2025

You must register for the meeting in order to submit abstracts.
After registering you will be sent a web link for abstract submission by email.
You may copy and paste your abstract from Word, Google Docs, or Notepad; abstracts are limited to ~2900 characters.

Program information: An electronic version of the program abstract book will be sent three working days prior to the first day of the meeting, and hard copies will be available for collection upon your arrival at Cold Spring Harbor Laboratory. First night and keynote speakers are informed of their session date and time, otherwise program information is only available upon release of the electronic version of the abstract book. The reason we do this is to try and maximize interactions by encouraging participants to stay for the duration of the meeting.

Please check your email for talk length, poster instructions, and how to have your poster printed at CSHL for collection upon arrival. 

Abstract Status

Presenting Author

Abstract Title

Talk/Poster

Adam, Nathan E

Investigating the role of blood-brain barrier microvascular endothelial cell infection in Rift Valley fever virus neuroinvasion

poster

Akassoglou, Katerina

Blood drivers of inflammation and tissue repair—Mechanisms and therapies

talk

Akcan, Ugur

The transcription factor RXRα, regulates the disease-associated gene signatures of myeloid cells in immune-mediated OCD

poster

Alexander, Kellianne D

Amyloid-β induces an upregulation of matrisome proteins and MMP activity in human blood-brain barrier cells

talk

Altunsu Kurt, Deniz

Blood-brain barrier disruption as a biomarker for early course psychosis—An In Vivo/Ex Vivo Investigation

poster

Andaloussi Mae, Maarja

Mechanistic studies on the blood-brain barrier

talk

Anquetil, Typhaine

SOX9 transcription factor governs neurotip cell specification and function

poster

Aydin, Sidar

Transcriptional and functional profiling of the tanycytic blood-cerebrospinal fluid barrier at the median eminence in health and neuroinflammation

talk

Biswas, Saptarshi

Blood-retinal barrier disruption precedes neuroinflammation and synaptic disorganization in response to abnormal neuronal activities

poster

Boye, Kevin

Drug Delivery across the blood brain barrier

talk

Burek, Malgorzata

Tjap 1 is a novel negative regulator of barrier properties in brain microvascular endothelial cells in vitro

poster

Burrage, Emily N

Endothelial TDP-43 contributions to cerebrovascular reactivity in neurodegenerative diseases

poster

Campbell, Matthew

Claudin-5 mediated regulation of the blood brain barrier

talk

Charvat, Vilem

A role of tanycytes in the transport of lipidized analogs of prolactin-releasing peptide from the periphery to the brain

poster

Cheemala, Ashok H

Single-allele TDP-43G348C mutation leads to endothelial dysfunction and blood-brain barrier defects in mouse model of amyotrophic lateral sclerosis and frontotemporal dementia

talk

Collignon, Adeline

Impact of stress-induced inflammation on blood-brain barrier transport

talk

Daigle, Beatrice

Impact of chronic stress on the neurovasculature during adolescence

poster

Daneman, Richard

Blood-brain barrier regulation of brain function and behavior

talk

Dani, Neil

Visualizing calcium dynamics in choroid plexus endothelial cells

talk

Datta, Dibyadyuti

A human pluripotent stem cell-derived model to investigate neuronal injury in cerebral malaria

poster

Dichgans, Martin

The stroke risk gene Foxf2 maintains brain endothelial cell function via Tie2 signaling and protects against neuronal ferroptosis

poster

Erturk, Ali

Skull marrow niches—A new frontier for neuroinflammation and therapeutics

talk

Fame, Ryann

Ultrasonic cerebrospinal fluid clearance improves outcomes in hemorrhagic brain injury models

talk

Figueroa Velez, Dario X

CSF glutamate suppresses choroid plexus epithelial cell function through the metabotropic glutamate receptor 8

poster

Florido, Mary Heather C

Investigating the role of apoptosis in brain endothelial cells—Implications for the aging brain

poster

Gall, Lewis

Pharmacological modulation of the blood-brain barrier to enhance glioblastoma treatment

poster

Gao, Zhihua

Regulation of posterior pituitary vasculature by neuroendocrine cells

poster

Garcia, Francisco J

Cell type-specific targeting of the brain vasculature delays progression of neurodegeneration in vivo

poster

Gaston-Breton, Romane

Injury factors in cerebrospinal-like fluid from choroid plexus organoids regulate neurogenesis contributing to hypoxic brain injury

poster

Goldwaser, Eric l

Blood-brain barrier functional improvements after transcranial magnetic stimulation in depression treatment outcomes

poster

Greaney, Aisling

The effect of substrate stiffness on astrocytes and leptomeningeal cells

poster

Guerit, Sylvaine

Engineered Gpr124-targeting Wnt surrogates activate β-catenin signaling in the blood-retina barrier and reverse disease phenotypes in vascular retinopathy models

poster

Halfon, Aviv

Dynamic adaptations in arcuate nucleus vasculature modulate hormonal transport in metabolic challenges

talk

Hehnly, Christine S

Unveiling the choroid plexus—A Key player in maintaining the brain immune landscape across development

talk

Herbert, Sarah C

Determining essential components of an iPSC-derived in vitro blood-brain barrier model for ischemic stroke research

poster

Hochstetler, Alexandra

Choroid plexus autotaxin—A key regulator of myelination and candidate therapy for white matter injury

talk

Huang, Sheng-Fu

Regional pericyte heterogeneity in the mouse brain is acquired during postnatal development and is altered during aging and disease

poster

Hudak, Abagael

Assessing cerebrovascular inflammation and cognitive function in a mouse model of pneumonia infection

poster

Iatrou, Artemis

Contributions of non-neuronal cell types to cortical transcriptomic changes in major depressive disorder

talk

Jamoul, Danny

Rab7a activation after ischemic stroke degrades select blood-brain barrier tight junction proteins

poster

Jimenez, Daniella

Clinically relevant FUS-BBBO increases the extent of the opening volume and microglial activation compared to pre-clinical parameters

poster

Jo, Haneul

The calcium pump ATP2B1/PMCA1 regulates CNS vascular development by facilitating Norrin/WNT7 canonical signaling

talk

Jones, Hannah E

Investigating the role of PDGF signaling in brain perivascular fibroblast development

poster

Juarez Anaya, Maria Fernanda

Substance P regulates Tacr1 neurons, which control nitric oxide-mediated neurovascular coupling in the mouse cortex

poster

Kearns, Nicola A

Single nuclei profiling reveals diverse cell populations within the aged human meninges

poster

Keller, Annika

Postnatal development of brain pericytes

talk

Khalin, Igor

Novel insights of microthrombi-mediated blood-brain-barrier dysfunction in CNS pathologies

talk

Kim, Brandon

Unconventional CRISPR-Cas methods to discover novel host-pathogen interactions between bacteria and brain endothelium

talk

Kim, Injune

Dll4 maintains cerebrovascular homeostasis by regulating endothelial transcriptomic and epigenetic landscapes

poster

Kim, Minah

Angiopoietin-2 aggravates Alzheimer’s disease by promoting BBB breakdown and neuroinflammation

talk

Kim, Namsuk

Natural light experience induces metabolic switch that promotes cerebrovascular maturation

poster

Kim, Sol

“An immune hub” function of ventricular ependymal cells in the brain

poster

Kim, Sol

Meningeal cell contribution to barrier breakdown during neonatal bacterial meningitis

talk

Kisby, Brent

Global changes in gene expression in brain micro-vessels in a mouse model of alcohol dependence

talk

Kompanikova, Petra

Deciphering cellular and molecular principles of hindbrain choroid plexus development

poster

Kotchetkov, Pavel

16p11.2 microdeletion compromises blood-brain barrier integrity in mice

poster

Kucharz, Krzysztof R

Vessel Types determine extent of blood-brain barrier paracellular leakage, adsorptive transcytosis increase, responses to treatments, and glial activation in Huntington’s disease

talk

Lacoste, Baptiste

P2 purinergic receptor activation rectifies autism-associated brain endothelial dysfunction

talk

Lai, Wanjing

Moesin deficiency leads to microglia-mediated synaptic pruning and social abnormality—A post-GWAS functional genomics study

poster

Larsen, Reid

Multi-omic analysis reveals the unique glycan landscape of the blood-brain barrier glycocalyx

talk

Lauritzen, Martin

The relation of BBB transport across to vascular location and flow rate

talk

Lee, Eunhyeong

Angiopoietin-2 aggravates Alzheimer’s disease by promoting BBB breakdown and neuroinflammation

poster

Levey, Jacklyn

A Frizzled4/LRP5 agonist restores retinal pericyte coverage and reduces hemorrhage in genetic models of pericyte loss

poster

Li, Jieying

Defining a blood-ganglion barrier in the peripheral nervous system

talk

Li, Joshua

A spatiotemporal analysis of brain microvascular Ca2+ signals and the influence of different anesthetics

poster

Li, Zhongming

Defining cis-regulatory elements in CNS endothelial cells in vivo

talk

Lou, Liang

BBBflash—A novel non-invasive transgenic zebrafish model for high-throughput assessment of brain barriers permeability in vivo

talk

Lutz, Sarah E

Caveolin-1 contributes to blood-brain barrier permeability and cognitive impairment in a mouse model of long COVID

talk

Martinez-Corral, Ines

An old friend with new tricks, VEGFR system in the crosstalk between brain and periphery

talk

Martins-Goncalves, Remy

Pharmacological induction of Wnt/β-catenin signaling prevents long-term neurological impairment in SARS-CoV-2 infected mice

poster

Matsuoka, Ryota

Identification of a multipotent cerebrovascular niche that generates BBB and fenestrated endothelial subtypes, and molecular mechanisms governing their angiogenic segregation

poster

Menegatti Bevilacqua, Laura

Sex-specific blood-brain barrier alterations in Parkinson’s disease

poster

Miglietta, Audrey

Blood-brain barrier regulation of hippocampal function

poster

Montagne, Axel

Dementia through the vascular lens—Exploring dysfunctional brain cell interactions

talk

Moore, Jessica L

Dag1 is essential for development of proper astrocyte morphology and perivascular processes

talk

Murphy, Patrick

Endothelial TDP-43 depletion disrupts core blood-brain barrier pathways in neurodegeneration

poster

Nasrollahi, Ava

Fibroblast-derived laminin repairs BBB injury and regulates fibroblast biology after ICH

poster

Nivitchanyong, Toey

Crossing the blood-brain barrier—Developing Alector’s next generation of investigational therapies for neurodegeneration

poster

Nusbaum, Amilia L

The effect of gut-derived metabolites on the blood-brain barrier

poster

O'Brown, Natasha M

Unraveling the molecular and cellular mechanisms of blood-brain barrier regulation using zebrafish

talk

Ogden, Pierce

The brain trancytosome—Pooled in vivo screening of 1000s of biologics characterizes novel “portal” receptors and mechanisms for macromolecule CNS delivery

talk

Osterhout, Jessica A

A connection between the immune system and the brain—The role of circumventricular organs in immunoception

talk

Palsa, Kondaiah

Mechanisms of blood-brain barrier endothelial cells mediated brain iron accumulation during brain inflammation

poster

Panji, Jay

Rapid and multimodal blood-brain barrier genetics by somatic mutagenesis

talk

Pisiren, Melis

The transport of tau across the blood-brain barrier

poster

Polenz, Chanele K

Investigating the relationship between atherosclerotic cardiovascular disease and depression/anxiety

poster

Porkolab, Gergo

Claudin-5 tightly regulates brain endothelial identity

poster

Potts, Thomas C

Identification of small molecule modulators of the blood-brain barrier in zebrafish via a novel high throughput screening platform

poster

Profaci, Caterina P

The role of mechanosensation at brain barriers

talk

Radzishevsky, Inna

BBB-dependent glutamine deficiency causes metabolic reprogramming and affects brain development

talk

Ramos Vega, Marta

Quantitative whole-brain imaging for characterizing the brain distribution of TfR1 shuttled antibodies

poster

Reardon, Erin

Investigating the role of the brain-meninges interface in traumatic brain injury

poster

Reid, Madigan M

Brain vascular single-cell multi-omics elucidates disease risk associations

talk

Rizalar, F. Sila

Investigating mechanisms of CD98hc transport in human brain endothelial cells

talk

Rogovsky, Artem

Lyme neuroborreliosis—An urgent need to develop suitable mouse models

poster

Ruan, Jingsong

Loss of mural-cell laminin aggravates Alzheimer’s disease pathology

poster

Salazar, Jonathan H

Ripk1 silencing rescues blood-brain barrier loss and hippocampal inflammation in a hyperlipidemic model

poster

Salvador, Ane

pH dependent anti-TfR NANOBODY® molecules deliver functional oligonucleotides to muscle and CNS

talk

Santisteban, Monica

Meningeal immunity and lymphatic function in hypertension

talk

Sapkota, Arjun

Disconnect between blood–brain barrier disruption and microglial activation in aged mice exposed to hypoxia—Implications for the pathogenesis of vascular dementia

poster

Sato, Kazuki

Novel antibody technology enabling efficient penetration and long-term retention in the central nervous tissues

poster

Schroger, Luise Sophia Klara

Excessive trans-endothelial iron influx causes neuronal ferroptosis in Foxf2-related small vessel disease

poster

Seegren, Philip

Innate immunity in the neonatal meninges—Investigating cell-specific responses to bacterial meningitis

poster

Segarra, Marta

Vascular FLRT2 regulates venous-mediated angiogenic expansion and CNS barriergenesis

poster

Shaban Pour, Mehran

Oligodendrocytic integrin-β1 regulates blood brain barrier integrity and hemorrhagic brain

poster

Shankar, Archana

Genetics of immune cell homing to the CNS using in vivo CRISPR-Cas9 screens

poster

Shi, Sophia M

Utilizing the cerebrovascular glycocalyx for the treatment of CNS diseases

talk

Shuken, Steven R

Deep proteomic analysis of mouse choroid plexus on the orbitrap astral mass spectrometer with data-independent acquisition

poster

Silva, Ana Isabel

Sex-specific neurovascular and astrocyte alterations in the medial prefrontal cortex following early-life stress

poster

Simoes Da Gama, Coraly

Impact of chronic peripheral inflammation on the blood-brain barrier—Case of epilepsy

poster

Smyth, Leon C

Amyloidosis in bridging veins impairs CSF clearance to the dura mater

talk

Stefancova, Dorota

Targeted ablation of brain pericytes reveals critical insights into pericyte-endothelial crosstalk

poster

Swarovski, Michelle S

Uncovering the role of circumventricular organs during infection

poster

Tai, Leon M

Brain endothelial cell APOE genotype as a regulator of neurovascular function

poster

Tamhankar, Soniya

Forward programming identifies inducers of blood-brain barrier properties in hPSC-derived endothelial cells

poster

Todorov, Mihail

Spatial mapping of vascular integrity and drug delivery across the blood-brain barrier using tissue clearing and light sheet microscopy

talk

Umlauf, Ben

Modulating cerebral spinal fluid flux enhances blood-brain barrier restoration post-traumatic brain injury

poster

Vanhollebeke, Benoit

Single-cell control mechanism of brain angiogenesis and blood-brain barrier formation

talk

Vidal-Paredes, Isaac A

Restoration of mitochondrial function in endothelial cells maintains the integrity of the blood-retinal barrier and prevents neurodegeneration in glaucoma

talk

Vo, Linh

Investigating the mechanism of TRPV4-mediated blood-neural barrier leakage using cellular models

poster

Wei, Shoupeng

Choroid plexus epithelial ALDH2 mediates ethanol-induced hypothermia in mice

poster

Westenskow, Peter D

Blood-retinal-barrier breakdown—Building advanced models and designing optimized vascular repair therapeutic strategies

poster

Williams, Dionna W

The blood brain barrier demonstrates capability to influence heterogenous tenofovir and emtricitabine metabolism and transport in the brain

talk

Wu, Lingzhi

Profiling the surface proteome of brain endothelial cells

poster

XU, JIYI

Choroid plexus-blood-CSF barrier controls ethanol-derived acetaldehyde and alcohol consumption

poster

Yaghoobi Hashjin, Fatemeh

Inducing blood-brain barrier properties in hPSC-derived endothelial cells by overexpressing KLF transcription factors using an inducible system

poster

Yao, Yao

Endothelial and mural laminin-α5 contributes to blood-brain barrier integrity maintenance

poster

Yeretz Peretz, Yoel

The role of the transcription factor LEF1 in blood-brain barrier maintenance

poster

Zhang, Zimo

Revealing physiological brain waste clearance pathways via neuronal protein labeling

talk

Zhou, Haoyue

An atlas of brain-permeable blood proteins unveils diverse neurological functions

talk