Mechanisms of Aging
September 26 - 30, 2016

You must register for the meeting in order to submit abstracts.
After registering you will be sent a web link for abstract submission by email.

Program information: An electronic version of the program abstract book will be sent three working days prior to the first day of the meeting, and hard copies will be available for collection upon your arrival at Cold Spring Harbor Laboratory. First night and keynote speakers are informed of their session date and time, otherwise program information is only available upon release of the electronic version of the abstract book. The reason we do this is to try and maximize interactions by encouraging participants to stay for the duration of the meeting.

Please check your email for talk length, poster instructions, and how to have your poster printed at CSHL for collection upon arrival. 

ABSTRACT STATUS

Presenting Author

Abstract Title

Talk/Poster

Adams, Peter

The epigenome—A conduit for pro-longevity and healthy aging interventions?

talk

Ahmed, Shawn

C. elegans piRNA mutants transmit a form of heritable stress

talk

Allsopp, Rich

Association of the protective FOXO3 longevity variant with telomere dynamics during aging

talk

Arriola Apelo, Sebastian I

Female sex hormones alter the metabolic impact of hepatic Rictor deletion

talk

Augereau, Adeline

Role of the naked mole rat TRF1 in telomere maintenance

talk

Azpurua, Jorge

Increased expression of the Drosophila matrix metalloproteinase 1 (dMMP1) gene in motor neurons contributes to behavior deficits during normal aging and TDP43-driven neurodegeneration

talk

Bagnall, Ciara N

The role of MAPK signaling in post-chemotherapy cognitive impairment

poster

Bai, Hua

The role of TGF-beta-Activin signaling in Drosophila cardiac aging

poster

Balch, William

Profiling reveals an aging signature in the lung responsive to influenza infection

poster

Benayoun, Berenice A

Genome-wide chromatin maps and transcriptomes across tissues during mouse aging

poster

Birch, Jodie

Rapamycin ameliorates senescence in the lung of a mouse model of chronic inflammation in a SASP-independent manner

poster

Blackwell, Keith

Modulation of stress responses and lifespan through redox signaling at the ER

talk

Bonkowski, Michael S

Divergent regulation of  SIRT1 within the neuroendocrine axis in response to calorie restriction

poster

Booth, Lauren N

Sexual interactions promote a premature aging signature in nematodes

talk

Borkowska, Joanna

Global 5-hydroxymethylation increases during aging of human subcutaneous fat and adipose stem cells.

poster

Brunet, Anne

Epigenetic regulation of aging neural stem cells

talk

Canaan, Allon

Mechanisms of pleiotropic impact on aging by FAT10

poster

Chakraborty, Tuhin Subhra

Death perception influences health and lifespan in Drosophila

talk

Chang, Sandy

TRF2 interacts with NBS1 to mediate telomere repair

talk

Cohen Berkman, Moran

A novel siRNA signal that promotes longevity upon germline removal in C. elegans

poster

Cohen, Haim

Weighty decisions by SIRT6 in fat oxidation

talk

Cooney, Michael C

DNA repair and cellular markers of aging in human cells engineered to express a tardigrade photolyase

poster

Csoka, Antonei B

Berberine and Gynostemma pentaphyllum extract effects on Progerin production in Hutchinson-Gilford progeria cells

poster

Cummings, Nicole E

Intervening in Hutchinson-Gilford progeria syndrome by reduction of specific dietary amino acids

poster

Dang, Weiwei

Activation of oxidative stress response via SIRT1 is required for successful adipogenic differentiation in mesenchymal stem cells

talk

Das, Abhirup

NAD and H2S reverse the effects of aging on endurance by triggering new capillary formation

talk

De Cecco, Marco

Architectural changes in genomes and derepression of transposable elements during replicative senescence of human fibroblasts

poster

Demarco, Rafael S

A lipid metabolism checkpoint regulates self-renewal and differentiation of germline stem cells

talk

Denzel, Martin S

Hexosamine pathway activation improves protein quality control in mammalian cells

talk

Derous, Davina

The signalling role of adipose tissue during calorie restriction

poster

Detienne, Giel J

Long live the Queen—Royalactin mediates longevity through epidermal growth factor (EGF) signaling and influences protein translation

talk

Di Francesco, Andrea

NQO1 is a novel regulator of mRNA translation, insulin sensitivity and energy metabolism

talk

Diaz-Ruiz, Alberto

Delineating S6K1-independent mechanisms induced by rapamycin

poster

Ear, Po Hien

The beneficial effect of nicotinamide riboside requires an optimal delivery method

poster

Fang, Evandro Fei

Reversal of defective nuclear-mitochondrial DNA damage signaling corrects neuromuscular phenotypes and extends lifespan in ataxia telangiectasia models

talk

Fuhrmann-Stroissnigg, Heike

Novel senotherapeutics for delaying onset of age-related diseases

poster

Gale, Debra

Highly selective fluorogenic probes for accurate and sensitive quantitation of nucleic acids

poster

Ghazi, Arjumand

Promotion of longevity by concomitant modulation of somatic lipid production and breakdown pathways in response to germline signals

talk

Gill, Matthew

Role and regulation of the truncated insulin receptor isoform DAF-2B in C. elegans

talk

Gladyshev, Vadim

Analysis of cancer genomes reveals basic features of human aging and its role in cancer development

talk

Glorioso, Christin A

Molecular brain aging and APOEε4 are independent and additive risk factors for Alzheimer’s disease

poster

Godinez, Ricardo

A platform to identify and validate novel bioactive peptides that control bioenergetics, metabolism and aging in mammals

poster

Gonzalez, Brenda

Elucidating the role of mitochondrial function in human longevity

poster

Grammatikakis, Ioannis

Identification of senescence-associated circular RNAs (SAC-RNAs) reveals senescence supressor CircPVT1

poster

Gurkar, Aditi

The role of endogenous DNA damage in driving senescence and aging

talk

Hanashiro, Jun

Gene regulation of Zizimin2 and its impact on immunosenescence

poster

Hansen, Malene

Spatiotemporal regulation of autophagy in C. elegans aging

poster

Harel, Itamar

Age-related loss of proteostasis as a driver of aging and disease in a new vertebrate model: the African turquoise killifish

talk

Harrington, Lea

Critically short telomeres induce differentiated cells to adopt a more primitive cell state

talk

Hartman, John L

Phenomic and metabolomic analysis of gene-nutrient interaction influences on S. cerevisiae chronological lifespan

poster

Hayano, Motoshi

Do epigenetic changes cause aging in mammals?

talk

He, Chong

Novel pipeline for discovery of compounds that alter cell cycle and extend lifespan in yeast

poster

Hekimi, Siegfried

Statistical analysis of mortality rates reveals different mechanisms of longevity in long-lived mouse and Caenorhabditis elegans mutants

poster

Henis-Korenblit, Sivan

Innate immunity mediated longevity and longevity induced by germ cell removal converge on the CTLD protein CTLD-F40F4.6

talk

Hoppe, Thorsten

Insulin receptor degradation controlled by the quality control ubiquitin ligase CHIP adjusts longevity and proteostasis

talk

Hsu, Ao-Lin

SAMS-1 as a nutrient sensor that mediates dietary restriction-induced longevity in C. elegans

talk

HU, CHI-KUO

Diapause in vertebrates—A natural form of suspended animation that protects organisms from stress and aging

poster

Hubbard, E. Jane

Aging germline stem cells

talk

Huh, Christine J

Maintenance of age in directly reprogrammed human neurons from fibroblasts

poster

Ieong, Iok Lou

Novel post-translational modification of KAP1 and its biological relevance

poster

Imai, Shin-Ichiro

The role of dorsomedial hypothalamic neurons in mammalian aging and longevity

talk

Iouk, Tatiana

Chemically regulated mitochondrial fusion and telomere-dependent longevity in yeast

poster

Ishii, Takamasa

Lipid peroxide-induced innate immune responses in premature aging gene SDHC-mutated paraganglioma's model mice

poster

Ishikawa, Shoma

Proteostasis failure and cellular senescence in primary rat hippocampal neurons

poster

Ito, Takahiro

Epigenetic regulation of cellular senescence by WNT-MYC-polycomb signaling

talk

Ivessa, Andreas

Low abundance of non-histone protein complexes in nuclei of replicative aging yeast cells results in reduced replication fork pausing/stalling at fragile chromosomal sites

talk

Iwashita, Yuji

Exploration and functional analysis of cellular senescence-associated long non-coding RNAs

poster

Jasper, Heinrich

Age-related stem cell dysfunction—Causes and consequences

talk

Jin, Kelly

Metabolomics of lifespan extension in calorically restricted fruit flies

poster

Jo, Jeong Hun

Age-associated pancreatic islet transcriptome analysis finds the involvement of glutamate decarboxylase 67 in compensatory insulin secretion

poster

Johnson, Jay E

Enzymatic depletion of methionine is sufficient to confer the cellular lifespan extension associated with methionine restriction

poster

Johnson, Sean E

Hippocampal dependent cognitive phenotypes in aged mice are recapitulated by CA1-specific NAMPT knockdown and rescued by nicotinamide mononucleotide

poster

Jones, Brian C

A somatic piRNA pathway in the Drosophila fat body suppresses transposable elements ensuring metabolic homeostasis

talk

Jung, Sukjoon

Genetic synthesis of age-dependent loss of survivorship in C. elegans

poster

Kaitsuka, Taku

The role of histone deacetylase 11 in the pluripotency of the mouse pluripotent stem cells

poster

Kang, Myung Jin

Negative regulation of lifespan by a potentially secreted type II DNA transposon

poster

Kang, Yun Kyoung

Role of RBM39-mediated mitochondrial dynamics in muscle-specific mitochondrial proteostasis and longevity.

poster

Kawamura, Yoshimi

Unique response of cancer- and senescence-resistant rodent “Naked mole-rat” to cellular senescence induction

poster

Ke, Zhonghe

Higher levels of niche HA of the NMR mediates the maintenance of LT-HSCs by reducing ROS levels

talk

Kenyon, Cynthia

Cellular quality control in the C. elegans germline

talk

Khodakarami, Amirabbas

Somatic increase of CCT8 mimics proteostasis of human embryonic stem cells and extends organismal longevity in C. elegans

talk

Khundmiri, Syed J

Salt-sensitivity in aging—A tale of two rat models

poster

Khussainova, Elmira

The role of SOD3 gene polymorphism in development of age-related diseases in Kazakhstan population

poster

Kim, Chuna

A telomerase-independent way to overcome replicative senescence in Caenorhabditis elegans

poster

Kim, Hyo Jung

Regulatory inversion in NAC network determines the timing of age-dependent cell death in plants

poster

Kim, Hyunmin

Positive feedback regulation between the circadian clock and an aging regulator in plants

talk

Kim, Keetae

miR-204 downregulates EphB2 in aging mouse hippocampal neurons

poster

Kim, Kyoung Mi

Novel senescence marker proteins SCAMP4 and DPP4 can regulate cellular senescence

poster

Kim, Sun Y

Defining chromatin network dynamics in aging neural stem cells

poster

Kim, Sunhee

C. elegans hijacks plant’s pathogen-defense peptide as an attractant signal to increase their fitness

poster

Kim, Sunhee

Age-dependent loss of physical strength is compensated by ZIP-2 via mitochondrial protection

poster

Kim, Youn-Jung

Restoration of environmental enrichment on cognitive  and auditory decline through the modulation of Sirt-1 and iNOS in aged rat brain

poster

Kocsisova, Zuzana

Reproductive aging of Caenorhabditis nematodes

poster

Kornfeld, Kerry

A genetic model of caloric restriction in C. elegans caused by food avoidance behavior

poster

Kreiling, Jill A.

Members of the miR465 family increase expression with age in mouse liver and influence the growth hormone receptor pathway

poster

Krizhanovsky, Valery

Quantitative identification of senescent cells and consequences of their pharmacological elimination

talk

Kumar, Sandeep

Identification of genes that regulate stress resistance and lifespan independent of FOXO transcription factor DAF-16 in Caenorhabditis elegans

poster

Kumsta, Caroline

HSF-1 jointly regulates autophagy and stress resistance in C. elegans

talk

Labunskyy, Vyacheslav

Amino acid permease deficiency extends Saccharomyces cerevisiae lifespan via translational activation of stress response genes

talk

Lamming, Dudley W

Decreased consumption of specific macronutrients promotes metabolic health and longevity

talk

Lapierre, Louis

Blocking lipid secretion promotes lipophagy and longevity

talk

Lee, Howon

Integrative transcriptome analysis to understand the hypothalamus ageing.

poster

Lee, Seung Jae

RNA surveillance via nonsense-mediated mRNA decay is crucial for longevity in C. elegans

talk

Lee, Siu Sylvia

Dynamic changes of gene-body H3K4me3 with age in C. elegans somatic cells

poster

Lee, Wei-Hua

Mouse Tmem135 mutation reveals a mechanism involving mitochondrial dynamics that leads to age-related macular degeneration (AMD) pathologies

poster

Lee, Wonhee

Potential regulatory switch modules that are involved in transition of physical status during aging in C. elegans

poster

Lee, Wonhee

Theoretical and experimental investigation on a plausible ‘aging clock’ system

poster

Leith, Andrew M

Expression of transposable elements in human aging

poster

Li, Jun

A conserved NAD binding pocket that regulates protein-protein interactions during aging

poster

Li, Li

PGC-1a-GABPa-AKT pathway modulates ageing and neurodegeneration

talk

Liberman, Noa

A screen of the human ORFeome for novel longevity regulators identifies CPNE2 as a lysosomal-mitochondrial regulator

poster

Libert, Sergiy V

Therapeutic suppression of SIRT6 protects from Parkinson’s disease

talk

Lim, Junhyun

Latitudinal evolution in aging—How do plants use latitudinal information to regulate aging?

poster

LIU, JIE-YU

Identification of senescent cells by the p16Ink4a tdTomato reporter mice

poster

Lopez-Dominguez, Jose Alberto

A very low-carbohydrate, ketogenic diet extends longevity and improves healthspan parameters in adult mice

poster

Lu, Jiongming

TORC1 amino-acid sensing pathway in lifespan regulation of Drosophila melanogaster

poster

Luo, Hanzhi

The regulation of mitochondrial metabolic checkpoint in HSC aging

poster

Luo, Ying

The loss of p21 function accelerated aging in Werner syndrome mouse model

poster

Luo, Ying

The potential of traditional Chinese medicine in balancing anti-aging and anti-tumor

poster

Lyu, Yang

Protein valuation modulates aging under a complex nutritional environment

talk

Macchiarini, Francesca

Research funding for studies of aging biology

poster

Magalhaes, Joao Pedro

Biodiversity of ageing—Old evolutionary mechanisms and new genomic approaches

talk

Mahmoudi, Salah

Old fibroblasts exhibit persistent inflammaging features that are linked with increased individual-to-individual variability in cellular reprogramming

poster

Mair, William

Dietary restriction and TORC1 promote longevity via splicing factor 1 modulation of pre-mRNA splicing homeostasis

talk

Malucelli, Lucca

Premature aging induced by visible light (simulated solar radiation) in adult human fibroblasts

poster

Marques, Francisco D

Epigenome-metabolic cross talk in senescence—Pyruvate-induced senescence

poster

Marttila, Saara

Aging-associated changes in the expression of human endogenous retrovirus family HERV-K(HML-2)

talk

Maulik, Malabika

Alaskan blueberry and Sirtuin 1-mediated signaling in a Caenorhabditis elegans  model of Parkinson's disease

poster

Mayr, Felix

In vivo protein folding capacity of the ribosome implicated in cytosolic protein folding capacity

poster

McGrath, Patrick T

Positive selection on a subunit of the NURF chromatin remodeler extends lifespan in a domesticated C. elegans strain

poster

Mihaylova, Maria M

Fasting-activated fatty acid oxidation enhances intestinal stem cell function in aging

talk

Miller, Dana L

Epigenetic bookmarking of hydrogen sulfide exposure

talk

Mills, Kathryn F

Long-term administration of nicotinamide mononucleotide mitigates age-associated functional decline in mice

talk

Miura, Kyoko

Tumour resistance in induced pluripotent stem cells derived from naked mole-rats

talk

Monnier, Vincent

The double-edge sword of vitamin C—An anti-aging vitamin that promotes oxoaldehyde stress in the aging lens and brain

poster

Moreno Blas, Daniel

Defective autophagy in neuronal senescence

poster

Morrissey, Christapher S

Meta-analysis leads to deeper understanding of cellular senescence

poster

Moskalev, Alexey

Effects of pharmacological inhibition of aging-associated pathways on Drosophila lifespan and healthspan

poster

Mucino Hernandez, Gabriel

NR4A nuclear receptor family and autophagy in the DNA damage response

poster

Nathan, Kousalya

Effect of abrupt and gradual calorie restriction regimens on biochemical and behavioral markers in obese mice

poster

Neretti, Nicola

Changes in chromosome architecture and transcriptional landscape in cellular senescence

talk

Newman, John C

Longevity and healthspan effects of ketogenic and high-fat diets in mice

poster

Nichenametla, Sailendra N

Methionine-restricted and low-calorie diets induce contrasting changes in gut microbiome and bile acid profile

poster

Noguchi, Eishi

Maf1-dependent transcriptional regulation of tRNAs extends lifespan under calorie-restricted conditions in fission yeast

poster

Noh, Ji Heon

Loss of GRSF1 triggers cellular senescence, elevates IL6 production

poster

Oberdoerffer, Philipp

Replication stress promotes persistent, DNA damage-induced epigenetic dysfunction with cellular age

talk

Ondracek, Caitlin R

Enhanced function of novel sirtuin enzymes achieved through directed evolution

talk

Ovadya, Yossi

Impaired immune clearance of senescent cells promotes aging in mice

poster

Owusu-Ansah, Edward

Regulation of mitochondrial complex I biogenesis in Drosophila skeletal muscles

poster

Park, Hi-Joon

Melanin-concentrating hormone (MCH) rescues dopaminergic neurons in Parkinson’s disease model—Increase of MCH by acupuncture treatment

poster

Park, Junsoo

Age-associated impairment of autophagy is regulated by miR-210 in hypothalamus

poster

Partridge, Linda

Exome matching predicts anabolic traits in Drosophila and mouse

talk

Petrashen, Anna P

Translational regulation of insulin-like growth factor 1 by MYC

poster

Pichardo, Israel

Screening of the mammalian proteome for small peptides that function as longevity factors

poster

Prahlad, Veena

Neurosensory control of the heat shock transcription factor, HSF1

poster

Promislow, Daniel

Canine aging—Can old dogs teach us new tricks?

talk

Rabinovitch, Peter S

Reversing cardiac aging by enhancing mitochondrial function

talk

Rezazadeh, Sarallah

Activation versus silencing—Towards a model for SIRT6-mediated Heme Oxygenase-1 promoter activation

poster

Riedel, Christian G

DAF-16/FOXO and HLH-30/TFEB cooperate as combinatorial transcription factors to regulate stress responses and aging in C. elegans

talk

Rodriguez-Fernandez, Imilce A

A new proteostasis checkpoint in Drosophila intestinal stem cells: implications for age-related tissue dysfunction

talk

Ross, Jaime M

Using proteomics to elucidate how voluntary exercise counteracts prematurely aging phenotypes in mtDNA mutator mice

poster

Saini, Natalie

The impact of environmental and endogenous damage on the accumulation of somatic mutation load in adult humans

poster

Scharf, Andrea

Analysis of C. elegans population dynamics to investigate aging

poster

Schultz, Michael B

Activation of CD38 and NAD depletion as a cause of inflammaging

poster

Sell, Christian

Metabolic  stress as a trigger for cellular senescence

poster

Seluanov, Andrei

SIRT6 contributes to more efficient DNA double strand break repair in long-lived rodent species

talk

Sharpless, Norman E

The role of CDKN2a in mammalian aging

talk

Shaw, Albert

Age-associated defect in human NLRP3 inflammasome function

talk

Shim, Jaewon

Expansion of lifespan of Drosophila by food extracts

poster

Simic, Milos

The activation of the UPRER is an essential step in the acquisition of pluripotency during reprogramming

talk

Simon, Matthew A

Fighting the legion—Suppression of mobilized LINE1 elements combats premature aging in SIRT6 knockout mice

talk

Simons, Mirre

Instant control of mortality rate by reduced Tor signalling

poster

Sinclair, David

Insights into the causes and reversibility of aging

talk

Smith Jr, Daniel L

Yeast phenomic analysis suggests association between hydrogen sulfide production and chronological lifespan

poster

Smith, Jessica L.

A sizeable role for the cell cycle in longevity

poster

Spurrier, Josh

Cdk5 dysfunction increases the intrinsic rate of aging

poster

Stroustrup, Nicholas E

The temporal scaling of C. elegans aging

talk

Suh, Yousin

Enhancer mechanisms in human aging and disease

talk

Sunderland, Piotr

Mechanisms of senescence in neural cells – role of ATM and oxidative stress

poster

Sural, Surojit

Inhibition of HSB-1 induces an altered heat shock factor-1-associated transcriptional profile to promote longevity

poster

Taguchi, Taketo

Potential application of high-molecular weight hyaluronic acid for osteoarthritis

poster

Takasugi, Masaki

DNA damage response triggers compositional and functional alterations of exosomes secreted by senescent cells

poster

Tatar, Marc

Water-loss dehydration triggers ecdysone-mediated innate immune priming and immunosenescence in Drosophila renal tubules

talk

Tazearslan, Cagdas

Enhancer and epigenetic regulation of replicative senescence

talk

Tian, Xiao

Hyaluronan synthesis suppresses mTOR pathway and is a potential anti-aging mechanism in naked mole rat

talk

Tombline, Gregory

Naked mole rat cells have stable epigenome that resists iPSC reprogramming

poster

Tremmel, Sarah I

How does the hexosamine pathway improve protein quality control?

poster

Tyshkovskiy, Alexander

Gene expression analyses across lifespan-extending interventions identify the associated molecular mechanisms

poster

Unselt, Desiree M

Drosophila lifespan— Effects of RNA interference (RNAi)-suppression

poster

Valenzano, Dario Riccardo

Regulation of lifespan by gut microbiota transfer in the turquoise killifish

talk

von Zglinicki, Thomas

How does cell senescence drive ageing?

talk

Walker, David

Examining the interplay between mitochondrial dynamics, mitophagy and aging

talk

Wang, Horng-Dar

Phosphofructokinase 2 regulates female lifespan in Drosophila and C. elegans

poster

Wang, Meng

Micro-regulation of lipid metabolism and longevity

talk

Webb, Ashley E

Elucidation of transcriptional networks that preserve adult neural stem cell function during aging

talk

Wilkinson, Erby J

The establishment of age-related histological endpoints in mice using the Geropathology Grading Platform

poster

Wood, Jason G

Chromatin modifying genetic interventions suppress age-associated transposable element activation and extend lifespan in Drosophila

poster

Wu, Lindsay

SIRT2 preserves female fertility into old age

poster

Xu, Xiao

TRAP analysis reveals cell-type specific gene expression changes in the mammalian central nervous system

poster

Yan, Anqi

Age-dependent beneficial metabolic effect of PI3K p110α pathway down-regulation in the adipose tissue

poster

Yanase, Sumino

Impaired p53/CEP-1 induces lifespan extension via an adaptive metabolic transition in Caenorhabditis elegans

poster

Yang, Jae-Hyun

Evidence for epigenomic change as a cause of mammalian aging

poster

Yasuda, Kayo

Oxidative stress response of the transcription factor MXL-3 in the nematode C. elegans

poster

Yim, Sun Hee

Metabolomics of brain aging

poster

YOO, SANG DONG

Regulatory mechanisms underlying the evolutionarily conserved calorie restriction dependent ageing delay in energy self sufficient photosynthetic plants

talk

Zhang, Ran

Calorie restriction protects against abdominal aortic aneurysms in mice.

poster

Zhao, Jing

Genetic reduction in ATM alleviates DNA damage-induced senescence, improves stem cell function and extends healthspan in a mouse model of accelerated aging

talk

Zhao, Yang

Cancer resistance in a long-lived rodent the blind mole rat is mediated by a methylation-sensing mechanism

poster

Zullo, Joseph M

Regulation of lifespan, FoxO, and insulin signaling by the transcription factor NRSF/REST

talk