Probabilistic Modeling In Genomics
November 4 - 7, 2018

You must register for the meeting in order to submit abstracts.
After registering you will be sent a web link for abstract submission by email.

Program information: An electronic version of the program abstract book will be sent three working days prior to the first day of the meeting, and hard copies will be available for collection upon your arrival at Cold Spring Harbor Laboratory. First night and keynote speakers are informed of their session date and time, otherwise program information is only available upon release of the electronic version of the abstract book. The reason we do this is to try and maximize interactions by encouraging participants to stay for the duration of the meeting.

Please check your email for talk length, poster instructions, and how to have your poster printed at CSHL for collection upon arrival. 

Abstract Status

Presenting Author

Abstract Title

Talk/Poster

Ahlquist, Kaileigh

Statistical detection of genomic targets of balancing selection

poster

Antonio, Margaret L

Detecting signals of selection in time-series genomic data

poster

Avadhanam, Siddharth N

Inferring population ancestry of sample parents using ancestry homozygosity and tract lengths

poster

Avdeeva, Maria

Lineage tracing of tumor cells based on copy number aberrations observed from single-cell transcriptomics data

talk

Balding, David

Improved models for the genetic basis of complex human traits using association statistics

talk

Baumdicker, Franz

Analyzing the genomic pattern of CRISPR defense memory in bacteria and archaea

poster

Berg, Jeremy J

Complex disease at mutation-selection-drift balance

talk

Besenbacher, Søren

Improved prediction of site specific mutation rates using k-mer pattern partition

poster

Bloemendal, Alex A

A method to estimate the sampling variance of genotype principal components and residual confounding due to incomplete capture of population structure

poster

Bredikhin, Danila

Multi-group factor decomposition of single-cell transcriptome profiles

talk

Brock, Kelly P

Using evolutionary couplings to help accelerate structure determination

poster

Brown, Richard

A deep learning model for unbiased splice site prediction

poster

Browning, Brian L

Efficient probabilistic modeling of large-scale sequence data

talk

Browning, Sharon R

Quantifying uncertainty at the ends of identity by descent segments

poster

Caggiano, Christa

Epigenetic state of circulating cell-free DNA as diagnostic biomarker of ALS

poster

Caldas, Ian Vasconcellos

Localization, classification, and parameter inference of hard and soft selective sweeps by supervised learning

poster

Cappello, Lorenzo

Sequential importance sampling algorithms for multi-resolution Kingman-Tajima coalescent enumeration

poster

Cartwright, Reed A

Probabilistic methods for detecting somatic and germline de novo mutations in large pedigrees

poster

Cheng, Wei

Estimating gene-level effect sizes from summary statistics

poster

Clark, Andrew

The Elston-Stewart algorithm meets wild pedigreed populations

talk

Darnell, Gregory

A flexible linear mixed model for estimating heritability of categorical phenotypes

poster

Davenport, Emily R

Simultaneously modeling host genetics and microbiome composition reveals the heritability and the proportion of variance explained due to the microbiome of immune-related traits

talk

DeWitt, William S

Using ancient Eurasian genomes to trace mutation spectrum evolution

poster

Drewe-Boss, Philipp

omniCLIP—Probabilistic identification of protein-RNA interactions from CLIP-seq data

poster

Dukler, Noah

Detecting lineage and group-specific selection in cis-regulatory elements

talk

Durbin, Richard

New approaches to diploid genome assembly

talk

Enard, David

Detecting ancient epidemics in human evolution

talk

Engelhardt, Barbara

Experimental design and single cell RNA-sequencing

talk

Fariello, Maria I

Retrieving “Charrúas” genomic tracts and structure from the general Uruguayan population

poster

Fiaux, Patrick C

Identifying novel regulatory elements using RELICS, a statistical framework for the analysis of CRISPR regulatory screens

poster

Gao, Ziyue

Overlooked roles of DNA damage and maternal age in generating human germline mutations

talk

Gibling, Heather M

Accurate genotyping in polymorphic repetitive loci using k-mer count profiles

poster

Gladstein, Ariella L

Substructured population growth in the Ashkenazi Jews inferred with approximate Bayesian computation

poster

Goldberg, Michael E

Diversity and mutational signatures of endogenous retroviruses in great apes

poster

Green, Anna G

Computational inference of protein-protein interactions with residue-level resolution at a genome-wide scale

talk

Greenberg, Anthony

Methods for robust Bayesian analyses of complex genetic experiments

poster

Gronau, Ilan

Bayesian model comparison of population histories

talk

Guang, August

Revising transcriptome assemblies with phylogenetic information

poster

Guo, Weihua

The relative importance of different drivers of DNA methylation in response to the environment in Phragmites australis

poster

Gutenkunst, Ryan N

DFEnitely different—The joint distribution of mutation fitness effects between populations

talk

Harris, Kelley

Using archaic introgression to probe enhancer function and evolution

talk

Hateley, Shannon L

Variant history discovery through identity by decent connections and family trees

poster

Hayward, Laura K

Polygenic adaptation in response to a sudden change in the environment

talk

Hejase, Hussein

Inference of selective sweeps using machine learning in rapid avian radiation

poster

Hernandez, Ryan D

Rampant purifying selection drives singleton variants to be major source of heritability for human gene expression

poster

Hoffman, Michael M

Segway and the Graphical Models Toolkit—A framework for probabilistic genomic inference

talk

Holmes, Ian

Boss Machine decodes noisy neural networks and nanopore reads

poster

Jewett, Ethan M

Updating an efficient pipeline for local ancestry inference

poster

Johnson, Kelsey E

A method to identify recurrent mutations from unphased population-level sequencing data

talk

Johnson, Ruth D

A scalable Bayesian model for estimating the genetic architecture of complex traits using summary statistics from GWAS

talk

Jun, Seong-Hwan

Accurate reconstruction of tumor phylogeny via joint analysis of bulk DNA and single cell RNA-seq data

poster

Kelleher, Jerome

Inferring ARGs for millions of chromosomes

poster

Koptagel, Hazal

SCuPhr---A probabilistic framework for cell lineage tree reconstruction

poster

Kreuzhuber, Roman

Kipoi—Accelerating the community exchange and reuse of predictive models for genomics

poster

Krishnaswamy, Smita

Manifold learning yields insight into cellular state space under complex experimental conditions

talk

Kumar, Vivek

High-throughput inference and modeling of biological functions using US DOE Systems Biology Knowledgebase (KBase)

poster

Lauterbur, M. Elise

Small effective population size affects coalescent conclusions

poster

Loh, Po-Ru

Mosaic chromosomal alterations increase proliferative loads from rare coding variants and common polygenic risk

poster

Long, Quan

Less-is-more in integrating multi-scale -omics with polygenic phenotype predictors

poster

Lunter, Gerton

Demographic Inference using particle filters indicate late Pleistocene migration from Europe back to Africa

poster

Maklin, Tommi

Accurate bacterial genome assembly from multi-strain enrichment cultures

poster

Marchini, Jonathan

Scalable Bayesian whole genome regression with interactions to high dimensional environments

poster

Mathieson, Iain N

Tracking holocene natural selection using ancient DNA

talk

McCandlish, David

Modeling higher-order genetic interactions

talk

Messer, Philipp W

Realistic evolutionary simulations for population genetic inferences with SLiM 3

poster

Moorjani, Priya

Evidence for recent increase in human generation time inferred from changes in the mutation spectrum over time

poster

Morris, Quaid D

MutPairtree—A novel algorithm for determining the evolutionary history of cancer using multiple tissue samples

talk

Morrison, Jean V

Accounting for confounding in Mendelian randomization using genome wide summary statistics

talk

Moss, Matthew

The epigenomic dynamics of mammary epithelial cells before, during and after pregnancy—An enhancer based analysis

poster

Mostafavi, Hakhamanesh

Decomposing factors that influence the portability of polygenic scores across human populations

poster

Nanda, Pariksheet

Transcription rates from Bayesian modeling of nascent RNA time course

poster

Nelson, Dominic

An extended msprime coalescent simulation framework avoids biases from large sample sizes, and increases performance when simulating long regions

poster

Ochoa, Alejandro

Relatedness and differentiation in arbitrary population structures

poster

Phung, Tanya N

Inference of the mutational size supports the omnigenic model for complex traits

talk

Pimentel, Harold

Fast intron retention quantitative trait loci discovery

talk

Plavskin, Yevgeniy

Distinct distributions of mutational effects on fitness revealed by a model integrating high-throughput phenotype and sequence data

talk

Prufer, Kay

Calling genotypes from ancient DNA with snpAD

poster

Qiao, Ying

Disambiguating second degree relationships using identity by descent sharing to mutual relatives

poster

Ragsdale, Aaron P

Multi-population linkage statistics from exact moment equations

poster

Ralph, Peter

Fast computation with tree sequences

poster

Rice, Daniel

Distinguishing among coalescent models using two-site frequency spectra

poster

Salichos, Leonidas

Identifying growth patterns and driver effects during tumor progression

poster

Salman-Minkov, Ayelet

Using ARGweaver to study speciation genomics

poster

Sankararaman, Sriram

A statistical model for reference free archaic local ancestry inference

talk

Sankoff, David

Birth-and-death with sibling rivalry and the distribution of homologous gene pair similarities in the context of recurrent whole genome doubling, fractionation and speciation

poster

Sannerud, Jens G

Inferring the sex of missing parents in second degree relationships using sex-specific recombination maps

poster

Sarkar, Abhishek

Discovery and characterization of variance QTLs in human induced pluripotent stem cells

poster

Schaefer, Nathan K

Insights from fast, heuristic ancestral recombination graph inference

poster

Schraiber, Joshua G

Analysis of selection on domestication-related QTL

poster

Sedghifar, Alisa

Performance analysis of Polly, a haplotype model-based approach for estimating admixture in individuals

poster

Seidman, Daniel N

Rapid, phase-free detection of long Identical by Descent segments enables fast relationship classification

poster

Seth, Sahil

Functional heterogeneity of long-term self-renewing compartment, the origin of treatment resistance

poster

Shafquat, Afrah

A hierarchical Bayesian latent variable model for detecting misclassified phenotypes and identifying novel associations in GWAS

poster

Shahamatdar, Sahar

Germline variants associated with immune infiltration in solid tumors

poster

Shchur, Vladimir

Estimation of population split times and migration rates with variable population sizes

poster

Shin, June

Predicting ligand-protein binding partners using probabilistic models of sequences and drugs

poster

Siewert, Katherine M

A standardized statistic improves power to detect long-term balancing selection

poster

Silverman, Justin D

Statistical and geometric methods for the analysis of sequence count data

poster

Smith, Samuel A

Hierarchical clustering reveals differential genetic architecture between immunological and metabolic phenotypes

talk

Speidel, Leo

Reconstructing the genealogies of humans and wild mice

talk

Sugden, Lauren A

Integrating selection scans across different genomic scales into a single hidden Markov model framework

talk

Suvorov, Anton

Learning tree topologies from alignments using convolutional neuronal networks

poster

Terhorst, Jonathan G

Massively parallel estimation of local ancestry using GPUs

poster

Teterina, Anastasia

Mode of reproduction drives the distribution of polymorphism across the genome—Theory and empirical tests in Caenorhabditis nematodes

talk

Thornlow, Bryan

Predicting transfer RNA gene expression from genome variation data

poster

Turchin, Michael C

Differences in polygenic architecture between multiple ethnic human populations revealed by pathway and epistasis analysis

poster

Upadhya, Gautam

A general coalescent hidden Markov model framework for inferring complex demographic histories

poster

Vaughn, Andrew H

Source-sink populations and spurious bottlenecks—Coalescence Ne in the presence of biased migration

poster

Waples, Ryan K

Allele frequency-free inference of close familial relationships

poster

Weinstein, Eli N

Searching for programmable genetic systems

poster

Weiss, Clemens

Targeted retrieval of nuclear grapevine DNA from cave sediments

poster

Weissbrod, Omer

Fine-mapping with polygenic functional priors

poster

Wells, Daniel J

Decomposition of mouse spermatogenesis at single-cell resolution reveals dynamic transcriptional programs orchestrated by a rich regulatory repertoire

talk

Williams, Amy

Inferring parental genomes and parent-of-origin using genotypes from siblings

poster

Wohns, Wilder

Estimating the relative age of alleles from population sequencing data

poster

Wu, Yingzhou

Improved pathogenic variant detection by learning rules of functional constraint from massively parallel variant effect assays

talk

Wu, Yue

Scalable estimation of heritability and genetic correlation for biobank-scale data

poster

Young, Adamo J

Genome gerrymandering—Understanding mutational signatures with genome segmentation

poster

Zhou, Ying

Constructing recombination maps with identical by decent segments

poster