Systems Biology: Global Regulation of Gene Expression
March 15 - 19, 2016

You must register for the meeting in order to submit abstracts.
After registering you will be sent a web link for abstract submission by email.

Program information: An electronic version of the program abstract book will be sent three working days prior to the first day of the meeting, and hard copies will be available for collection upon your arrival at Cold Spring Harbor Laboratory. First night and keynote speakers are informed of their session date and time, otherwise program information is only available upon release of the electronic version of the abstract book. The reason we do this is to try and maximize interactions by encouraging participants to stay for the duration of the meeting.

Please check your email for talk length, poster instructions, and how to have your poster printed at CSHL for collection upon arrival. 

Abstract Status

Presenting Author

Abstract Title

Talk/Poster

Aerts, S.

Multiplex enhancer-reporter assays reveal unsophisticated p53 enhancer logic

talk

Afek, A.

Protein−DNA binding in the absence of specific base-pair recognition significantly affects transcriptional regulation

poster

Ahituv, N.

Functional characterization of gene regulatory elements

talk

Ahringer, J.

Properties and activities of enhancers

talk

Akhtar, A.

Epigenetic regulation by MOF containing complexes—Old players, new facts

talk

Andrilenas, K.

Characterizing the DNA-binding differences between IRF transcription factors

poster

Ansari, A.Z.

Differential specificity and energy landscapes (Di-SEL) unmask sequence preferences of transcription factors that bind indistinguishably to consensus DNA motifs

talk

Arnosti, D.N.

Dynamic action of repressors on non-target elements challenges assumptions for genome-wide identification of enhancers

talk

Azizi, E.

Bayesian modeling of cell sub-populations using single-cell transcriptomic data

poster

Ballouz, S.

AuPairWise—Biologically focused RNA-seq quality control using co-expression

poster

Baran-Gale, J.

Dynamics of estrogen stimulated regulatory networks in breast cancer

poster

Batchelor, E.P.

Systems-level analysis of the regulation and function of p53 dynamics

talk

Beer, M.A.

Comparative assessment of training data and computational methods for predicting cell-type specific enhancer activity and the impact of regulatory mutations

poster

Bennett, C.G.

Transcriptome-wide identification of Musashi-2 targets reveals novel regulatory mechanisms and functions

poster

Biette, K.

Shadow enhancers control gene expression dynamics in Drosophila development

poster

Birnbaum, R.Y.

Functional characterization of gene regulatory elements of epilepsy-associated genes

poster

Blumberg, A.

Novel NGS-based approach to analyze mtDNA transcription initiation

poster

Brent, M.R.

Exploiting sequence similarity between DNA binding domains significantly improves the accuracy of TF network mapping

poster

Campitelli, L.F.

Multiparameter functional diversity of human C2H2 zinc finger proteins

poster

Celik, S.

Unsupervised learning of features in multiple gene expression datasets reveals a potential driver for tumor-associated stroma

poster

Chaitankar, V.

Gene network dynamics of mammalian rod photoreceptor

poster

Chasman, D.

Predicting cell type-specific long-range regulatory interactions in rare cell types

poster

Chatterjee, S.

Multiple enhancer-driven polymorphisms disrupt the entire RET Gene Regulatory Network (GRN) in Hirschsprung disease

poster

Chaudhari, H.G.

Local sequence context determines AP-1 binding site activity

talk

Chen, L.

Conservation of the enhancer sequence code across mammals

poster

Cho, H.

Memory of inflammation in regulatory T cells

poster

Churchman, S.

Synchronized translation programs across cellular compartments

talk

Combs, P.A.

Genome-wide measurement of spatial expression in patterning mutants of Drosophila melanogaster

talk

Cramer, P.

TT-Seq captures the human transient transcriptome

talk

Crow, M.

Assessing the reproducibility of single cell RNA-seq co-expression

poster

Cui, M.

Genomic control of endoderm-specifically expressed posterior Hox gene

talk

Danko, C.G.

Widespread stabilizing and positive selection govern primate enhancer evolution

talk

Demchak, B.

No more silos—The cytoscape CI enables best of breed functionality and improved productivity

poster

Diamanti, K.

Genome-wide maps of putative regulatory regions and genomic signal interactions

poster

Dowell, R.D.

RNA Pol II modeling predicts active transcription factors

talk

Dukler, N.

Analyzing the interplay between enhancers and genes in the transcriptional response to celastrol

poster

Eddy, S.

A statistical test of RNA base pair covariation applied to proposed lncRNA structures

talk

Engelhardt, B.

Tissue-specific expression QTLs

talk

Engreitz, J.

Many promoters of lncRNAs and mRNAs act as enhancers in local gene regulatory networks

talk

Favé, M.

Integrating genomic and environmental features to map critical factors in individual development of chronic diseases

talk

Fish, A.E.

Genomic context drives the conservation of enhancer activity across species

poster

FitzPatrick, V.D.

Discovering the autonomous rules by which sequence drives transcription using a novel massively parallel barcoded reporter assay

poster

Friedman, N.

Elucidating chromatin architecture by combinatorial co-immuneprecipitation (co-ChIP)

talk

Fuxman Bass, J.I.

A transcription factor-wide protein-DNA interaction network for ~15% of C. elegans genes

poster

Gasch, A.P.

Integrating signaling networks inferred from stress-induced transcriptomic and phospho-proteomic responses in yeast reveals an ancient signaling network linked to disease biology

poster

Gatto, S.

Epigenomic mechanisms driving hESC conversion into skeletal muscle cells

talk

Ge, X.

Speculations on gene regulation in early embryogenesis by exploratory bioinformatics

poster

Georgakopoulos-Soares, I.

Combinatorial analysis of transcription factor binding sites identifies higher organization patterns at regulatory elements

poster

Gerard, D.P.

Time-course analysis of gene regulatory network dynamics during mesenchymal lineage commitment

poster

Gerber, A.

Cistrome profiling pinpoints cooperative regulation of anti-inflammatory nodes by the glucocorticoid receptor and NF-κB

talk

Gertz, J.

Functional dissection of estrogen receptor α bound enhancers at their endogenous loci

talk

Gilad, Y.

Mapping variation in gene regulation—From DNA to protein

talk

Gordan, R.M.

How do closely related transcription factors target distinct genomic regions?

talk

Gray, J.M.

High-throughput functional comparison of promoter and enhancer activities

poster

Greenleaf, W.J.

Single-cell chromatin accessibility reveals principles of regulatory variation

talk

Gruber, A.

A comprehensive analysis of 3' end sequencing data sets reveals novel polyadenylation signals and the repressive role of HNRNPC on cleavage and polyadenylation

poster

Hammell, C.M.

A developmental oscillator and its importance in establishing sequential cell fate transitions in C. elegans

talk

Harrison, M.M.

Programming chromatin accessibility for transcription factor binding and gene expression in the early embryo

poster

Hemberg, M.

SC3—Consensus clustering of single-cell RNA-Seq data

poster

Hendrickson, D.G.

Surveying chromatin accessibility and gene expression dynamics in response to DNA-binding protein activation

poster

Herzel, L.

Capturing the kinetics of pre-mRNA splicing in vivo by single molecule RNA-Seq

talk

Hickey, S.L.

FOXP2 modifies the chromatin landscape of developing neurons

poster

Higgins, G.A.

High-throughput, genomewide detection of pharmacodynamic circuits in human brain using epigenome pathway analysis

poster

Ho, .E.

Stress-dependent transcriptome changes serve to reallocate translational capacity during stress acclimation.

talk

Huang, D.

Gene regulatory changes in carcinogenesis

poster

Huang, J.

Dynamic control of enhancer repertoires drives lineage and stage-specific transcription during hematopoiesis

poster

Huang, S.C.

Base-pair resolution atlases of the Arabidopsis cistrome and epicistrome

talk

Huang, Y.

A scalable framework for inferring fitness consequences of noncoding mutations in the human genome

poster

Hughes, K.J.

Gene fusions in cancer—Determining the oncogenic potential of a fusion event and its regulatory effect on pathway neighbors

poster

Hughes, T.R.

RNAcompete-S—Complex RNA sequence/structure models derived from a single-step in vitro selection

talk

Hwang, T.

Dynamic regulation of RNA editing in human brain development and disease

poster

Ibrahim, M.

Integration and modeling of genome-wide time-course data reveals principles of directed motor neuron programming

poster

Jaimovich, A.

A slow activator outcompetes a fast suppressor to robustly delay the transition from quiescence to proliferation

talk

Ji, H.

Global prediction of chromatin accessibility using RNA-seq from small number of cells

poster

Jothi, R.

Transcription at intragenic enhancers attenuate gene expression

poster

Kaminski, J.J.

The epigenetic landscape of T cell exhaustion

poster

Kaplan, T.

Finding hierarchical topological domains using a unified probabilistic model of Hi-C data

talk

Kapoor, A.

Identification of functional enhancers at SCN5A that modulate QT interval variation

talk

Karimzadeh, M.

Transcription factor binding variability in human cell types and association with cooperative motifs

poster

Katou, Y.

RNA dependent protein binding revealed by ChIP-seq

poster

Katz, S.

Using a network and pathway centric model for the comprehensive and unbiased hit selection from genome-wide genetic screens in human and mouse macrophages to infer comprehensive regulatory landscapes

poster

Kaya, K.D.

Ret-SEQ—A retina centric online platform empowering discovery by integration of Next Generation Sequencing resources

poster

Keenan, J.L.

A high-throughput approach for designing novel cell-based signal integrators

poster

Kim, J.

Phylogenetic and epigenetic footprinting of the putative enhancers of the Peg3 domain

poster

Knaack, S.A.

Evolution of modular organization of chromatin states

poster

Komorowski, J.

Mutated motifs for CTCF and other transcription factors affect nearby cancer genes

poster

Kreimer, A.

The regulatory landscape of early neural differentiation 

poster

Kribelbauer, J.F.

Structural insight into adaptive DNA binding by a multi-protein Hox complex obtained through SELEX-seq analysis

talk

Kugler, H.

Synthesizing a gene regulatory network for sea urchin development

poster

Kundaje, A.B.

Integrative, interpretable deep learning frameworks for regulatory genomics and epigenomics

talk

Kurland, J.V.

Survey of variation in human transcription factors reveals prevalent DNA binding changes

talk

Kuzu, G.

Expansion of GA dinucleotide repeats on the X-chromosome promotes the evolution of Drosophila dosage compensation

poster

Lahesmaa, R.

Genome-wide analysis of human Th17 differentiation reveals novel human specific factors and regulatory regions that co-localise with immune disease associated SNPs

talk

Lazar, J.

Genomic mechanisms of LSD1 inhibitors

talk

Lee, R.E.C.

Cell fate decisions in response to a short pulse of TNF

talk

Lee, D.

Sequence-based predictions of cis-regulatory DNA elements active in the human heart

poster

Lee, S.

A machine learning technique to learn the biomarker potential identifies novel markers for sensitivity to chemotherapy drugs

poster

Lee, T.A.

How protein and promoter differences contribute to the divergence of the yeast transcription factor family members Met31 and Met32

poster

Levens, D.L.

RNA polymerase II stimulates topoisomerase 1 activity to promote efficient transcription

talk

Li, S.

Fragile enhancers and stable enhancers together define lineage-specifcity

poster

Liu, G.

A wave-like model for gene regulatory networks in Drosophila embryos

poster

Liu, Y.

Systematic identification of predictive causal GWAS SNPs within transcription factor binding sites that control chromatin landscape

poster

Ljungman, M.

Roles of gene length and H3K79me2 modifications in establishing temporal gene expression

poster

Lu, Y.

High-throughput assays reveal miR-155’s context-specific regulation of immune system

poster

Luca, F.

High-throughput allele-specific expression across 250 environmental conditions

talk

Lunt, B.J.

Deep learning methods predict chromatin accessibility from genome annotation of putative pioneer factor binding sites

poster

Lyon, G.J.

A rare genetic "transcriptomopathy" syndrome leading to insights into more common neurologic disorders

poster

Mahony, S.

Cooperative transcription factor binding dynamics underlie direct motor neuron programming

talk

Martini, G.

Distinct specificities of the androgen and glucocorticoid receptors revealed using feature-based recognition model analysis of SELEX data

poster

Maurano, M.

Sequence variation affecting transcription factor occupancy in highly diverged mouse strains

talk

McIsaac, S.

Mapping causal regulatory interactions on a global scale through dynamic perturbations in a eukaryotic system

talk

Mitra, R.D.

Recording Olig 2 binding during the motor-neuron/glia cell fate decision

talk

Momen-Roknabadi, A.

Transcriptional timers regulating mitosis in early Drosophila embryos

poster

Murray, J.I.

Decoding animal development at single cell resolution

poster

Nakaki, R.

Hetero-DGF—A novel algorithm to decompose heterogeneous binding footprints of transcription factors

poster

Nakato, R.

Integrative epigenome profiling reveals tissue-specific gene regulations of human vascular endothelial cells

poster

Nguyen, K.T.

Discovery and characterization of an epigenomic signature of late-stage differentiation

poster

Nikolov, M.

Functional analysis of Drosophila core promoter architecture using synthetic promoters

poster

Nord, A.S.

Basal ganglia development through the lens of transcription factor profiling, enhancer activity, and single-cell transcriptomics

poster

Oikonomou, P.

Revealing functional regulatory elements controlling the maternal to zygotic transition during zebrafish development

poster

Oki, S.

ChIP-Atlas—Comprehensive and integrative database for visualizing and mining all published ChIP-seq data

poster

Pai, A.A.

Widespread shortening of 3' UTRs and increased exon inclusion are evolutionarily conserved features of innate immune response to infection

talk

Pe'er, D.

MAGIC

talk

Penvose, A.R.

Decoding genomic regulation by the type II nuclear receptors

poster

Pinello, L.

CRISPResso—Sequencing analysis toolbox for CRISPR-Cas9 genome editing

poster

Pique-Regi, R.

Characterizing condition specific transcription factor binding with ATAC-seq

poster

Pique-Regi, R.

Gene expression networks of transcriptional response to 78 cellular environment perturbations

poster

Pott, S.

Simultaneous measurement of chromatin accessibility and DNA methylation in single cells

talk

Prescott, S.

Cellular anthropology can be used to identify cis-regulatory divergence in the human and chimp neural crest

talk

Pritykin, Y.

Computational analysis of mRNA-seq in multiple mutants and genome-wide Ago2 binding profiles provides detailed view of miR-17~92 activity in mouse embryonic development

poster

Przytycka, T.M.

AptaTRACE—Elucidating sequence-structure binding motifs by uncovering selection trends in HT-SELEX experiments

poster

Pujato, M.A.

Non-coding genetic variants result in allele-dependent binding of transcription factors in autoimmune diseases

poster

Qu, W.

Identification of splicing eQTLs in lead-treated Drosophila model

poster

Rajagopal, N.

High-throughput mapping of regulatory DNA

talk

Rastogi, C.

A versatile framework for learning feature-based protein-DNA recognition models directly from SELEX data

poster

Reimand, J.

Network-driven discovery and interpretation of cancer driver mutations

poster

Riley, T.R.

The Affinity Data Bank—An online suite of tools for investigation of protein-nucleic acid affinity models and biophysical analysis of regulatory sequences

poster

Rohs, R.

Deciphering the role of various mechanisms in transcription factor-DNA binding on a protein family-specific basis

talk

Roy, S.

Computational approaches to study dynamics of long-range gene regulation

poster

Sadeh, R.

Ubiquitin-mediated degradation of histone H3 promotes nucleosome turnover at gene promoters to regulate gene expression

poster

Sakurai, K.

SHOGoiN Database: a database to integrate standardized data and diverse knowledge of cells

poster

Schmid, A.K.

An archaeal histone functions as a transcription factor regulating cell shape

talk

Scholes, C.

Integration of regulatory information at promoters through combinatorial control of the transcriptional cycle

talk

Schubeler, D.

Reading and writing DNA methylation

talk

Sethi, A.

Tissue and developmental time stage specific enhancer prediction using pattern recognition

poster

Setty, M.

Wishbone identifies bifurcating developmental trajectories from single cell data

poster

Siebenthall, K.

The regulatory landscape of endocrine disruptor exposure

poster

Singh, I.

Non-coding isoforms of coding genes in B cell development and malignancies

talk

Starmer, J.

singleCellQuest!—Easy to use single-cell-RNA-seq software for exploring and visualizing data

poster

Stubbington, M.

Exploring T cell fate choices at single-cell resolution

talk

Sureshchandra, S.

The impact of pre-gravid obesity on neonatal monocyte gene regulation and expression

poster

Tang, M.

Transcriptional networks of M2 macrophages derived from recruited monocytes or tissue resident macrophage lineages

poster

Thomas, L.D.

Differentially co-expressed genes are critical regulators in co-expression networks

poster

Tsutsumi, S.

A bias-correcting Capture Hi-C analysis revealed the interactions between p53 binding sites and the target genes

poster

Tyssowski, K.M.

Transient elevations in neuronal activity induce a subset of the neuronal activity-regulated gene program defined by MAPK/ERK-dependent enhancers

poster

Udatha, D.

Systems analysis of the autoimmune response in primary sclerosing cholangitis

poster

Van Steensel, B.

Unraveling human promoter regulation by an ultra-high throughput functional assay.

talk

Vejnar, C.E.

Uncovering the RNA-protein interaction network that control vertebrate embryogenesis

talk

Vinson, C.R.

Double stranding Agilent DNA microarrays with 5mC and 5hmC—Effects on transcription factor binding

talk

Wang, B.

Gene similarity network reveals sub-populations of cells in single-cell RNA-seq data

poster

Wang, D.

DREISS—Using state-space models to infer the dynamics of gene expression driven by external and internal regulatory networks

poster

Wang, J.

De-novo inference of enhancer-gene networks in diverse cellular contexts reveals the long-range regulatory impact of disease-associated variants

poster

Welch, L.R.

The coverage-based paradigm for cistrome discovery

poster

White, M.A.

A simple regulatory grammar distinguishes activating from repressing cis-regulatory elements in photoreceptors

poster

Wu, H.

A computational strategy to adjust for copy number in tumor Hi-C data

poster

Wu, S.

New strategies to identify transcription factor regulatory relationships important for organ system development

talk

Xu, J.

Random mono-allelic regulation in diploid genome by allelic specific ATAC-seq

talk

Yaakov, G.

Coupling phenotypic persistence to DNA damage increases genetic diversity under severe stress conditions

poster

Yamada, N.

CX-4945, a potent CK2 inhibitor, mediates alterations in enhancer and heterochromatin landscapes in acute myeloid leukemia

poster

Yang, R.

Differential contribution of cis-regulatory elements to higher order chromatin structure and expression of the CFTR locus

poster

Yu, Y.

Panoramix/CG9754 enforces piRNA-dependent cotranscriptional silencing

poster

Yuan, X.

Identifying novel regulators of early cardiac development in zebrafish using a heterologous enhancer

poster

Yuan, Y.

Processing of bulged pri-miRNAs by Arabidopsis Dicer-Like 3 inhibited by phosphate

poster

Zacharias, A.L.

Quantitative characterization of the influence of context on developmental enhancer activity and robustness with cellular and temporal resolution

talk

Zhao, c.

Dual regulatory switch through serial interactions of Tcf7l2/Tcf4 with stage-specific partners propels oligodendroglial maturation

poster

Zhu, F.

Systematic identification of nucleosome-disfavoring sequences

poster

Zhu, Y.

Elucidating the enhancer code in 9p21 locus underlying aging-related diseases

poster