Retroviruses
May 20 - 25, 2019

You must register for the meeting in order to submit abstracts.
After registering you will be sent a web link for abstract submission by email.
You may copy and paste your abstract from Word, Google Docs, or Notepad; abstracts are limited to ~2900 characters.

Program information: An electronic version of the program abstract book will be sent three working days prior to the first day of the meeting, and hard copies will be available for collection upon your arrival at Cold Spring Harbor Laboratory. First night and keynote speakers are informed of their session date and time, otherwise program information is only available upon release of the electronic version of the abstract book. The reason we do this is to try and maximize interactions by encouraging participants to stay for the duration of the meeting.

Please check your email for talk length, poster instructions, and how to have your poster printed at CSHL for collection upon arrival. 

Abstract Status

Presenting Author

Abstract Title

Talk/Poster

Aida, Yoko

Novel virus-like particle vaccine of BLV efficiently suppresses the level of proviral load and disease progression

poster

Aiken, Chris

Determinants and consequences of IP6 binding to the HIV-1 capsid

poster

Aiken, Chris

Specific and functional binding of the gp41 cytoplasmic tail to delipidated immature HIV-1 virus-like particles

talk

Akiyama, Hisashi

Innate immune activation in microglia is induced by expression of intron-containing HIV-1 RNA

talk

Alanazi, Awadh

Novel HIV-1 transcription inhibitors targeting TAR RNA

poster

Anand, Sai Priya

Antibody-induced internalization of HIV-1 Env proteins limits the surface expression of the closed conformation of Env

talk

Ananth, Swetha

Characterization of the multi-functional Nef-associated kinase complex (NAKC) binding site of HIV-1 Nef

poster

Anraku, Kensaku

Design and synthesis of phospholipid derivatives exhibiting high-affinity binding for the HIV-1 MA domain

poster

Ariumi, Yasuo

HIV-1 Vpr and p21 restrict LINE-1 mobility

poster

Arriagada, Gloria L

Dynein light chain Dynlrb2 is important for nuclear localization of MLV

poster

Barklis, Eric

Characterization of HIV-1 matrix-envelope cytoplasmic tail interactions

talk

Basukala, Binita

Disabling HIV-1 provirus by promoting chromatinization using CRISPR-Cas9

talk

Batisse, Julien

The HIV-1 Integrase/LEDGF complex—Toward a high-resolution structure

poster

Bayliss, Rebecca

Identification of host factors involved in trafficking of HIV-1 to the virological synapse in dendritic cells.

poster

Bejarano, David

Effects of PF74 treatment and altered CA lattice stability on RTC/PIC formation and trafficking and on innate response in HIV-1 infected macrophages

talk

Beloor, Jagadish

In vivo gene editing of human T-cells in humanized mice for HIV therapy

poster

Berchowitz, Luke E

Meiosis-specific translational repression of yeast retrotransposon mRNA

talk

Bertelli, Cinzia

The anti-retroviral activity of human SERINC proteins and the counteracting abilities of retroviral antagonists

poster

Betancor Quintana, Gilberto J

The GTPase domain of MX2 interacts with the HIV-1 capsid enabling its short isoform to moderate antiviral restriction

talk

Bhargava, Anvita

Modulation of HIV infection and nuclear morphology by SUN1 and SUN2

poster

Biswas, Banhi

Role of C-terminal p6 domain of HIV-1 Gag in packaging of the viral genomic RNA

poster

Bouaziz, Serge

EP39 inhibits the maturation of HIV-1 particles by interfering with the dynamic equilibrium of the alpha helix in the CA-SP1 junction

poster

Browne, Edward P

Single cell transcriptomic and epigenomic analysis of HIV latency indicates a role for GATA3 in counteracting HIV silencing

talk

Bruce, James W

HIV-1 transcription repression by cellular factor ZBTB2 is regulated by ZASC1, cellular tyrosine kinase signaling pathways and the DNA damage response

talk

Bruch, Eduardo

Nucleosomes as a target for HIV-1 pre-integration complexes

poster

Burdick, Ryan

Visualization of HIV-1 nuclear uncoating shortly before and near viral integration sites

talk

Carter, Carol

The vestigial active site in the ubiquitin E2-variant domain of Tsg101 binds ubiquitin and controls HIV-1 Gag interaction with Tsg101

poster

Chakrabarti, Lisa

Low CCR5 expression protects HIV-specific CD4+ T cells of elite controllers from viral entry

poster

Chameettachal, Akhil

A stretch of single-stranded purines (ssPurines) adjacent to the mouse mammary tumor virus (MMTV) gRNA dimerization initiation site is the major binding site for MMTV Pr77Gag

talk

Chang, Jordan

Nuclear interactions of retroviral Gag proteins with unspliced viral RNA

poster

Chelico, Linda

Role of co-expressed APOBEC3F and APOBEC3G in inducing HIV-1 drug resistance

poster

Chen, Benjamin K

Rapid exchange of Env and immobile Gag lattice at HIV-1 virological synapses revealed by dynamic photobleaching studies

poster

Chen, Jianbo

Visualizing the translation of HIV-1 full-length RNA

talk

Cherepanov, Peter

Cryo-EM structures of SIV intasomes reveal essential features of the second-generation HIV integrase inhibitor functionality

talk

Cingoz, Oya

Vpx augments IFN responses to retroviral infection in human macrophages

poster

Coggins, Si'Ana

Efficient pre-catalytic conformational change of reverse transcriptases from SAMHD1 non-counteracting lentiviruses during dNTP incorporation

talk

Colomer Lluch, Marta

Limited contribution of viral factors to the viremic nonprogressor phenotype in adult and pediatric HIV-1 infection

poster

Coomer, Charles

Single-cell resolution of metabolic control over HIV-1 entry and a role for membrane lipid order and tension

poster

Cottee, Matthew A

Structures of D. melanogaster Arc reveal a CA-like protein which shares characteristics with spuma and ortho-retroviral Gag

talk

Dash, Chandravanu

PF74 Inhibits HIV-1 Integration

poster

Davids, Benem-Orom A

TREX1 affects HIV-1 preintegration complex function

poster

De Wit, Flore

Visualization of the HIV-1 cDNA by click chemistry

poster

Dharan, Adarsh

Measurement of nuclear import kinetics reveals nuclear import precedes completion of reverse transcription in macrophages

talk

Di Nunzio, Francesca

Partial cores lead HIV-1 pre-integration complexes in the nucleus of human lymphocytes

talk

Diaz-Griffero, Felipe

The role of HIV-1 capsid in the nucleus

talk

Diehl, William E

Allelic variants of human TRIM5 alter HIV pathogenesis

talk

Digianantonio, Katie

Uncovering the binding mode of TRIMCyp for HIV capsid assemblies

poster

Ding, Jiwei

Schlafen 5 acts as a transcriptional repressor of HIV-1 through targeting to sequences of U5-R region in 5’-LTR

poster

Ding, Shilei

Fc-glycosylation variants enhance the ability of plant-produced bNAbs to eliminate HIV-1-infected cells

poster

Dixit, Updesh K

TAR RNA mimicry and viral RNA binding activities of INI1 influences HIV-1 replication

poster

Dostalkova, Alzbeta

Quantification of stability effect of polyanions on assembly and disassembly of retroviral particles

poster

Duchon, Alice

Exploring the requirements for RNA packaging through a non-viral RNA binding protein

poster

Dupont, Liane

HIV-1 Vpr induces degradation of an SMC5/6 complex associated factor to counteract silencing of unintegrated lentivirus

talk

Ebrahimi, Diako

Interaction between HIV-1 protease and an archaic APOBEC3H in modern humans

talk

Elleder, Daniel

Antiviral activity of chicken tetherin

poster

Emery, Ann L

Control of HIV-1 splicing and oversplicing by cis-acting sequence elements

talk

Eschbach, Jenna

HIV-1 capsid lattice protects the vRNPs from degradation in target cells

poster

Evans, David

Antibody dependent cellular cytoxicity in the absence of neutralization is not sufficient for protection against pathogenic SIV challenge

talk

Evans, Edward L

HIV-1 Vif induces a prolonged metaphase arrest characterized by centrosome amplification and mitotic spindle defects

poster

Fabryova-Farkasova, Helena

A novel Vpr-interacting protein that affects HIV-1 Env expression and inhibits viral infectivity

talk

Featherstone, Austin B

Quantitation of the levels of SERINC5 incorporation into HIV-1 particles and correlation with inhibition of HIV-1 infectivity

poster

Featherstone, Austin B

SERINC5 inhibits HIV-1 infectivity by altering the conformation of gp120 on HIV-1 particles

talk

Fernandez, Juliette

Transportin-1 (TRN) coordinates HIV-1 uncoating and nuclear import

poster

Fernandez, Melissa V

Role of endosomal trafficking in Env incorporation into virions

poster

Ficarelli, Mattia

Identification of a novel ZAP cofactor that inhibits HIV-1 containing clustered CpG dinucleotides

talk

Fink, Douglas

Vpx enhances DNA sensing by cGAS/STING

talk

Finzi, Andrés

Identification of a new HIV-1 Env conformation vulnerable to antibody attack

talk

Flower, Thomas G

Structure of a helical assembly of the human ESCRT-I complex that mediates HIV-1 virion release

talk

Francis, Ashwanth C

HIV-1 uncoating, nuclear entry and intranuclear transport in primary monocyte-derived macrophages

talk

Freeman, Michael M

Functional characterization of insertionally polymorphic HERV-K (HML-2) proviruses in the gorilla genome

talk

Fregoso, Oliver I

HIV Vpr represses double-strand DNA break repair

poster

Fremont, Stephane

Remodeling of the actin cytoskeleton for successful HIV-1 budding

poster

Galais, Mathilde

HIV-1 Env-induced autophagy degrades essential organelles for homeostasis—Peroxisomes

poster

Gallois-Montbrun, Sarah M

Characterization of HIV-1 alternative splicing by Nanopore Long-read sequencing

poster

Geis, Franziska K

Unintegrated HIV-1 DNAs are loaded with histones and transcriptionally silenced after nuclear entry prior to retroviral integration

poster

Goffinet, Christine

Absence of cGAS-mediated Type I IFN induction in HIV-1-infected T-cells

talk

Goncalves-Carneiro, Daniel

Coevolution of TRIM25 and ZAP

talk

Gopal, Devi

Inhibition of HIV by plant microRNA derived from Artabotrys odoratissimus

poster

Goudey, Sophie

Non-canonical roles of Argonaute proteins in the HIV-1 expression

poster

Gouzoulis, Monica

Anatomic distribution of individuals undergoing long-term antiretroviral therapy—Analysis of autopsy tissue

poster

Gramberg, Thomas

Human TRIM5α senses and blocks the replication of LINE-1 retroelements

talk

Grandgenett, Duane

Cryo-EM structure of the RSV stable synaptic complex stabilized by an HIV-1 integrase strand transfer inhibitor

talk

Gray, Laurie R

HIV-1 Rev proteins and HERV-K Rec proteins function differentially with selected HERV-K RcREs present in the human genome

talk

Grover, Jonathan R

The State 1 conformation of the HIV-1 envelope glycoprotein is stabilized by cholesterol interactions

talk

Groves, Nicholas S

Direct visualization of HIV-1 envelope incorporation into nascent virions

poster

Guedan, Anabel

Investigating the replication of a hyperstable HIV-1 core

poster

Guney, Hakan H

Functional characterization of putative enhancer elements in human dendritic cells

poster

Gupta, Kushol

Higher-order structures of HIV integrase—Drug-induced aggregates of HIV integrase are weak gels

poster

Haider, Tafhima

Exploring the truncation of lentivirus envelope glycoproteins

poster

Hall, Ross

Characterising the Vpr cell cycle arrest phenotype

talk

Hammarskjold, Marie-Louise

Detection of  functional HERV-K Rec proteins in cancer cells using a novel lentiviral vector

poster

Harada, Shigeyoshi

Efficacy of a novel triterpene derivative in combination with neutralizing antibodies against HIV-1 infection

poster

Haugh, Kelsey

Whole body imaging-guided analyses of MLV spread reveal roles for the I-type lectin CD169 in three relevant routes of retrovirus transmission

talk

Hauser, Alexandra

Novel HIV-1 clade C envelope trimers as vaccine candidates exhibit optimal antigenic traits in vitro and in vivo

poster

Henke, Wyatt A

The HSV-1 gH/gL heterodimer restricts the release of infectious HIV-1 by preventing the incorporation of Env into viral particles

poster

Herschhorn, Alon

Determinants of alternative fates of HIV-1 infection

poster

Herschhorn, Alon

Molecular mechanisms of HIV-1 resistance to broadly neutralizing antibodies

talk

Hope, Thomas J.

Live cell imaging of HIV-1 reverse transcription shows cytoplasmic access to the genome associated with infection

talk

Huik, Kristi

Emergence and persistence of integrase mutation T97A during dolutegravir therapy

poster

Hulme, Amy E

HIV-1 uncoating in a human microglial cell line

poster

Hwang, Eung Soo

Defective characteristics of PERV in SNU miniature pigs

poster

Ikeda, Terumasa (Teru)

HIV-1 restriction by APOBEC3G in the myeloid cell line THP-1

poster

Innis, Emily A

Investigating HIV-1 driven LINE-1 retrotransposition

poster

Irwan, Ishak

Characterizing the mechanism behind the epigenetic silencing of unintegrated HIV DNA genomes by cellular antiviral restriction factors

poster

Ishima, Rieko

Conformational change in HIV-1 reverse transcriptase that facilitates its maturation

poster

Ito, Jumpei

Evolutionary conflict of endogenous retroviruses and APOBEC3 family genes in mammals

talk

Ivanov, Dmitri

Recognition of the GpsN pattern by SAMHD1 suggests a link between nucleic acid phosphorothioation, antiviral immunity and dNTP metabolism

talk

Iwatani, Yasumasa

Comparative analyses of primate antiviral APOBEC3C

talk

Jackson, Patrick

HIV Rev and RRE functional variation in primary isolates—Not just an on-off switch

talk

Jaguva Vasudevan, Ananda Ayyappan

Amino-terminal residues determine the anti-HIV-1 Δvif activity of APOBEC3C

poster

Janaka, Sanath

Substitutions in SIV Nef that selectively impair Anti-SERINC5 activity

poster

Jha, Sudhakar

TIP60 keeps the endogenous oncogenic demons repressed

poster

Jia, Xiaofei

Structural basis of CD4 surface downregulation by HIV-1 Nef

talk

Jin, Steven W

Variable SERINC3 and SERINC5 downregulation activities in primary HIV-1 Nef alleles

poster

Johansson, Emil

Development of a novel phenotypic assay to determine the impact of genetic linkage between HIV-1 gag, pol and env on virus replicative capacity

poster

Johnson, Jeffrey R

Modulation of histone H1 ubiquitination by Vpr-CRL4

talk

Johnson, Welkin E

Exploiting endogenous retrovirus (ERV) loci to gain insights into the evolution and structure of betaretrovirus Env glycoproteins

poster

Jurczyszak, Denise

Virion incorporation of m6A effector protein YTHDF3 limits the early steps of HIV replication

poster

Karthigeyan, Krithika

Metabolic flux through the lipogenic host enzyme fatty acid synthase (FASN) generates de novo fatty acyl groups for myristoylation of HIV-1 Gag

poster

Kieffer, Collin D

Application of a multiscale imaging platform to analyze HIV-infected lymphoid tissues from humanized mice and human patient samples with single cell to single virus resolution

talk

Kim, Kyusik

Cyclophilin A protects HIV-1 from restriction by human TRIM5α

talk

Kirchhoff, Frank

IFI16 sequesters SP1 to restrict HIV-1 but is evaded by subtype C strains

talk

Kitzrow, Jonathan P

Intrinsic conformational dynamics of the HIV-1 genomic RNA 5′ UTR

talk

Knecht, Kirsten

Mapping interactions between MVV Vif and its cofactor CypA

poster

Knoener, Rachel

Elucidation and functional analysis of HIV-1 splice variant interactomes

talk

Kozak, Christine

ResERV, an endogenous retroviral sequence conserved in mammals that has broad antiretroviral activity

talk

Kroupa, Tomas

HTLV-I Rex protein interaction with HIV-1 RRE sequence

poster

Kruize, Zita

Nef obtained from HIV-1 infected individuals vary in their ability to antagonize SERINC3 and SERINC5 mediated HIV-1 restriction

poster

Kutluay, Sebla

HIV-1 capsid lattice protects the vRNPs from degradation in target cells

talk

Laliberte, Alexandre

BST2 antagonism and control of plasmacytoid dendritic cell (pDC) responses by Vpu from pandemic and non-pandemic HIV

poster

Lange, Camille M

Immune reconstitution inflammatory syndrome has long-term effects on persisting HIV populations on ART

poster

Lange, Margaret J

RNA aptamers selected against the HIV-1 capsid hexamer lattice alter capsid assembly and stability

poster

Lau, Derrick

In vitro reconstitution of capsid lattices to screen and study capsid binders

poster

Lawhorn, Brigitte E

Emergence of HIV-2 selected for adaptation to human Nup358-Cyp

talk

Lepont, Leslie

Contribution of Vpu to the expansion of virus-containing compartments in HIV-1 infected primary macrophages

poster

Lerner, Grigoriy

HIV-1 JR-FL envelope glycoprotein determinants mediating intracellular trapping by the Rab11-FIP1C Rab binding domain

poster

Levin, Henry L

LEDGF/p75 functions in transcription elongation to alter termination sites

poster

Li, Chenglei

New HIV-1 capsid labeling system does not support HIV-1 uncoating during nuclear import

poster

Li, Min

Assembly of multiple species of stable synaptic complex (SSC) intasomes is an intrinsic property of HIV-1 integrase

talk

Li, Qingsheng

SIVcpz or the inferred ancestral HIV-1 is less or non-pathogenic to humans after cross-species transmission in a Hu-BLT mouse model

poster

Lindemann, Dirk

Insights into innate sensing of prototype foamy viruses in myeloid cells

poster

Lindo, Natalie A

Analysis of rebound HIV viremia during PML-IRIS

poster

Liu, Bingfeng

Lovastatin inhibits HIV-1-induced MHC-I down-regulation through targeting Nef–AP-1 complex formation—A new strategy to boost the immune eradication of HIV-1 latent reservoirs

poster

Liu, Qian

The domains in MOV10 involved in its function to control LINE-1 retrotransposition

poster

Liu, Shan-Lu

IFN-inducible LY6E modulates HIV-1 entry in a CD4-dependent manner

poster

Lodge, Robert

P53-regulated micro-RNA 103 modulates the expression of CCR5 and HIV-1 infection in macrophages

poster

Lun, Cheng man

Mechanism of viral envelope glycoprotein targeting by membrane-associated-RING-CH (MARCH) proteins

talk

Lyumkis, Dmitry

Structural basis for inhibition of HIV-1 intasomes by integrase strand transfer inhibitors

talk

Maeda, Kenji

A novel in vitro model of HIV-1-provirus elimination by latency-reversing agents (LRA) and other antiretroviral drugs

poster

Mahboubi, Bijan

Host SAMHD1 protein restricts endogenous reverse transcription of HIV-1 in nondividing macrophages

poster

Malim, Michael

Immunoproteasome activation enables human TRIM5α restriction of HIV-1

poster

Mamede, João I

Spatial and temporal step-wise recruitment of PQBP1 and cGAS to incoming HIV viral particles depends on fusion, initiation of uncoating, and reverse transcription in cells of myeloid origin

poster

Manganaro, Lara

Analysis of the role of IL-15 in HIV latency establishment in different primary human CD4 T cell subsets

poster

Mansky, Louis M

Hitting the guardrails—The actin cortex serves as a physical barrier of retroviral assembly

talk

Marelli, Sara

Identification and characterization of APOBEC3-independent targets of HIV-1 Vif

talk

Marin, Mariana

Insights in the mechanism of HIV-1 restriction by SERINC5

talk

Marongiu, Michaela

Bacterial artificial chromosomes for rapid generation of high titre stable suspension producer cell lines for lentiviral vector manufacture

poster

Matsuda, Zene

Analysis of the insertion mutants in the distal α9 portion of C-terminal heptad repeat (CHR) of the HIV-1 gp41 subunit

poster

Matsuoka, Kazuhiro

HIV-1 Vif PPLP region plays a critical role in the Vif-mediated APOBEC3 ubiquitination/degradation

poster

Matsuura, Ryosuke

Three YXXL sequences of transmembrane subunit gp30 of BLV independently regulate syncytium-froreming and incorporation of envelope protein into virion

poster

McGregor, Emma L

Variation and regulation of APOBEC3A expression in primary human cells

poster

Menager, Mickaël P

A comprehensive map of the dendritic cell transcriptional network engaged upon innate sensing of HIV

poster

Mendes Passos, Vania P

Endogenous SERINC5 is modulated by type I IFN and antagonized by HIV-1 Nef despite incorporation into virions

talk

Mendonca, Luiza

Cryo-electron tomography and sub-tomogram averaging of HIV-1 VLPs using emClarity

poster

Merchant, Monique K

An endogenous retrovirus from human hookworm encodes an ancient phlebovirus-like class II envelope fusion protein

poster

Mesner, Dejan

Nef-mediated CD3 downmodulation results in decreased lentiviral cell-cell spread

talk

Miller, Caitlin

Transgenic expression of a picornavirus RNA-dependent RNA polymerase outside the viral context protects against retroviral infection with Friend leukemia virus

poster

Miyagi, Eri

Inhibition of virus-associated APOBEC3G antiviral activity by HIV-1 Vif in virions

poster

Mlcochova, Petra

TLR4 activation blocks HIV-1 infection in a SAMHD1 dependent manner

talk

Monde, Kazuaki

Retrotransposition of HERV-K in Sox2-expressing cells

poster

Morris, Elizabeth R

A SAMHD1 structural tool for capturing the pre-catalytic state during hydrolysis of dNTPs and antiviral analogues

poster

Morrison, James

A potent primate lentivirus-specific restriction in Megachiropteran bats

talk

Mulder, Lubbertus C

Mapping of the HIV-dependent HERV-K protein expression, a proteogenomic approach

poster

Munshi, Mohamed Husen M

Identification of HIV-1 capsid determinants that influence nuclear envelope docking and import kinetics

poster

Murakami, Tomoyuki

PSGL-1 and CD43 incorporated into virions inhibit HIV-1 entry

talk

Murlidaran, Sruthi

Molecular mechanism of potent capsid-targeting antiretroviral drugs

poster

Musier-Forsyth, Karin

Secondary structure of the HIV-1 5´UTR is sensitive to varying transcription start sites

poster

Negroni, Matteo

Modulation of HIV-1 proviral DNA nuclear import and integration by a motif that generates a positive electrostatic surface in the C-ter domain of the integrase

poster

Nikolaitchik, Olga A

The role of unpaired guanosines in the encapsidation of HIV-1 genomic RNA

poster

Nitta, Takayuki

Role of Rab5 and Geranylgeranylation in MuLV replication

poster

Nodder, Sarah B

HIV-2/SIVmac239 Vpr suppresses a type III IFN response in monocyte-derived dendritic cells in a DCAFCRL4-dependent manner

talk

Novikova, Mariia

Importance of the MA trimer formation for HIV-1 Env incorporation

talk

O'Carroll, Ina

Structural studies on the HERV-K nuclear export signal

poster

OhAinle, Molly

HIV-CRISPR screening identifies TRIM34 as a restriction factor for HIV and SIV capsids

talk

Olety, Balaji

Evidence for a novel restriction factor that is counteracted by Nef

talk

Oo, Adrian

Vpx reduces the incorporation of non-canonical and mutagenic rNTPs during HIV-1 reverse transcription in macrophages

talk

Oom, Aaron L

Investigating the interaction of SERINC5 with HIV-1 Env and Nef using proximity-based labeling

poster

Osei Kuffour, Edmund

UBP43 (USP18) negatively regulates innate immune sensing of HIV-1

poster

Padron, Adrian

Examining the role of cyclophilin A in HIV-1 pre-integration complex (PIC) function

poster

Paillart, Jean-Christophe

Translational control of APOBEC3G via HIV-1 Vif-regulated upstream open reading frame

poster

Pathak, Rajiv

Single cell RNA-seq analysis combined with a quantitative single cell, single molecule RNA-FISH+IF (SMIRA) reveals stochasticity of reactivation of latent HIV-1 proviruses

talk

Patro, Sean C

Characterization of HIV-1 proviruses and their sites of integration informs intra-patient viral dynamics and reconstruction of replication-competent viral ancestors

poster

Pazgier, Marzena E

Structural basis for C1/C2 epitopes involved in ADCC response of the RV114 and RV305 vaccine trials

poster

Perot, Brieuc P

Tetraspanin 7, a novel mediator of HIV-1–induced dendritic cell maturation and inflammatory response

poster

Pi, Ruoxi

B-1 cells are early targets in murine leukemia virus infection in mice and promote viral spread to the B-2 cell population

talk

Planas, Delphine

Pharmacological inhibition of PPARγ reverses HIV latency but prevents viral production/infectivity while boosting Th17 functions

poster

Polpitiya Arachchige, Sachith O

The HSV-1 glycoprotein D restricts the release of infectious HIV-1

poster

Prado, Julia Garcia

PD-1 blockade boost vaccine-induced antiviral CD8+ T-cell responses in early treated HIV-1 infected individuals

poster

Prevost, Jeremie

A complex interplay between the HIV-1 Env gp120 inner domain and the Phe43 cavity shapes the highly-conserved CD4 binding site

poster

Pye, Valerie E

Structural characterisation of a SERINC family member

talk

Qin, Zhihua

The dNTPase activity of SAMHD1 is required for its suppression of innate immune responses in differentiated monocytic cells

talk

Rai, Padmani

RSV genome dimerization occurs in the nucleus

poster

Rawson, Jonathan M

Identification of Gag determinants of RNA packaging specificity in HIV-1 and HIV-2

poster

Raymond Marchand, Laurence R

Improved HIV reactivation via optimized cell-culture, retinoic acid stimulation, and CCR6+CD4+ T-cell enrichment

poster

Rein, Alan

Oligonucleotide-induced dimerization of HIV-1 Gag protein

talk

Ren, Xuefeng

Cryo-EM structural study of SIV Nef hijacking of AP-2 in tetherin downregulation reveals a unique cargo binding site and mechanism

talk

Reuschl, Ann-Kathrin

HIV-1 exploits cell-cell spread to infect resting CD4 memory T cells

talk

Ricana, Clifton L

Inositol phosphates are essential for replication of some but not all retroviruses

talk

Richard, Jonathan

Upregulation of BST-2 by type I IFNs reduce the capacity of Vpu to protect HIV-1-infected cells from NK cell responses

poster

Rizvi, Tahir A

The conserved stem loop 2 (SL2) present at the 5’ end of the (M-PMV) and the mouse mammary tumor virus (MMTV) genome is dispensable for their genomic RNA packaging

poster

Robinson, Carolyn

Development of novel small-molecule inhibitors of Vpu

talk

Rosa, Annachiara C

Analysis of SERINC5 palmitoylation

poster

Roth, Monica

Disrupting BET interactions promotes MLV integration into quiescent chromatin and delays tumorigenesis in the MYC/Runx2 mouse model

poster

Roy, Chandra Nath

Imaging HIV-1 transmission and dissemination in humanized mice

poster

Rui, Yajuan

Characterization of Vpx mediated SAMHD1 and cGAS/STING inhibition

poster

Russell, Ronnie M

The antigenicity of the envelope trimer apex is highly conserved among primate lentiviruses

poster

Sabo, Yosef

IQGAP1 inhibits HIV-1 budding by preventing Gag protein accumulation at the plasma membrane

talk

Sapp, Nicklas E

Human nucleosome structure and chromatin binding proteins affect HIV-1 preintegration complex mediated DNA integration

poster

Sarafianos, Stefan

Design and characterization of capsid-targeting antivirals based on the PF74 scaffold to probe various stages of HIV-1 replication

talk

Satija, Namita

A genetically encoded switch to monitor HIV infection and latency within humanized mice reveals HIV-susceptibility and latency associated with diverse T cell transcriptional states

talk

Sato, Yorifumi

Underlying mechanisms of experimental HIV-1 cure observed in the newly developed in vitro model named WIPE assay

poster

Sebrow, Jeffrey

Electroporation nonspecifically increases susceptibility of CD34+ cells to retroviral infection

poster

Seissler, Tanja

Identification of cellular factors involved in the translational inhibition of APOBEC3G restriction factor by the HIV-1 Vif protein

poster

Serra-Moreno, Ruth

Yet another mechanism for immune evasion by HIV Nef—Autophagy antagonism

talk

Sharma, Shilpi

The C-terminal end of HIV-1 viral protein U (Vpu) encodes a clade-specific determinant to antagonize BST-2 and facilitate virion release

poster

Shaw, Andrew

The 'antiviral state' has shaped the CpG composition of the vertebrate interferome

talk

Shema Mugisha, Christian

Integrase-RNA binding is crucial for virion morphogenesis in HIV and other retroviruses

poster

Sherburn, Rebekah

Elucidating the rules governing Fc-mediated effector functions to HIV

poster

Sherer, Nathan M

“Burst” RNA nuclear export dynamics are a conserved feature of diverse lentiviral and deltaretroviral Rev and Rex RNA export modules

poster

Sherrill-Mix, Scott

HIV-1 isolates from treatment interruption rebound plasma but not latent viral outgrowth are highly interferon resistant

talk

Shimagaki, Kazunori

HIV-2 Vpx/Vpr regulate their stability using zinc-binding site and poly-proline motif

poster

Shindo, Keisuke

Defining HIV-1 Vif determinants for inducing the cell cycle arrest

poster

Shivkumar, Maitreyi

Investigating the role of T cell signaling during HIV-1 cell-cell spread

poster

Silverstein, Noah J

Development of piRNA genome defense to retroviral invasion

poster

Skowronski, Jacek

HIV-1 Vpr counteracts restriction of HIV-1 infection mediated by HLTF DNA helicase and Exonuclease I

talk

Smith, Steven J

Integrase strand transfer inhibitors (INSTIs) that are broadly effective against INSTI-resistant HIV-1 mutants

talk

Snetkov, Xenia

A single residue in the cytoplasmic tail of  HIV-1 Envelope is required to mediate viral spread between T cells

talk

Su, Jiaming

HIV-2/SIV Vpx selectively inhibits cGAS-STING mediated innate immune activation to promote viral replication

poster

Sultana, Tahmina

Identification of mutations in HIV CA that increase the rate of reverse transcription and the initiation of uncoating

talk

Sumner, Christopher A

MA-tRNA interactions and their role in regulating the plasma membrane specificity of HIV-1 Gag

poster

Sumner, Rebecca

HIV-1 protease inhibitors cause formation of defective viral particles that activate a cGAS-dependent innate immune response

talk

Sutton, Richard

Luciferase complementation assay to quantify HIV-1 Rev-Rev interaction in a high throughput manner

poster

Swanson, Chad

CpG dinucleotides inhibit HIV-1 replication through multiple mechanisms

poster

Symeonides, Menelaos

A novel immunomagnetic approach for the physical isolation of syncytia from HIV-1-infected T cell cultures

poster

Tada, Takuya

Checkpoint inhibitor lentiviral DC vaccine suppresses HIV replication in a humanized mice model

talk

Takata, Matthew

ZAP cofactor requirement for antiviral activity against CG-enriched HIV-1

poster

Tan, Toong Seng

A single amino acid change in an extracellular loop of SERINC5 attenuates the ability to restrict HIV-1 infectivity

poster

Taube, Ran

Fused in sarcoma silences HIV gene transcription and maintains viral latency through suppressing AFF4 activation and competing with Tat on TAR

talk

Tauzin, Alexandra

Rev interferes with the nuclear phase of HIV infection

poster

Taylor, Harry

MTOR regulates microtubule stabilization necessary for HIV-1 reservoir establishment

poster

Taylor, Ian A

High-resolution cryo-EM structures of retroviral CA fullerene shell assemblies

talk

Thornhill, Dishari

A potential role for MA-HBR residues in a step beyond PM-specific localization of Gag

poster

Twizerimana, Augustin Penda

Cyclosporin A modulates the activity of HIV/SIV capsid destabilisers PF74 and PF-3759857 (PF57) in the presence or absence of cyclophilin A

poster

Unali, Giulia

Identification of cell-type specific co-factors required for IFITM3-mediated block to viral entry in human hematopoietic stem cells

poster

van Duyne, Rachel

Elucidating mechanisms by which mutations in Env contribute to broad, multi-class HIV-1 drug resistance

poster

van Engelenburg, Schuyler B

Spying on HIV-1 envelope to uncover the mechanisms of virus incorporation

talk

Vansant, Gerlinde

HIV-1 integration site selection affects transcription

talk

Volodina, Olga

A novel humanized CCST mouse model developed with the use of postnatal thymus supports HIV-1 infection and persistence

talk

Waheed, Abdul A

PSGL-1 restricts HIV-1 infectivity by blocking Env incorporation into virions

talk

Waheed, Abdul A

The autophagy protein ATG9A promotes HIV-1 infectivity

poster

Wang, Jiayi

A role for RNA in HIV-1 Vif-mediated degradation of human APOBEC3H?

talk

Weaver, Nick C

The role of KIF16B in HIV-1 envelope glycoprotein complex trafficking

talk

Wei, Wei

Anti-viral SAMHD1 recognizes HIV-1 core

poster

Whitaker, Emily E

Characterization of T cell syncytia, a unique subpopulation of HIV-1-infected cells

poster

Willkomm, Nora A

Interrogation of human retrovirus capsid protein function in viral replication by comparative analysis

poster

Winans, Shelby

Characterization of host cell factors interacting with betaretroviral integrase

poster

Wright, Joshua D

Insights into SAMHD1 recruitment to the host cell CRL4 ubiquitin E3 ligase by the lentiviral accessory proteins, Vpr and Vpx

poster

Wu, Li

HIV-1 envelope proteins up-regulate N6-methyladenosine levels of cellular RNA independently of viral replication

talk

Wu, Li

The polar region of HIV-1 envelope protein determines viral fusion and infectivity by stabilizing gp120-gp41 association

poster

Wu, Yuanfei

Inhibition of HIV-1 replication by SERINC5 in the presence of a SERINC5-resistant Env

poster

Wu, Yuanfei

The cell polarity regulator CDC42 controls HIV spreading

talk

Xu, Chaoyi

Molecular mechanism of nucleotide translocation through HIV-1 CA hexamers

talk

Xu, Joella

dNTP pool bias induced error catastrophe of HIV-1 in macrophages

talk

Yang, Haitao

HIV and TB co-infection—Development of new antibiotics targeting MTB

poster

Yapo, Assi

Study of hiv-1 and hiv-2 dual infections at the single cell level

poster

Yedavalli, Venkat

ERV-L related intact endogenous retrovirus Xenopus that encodes an envelope protein

talk

Yimer, Diborah

IFITM3 inhibits retroviral infectivity by limiting envelope abundance and function in virions

poster

Yoh, Sunnie M

PQBP1/cGAS recruitment to incoming HIV-1 capsid enables sensing of HIV-1 infection

poster

Yu, Corey

FRET-based assay to monitor transient oligomerization of SAMHD1

poster

Zamborlini, Alessia

SUMOylation of K595 and phosphorylation of T592 cooperate to regulate the antiviral activity of SAMHD1

talk

Zhang, Fengwen

Degradation of nuclear factors by HIV-1 Vpr contributes to cell cycle arrest

talk

Zhang, Hui

X4-tropic HIV-1 preferentially accumulates in peripheral follicular helper T cells

poster

Zhang, Peijun

Near-atomic resolution structures of capsid assembly and in complex with CypA

talk

Zhang, Shijian

Effects of reversible and irreversible BMS-378806 analogues on the conformation  of HIV-1 envelope glycoproteins

poster

Zheng, Yong-Hui

Env conformation and CD4 expression are critical features of HIV-1 restriction by SERINC5

talk

Zheng, Yue

Knockout of cleavage and polyadenylation specific factor 6 inhibits reactivation of HIV latent cells

poster

Zhong, Zhou

HIV-1 interacts with cytoplasmic CPSF6 during trafficking on microtubules

poster

Zhou, Xiaohong

HIV-1 Vpr activates the CRL4-DCAF1 E3 ligase to degrade a histone deacetylase SIRT7

talk

Zhu, Yiping

Function of FANCI in HIV-1 infection

poster

Zila, Vojtech

Visualization of HIV-1 post-fusion complexes in a human CD4+ T cell line

talk

Zou, Chengcheng

DNA repair protein Rad18 suppresses the late step of HIV-1 replication

poster

Zuliani-Alvarez, Lorena

Non-pandemic HIV capsids fail to protect viral DNA from DNA sensors and nucleases

talk