Molecular Chaperones
& Stress Responses
May 4 - 8, 2010
Abstract Deadline: February 12, 2010

Organizers:
F. Ulrich Hartl, Max Planck Institute for Biochemistry, Germany
David Ron, New York University School of Medicine
Jonathan Weissman, HHMI/University of California San Francisco

past program

You are cordially invited to participate in the meeting on Molecular Chaperones and Stress Responses which will be held at Cold Spring Harbor Laboratory, 28 years after the inaugural meeting in this series. The meeting will begin on Tuesday, May 4, 2010, and will conclude with lunch on Saturday, May 8.

The meeting will feature advances in the areas of structure and mechanism of action of molecular chaperones; mechanisms of induction of the stress response; the role of chaperones in protein degradation, and chaperone function in disease, development and organellar homeostasis. Chaperones are intimately involved in basic biological processes such as protein translation, folding, complex assembly and disassembly, translocation across membranes and protein degradation.

The contribution of heat shock proteins, to protein folding in vivo across the entire proteome will be described alongside function of specialized chaperones with more limited clientele. The interactions of chaperones and unfolded and misfolded proteins will be discussed in molecular and atomic detail. At the cellular level, the interactions between chaperones in the formation of protein folding networks will be discussed and at the physiological level the impact of altered chaperone buffering capacity on organeller, cellular and organismal function will be discussed.

Sessions & Discussion Leaders:
CHAPERONE BIOCHEMISTRY & PROTEIN FOLDING
Chairperson: James Bardwell
Invited speakers: Helen Sabil , Art Horwich (tent.)

CHAPERONE FUNCTION IN DISEASE & DEVELOPMENT
Chairperson: Sue Lindquist
Invited speaker: Elke Duerling

EVOLUTION & REGULATION OF
PROTEIN FOLDING MACHINES
Chairperson: Judith Frydman
Invited speakers: Hanna El-Samad , Vijay Pande

QUALITY CONTROL & PROTEIN TRAFFICKING
Chairperson: Ramanujan Hegde
Invited speaker: Kenji Kohno

CHAPERONES & PROTEOLYSIS
Chairperson: Bob Sauer
Invited speaker: Thomas Langer

DISEASES OF PROTEIN MISFOLDING
Chairperson: Andy Dillin
Invited speaker: David Eisenberg

MANIPULATING CHAPERONE NETWORKS
& PROTEIN FOLDING PATHWAYS
Chairperson: Bill Balch
Invited speaker: Peter Walter

The format of the meeting will include morning and evening sessions consisting of 2/3 25 minute talks and between six to eight or short talks per session, selected from the abstracts, principally on unpublished work. In addition, there will be three poster sessions, held in the afternoons. The organizers will decide the suitability of each abstract for oral or poster presentation, but please specify if you prefer a poster.

We are eager to have as many young people as possible attend since they are likely to benefit most from this meeting. We have applied for funds from government and industry to partially support graduate students and postdocs. Apply in writing to beavers@cshl.edu stating need for financial support - preference is given to those submitting abstracts.

Status of abstracts will be posted on our web site as soon as decisions have been made by the Organizers. Please bring this notice to the attention of any of your colleagues who may be interested. We hope to see you at Cold Spring Harbor in May.

All questions pertaining to registration, fees, housing, meals, transportation, visas, abstract submission or any other matters may be directed to beavers@cshl.edu

This conference may be supported in part by funds provided by:
National Institute of Neurological Diseases & Stroke, part of the National Institutes of Health

We have funds to provide partial scholarships for individuals who are US citizens/permanent residents from minority groups under-represented in the life sciences. Please provide justification in writing to beavers@cshl.edu and state your financial needs. Preference will be given to those applying who submit abstracts to the meeting.

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Regular packages are all inclusive and cover registration, food, housing, parking, wine-and-cheese party, lobster banquet, etc. No Housing packages include all costs except housing. Full payment is due 4 weeks prior to the meeting.