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RETROVIRUSES

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Abstracts are listed alphabetically by presenting author.

Presenting Author

Abstract Title

Talk/Poster

Akari, H.

HIV-1 Vif protein packaged in virions augments viral infectivity by a novel mechanism—Implication of p33 Gag intermediate

poster

Ako-Adjei, D.

Gag proteins follow a common assembly pathway independent of the RNA export pathway

talk

Alfadhli, A.N.

Membrane-binding characteristics of the HIV-1 matrix protein

poster

Andresdottir, V.

Transmission of antigenic escape variants of MVV by natural routes

poster

Andresen, V.

The HTLV-I p13II protein binds to Tax, inhibits Tax dependent transcription and decreases viral replication

talk

Aoki, T.

Functional substitution of the myristoylation signal of HIV-1 Gag with phospholipase C d 1 pleckstrin homology domain

poster

Apolonia, L.

Non-integrating lentiviral vectors display lower transcription activity than their integrating counterparts

poster

Arriagada, G.L.

Role of capsid SUMOylation in nuclear entry of MoMLV

poster

Bacharach, E.

Basal budding and replication of the MLV are independent of the Gag L-domains

poster

Bartholomeeusen, K.

Analysis of the interaction between the HIV-1 tethering factor LEDGF/p75 and its cellular interaction partner POGz

poster

Bauby, H.

TIP47 promotes the efficient release of infectious HIV-1 from the assembly compartment of macrophages

talk

Belshan, M.

Biochemical profiles of HIV nucleoprotein complexes purified by velocity gradient centrifugation

poster

Belzile, J.

Cytoplasmic recruitment of the DDB1-CUL4ADCAF1 E3 ubiquitin ligase by HIV-1 Vpr

poster

Benachenhou, F.

Modular structure of vertebrate retroviral LTRs allows novel ORFs and other adaptations—Detection of single LTRs in genomic data

poster

Bérubé, J.

Investigating the TRIM5 restriction defect in D17 cells

poster

Beyer, A.R.

Interaction of ribosomal proteins with MMTV Gag in the nucleus

poster

Bhakta, S.J.

Functional analysis of intracellular targeting motifs within HIV-1 envelope cytoplasmic domain

talk

Bialuk, I.

Analysis of p12 isoforms from ex vivo samples of HTLV-I infected individuals

poster

Bieniasz, P.D.

Towards a mechanism for tetherin-mediated inhibition of retrovirus release

talk

Bishop, K.N.

Investigating the mechanisms of APOBEC-mediated restriction of HIV-1

talk

Blanchard, Y.

High CpG islands density areas favor the integration of PERV

poster

Boeras, D.I.

HIV in genital fluids during heterosexual transmission

poster

Boeras, I.

Restriction of HBRV/MMTV Gag gene expression

poster

Bouamr, F.

Potent block of HIV-1 in early steps of morphogenesis by an N-terminal fragment of Alix

poster

Bouaziz, S.

NMR structure of the C-terminal domain of p6, evidences for an interaction with Vpr

poster

Bouchard, A.

In vitro molecular evolution of TRIM5a

poster

Boulanger, P.A.

Vif protein counteracts the negative effect of 3-0-(3',3'-dimethylsuccinyl)-betulinic acid (DSB) on HIV-1 virus-like particle assembly, a function which requires the integrity of its zinc-binding domain

poster

Brady, T.L.

De novo integration site selection by a resurrected HERV-K differs significantly from the pattern of fixed HERVs in the human genome

talk

Bruce, J. A cellular pathway that contributes to a step of retroviral infection that is coincident with viral DNA integration

talk

Bulliard, Y.

Structure/function analysis of the N-terminal moiety of APOBEC3G in HIV-1, HBV and Alu inhibition

poster

Burns, A.E.

Two X-ray crystal structures of MMLV capsid protein suggest a potential mechanism for virion maturation

talk

Campbell, E.M.

HIV-1 induces the formation and dissipation of rhesus TRIM5a cytoplasmic bodies

talk

Cano, J.

A Sin3a/HDAC1 complex is incorporated into HIV-1 but not SIV virions and specifically modulates HIV-1 replication

poster

Cano, J.

Targeting INI1 transdominant negative mutant S6 to subnuclear compartments and its effect on inhibition of HIV-1 particle production

poster

Caporale, M.

The signal peptide of the JSRV envelope can function as an RNA export protein

poster

Carlton, J.

Differential roles for Alix and ESCRT-III in cytokinesis and HIV-1 release

talk

Carpenter, S.

Secondary structural analysis of the EIAV RRE—Identification of a conserved RNA structural motif required for high affinity Rev binding in both EIAV and HIV-1

poster

Carthagena, L.

Implication of TRIM5 proteins in interferon-induced anti-retroviral response

poster

Cattoglio, C.

Retroviral integration into the human genome is biased by specific subsets of transcription factor binding sites

poster

Cecchinato, V.

HTLV-II induces a persistent infection in the gastro-intestinal tract of rhesus macaques

poster

Chan, J.

Chimeric RSV Gag assemblies as an integral membrane protein

poster

Chatterjee, A.

The chromodomain of Tf1 integrase is critical for integration and target site selection

poster

Checkley, M.

Localization of Ty1 RNA and VLP assembly sites in S. cerevisiae

talk

Cherepanov, P.P.

Functional and structural characterization of integrase from a spumaretrovirus

poster

Chin, M.P.

The viability and replication fitness of HIV-1 intersubtype recombinants

poster

Chow, S.A.

Integration site preference of XMRV, a new human retrovirus associated with prostate cancer

talk

Christiansen, K.A.

The spacer domain of Ty3, a retrotransposon in S. cerevisiae, contributes to particle morphogenesis, efficiency of polyprotein processing, and Ty3 transposition

poster

Chukkapalli, V.

Basic residues in the matrix domain of HIV-1 Gag have opposing roles in membrane binding

poster

Cimarelli, A.

Deciphering SIVSM/HIV-2 Vpx function in the infection of macrophages and dendritic cells

talk

Ciminale, V.

Remodeling of mitochondrial function by the p13 protein of HTLV-I promotes accumulation of reactive oxygen species and cell death

poster

Ciminale, V.

Temporal regulation of HTLV-I expression following viral reactivation

poster

Clark, J.M.

Construction of a MPMV Gag-GFP fusion—Visualization of viral capsid assembly and transport in live cells

poster

Contreras, X.

Activation of HIV transcription in latently infected PBMCs from HAART treated patients using hydroxamic acid—Involvement of P-TEFb

talk

Contreras, X.

PKC-d is required in human macrophages for completion of HIV-1 reverse transcription

poster

Costa, L.J.

HIV-1 Nef protein binds the MB1MB2 sub-domains of the central V region of the cellular protein Alix/AIP-1

poster

Costa, L.J.

Nef alleles from SIVmac239 are able to interact in cells with Alix/AIP-1 and rescue a HIV-1 late domain-deficient phenotype

poster

Courgnaud, V.

TRIM5a restriction of different SIVs

poster

Craven, R.C.

Second-site suppressors of CA CTD mutations provide insights into the early steps of capsid assembly

talk

Crawford, L.

Role of HBZ in HTLV-I leukemogenesis in humanized SCID mice

talk

Crist, R.M.

Assembly properties of Gag-Zipper chimeras

talk

Dang, Y.

Polyubiquitylation of APOBEC3G is not required for Vif-triggered proteasomal turnover

poster

Dapp, M.

Demonstration of a dual mechanism for mutagenic ribonucleosides in decreasing viral infectivity and inducing HIV-1 mutagenesis

poster

Das, S.

Multimerization and IN-interaction of INI1 and its effect on HIV-1 integrase activity in vitro

poster

De Rijck, J.

Transportin-SR2 imports HIV into the nucleus

talk

De Rocquigny, H.M.

NCp7 chaperoning activity for the second strand transfer during HIV-1 DNA synthesis

poster

Derse, D.

Exploring the mechanisms of cell-to-cell transmission of retroviruses—Quantitative measurement of HIV-1 and HTLV-I infection/replication in coculture

talk

DeStefano, J.J.

A new application of aminoglycoside antibiotics for treatment of HIV infection—Potent antiviral activity in cell culture and alteration in frameshifting by the common antibiotic gentamicin

poster

Diamond, T.L.

Characterization of novel host factors involved in HIV integration using genome-wide siRNA and yeast two-hybrid screens

poster

Diaz-Griffero, F.

A human TRIM5a B30.2/SPRY domain mutant gains the ability to restrict and prematurely uncoat B-tropic MLV

poster

Diaz-Griffero, F.

Second-site revertants on the surface of the B-box 2 domain restore the antiretroviral activity of TRIM5a rh with effector function defects

poster

Diehl, W.E.

Species-specific differences in receptor utilization by MPMV envelope glycoprotein

talk

Dilley, K.A.

The role of Alix and the LYPSL motif in RSV budding

poster

Dong, C.

Postentry restriction of HIV-1 infection in human monocytes

poster

Dong, X.

Filamin A is involved in HIV-1 assembly through direct interaction with Gag

poster

Dou, J.

Striking similarities between myristoylated, monomeric Gag and non-myristoylated Gag

poster

Duclair, S.

RNA aptamers targeted to HIV-1 protease—Characterization, in vitro efficacy and specificity

poster

Dudley, J.

HIV Rev and HTLV Rex enhance expression from the MMTV Rem-responsive element after nuclear export

poster

Ebina, H.

The integrase of Tf1 targets the promoter of fbp1 by forming a complex with the transcription factor Atf1p and target DNA

poster

Ehrlich, L.S.

PI(4,5)P2 hydrolysis and IP3-receptor-gated CA2+ release regulate HIV-1 Gag exocytosis

talk

Elleder, D.

Identification of a potent and new reverse transcriptase inhibitor scaffold from an expandable pharmacophore library

poster

Engelman, A.

The role of the LEDGF/p75 PWWP domain in HIV-1 infection and integration

talk

Eugenin, E.A.

Mechanisms of gap junctions mediated HIV-bystander killing in astrocytes

poster

Federspiel, M.J.

The unique HGHG motif of the ASLV transmembrane glycoprotein hinge region is a determinant of the low-pH dependent envelope conformation triggering required for efficient entry

talk

Feuer, G.

HTLV-I infection of human CD34+ HPCs recapitulates adult T cell leukemia/lymphoma (ATL) development in humanized NOD/SCID mice

talk

Figueiredo, A.P.

The microtubule network regulates rhesus TRIM5a dynamics and turnover and supports rhesus TRIM5a -restriction of HIV-1

poster

Foster, J.L.

Mechanism of HIV-1 Nef downregulation of MHCI

poster

Freed, E.O.

Functional replacement of a retroviral late domain by ubiquitin fusion

talk

Friew, Y.N.

analysis of intracellular interactions between APOBEC3G, RNA and HIV-1 Gag using biomolecular fluorescence complementation

poster

Fritz, J.V.

Direct evidence of HIV-1 Vpr oligomerization in living cells by two photon fluorescence correlation spectroscopy and fluorescence lifetime imaging

talk

Fryrear, K.A.

Novel domains regulate subcellular localization of HTLV-I Tax

poster

Fukumoto, R.

In vivo genetic mutations define predominant functions of the HTLV p12I protein

talk

Galla, M.

Cellular restriction of retrovirus particle mediated mRNA transfer

poster

Gallo, D.E.

Nuclear-cytoplasmic shuttling of rhTRIM5a

poster

Gao, J.

DNA damage blocks integration of the yeast retrotransposon Ty5

poster

Gao, L.

Factors that determine hotspots for recombination during HIV-1 replication

poster

Garforth, S.J.

The effect of K65A substitution in the b 3-b 4 loop of HIV-1 reverse transcriptase on mismatched primer extension

poster

Garforth, S.J.

Utilization of a deoxynucleoside diphosphate substrate by HIV-1 reverse transcriptase—Inorganic phosphate dependent phosphorolysis as a potential mechanism of AZT resistance

poster

Garg, M.

Radiolabeling, pharmacoscintigraphic evaluation and antiretroviral efficacy of stavudine loaded 99mTc labeled galactosylated liposomes

poster

Garvey, E.P.

Comparison of kinetics of two-metal binding HIV-1 integrase inhibitors inhibiting recombinant enzyme versus preintegration complex

poster

Goettlinger, H.G.

Efficient rescue of HIV-1 budding defects by a Nedd4-like ubiquitin ligase

talk

Gramberg, T.

Vpx counteracts an inhibitory factor during SIV infection of primary cells

talk

Grandgenett, D.P.

HIV-1 synaptic complexes—Uncovering mechanisms associated with concerted integration

poster

Green, P.

HTLV-I Hbz promotes T-lymphocyte proliferation in culture and tumor growth in NOD/SCID g c-/-(NOG) mice

talk

Gregory, D.A.

Specific membrane targeting of Gag is sufficient for Env recruitment to budding virions

talk

Groom, H.C.

The role of viral factors in translation of HIV-1 RNA

poster

Guatelli, J.C.

The interferon-induced protein BST-2/CD317 restricts release of virus particles from infected cells and is down-regulated from the cell surface by HIV-1 Vpu

talk

Gudleski, N.

Structural analysis of RSV Gag polyprotein in complex with nucleic acids

talk

Gudmundsdottir, E.T.

Cell tropisms of MVV is determined at the level of transcriptional or mRNA regulation

poster

Gummuluru, R.

Cell-type and envelope glycoprotein dependent restriction of MLV by mouse APOBEC3

poster

Haedicke, J.

The role of FEZ1 (fasciculation and elongation protein zeta-1 in retroviral infection of brain cells

poster

Hahn, S.S.

Targeting HIV-1 Gag into the DRiP-pathway enhances MHC class I antigen presentation and CD8+ T cell activation

poster

Haim, H.

Soluble CD4 and CD4-mimetic compounds induce metastable activation of the HIV-1 envelope glycoproteins

talk

Han, Y.

APOBEC3G requires an endogenous cofactor to block HIV-1 replication

talk

Hare, S.

Structural basis for the high affinity integrase-LEDGF interaction

talk

Harmon, B.N.

HIV envelope induction of the G-a q signaling pathway is required for virus entry

poster

Harrich, D.

Purification of cellular factors important for HIV-1 late DNA synthesis

talk

Harris, R.S.

Analyses of the 2 APOBEC3 genes of artiodactyls indicate that the 7 human homologs arose by frequent recombination prior to primatification

poster

Harris, R.S.

Evolution of HIV-1 isolates that use a novel Vif-independent mechanism to resist restriction by human APOBEC3G

talk

Hartl, M.J.

AZT resistance of SFV reverse transcriptase is based on the excision of AZTMP in the presence of ATP

poster

Hartl, M.J.

Solution structure of a monomeric SFV protease

poster

Hatziioannou, T.

Primate lentivirus susceptibility to TRIM5 proteins

talk

Hauser, H.

Subcellular distribution and functional analysis of Vpu proteins form subtype B and C isolates of HIV-1

talk

Henning, M.S.

ERM family members moesin and ezrin are natural determinants of retroviral infectivity

poster

Herrmann, M.

HIV-1 gp120 interacts with the voltage gated potassium channel BEC1

poster

Heslin, D.J.

A single amino acid substitution in a region of HERV-K Gag with similarity to HIV Gag abrogates infectivity of a HERV-K provirus in the human genome

poster

Hofmann, H.

Encapsidation of APOBEC3C is not mediated by its Zn2+-finger but by an unknown factor interacting with the largest cavity proximal from the active site

poster

Hogg, B.

Biochemical analysis of HIV messenger RNP assembly

poster

Hogue, I.B.

The relative contributions of Gag capsid and nucleocapsid domains in Gag multimerization

poster

Hokello, J.F.

Coordinated activation of HIV transcriptional elongation and initiation is mediated by T-cell receptor signaling

talk

Houck-Loomis, B.R.

The MoMLV pseudoknot—A novel pH-dependent riboswitch

talk

Hout, D.R.

The host cell translation elongation factor EF1a stimulates HIV-1 uncoating

talk

Huebner, W.

Induction of HIV assembly, endocytic transfer, and infection at T cell virological synapses

talk

Hussein, I.T.

Selection of the HIV-1 dimerization initiation signal

poster

Huthoff, H.

A structure model of the APOBEC3G dimer

poster

Iha, H.

Molecular chaperon inhibitor as a new therapeutic candidate for adult T-cell leukemia

poster

Ikeda, Y.

Further characterization of rhesus monkey TRIM5a -mediated late restriction

poster

Ilina, T.V.

Mutations in the p51 thumb subdomain of HIV-1 reverse transcriptase (RT) provide resistance to acylgydrazone inhibitors of RT ribonuclease H activity

poster

Ilinskaya, A.N.

A tyrosine based motif and cellular adaptor proteins regulate HTLV-I envelope trafficking

poster

Ivanova, A.

Transcriptional repressor CTCF mRNA up-regulation coincides with the induction of anti-HIV-1 responses in CD4+ T cells

poster

Janas, A.M.

Productive infection of HIV-1 in dendritic cells requires fusion-mediated viral entry

talk

Jern, P.

Role of APOBEC3 in retrovirus evolution and genetic diversity

poster

Jin, J.

A mouse-like block for pre-dependent HIV Gag in human cells

poster

Jolicoeur, P.

Generation of a novel inducible model of AIDS in mice

talk

Jolicoeur, P.

HIV Nef blocks maturation of CD4+ thymic T cells by altering CD4/Lck coreceptor function

poster

Jones, C.P.

Dissecting the nucleic acid chaperone activity of HIV-1 Gag

poster

Jones, K.S.

Molecular complexes involved in HTLV-III Env-mediated entry are distinct from, but overlap with, those involved in HTLV-I and HTLV-II entry

talk

Jonsson, S.R.

Two mutations in the Vif gene of MVV have different phenotypes, indicating more than one function of Vif

poster

Jouvenet, N.

Visualizing the biogenesis of individual HIV-1 virions in live cells

talk

Kassa, A.

Identification of HIV-1 envelope glycoprotein variant resistant to cold inactivation

poster

Kassa, A.

Transitions to and from the CD4-bound conformation are modulated by a change in the HIV-1 gp120 inner domain

talk

Katzman, M.

Development of a high-throughput screening assay for identifying novel stimulators of the nonspecific nuclease activity of HIV-1 integrase

poster

Kaufmann, S.

Rec, a protein of the human endogenous retrovirus K (HERV-K(HML-2)) interacts with the human testis zinc finger protein (TZFP)

poster

Kelley, Z.L.

Mutant HIV-1 RTs with modified dNTP binding pockets effects on polymerase kinetics and viral transduction

poster

Kennedy, E.M.

Kconf or Kcat—Elucidating the specific role of HIV-1 reverse transcriptase Q151 in mismatch extension

poster

Khan, M.A.

Functional properties of naturally occurring truncated forms of HIV-1 Vif

poster

Kieffer, C.D.

VPS4 contains two distinct MIT binding modes required for HIV-1 budding

talk

King, J.E.

Modulation of the NMDA receptor during HIV-Tat induced neuronal apoptosis

poster

King, S.R.

Efficient mismatch extension by HIV-1 reverse transcriptase during forced copy choice recombination

poster

Kirby, K.

High resolution crystal structure of the Fab fragment of KD-247, a humanized anti-V3 monoclonal antibody that inhibits HIV-1 entry

talk

Kirchhoff, F.

Protective Nef functions in natural SIV infection

talk

Kirchhoff, F.

Two types of PAP fragments in semen form amyloid fibrils enhancing HIV infection and reducing viral sensitivity to microbicides

poster

Kloke, B.

Generation of an SIVsmmPBj-derived vector system for transduction of quiescent cells

poster

Ko, N.

HTLV-III human retrovirus genome encodes several accessory proteins

poster

Koenig, R.R.

Global analysis and characterization of host-factors which regulate early stage HIV-1 replication

talk

Kootstra, N.A.

The effect of TRIM5 polymorphisms and regulatory polymorphism in CyPA on the clinical course of HIV-1 infection

talk

Kotler, M.

Deamination in 3D—Intra- and intersegmental transfer of APOBEC3G cytidine deaminase

poster

Koyanagi, Y.

HIV-1 Vpr in mitochondria impairs neuronal progenitor cell differentiation

poster

Krementsov, D.N.

Tetraspanins regulate cell-to-cell transmission of HIV-1

talk

Kula, A.

A tagged-RNA proteomic approach coupled to real-time monitoring of protein-RNA association in living cells for the identification of proteins involved in HIV-1 RNA biogenesis, processing and export

poster

Kvaratskhelia, M.

Cellular cofactor LEDGF/p75 profoundly affects HIV-1 integrase subunit-subunit interactions

talk

Lairmore, M.

HTLV-I p30 binds ATM kinase, activates DNA damage signaling and enhances retroviral vector integration

talk

lecellier, c.

The Gag protein of the PFV provides an entry route to the host miRNA pathway

poster

Lee, K.

Restriction of HIV-1 nuclear entry suggests a role of nuclear pore associated factors

poster

Lee, Y.

In vitro and ancient in vivo hypermutation of HERV-K by APOBEC3 proteins

talk

Leem, Y.

Retrotransposon Tf1 is targeted to Pol II promoters by transcription activators

poster

Lenassi, M.

HIV protein Nef is released from cells with exosomes

poster

Leonard, J.A.

Mechanism by which HIV Nef disrupts the intracellular trafficking of host proteins

poster

L'Hernault, A.

Functional analysis of the stem-loop 1 of the HIV-2 RNA leader

talk

Li, M.

In-gel FRET analysis and visualization of stable complexes of HIV-1 integrase with viral DNA

talk

Life, R.B.

Mutations in the amino-terminus of FV Gag disrupt morphology and infectivity, but not targeting of assembly

talk

Lindemann, D.

Restriction of FVs by primate TRIM5a

talk

Liu, S.

ENTV requires a very acidic pH for fusion and cell entry

talk

llewellyn, N.

Role of uropods in HIV-1 replication

talk

Lochmann, T.

Nucleolar trafficking of the retroviral Gag protein—Implications for genomic RNA packaging

poster

Logue, E.C.

Characterization of the cytidine deaminase APOBEC3A

poster

Luttge, B.G.

Selection for FIV resistance to a dominant-negative mutant of TSG101

poster

MALBEC, M.M.

An RNA interference-based genetic screen to identify cellular proteins important for TRIM5-mediated restriction

poster

Maldarelli, F.

Variation in the level of HIV-1 viremia in patients suppressed on antiretroviral therapy

poster

Mandal, D.

Regulation of HIV-1 vif mRNA splicing by multiple competing cellular factors is required for efficient virus replication in cells expressing high levels of APOBEC3G

poster

Mangeat, B.

Arsenic relocalizes APOBEC3G to high molecular mass complexes in primary blood derived dendritic cells

poster

Marchand, B.

Resistance mutations to translocation-deficient reverse transcriptase inhibitors (TDRTIs) lead to discrimination of the inhibitor and decreased replication capacity

talk

Martinez, N.W.

The kinesin KIF4 regulates intracellular trafficking and stability of the HIV-1 Gag polyprotein

poster

Masse, G.X.

Role of chromatin remodeling complexes in controlling HIV-1 expression in primary CD4+ T cells

poster

Mathew, S.

The role of INI1 and interferon signaling in HIV-1 replication

poster

Matsuo, H.

Structural studies of the deaminase domain of APOBEC3G

talk

Mazari, P.M.

Receptor isolation and characterization of a novel FLV envelope with high titers on human osteosarcoma cell lines

talk

McDonald, D.

Mature dendritic cells sequester HIV in a specialized, surface-accessible intracellular compartment prior to trans-infection

talk

McEwan, W.A.

Characterization of retroviral restriction and TRIM5 amongst felids

poster

Meehan, A.M.

LEDGF/p75 proteins with alternative chromatin tethers are functional HIV cofactors

talk

Menéndez-Arias, L.

Mechanistic basis of zidovudine hypersusceptibility and lamivudine resistance conferred by deleting codon 69 in the reverse transcriptase-coding region of HIV-1

poster

Meredith, L.W.

Evidence of a U5 RNA suppressor of HIV-1 reverse transcription

poster

Mertz, J.A.

MMTV encodes a functional nuclear signal peptide product from either envelope or REM messenger RNA

talk

Michailidis, L.

Novel inhibition mechanism and potent antiviral activity of translocation-deficient reverse transcriptase inhibitors

poster

Miyagi, E.

Physiological level of APOBEC3F does not have anti viral activity against HIV-1

poster

Miyauchi, K.

A relationship between the kinetics of HIV-cell fusion and resistance to gp41-derived inhibitory peptides

poster

Moore, M.D.

HIV-1 RNA dimerization—Investigations into its subcellular localization and export requirements

talk

Morales, I.J.

Dissecting the role of cellular factors in retroviral budding via heterodimerizer-mediated virus-host protein interaction

talk

Mulder, L.

Vif, APOBEC3G, recombination and drug resistance