MOLECULAR CHAPERONES & STRESS RESPONSES

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Abstracts are listed alphabetically by presenting author.

Presenting Author

Abstract Title

Talk/Poster

Albanese, V.

Chaperones anchored ribosomes have a role in ribosome biogenesis

poster

Amanso, A.M.

Crucial requirement of ubiquitin-proteasome system for increased Nox4 mRNA levels during unfolded protein response—Contribution to proapoptotic signaling

poster

Anckar, J.

SIRT1 regulates the activity of heat shock factor HSF1

poster

Argon, Y.

GRP94 is essential for cell proliferation, differentiation and apoptosis because it chaperones insulin-like growth factors

poster

Audas, T.E.

A novel protein, luman recruitment factor (LRF), inhibits luman activation of the unfolded protein response

poster

Baker, T.

Strategies for substrate recognition by the AAA+ unfoldases and proteases

talk

Barak, N.N.

Structural and functional studies on mammalian ERp29

talk

Barral, J.M.

Translation rates and protein folding efficiency

talk

Basu, D.

GroEL of M. tuberculosis is a DNA binding protein and might be involved in nucleoid formation

poster

Belova, L.

Chaperoning the PI3-K/SGK-1 stress response pathway

poster

Blais, J.D.

Screening for small molecule inhibitors of PERK signaling

poster

Bolon, D.N.

The role of dimerization in the ATPase driven conformational cycle of Hsp90

poster

Botha, M.

The Hsp40 proteins of P. falciparum—Exploiting chaperone power in the malaria parasite and infected human erythrocyte

poster

Bouman, L.

Parkin integrates cytosolic and ER stress pathways

poster

Bouttenot, R.

A novel Hsp104 allele masks prion propagation

poster

Bracher, A.

Structural basis for cooperative protein folding by Hsp70 and Hsp110 molecular chaperones

talk

Brackley, K.I.

Studies on CCT monomer localization using epitope tagged subunits in mammalian cell lines

poster

Breiman, A.

The Arabidopsis ROF1 (FKBP 62) is essential in acquired thermotolerance by affecting the level of small heat stress proteins transcribed by HsfA2 which associates with ROF1-Hsp90.1 and translocates the complex to the nucleus

poster

Brockmeier, U.

Lectin-deficient calreticulin retains full functionality as a molecular chaperone for class I histocompatibility molecules

poster

Brodsky, J.L.

The chaperone-mediated selection and retro-translocation of membrane proteins during ER associated degradation (ERAD)

talk

Bromberg, Z.

Capsaicin and Capsazepine—A novel activator and inhibitor of the heat shock response through specific membrane cell receptor?

poster

Bross, P.

Application of advanced mass-spectrometric techniques in studies of the molecular pathogenesis of hereditary spastic paraplegia caused by a mutation in the gene encoding Hsp60

poster

Buchner, J.

Regulation of the Hsp90 chaperone machinery

talk

Bukau, B.

Mechanism of the ClpB/Hsp104 chaperone

talk

Burnett, H.F.

HSV-1 infection modulates unfolded protein response through the viral immediate early protein ICP0

poster

Calamini, B.

High throughput assay screen for small molecule activators of the heat shock response

poster

Calderwood, S.K.

SREC-1 expression in dendritic cells requires TLR signaling and mediates T cell activation by Hsp70

poster

Camberg, J.L.

Degradation of the cell division protein, FtsZ, by E. coli ClpXP

poster

Cappello, F.

Hsp60/procaspase-3 complex formation in human cells—Impact on apoptosis and carcinogenes

poster

Cashikar, A.G.

Conversion of toxic oligomers into non-toxic inclusions by the molecular chaperone, Hsp27

poster

Cashikar, A.G.

Regulation of Hsp104-mediated protein disaggregation in S. cerevisiae

poster

Chadli, A.

How the co-chaperone GCUNC45 contributes to our understanding of the Hsp90 machine biology

poster

Chambers, J.e.

Redox interactions of MHC class I heavy chain give a more detailed insight into its maturation from translation to peptide loading

poster

Chen, S.

Nuclear receptor interaction protein, a coactivator of androgen receptors (AR), is regulated by AR and Sp1 to feed forward activate its own gene expression through AR protein stability

poster

Chowdhury, T.

Elucidating the specificity determinants responsible for ClpX-adaptor interaction

poster

Christianson, J.C.

OS-9 and GRP94 deliver misfolded substrates to the Hrd1-SEL1L ubiquitin ligase complex for ERAD

talk

Cohen, E.

Compromised insulin signaling protects mice from Aβ aggregation-mediated proteotoxicity

talk

Cross, B.C.

A global inhibitor of Sec61-mediated protein translocation

poster

Cybulsky, A.V.

Cytosolic phospholipase A2 (cPLA2) enhances induction of endoplasmic reticulum (ER) stress

poster

Dai, C.

Heat-shock factor 1 is a powerful multifaceted modifier of carcinogenesis

talk

David, D.C.

Proteomic study of age-related protein aggregation

poster

Davis, J.H.

A small-molecule controlled protein degradation system

talk

de Keyzer, J.

Disruption of the ATP binding pocket of Lhs1 abolishes function in vitro and in vivo

poster

Dehbi, M.

Expression profiling of heat shock proteins in a primate non-human model of heatstroke

poster

Di Nardo, A.

Stress response in TSC

poster

Dickey, C.A.

Kinases and chaperones converge to regulate tau biology

poster

Dillin, A.G.

A trans-activator elevates proteasome activity in an aging dependent manner

poster

Dong, M.

The function of ERdj4 in ER stress

poster

Douglas, P.M.

Chaperone-dependent amyloid assembly protects cells from prion toxicity

poster

Doyle, S.M.

Collaboration between ClpB and the DnaK system in protein disaggregation

poster

Dudek, J.

Functional characterization of the ribosomal tunnel exit ligand ERj1

poster

Duennwald, M.L.

Making or breaking aggregates—How the heat shock response antagonizes polyglutamine toxicity

talk

Dulle, J.E.

Hsp104 mutants cause inheritance defects in the propagation of the [PSI+] prion

poster

Dyson, J.

H/D exchange strategy to delineate contact sites in chaperone complexes

talk

Dzubina, H.

Effect of salicylic acid on synthesis of Hsps A. thaliana cell culture

poster

Elias, A.-.

Investigating the role of protein phosphatase 5 in the Hsp90 chaperone complex

poster

Emanuelsson, C.S.

Protein-protein interactions between small heat shock proteins and the N- and C-terminal parts in thermosensitive citrate synthase

poster

Etchells, S.A.

The PPIase domain of trigger factor participates in nascent chain binding and can delay folding

poster

Finley, D.

Regulation of the proteasome by ubiquitin stress—Central role of a deubiquitinating enzyme

talk

Flores-Rozas, H.A.

A role for heat-shock proteins in the protection from cytotoxic drugs

poster

Foit, L.

Optimization of protein folding in vivo

talk

Francis, S.P.

Celastrol, an antioxidant and anti-inflammatory, induces the heat shock response and inhibits aminoglycoside-induced inner ear hair cell death

poster

Franzmann, T.M.

Temperature-activation of the molecular chaperone Hsp26 is controlled by the intrinsic structure rearrangement of its thermosensor domain

poster

Freeman, B.C.

Hsp90 has multiple telomere functions

poster

Frydman, J.

Ubiquitination determines the partitioning of misfolded proteins between two distinct subcellular quality control compartments

talk

Fujiwara, K.

Filamentous morphology in GroE-depleted E. coli induced by impaired folding of FtsE

poster

Gadura, N.

Functional significance of PKCa and Hsp90 interactions in a yeast model

poster

Gauss, R.

The HRD ligase actively participates in ER protein quality control

poster

Gebendorfer, K.M.

Identification and characterization of a novel transcription factor involved in oxidative stress resistance of E. coli

poster

Gestwicki, J.E.

Chemical inhibitors of Hsp70—Artificial co-chaperones that modulate function

poster

Gewirth, D.

Structure and mechanism of GRP94

poster

Ghosh, R.

IRE1 signaling is essential for VEGF upregulation under ER stress

poster

Gibney, P.A.

Molecular basis of Hsp90-Hsp110 collaboration

poster

Gidalevitz, T.

Is disruption of cellular protein folding a common mechanism of gain-of-function proteotoxicity?

poster

Glynn, S.E.

Asymmetric structure of the AAA+ unfoldase ClpX

talk

Godar, J.A.

Detection of small heat shock protein oligomerization and substrate binding by electrospray mass spectrometry

poster

Goeckeler, J.L.

The ATPase activity of the yeast Hsp110, Sse1p, is not peptide stimulated

poster

Goloubinoff, P.A.

The plasma membrane controls the plant heat-shock response by way of specific temperature- and fluidity-sensitive calcium channels

poster

Gomes, C.M.

Friedreich's Ataxia mutations in the mitochondrial iron chaperone, frataxin—Implications in protein folding, structure and function

poster

Gross, C.A.

Controlling the heat shock response in E. coli

talk

Guo, W.

UNC-45 isoform and spliceoform expression in cancer

poster

Hageman, J.

Newly identified molecular chaperones with high activity in the suppression of polyglutamine aggregation

poster

Haslbeck, M.

T. gondii small heat shock proteins—A comparative survey

poster

Haslberger, T.

Mixed protein aggregates consisting of unfolded and native domains uncover mechanistic differences between AAA+ proteins linked to substrate degradation or reactivation

poster

Hayer-Hartl, M.

Monitoring protein conformation along the pathway of chaperonin-assisted folding

talk

Haynes, C.M.

Mutations that attenuate mitochondrial matrix protein degradation and peptide efflux inhibit the mitochondrial UPR in C. elegans

talk

Heikkila, J.J.

The synergistic effect of combined stressors on Hsp gene expression in X. laevis A6 kidney epithelial cells

poster

Hendershot, L.M.

Characterization of an ERAD pathway for non-glycosylated BiP substrates which requires Herp

talk

Hendrickson, W.A.

Structural insights into allosteric coupling between ATP and polypeptide binding sites in Hsp70 chaperones

talk

Hermosilla, R.E.

Lithium-induced cell stress in rat inner medullary collecting duct cells

poster

Higurashi, T.

J-protein Sis1 is necessary for propagation of the three major yeast prions, [RNQ+], [PSI+] and [URE3]

talk

Hirayama, S.

MKKS is a centrosome-shuttling protein whose disease-causing mutants are degraded via quality control E3 enzyme CHIP

poster

Horvath, I.

A mutant small heat shock protein with increased thylakoid association provides an elevated resistance against UV-B damage in Synechocystis 6803

poster

Horwich, A.L.

Requirements for forming the GroEL-GroES folding chamber—Multiple ATPs and concordant movement

talk

Hoseki, J.

ERdj5 is required as a disulfide reductase for ER-associated degradation of misfolded proteins

poster

Houry, W.A.

The interaction of a novel AAA+ protein with the E. coli inducible lysine decarboxylase (LdcI/CadA)—Implications to the bacterial acid stress response

talk

Howard, M.

Activation of the stress protein response inhibits the STAT1 signaling pathway and iNOS function in alveolar macrophages—Role of Hsp90 and Hsp70

poster

Hsu, C.T.

The expression of Hsp in acute and chronic liver damage induced by bile duct ligation

poster

Ilbert, M.

The redox-domain of Hsp33 functions as dual stress sensor

talk

Inoue, Y.

A new factor that severs amyloid fibrils of yeast prion Sup35

poster

Ishida, Y.

Misfolded collagens accumulated in the ER by the absence of Hsp47 are disposed via autophagy-lysosome system

poster

Ishigaki, S.

AATF regulates survival pathways in ER stress signaling by modulating Akt1 transcription

poster

Jacques, S.L.

Ratio of entropy to enthalpy for triggering a heat shock response, and possible role in early evolution

poster

Jin, Y.

Functional interaction with BiP is required to release ERdj3, an ER localized DnaJ family member, from unfolded substrates

poster

Johnson, A.E.

Multi-spanning membrane protein integration into the ER membrane

talk

Johnson, J.L.

Domain requirements for the in vivo interaction of the Hsp40 Ydj1 with two distinct Hsp90 client proteins

poster

Josse, L.J.

Identification of chaperones that prevent protein misfolding and aggregation in CHO cell lines

poster

Kaiser, C.

Analysis of myosin motor domain folding by single molecule force spectroscopy

poster

Kampinga, H.H.

Reverse genetic screens of the HspA, and DnaJ families reveal functional diversities and non-canonical mechanisms in regulation of proteohomeostasis

talk

Kanzaki, T.

ATP-dependent conformational change mechanism of group II chaperones elucidated using chaperonin complexes containing mutant subunits in the ordered fashion

poster

Katz, E.

Mood dependent regulation of glucocortcoid receptor co-chaperones by steroid hormones in pregnant women with a history of depression

poster

Kawata, Y.

Fibril formation of Hsp10 proteins and determination of fibril core regions—Differences in fibril core regions dependent on subtle differences in amino acid sequence

poster

Kikis, E.A.

Modifiers of protein misfolding in C. elegans polyglutamine disease models

poster

Kim, H.L.

Carbonic anhydrase IX has chaperone-like functions and is an immunoadjuvant

poster

Klaips, C.L.

Sup35 sequence requirements for [PSI+] curing by Hsp104

poster

Knowlton, A.A.

Post-translational modification of Hsp60 regulates translocation to the plasma membrane

poster

Kryndushkin, D.S.

Chaperone-typing of yeast prions

poster

Kumar, S.C.

Activity restoration of a naturally inactive chaperonin via facilitated oligomerization

poster

Kundrat, L.

CHIP—The link between protein folding and protein degradation

poster

Kusmierczyk, A.R.

A proteasome-specific chaperone regulates assembly of alternative proteasomes—Implications for a conserved stress response

poster

Lautz, K.

Cellular response to ER stress caused by disease-causing V2 vasopressin receptor mutants

poster

Lee, K.P.

Structure of the dual enzyme Ire1 reveals the basis for catalysis and regulation in nonconventional RNA splicing

talk

Lee, M.E.

Exploring the molecular basis for communication between the peptidase ClpP and its cognate unfoldase ClpX

poster

Leroux, M.

Interaction network of the eukaryotic chaperonin CCT

talk

Li, L.

The yeast chromatin remodeling factor SWI1 can exist as a prion modifying SWI/SNF function

talk

Li, Y.

An isoform of Zhangfei activates CHOP through a CCAAT/enhancer-binding protein (C/EBP)-ATF element

poster

Li, Z.

Heat shock protein gp96 (grp94, Hsp90b1) optimizes B cell function via chaperoning integrins and Toll-like receptors but not immunoglobulins

poster

Lin, J.H.

IRE1 signaling affects cell fate during the unfolded protein response

poster

Lipan, O.

Experimental evidence of a quantitative law describing the heat shock response in Chinese hamster ovary cells

poster

Löwe, T.

Investigating oligomerization dependencies of CHN-1 for determining substrate specifity

poster

Lu, H.

Role of zinc-binding and molecular chaperone on the import of mitochondrial small Tim proteins

poster

Lu, Q.

Inhibition of small GTPase post-translational processing promoted endothelial cell apoptosis through alterations of ER chaperones

poster

Macario, A.

Cigarette smoke exposure downregulates two isoelectric variants of human Hsp10 in lung epithelial cells and fibroblasts—A proteomic study

poster

Machida, K.

Identification of the functionally critical amino acid sequence in the flexible C-terminal region of GroEL

poster

Mandal, A.K.

An integrated model of chaperone function in folding and degradation during nascent chain quality control

poster

Mapa, K.

Import motor of the mitochondrial TIM23 complex

poster

Mathur, V.

The actin cytoskeleton is involved in the formation of the non-Q/N-rich prion [Het-s]y in S. cerevisiae

poster

Matts, R.L.

Differential effects of geldanamycin and novobiocin on gene expression profiles in cultured MCF-7 cells

poster

McDonald, E.T.

Binding of T4 lysozyme (T4L) mutants to heat shock protein 27 (Hsp27) and the engineered variant of small heat shock protein (Hsp16.5)

poster

Mchaourab, H.S.

Cryo-EM and crystallographic analysis of the structure and substrate binding of an activated mutant of Hsp16.5

poster

Meng, L.

Heat shock response is required for NeuT induced MCF10A transformation and tumor development

poster

Meyer, A.S.

ClpXP degradation of the DNA-protection protein Dps requires auto-tethering to the enzyme

poster

Michels, C.A.

Aha1 cochaperone is a negative regulator of Saccharomyces MAL-activator and acts early in its activation by the Hsp90/Hsp70 chaperone machine

poster

Mitchell, B.

Proteins of the calnexin cycle regulate the surface expression of the a IIbb 3integrin in human megakaryocytic cells

poster

Mivechi, N.F.

Impact of Hsf1 or Hsps deficiencies on CNS homeostasis and disease during animal models

poster

Mkrtchian, S.

Endoplasmic reticulum associated degradation of misfolded null Hong Kong a 1-antitrypsin is modified by ERp29, an ER secretion factor

poster

Mokranjac, D.

Hsp70 system in the import motor of the mitochondrial Tim 23 complex

talk

Molinari, M.

ERAD tuning—Segregation and rapid turnover of EDEM1 modulate standard ERAD and folding activities

poster

Morano, K.A.

Activation of heat shock and antioxidant responses by the natural product celastrol—Transcriptional signatures of a thiol-targeted molecule

poster

Morimoto, R.I.

Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging

talk

Morito, D.

Gp78 cooperates with RMA1 in ER-associated degradation of CFTRD F508

poster

Mosser, D.D.

Noxa controls heat-induced apoptosis by regulating Mcl-1 stability

poster

Motojima, F.

GroEL/ES-assisted folding of BFP starts from an extended state and is faster than free folding

talk

Mukherjee, K.

Comprehensive analysis of the human genome reveals new hsp60 gene classes and evolutionary relations

poster

Nakai, A.

Specific and redundant occupancy of members of HSF family on whole genome in developing mouse lens

poster

Nakamura, D.

IRE1b specifically attenuates the translation of ER proteins

poster

Neckers, L.

Regulation of Hsp90 by pharmacologic inhibition and post-translational modification

talk

Needham, P.G.

[PSI+] impairing mutations in yeast Ssa1 (Hsp70) alter different enzymatic functions of the protein

poster

Ng, C.L.

TRAM1 is involved in ER quality control

poster

Ng, S.

Arimoclomol, an orally active chaperone amplifier, accelerates functional recovery in rat models of stroke

talk

Ni, W.

Genetic dissection of UNC-45—Hsp90 interaction

poster

Nicchitta, C.

Gp93, the Drosophila endoplasmic reticulum Hsp90, is required for metazoan growth control

talk

Niknejad, N.N.

ATF3 regulates lovastatin-induced apoptosis in squamous cell carcinoma cells

poster

Nillegoda, N.B.

UBR1 and UBR2 ubiquitin ligases promote nascent chain quality control in association with molecular chaperones

poster

Niwa, T.

Global folding analysis of the whole E. coli proteins using a reconstituted cell-free translation system

poster

Nukina, N.

Amelioration of the pathological processes related to Huntington disease by targeting the mutant Huntingtin to chaperone-mediated autophagy

talk

Oglesbee, M.J.

Hsp72 is a determinant of viral neurovirulence in an MHC-dependent manner

poster

O'Neill, H.A.

Small heat shock protein, Hsp16.6, is essential for survival of Synechocystis during oxidative stress

poster

Oresic, K.

Linking ER quality control to the development of the lysosomal storage disease NCL type 6

poster

Ortega, J.

Functional requirements of the bacterial DegP protein

poster

Papa, F.R.

Engaging the pseudokinase domain of IRE1a with a kinase inhibitor to study signaling and physiology in the UPR

poster

Park, Y.

Sup35p-GFP foci are the propagons that maintain the [PSI+] phenotype

poster

Petrova, K.

Retrograde regulation of J-protein binding to misfolded substrates

poster

Pfanner, N.

TITLE ONLY: Translocation and assembly of mitochondrial proteins

talk

Piccione, E.C.

A novel variant of the EGFR induces transcription of GRP78 and GRP94 via the ER stress response element

poster

Pollard, H.B.

Functional rescue of mutant CFTR by activation of the SGK1/NEDD4-2 signaling pathway in cystic fibrosis epithelial cells

poster

Prahlad, V.

Cell non-autonomous regulation of the heat shock response in C. elegans by the thermosensory neuronal network

poster

Prince, T.

Cdc37 depletion inhibits multiple protein kinase signaling pathways

poster

Radford, S.E.

Sequence-specific effects and the ruggedness of protein folding and misfolding energy landscapes

talk

Rajagopal, P.

a B-crystallin—A structure finally revealed

talk

Ramos, C.H.

Biophysical studies of chimeric type I and type II Hsp40s reveal that conserved central modules control the quaternary structure of Hsp40 family members

poster

Rampelt, H.

Hsp110 chaperones regulate prion formation and propagation in S. cerevisiae by two discrete activities

poster

Reefschlaeger, L.

Interaction of the v-Src kinase with Hsp90 at elevated temperatures

poster

Richter, K.

Functional characterization of the Hop-homolog from C. elegans

poster

Riemer, J.

A novel protein complex in endoplasmic reticulum associated degradation

talk

Rodrigues, J.V.

Impact of oxidative damage on human electron transfer flavoprotein and folding rescue by the flavin cofactors—Implications in MADD deficiency

poster

Rosser, M.

Folding and misfolding of CFTR

poster

Rotblat, B.

Hace1—Linking misfolded protein load and oncogenesis

poster

Roth, J.

The ERAD factor EDEM1 is degraded by autophagy

poster

Rousaki, A.

Structural basis for small-molecule regulation of Hsp70

poster

Ruiz, C.

Molecular chaperones regulate assembly and expression of synaptic acetylcholinesterase in skeletal muscle cells—Role of muscle activity

poster

Rye, H.S.

A single particle fluorescence assay detects cooperative and rapid disassembly of clathrin coats by Hsc70

poster

Rye, H.S.

GroEL stimulates protein folding through forced unfolding

talk

Saito, Y.

Hsp105b is expressed in the nucleus and induces the expression of Hsp70 in mammalian cells

poster

Santiago-Schwarz, F.I.

Extracellular and intracellular heat shock protein 70 responses are selectively triggered in monocyte-derived dendritic cells (DC) by inflammatory cytokines independently of heat and are linked to DC growth

poster

Schlehe, J.

Aberrant folding of pathogenic parkin mutants—Aggregation versus degradation

poster

Schulz-Raffelt, M.

Dissection of the heat stress response in the uni-cellular green alga C. reinhardtii

poster

Scroggins, B.

Acetylation as a regulator of Hsp90 function

poster

Selkoe, D.J.

Pathogenic protein misfolding—Soluble Ab dimers isolated directly from Alzheimer brains impair synaptic function

talk

Serio, T.R.

Loss of the Sup35/[PSI+] prion by excess Hsp104

poster

SHARMA, D.K.

Different anti-prion effects of nearly identical yeast Hsp70 chaperones

poster

Shewmaker, F.P.

Different primary sequences, but a common amyloid structure for yeast prions

poster

Shimizu, Y.

A lymphoid specific oxidoreductase with a unique structure forms mixed disulfide bonds with assembling immunoglobulin intermediates and oxidizes the CH1 domain

poster

Simpson, N.

The mechanisms of p23-dependent gene regulation in tumor metastasis and drug resistance

poster

Singh, L.R.

Deletion of Hsp26 rescues inactivity of mutant human cystathionine b synthase

poster

Singh, R.

The UNC-45 isoforms perform essential functions in early mammalian embryonic development

poster

Smith, M.E.

Over-expression of the molecular chaperone CCT, the cellular response(s) and protein biosynthesis

poster

Soroka, J.

Conserved ATP-induced conformational changes in the ATPase cycle of human Hsp90

poster

Sousa, R.

Conformational cycles and cochaperone interactions in Hsp70 function

talk

Srinivas, P.N.

Significance of a -crystallin heteropolymer with respect to its molecular chaperone function

poster

Stepanov, A.V.

Mitochondrial Hsp60 is released to cytosol during a programmed cell death in yeast and plant cells

poster

Stewart, G.A.

Constitutive expression of the mutant SP-CL188Q protein, cell adaptation and chaperone therapy

poster

Taguchi, H.

Direct observation of yeast prion Sup35 dynamics in single-living cells

talk

Tanaka, M.

Molecular basis of yeast prion [PSI+] strains

poster

Tapley, T.L.

Interactions between the chaperone HdeA and acid-denatured model substrate proteins

poster

Tatu, U.S.

Heat shock protein 90 as a potential drug target against malaria—Structure-activity relationship and pre-clinical validation of the target

poster

Tatzelt, J.

Stress-protective signaling of prion protein is corrupted by scrapie-prions

talk

Theodoraki, M.A.

Quality control and system robustness—A link between the kinase specific chaperone CDC37 and genome integrity

poster

Treusch, S.

Chaperone-dependent amyloid assembly protects cells from prion toxicity

poster

Tsai, F.T.

Structure of a prion-remodeling machine

talk

Tsutsumi, S.

Hinge region of Hsp90 regulates secretion and chaperone function

poster

Tuite, M.F.

Cis- and trans-acting factors required for the elimination of the yeast [PSI+] prion by overexpression of Hsp104

poster

Vabulas, M.

Cytotoxity of artificial amyloid-like proteins

poster

van Ham, T.J.

C. elegans model identifies genetic modifiers of a -synuclein inclusion formation during aging

poster

Van Wijk, K.J.

Large scale comparative proteome analysis of a chloroplast ClpR2 protease mutant

poster

Vembar, S.S.

Peptide affinity and Hsp40 J-domain interaction differentially affect the function of yeast BiP

poster

Verma, R.

Requirement for Cdc48/p97 function in the proteolysis of Hsl1, a morphogenesis checkpoint kinase in budding yeast

poster

Vigh, L.

The Hsp co-inducer hydroxylamines may normalize the dysregulated stress protein expression by correcting the raft-associated signaling platforms

poster

Voisine, C.M.

Deciphering the chaperone code for protein homeostasis using C. elegans models

poster

Vos, M.J.

The Drosophila small Hsp family—From functional diversity to lifespan extension

poster

Wang, N.

Study of cellular toxicity in C. elegans models of compartmentalized protein misfolding and aggregation

poster

Wang, X.

Specific ERAD of MHC-I by viral E3 ligase requires the adaptor protein TAP and is dependent upon ubiquitination of serine, threonine, or lysine residues

poster

Weissman, J.S.

The building of a cellular folding compartment—a holistic view of the ER function provided by quantitative genetic interaction maps

talk

Wek, R.C.

Integration of general control and nitrogen regulatory pathways during nutrient stress in yeast

poster

Wek, R.C.

Phosphorylation of eIF2 directs ATF5 translational control in response to stress conditions

poster

Wickner, S.

Protein disaggregation by ClpB in cooperation with the DnaK chaperone system

talk

Williams, D.B.

The aggregation suppression function of calnexin resides in its globular domain at a location distinct from its lectin site

poster

Williams, T.

Coevolution between Hsp90a and b and their cochaperones

poster

Xu, W.

Hsp90 dependence of somatically mutated epidermal growth factor receptor and ErbB2

poster

Yamamoto, S.

HOP (Hsp70/Hsp90 organizing protein) possesses both ATPase and ADPase activities

poster

Yanagitani, K.

Membrane localization of XBP1 mRNA contributes the efficiency of IRE1a -dependent cytoplasmic splicing

poster

Yang, T.T.

Heat shock protein 70 expression in epilepsy suggests stress rather than protection

poster

Yang, Z.

Overproduction of QN-rich proteins destabilize the [PSI+] prion

poster

Yano, A.

17-allylamino-17-demethoxygeldanamycin induces osteoclast differentiation through Src kinase activation

poster

Ye, Y.

Eeyarestatin I targets a p97 complex to inhibit ERAD and induce ER stress

poster

Yohda, M.

Substrate recognition mechanism of Pyrococcus prefoldin revealed by X-ray crystal structure analysis and molecular dynamics simulation

poster

Yonath, A.

Cotranslational chaperone activities

talk

Yoshida, H.

Promoter analysis of target genes of Golgi stress response

poster

Yoshida, M.

New membrane chaperone

talk

Young, J.C.

Functional diversity of Hsc70 and Hsp90 co-chaperones