YEAST GENETICS & GENOMICS
July 22 - August 11, 2008
Application Deadline: March 15, 2008

Instructors:
Beverly Errede, University of North Carolina Chapel Hill
Frank Luca, University of Pennsylvania
Malcolm Whiteway, National Research Council of Canada

The Yeast Genetics & Genomics course is a modern, state of the art laboratory course designed to teach the students the full repertoire of genetic approaches needed to dissect complex problems in the yeast Saccharomyces cerevisiae. Combinations of classical genetic approaches are emphasized, including the isolation and characterization of mutants, tetrad analysis, complementation, and mitotic recombination. Molecular genetic techniques, including various types of yeast transformation, gene replacement with plasmids and PCR, construction and analysis of gene fusions, and generation of mutations in cloned genes, will also be emphasized. Students will use classical and molecular approaches to gain experience in identifying and interpreting various kinds of genetic interactions including suppression and synthetic lethality. Students will be immersed in yeast genomics and will perform and interpret experiments with DNA arrays. Students will gain first-hand experience in modern cytological approaches such as epitope tagging and imaging yeast cells using indirect immunofluorescence, GFP-protein fusions and a variety of fluorescent indicators for various subcellular organelles. Lectures on fundamental aspects of yeast genetics will be presented along with seminars given by outside speakers on topics of current interest.

Last year's speakers included:
David Amberg, SUNY Upstate Medical University
Angelika Amon, Massachusetts Institute of Technology
Judith Berman, University of Minnesota
Charlie Boone, University of Toronto, Canada
James Broach, Princeton University
Dan Burke,University of Virginia
Dean Dawson, OMRF
Kara Dolinski, Princeton University
Daniel Finley, Harvard Medical School
Daniel Lew, Duke University
Andrew Murray, Harvard University
Liza Pon, Columbia University
Jeffrey Strathern, National Cancer Institute
Lorraine Symington, Columbia University College of P&S

This course is supported with funds provided by National Human Genome Research Institute and the Howard Hughes Medical Institute

Cost (including board and lodging): $3,850
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