IMAGING STRUCTURE & FUNCTION
IN THE NERVOUS SYSTEM
July 24 - August 13, 2007
Application Deadline: March 15, 2007

Instructors:
Florian Engert, Harvard University
Mark Hubener, Max-Planck Institute of Neurobiology, Germany
David Kleinfeld, University of California, San Diego
Jack Waters, Northwestern University

Advances in light microscopy, digital image processing, and the development of a variety of powerful fluorescent probes present expanding opportunities for investigating the nervous system, from synaptic spines to networks in the brain. This intensive laboratory and lecture course will provide participants with the theoretical and practical knowledge to utilize emerging imaging technologies. The primary emphasis of the course will be on vital light microscopy. Students will learn the principles of light microscopy, as well as use of different types of electronic cameras, laser scanning systems, functional fluorophores, delivery techniques, and digital image-processing software. In addition to transmitted light microscopy for viewing cellular motility, the course will examine a variety of molecular probes of cell function, including calcium-sensitive dyes, voltage-sensitive dyes, photo-activated ("caged") compounds, and exocytosis tracers. Issues arising in the combination of imaging with electrophysiological methods will be covered. Particular weight will be given to multi-photon laser scanning microscopy and to newly available biological fluorophores, especially Green-Fluorescent Protein (GFP) and its variants. We will use a spectrum of neural and cell biological systems, including living animals, brain slices, and cultured cells. Applicants should have a strong background in the neurosciences or in cell biology.

Lecturers in the 2006 course included:
Wolfhard Almers, Oregon Health & Science University
William Betz, University of Colorado Medical School
Winfried Denk, Max-Planck Institute for Medical Research, Germany
Anna Devor, MGH/Harvard Medical School
Oliver Griesbeck, Max Planck Institute of Neurobiology, Germany
Fred Lanni, Carnegie-Mellon University
Greg Law, Perkin Elmer
Jeff Lichtman, Harvard University
Jerome Mertz, Boston University
Venkatesh Murthy, Harvard University
Valentin Nägerl, Max Planck Institute of Neurobiology
Mark Schnitzer, Stanford University
Steve Vogel, NIH/NIAAA/DICBR
Katrin Willig, Max-Planck Institute for Biophysical Chemistry, Germany

This course is supported with funds provided by the National Institute of Mental Health, the National Institute of Neurological Disorders & Stroke and the Howard Hughes Medical Institute.

Scientists from developing countries accepted into this course may be eligible for scholarships provided by the International Brain Research Organization (Click here for details)

Cost (including board and lodging): $3,690
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