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YEAST GENETICS & GENOMICS
July 22 - August 11, 2014
Application Deadline: April 15, 2014

Instructors:
Grant Brown, University of Toronto, Canada
Maitreya Dunham, University of Washington
Marc Gartenberg, Robert Wood Johnson Medical School


See the roll of honor - who's taken the course in the past

The Yeast Genetics & Genomics course is a modern, state of the art laboratory course designed to teach students the full repertoire of genetic approaches needed to dissect complex problems in the yeast Saccharomyces cerevisiae. Combinations of classical and modern genetic approaches are emphasized, including the isolation and characterization of mutants, tetrad analysis, complementation, and mitotic recombination. Students will learn array-based methods, next generation sequencing, and genome-based methods of analysis facilitated by the yeast genome sequence, the deletion collection, and other genomic resources available to the community. Molecular genetic techniques, including yeast transformation, gene replacement by PCR, construction and analysis of gene fusions, and generation of mutations, will also be emphasized.

Students will use classical approaches and modern whole genome sequencing to gain experience in identifying and interpreting various kinds of genetic interactions including suppression and synthetic lethality (including SGA). Students will be immersed in yeast genomics and will perform and interpret experiments using DNA arrays, whole genome sequencing, and multiplexed DNA barcode sequencing. Students will gain first-hand experience in modern cytological approaches such as epitope tagging and imaging yeast cells using indirect immunofluorescence, GFP-protein fusions and a variety of fluorescent indicators for different subcellular organelles. Lectures on fundamental aspects of yeast genetics will be presented along with seminars given by prominent experts in the field on topics of current interest.

Confirmed speakers for 2014:
Maria Costanzo, Saccharomyces Genome Database, Stanford University
David Drubin, University of California, Berkeley
Scott Emr, Cornell University
Amy Gladfelter, Dartmouth College
Dan Gottschling, Fred Hutchinson Cancer Research Center
Steve Haase, Duke University
Sue Jaspersen, Stowers Institute for Medical Research
Jay Keasling, University of California, Berkeley
John McCusker, Duke University
Chad Myers, University of Minnesota
Oliver Rando, University of Massachusetts Medical School
Rodney Rothstein, Columbia University
Virginia Zakian, Princeton University

Applications are especially welcome from:
• Professors and instructors who wish to incorporate yeast into their undergraduate genetics classrooms
• Scientists trained in mathematical, computational, and/or engineering disciplines who are transitioning into bench science
• Researchers from small labs or institutions where it would otherwise be difficult to learn the fundamentals of yeast genetics/genomics

We anticipate this course will be supported with funds provided by National Science Foundation and the Howard Hughes Medical Institute

Cost (including board and lodging): $4,545
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