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How To Apply

Selection Process and Stipends


General Information

Campus Information

June 5 - 25, 2013
Application Deadline: March 15, 2013

Stephan Brenowitz, NIDCD/National Institutes of Health
Ian Duguid, University of Edinburgh, United Kingdom
Paul Kammermeier, University of Rochester Medical Center

The primary goal of this course is to investigate, through lectures and laboratory work, the properties of ion channels that allow neurons to carry out their unique physiological functions in a variety of neural systems. Areas of particular interest include channels that (1) are activated by neurotransmitter at central and peripheral synapses, (2) are activated by voltage changes in axons and dendrites, (3) respond to neuromodulators with changes in functional properties, (4) are developmentally required and regulated, or (5) are light-gated and engineered to express in specific neural subtypes. The research interests of guest lecturers reflect these areas of emphasis.

The laboratory component of the course introduces students to state-of-the-art electrophysiological approaches for the study of ion channels in their native environments. Hands-on exercises include patch-clamp recording of ion channel activity in acutely isolated or cultured cells or neurons in brain slice preparations. Different recording configurations are used (e.g. whole-cell, cell-attached, dendritic patches, and using voltage- and current-clamp configurations) to examine macroscopic or single-channel activity. Similarly, various methods of ligand and drug application are demonstrated. The advantages and disadvantages of each method, preparation and recording technique are considered in relation to the specific scientific questions being asked. Admissions priority is given to students and postdocs with a demonstrated interest, specific plans, and a supportive environment to apply these techniques to a defined problem.

Guest speakers in 2012 included:
Mark Farrant, Michael Hausser, Stephen Ikeda, Leonard Kaczmarek, Zayd Khaliq, Jeffrey Martens, Matthew Nolan, Andrew Plested, Trevor Shuttleworth, Jesper Sjostrom, Elise Stanley, Ben Strowbridge, Matthew Xu-Friedman, Tony Zador, Feng Zhang

This course is supported by the Howard Hughes Medical Institute

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Scientists from developing countries accepted into this course may be eligible for scholarships provided by the International Brain Research Organization (Click here for details)

Cost (including board and lodging): $4,545
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Cold Spring Harbor Laboratory
Meetings & Courses Program