RNA & OLIGONUCLEOTIDE THERAPEUTICS

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Abstracts are listed alphabetically by presenting author.

Presenting Author

Abstract Title

Talk/Poster

Aartsma-Rus, A.

Beyond clinical trials for antisense-mediated exon skipping for Duchenne muscular dystrophy

talk

Abdelmohsen, K.

Characterization of HuR-associated circular RNAs

talk

Aghajan, M.

Targeting TMPRSS6 using antisense technology for the treatment of beta-thalassemia

talk

Brown, B.D.

Delivery of Dicer-substrate siRNAs (DsiRNAs) to multiple patient-derived xenograft tumors

talk

Brown, J.D.

Multimeric siRNA agents for highly efficient sequence-specific gene silencing

poster

Cartegni, L.

Therapeutic targeting of EGFR signaling and resistance in cancer by antisense manipulation of RNA processing

talk

Chilton, J.

Novel microRNA-based, cell-selective strategy to treat cardiovascular disease

talk

Choe, J.

Guanidine modified polyethyleneimine-gpolyethylene glycol nanocarriers for long interfering RNA (liRNA) based advanced anticancer therapy

poster

Chu, C.

CD30 aptamer-RORC2 shRNA inhibit Th17 cells

poster

Corey, D.R.

RNAi in mammalian cell nuclei—Applications to noncoding RNA

talk

D'Adda di Fagagna, F.

The role of non-coding RNA in the control of DNA damage response

talk

Desviat, L.R.

Application of antisense therapies to correct splicing defects in neurometabolic diseases

talk

Dowdy, S.

Tackling a billion old barrier—Delivery of PhosphoTriester siRNNs

talk

Fesser, S.

mRNA-based immunotherapeutics against cancer

poster

Geall, A.

Non-viral delivery of self-amplifying mRNA vaccines

talk

Hong, S.

The 3'-end structure of siRNA strand affects the asymmetric siRNA (asiRNA) gene silencing potency and the RNA interference activity of each strand

poster

Hughes, S.A.

Protease activated receptor-2 (PAR-2) antisense oligonucleotides—A promising potential treatment for inflammatory bowel disease

talk

Ichim, C.V.

Development of DiffronC gene silencing technology for silencing of the novel leukemia stem cell target NR2F6

poster

Jiang, W.

Gene silencing oligonucleotides (GSOs) provide improved therapeutic index

talk

Johnston, B.H.

miR-direct—RT-qPCR analysis of circulating microRNAs without prior RNA extraction

poster

Kole, R.

Phosphorodiamidate morpholino oligomers (PMOs) for the treatment of Duchenne muscular dystrophy (DMD)—A class approach

talk

Krainer, A.R.

Antisense-mediated splicing correction in spinal muscular atrophy

talk

Krieg, A.M.

Enhancing antisense efficacy with multimers and multi-targeting oligonucleotides (MTOs) using cleavable linkers

talk

Lee, Y.

Nucleoside modifications differentially modulate activity of RNA sensing PRRs

poster

Levy, M.

A comparative analysis of cell targeting aptamers

talk

Li, C.

siRNAs with decreased off-target effect facilitate the identification of essential genes

poster

Lukin, M.

Novel 2'-deoxyguanosine analogs which have high affinity towards complementary DNA

talk

McCaffrey, A.

Optimizing mRNA for gene therapy applications—Evaluation of novel nucleotide modifications for improved activity

talk

Ming, X.

Enhancing the pharmacological effects of antisense and siRNA—Release of oligonucleotides from endosomes by small molecules or by light

talk

Mycko, M.P.

miR-155-3p drives the development of autoimmune demyelination in mice by regulation of heat shock protein 40

poster

Negi, V.

MicroRNA editing in iTregs counterbalance the immune tolerance

poster

Nomakuchi, T.

Antisense-oligonucleotide-directed inhibition of nonsense-mediated mRNA decay

talk

Oren, Y.

Restoration of the CFTR function by antisense oligonucleotide splicing modulation

poster

Pasteuning, S.

Antisense oligonucleotide-mediated knockdown of Myostatin type I receptor as a potential therapy for Duchenne muscular dystrophy

talk

Phillips, N.

In-vivo SELEX for generation of pancreatic islet-specific aptamers

talk

Poddar, S.

Exploring molecular features of viral RNA trans-splicing for trans-splicing RNA design

poster

Ravn, J.

Conjugated LNA antisense oligonucleotides

poster

Salomon, W.

Single-molecule imaging reveals Argonaute mechanisms in the miRNA and RNAi pathways that change the rules for nucleic acid hybridization

talk

Wada, T.

Combination of LNA antisense oligonucleotides complementary to 5’- and 3’- UTR ends of mRNA

talk

Wilcox, S.

SOMAmer® Reagents—Powerful protein binding tools

talk

Woo, C.J.

Selectively activating gene expression by targeting PRC2-associated lncRNAs in SMA

talk

Wu, B.

Screening and optimization of antisense oligonucleotide for skipping human dystrophin exon 51 and 53

poster

Wu, J.

Expression of a group of microRNAs during testis development and regulation of miR-125a on spermatogonial stem cells

poster

Zhou, H.

Establishment of an intermediate mouse model of spinal muscular atrophy and its rescue by repeated systemic administration of low-dose morpholino antisense oligomer

talk

 

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