Retroviruses
May 21 - 26, 2018

You must register for the meeting in order to submit abstracts.
After registering you will be sent a web link for abstract submission by email.

Program information: An electronic version of the program abstract book will be sent three working days prior to the first day of the meeting, and hard copies will be available for collection upon your arrival at Cold Spring Harbor Laboratory. First night and keynote speakers are informed of their session date and time, otherwise program information is only available upon release of the electronic version of the abstract book. The reason we do this is to try and maximize interactions by encouraging participants to stay for the duration of the meeting.

Please check your email for talk length, poster instructions, and how to have your poster printed at CSHL for collection upon arrival.

Abstract Status

Presenting Author

Abstract Title

Talk/Poster

Achuthan, Vasudevan

Capsid-CPSF6 interaction directs pan-nuclear HIV-1 localization and integration site selection

poster

Agosto, Luis M

Identification of novel transcription factors that influence HIV transcription using an unbiased functional screen

poster

Ahi, Yadvinder S

IFITM3 downregulates diverse envelope glycoproteins to broadly inhibit virus infectivity

poster

Aiken, Chris

Functional analysis of the secondary HIV-1 capsid binding site in the host protein cyclophilin A

poster

Allen, Audrey

Structures of HIV Integrase bound to allosteric integrase inhibitors (ALLINIs)

poster

Alsahafi, Nirmin

SOSIP changes affect human immunodeficiency virus (HIV-1) envelope glycoprotein conformation and CD4 engagement

talk

Anand, Sai Priya

Two families of anti-Env antibodies synergize for Fc-gamma receptor engagement

poster

Anderson, Elizabeth

HIV viremia is the product of a small fraction of HIV infected cells

talk

Antzin-Anduetza, Irati

Increasing the CpG dinucleotide abundance in the HIV-1 genomic RNA inhibits viral replication

poster

Anupam, Rajaneesh

GFP tagging to an intrinsically unstable HTLV-1 p30 enable its expression and flow cytometry analysis in bacterial expression system

poster

Apolonia, Luis

Redundancy within the cyclophilin family can dictate HIV-1 infectivity

talk

Ariumi, Yasuo

Apolipoprotein E is an HIV-1-inducible inhibitor of viral production in macrophages

talk

Arora, Sakshi

SART1 is a critical host dependency factor for post-entry events in HIV-1 infection

poster

Arriagada, Gloria L

Disseminated neoplasia and retrotransposons in Mytilus chilensis

talk

Barklis, Eric

Matrix protein interactions with Env and phospholipids

poster

Becker, Jordan T

Subcellular distribution of APOBEC3 proteins regulate interactions with and restriction of HIV-1

talk

Behrens, Ryan T

Comparative delineation of Rev- and Rex-dependent retroviral RNA transport pathways using multicolor live cell imaging

poster

Behrens, Ryan T

Editing host factors to silence HIV-1 gene expression in T cells

poster

Bejarano, David

HIV-1 nuclear import in macrophages is regulated by CPSF6-capsid interactions at the nuclear pore complex

talk

Betancor, Gilberto J

Domain mapping of the interaction between human MX2 and HIV-1 capsid

poster

Bhutoria, Savita

Rpt1 domain of INI1 is an RNA mimic that binds to HIV-1 Integrase

poster

Blanco, Guillermo

Ultrastructural conformation states of HIV-1 during the early steps of viral infection

talk

Boecking, Till

Single-molecule analysis of the effect of small molecules on different steps of HIV-1 capsid uncoating

poster

Bohn, Jennifer

A novel mode of RNA binding assists APOBEC3H in the molecular arms race against HIV-1

talk

Bouaziz, Serge

Mechanism of action of EP-39 a BVM derivative Inhibiting HIV-1 maturation

poster

Buffalo, Cosmo Z

HIV-1 Nefs are cargo-sensitive AP-1 trimerization switches in tetherin and MHC-I downregulation

poster

Buffone, Cindy

Nup153 unlocks the nuclear pore complex for HIV-1 in non-dividing cells

poster

Bulli, Lorenzo

The role of inner nuclear envelope associated proteins SUN1 and SUN2 in early HIV-1 infection steps

poster

Bunten, Sarah S

A cyclosporine-sensitive factor contributes to the type I IFN-induced early block to HIV-1

poster

Burdick, Ryan C

Nuclear localization of transcriptionally active proviruses

talk

Burk, Robin

Visualization of HIV-1 nuclear preintegration complexes using correlative light- and electron microscopy (CLEM)

talk

Carter, Carol

Proton pump inhibitors as anti-viral agents targeting the ubiquitin-binding pocket of Tsg101

poster

Cary, Daniele C

HIV transcription is independent of mediator kinases

poster

Chai, Qingqing

Amyloid precursor protein (APP) imposes a block to HIV-1, but not HIV-2 infection

poster

Chang, Jordan

HIV-1 Gag nuclear localization and Gag-associated host factors

poster

Chelico, Linda

APOBEC3 deoxycytidine deaminases can increase template switching frequency and decrease insertion fidelity of HIV-1 reverse transcriptase

poster

Chen, Chaoping

Context-dependent autoprocessing of human immunodeficiency virus type 1 protease precursors

poster

Chen, Shuliang

SAMHD1 suppresses innate immune responses to viral infections and inflammatory stimuli by inhibiting the NF-κB and interferon pathways

talk

Chen, Shumin

Schlafen 14 (SLFN14) targeted to P-TEFb inhibits transcription of HIV-1

poster

Chougui, Ghina

Antagonism of an epigenetic restriction by HIV-2/SIVsmm Vpx

talk

Cimarelli, Andrea

Regulation of the antiviral properties of the Interferon-Induced Transmembrane Protein 3 (IFITM3) against HIV-1

talk

Coomer, Charles

Monitoring the metabolic consequences of HIV-1 virus-cell fusion with fluorescence lifetime imaging

poster

Cottee, Matthew A

Structural studies of a gammaretrovirus CA assembly

talk

Cui, Wen

Structural studies of HIV restriction factor GBP5

poster

Dash, Chandravanu

HIV-1 capsid protein inhibits viral DNA integration

poster

Davids, Benem-Orom A

Cellular exonuclease TREX1 enhances HIV-1 PIC function

poster

Debyser, Zeger

LEDGIN treatment during virus production retargets residual provirus inducing a latent HIV reservoir refractory to reactivation

poster

Debyser, Zeger

Post-mitotic BET-induced integrase quaternary structure change supports wild-type MLV integration

talk

Desimmie, Belete

HIV-2 and HIV-1 Vif induce degradation of APOBC3G by utilizing different host protein degradation pathways

talk

Dharan, Adarsh

A novel assay to measure HIV-1 nuclear import kinetics

poster

Diaz-Griffero, Felipe

SAMHD1 deficient human monocytes autonomously trigger type I interferon

poster

Dick, Robert A

Role of inositol phosphates in retrovirus assembly

talk

Digianantonio, Katie

Investigating the mechanism by which TRIM5 proteins sense HIV capsid assemblies

talk

Ding, Jiwei

Schlafen 5 acts as a transcriptional repressor of HIV-1 through targeting to sequences of U5-R region in 5’-LTR

talk

Ding, Shilei

CD4-mimetic compounds sensitize SHIV infected cells to ADCC

poster

D'Orso, Iván

Transcriptional fragility influences HIV proviral fate and latency-reversal potential

talk

Douville, Renee N

HERV-K encodes a conotoxin-like protein

poster

Dudley, Jaquelin

Retrotranslocation of the MMTV-encoded Rev-like signal peptide

poster

Eichorst, John P

Visualizing the initiation of Gag oligomerization by superresolution microscopy

poster

Emery, Ann L

HIV-1 splicing suppression as a possible therapeutic target

talk

Fernandez, Melissa V

Investigation into the role of FIP1C in HIV-1 replication and Env incorporation

poster

Fernandez, Paloma

The murine restriction factor Fv1 from wild mice restricts multiple genera of retrovirus

poster

Fischer, Douglas K

Distinct host cell infectivity and capsid uncoating phenotypes in HIV-1NL4-3 and HIV-1LAI are caused by minor sequence differences in CA

poster

Flemming, Annica

Design and characterization of a bright and fast-maturing FRET-based sensor to monitor HIV-1 protease activity using live-cell imaging

poster

Flower, Thomas G

ESCRT membrane scission revealed by optical tweezers

talk

Francis, Ashwanth C

Live-cell imaging of single HIV-1 uncoating, nuclear import and infection

talk

Frank, John A

Human endogenous envelope-derived proteins offer potential protection from retroviral infection

talk

Gagne, Matthew J

T cell activation state determines initial HIV expression and reactivation from latency

talk

Geis, Franziska K

HIV-1-based lentiviral vectors are potently restricted in murine pluripotent stem cells

poster

Goncalves-Carneiro, Daniel

Zinc finger antiviral proteins of vertebrates present divergent antiviral activities

talk

Gondim, Marcos V

Type 1 interferon mediated viral control in early and late stage HIV-1 infection

talk

Gonzales, Baptiste

Type I phosphatidylinositol phosphate kinase α and γ are required for efficient HIV assembly

poster

Gramberg, Thomas

LINE-1 retroelements are blocked by SAMHD1 in cycling cells

talk

Greenwood, Edward J

Vpr drives massive cellular proteome remodelling in HIV infection

talk

Griffin, Daniel

Susceptibility of human CD34+ hematopoietic stem and progenitor cells to HIV-1-based lentiviral vectors correlates with the RNA levels of various cellular cytosleketon genes, THBS1, GDF15, TUBB1, KRT79, HBD, and SPTB

poster

Gross, John D.

ARIH2 is a novel Vif-dependent regulator of CUL5-mediated APOBEC3G degradation in HIV infection

talk

Gummuluru, Rahm

Rev-dependent nuclear export of HIV-1 intron-containing RNA triggers innate immune sensing in macrophages

talk

Guney, Mehmet H

Interplay between the virion core and the glycoprotein determines sensitivity to SERINC5 antiviral activity

poster

Haim, Hillel

Spatial and temporal clustering patterns of volatility on the HIV-1 Env trimer allow accurate predictions of the in-host emergence of antibody escape variants

talk

Han, Han

Protein translocation by the Vps4 AAA ATPase

talk

Haugh, Kelsey

Reporter viruses for studying retroviral dissemination in living mice

poster

Hayward, Joshua

Identification of a novel bat retrovirus

talk

Hein-Fuchs, Nina V

Insights into the role of PQBP1 in innate immune sensing using human iPSCs

poster

Herschhorn, Alon

Conformation-dependent interactions between HIV-1 envelope glycoproteins and broadly neutralizing antibodies

poster

Hidalgo-Lumbreras, Laura

Regulation of CD4 T cell and HIV-1 gene expression by Sam68

poster

Hikichi, Yuta

Resistance of HIV-1 to small-molecule fusion inhibitors requires mutations in the ectodomain of gp41

poster

Ho, Ya-Chi

Aberrant integrant-driven host gene expression contributes to HIV-1 persistence

talk

Hope, Thomas J.

Utilizing correlative positronic emission tomography (PET) to track virus and antibodies in non-human primates

talk

Hu, Yingxia

Investigation of the interactions of HIV-1 Vif and A3F

talk

Hultquist, Judd F

Identification of Novel HIV host factors in primary CD4+ T cells using a CRISPR-Cas9 functional genomics platform

talk

Hwang, Eung Soo

The discrimination of the replication of PERV and the microchimerism in xenotransplanted primates with nucleic acid amplification

poster

Ikeda, Terumasa

HIV-1 adaptation studies reveal a novel Env-mediated homeostasis mechanism for evading lethal hypermutation by APOBEC3G

poster

Imam, Sabrina

Molecular determinants of TRIM5α restriction and association with autophagic effectors

talk

Inderbitzin, Anne

CRISPR/Cas9-mediated insertion of HIV-1-based vector into BACH2 does not lead to viral latency in Jurkat T cells

poster

Ishima, Rieko

Conformational asymmetry of HIV-1 RT homodimer introduced upon ligand binding

poster

Ivanov, Dmitri

Structural basis of SAMHD1 inhibition by nucleic acid binding

talk

Iwatani, Yasumasa

Structural insights of chimpanzee APOBEC3H-RNA duplex complex into Vif interaction

talk

Jacques, David A

Capsid dependent evasion of innate sensing in macrophages distinguishes pandemic HIV-1(M) and non-pandemic HIV-1(O)

poster

Janaka, Sanath Kumar

Polymorphisms in rhesus macaque tetherin are associated with differences in peak viremia during acute infection with SIV  ΔNef

talk

Jarosz, Abigail S

Expression  of ERVs in canine-cancer derived cell lines

poster

Jin, Danni

Non-canonical function of glutamyl-prolyl-tRNA synthetase (EPRS) in HIV-1 infection

poster

Johnson, Jacklyn M

Membrane cholesterol maintains structural stability of the HIV-1 envelope glycoproteins and their resistance to antibody neutralization

poster

Johnson, Jarrod S

Reshaping of the dendritic cell chromatin landscape and interferon pathways during HIV infection

poster

Johnson, Marc C

Characterization of novel small molecule inhibitors of Vpu

poster

Jones, Amber D

Understanding the mechanism of HIV suppression in long-term nonprogressors

poster

Kaddis Maldonado, Rebecca

Sequences in the 5’UTR necessary and sufficient for RSV Gag interactions with viral RNA in the nucleus

poster

Kane, Melissa

Inhibition of spumaretrovirus replication by the interferon stimulated gene PHF11

poster

Khan, Hataf

Vpr promotes HIV-1 replication by suppressing innate immune activation

talk

Kharytonchyk, Siarhei

Minimal determinants of HIV-1 RNA competitive packaging

poster

Kieffer, Collin D

Multiscale imaging reveals mechanisms of HIV dissemination in the bone marrow of BLT humanized mice

talk

Kim, Kyusik

Cyclophilin A protects HIV-1 from restriction by human TRIM5α

talk

Kirchhoff, Frank

Vpu modulates DNA repair to prevent innate sensing and hyper-integration of HIV-1

talk

Kirmaier, Andrea

Characterization of a 130 million year old endogenous viral envelope

poster

Kirschman, Jung Hwa C

SERINC5 induces structural reorganization of HIV-1 Env glycoprotein leading to spontaneous loss of Env function

poster

Kirui, James

Development of highly sensitive bioluminescent HIV-1 reporter viruses for measuring virus production

poster

Kitzrow, Jonathan P

Probing 5′UTR conformational dynamics by FRET

poster

Kmiec, Dorota

SERINC5 antagonism by SIVcol Nef enhances HIV-1 infectivity but not replication in human T cells and lymphoid tissue ex vivo

talk

Knecht, Kirsten

The structural basis for viral and cancer drug interactions with the catalytic and allosteric sites of SAMHD1

poster

Knoener, Rachel A

Elucidating HIV-1 RNA interactomes

talk

Kojima, Kenji

Diversity of ERVs seen in Repbase

poster

Komurlu Keceli, Sevnur

Defects in assembly explain the reduced antiviral activity of the G249D polymorphism in human TRIM5α

poster

Koneru, Pratibha Chowdary

Sequence and structure specific binding of HIV-1 integrase to the viral RNA genome

talk

Konig, Renate R

Cell-cycle dependent regulation of dephosphorylation of SAMHD1

poster

Kotani, Osamu

A proposal of molecular dynamics based structural models of the full-length, ligand-free Pr55Gag precursor of HIV-1

poster

Kucharska, Iga

Biochemical reconstitution identifies functional elements that couple HIV-1 Gag lattice formation and genomic RNA packaging

talk

Kueck, Tonya

The aryl hydrocarbon receptor and IFN-gamma evoke an antiviral state by reducing dNTP levels

talk

Kumar, Priti

Direct in vivo engineering of human T cells for HIV resistance

talk

Kutluay, Sebla

Dissecting the roles of HIV-1 integrase multimerization and integrase-RNA interactions in particle maturation

talk

Kutzner, Juliane

Insights into the SAMHD1 viral restriction mechanism and cancer resistance to nucleoside analogue-based therapies by the analysis of naturally occurring cancer-associated single nucleotide polymorphisms

poster

Lahaye, Xavier

Identification of a capsid-binding protein that recognizes the nuclear HIV capsid to promote cGAS-mediated innate immune activation in dendritic cells

talk

Lam, Gary L

ALV activation at the TERT promoter locus in lymphomas

poster

Lange, Camille

HIV infected cell populations are affected by tuberculosis associated immune reconstitution syndrome

poster

Lange, Margaret J

Identification of JunB as a novel HIV-1 host toxicity factor

talk

Lange, Margaret J

Selection and characterization of RNA aptamers that bind to HIV-1 capsid protein assemblies

poster

Langer, Simon

Large-scale arrayed analysis of protein degradation reveals cellular targets for HIV-1 Vpu

poster

Larragoite, Erin T

Using barcoded HIV-1 to understand HIV latency

poster

Larsen, Kevin P

Architecture of an HIV-1 reverse transcriptase initiation complex

talk

Lawhorn, Brigitte E

Lentivirus capsid interactions with Nup358-Cyp are conserved and subject to selection during cross-species transmission

poster

Lee, KyeongEun

CypA prevents CPSF6 interaction with HIV-1 in the cytoplasm

talk

Levin, Henry L

Retrotransposon integration as a mechanism to wire gene regulatory networks

poster

Levin, Henry L

The role of LEDGF in mRNA splicing, transcription, and HIV-1 integration

poster

Li, Chuan

Chromatin environment at the HIV-1 promoter mediated by the Tat inhibitor, didehydro-Cortistatin A

poster

Li, Min

Both HIV-1 Sso7d-integrase and wild type integrase assemble multiple synaptic complex (SSC) intasomes that are active for concerted DNA integration in vitro

poster

Lim, Christopher S

Probing the interaction between SERINC3 and clathrin adaptor protein AP-2

poster

Lingappa, Jaisri

Soluble intracellular Gag is monomeric, while Gag dimers and multimers are in RNA-granule-derived capsid assembly intermediates that contain HIV-1 RNA and APOBEC3G

poster

Liu, Runxia

HIV-1 RNA splicing landscape upon latency reversal

poster

Liu, Shan-Lu

Nef antagonizes TIM-mediated inhibition of HIV-1 release—Role of SERINCs

talk

Lodge, Robert

Down-modulation of CD4 by microRNAs 221 and 222 impairs HIV-1 entry during infection of macrophages

poster

Lu, Maolin

Associating HIV-1 Env trimer structures with functional Env conformational states by smFRET analysis

talk

Lubow, Jay

HIV accessory proteins Vpr and Nef decrease steady state levels of mannose receptor in infected macrophages, increase spread, and increase steady state levels of HIV Env

poster

Lun, Cheng man

Mechanism of membrane-associated-RING-CH8 (MARCH8) targeting of the HIV-1 envelope glycoprotein

poster

Ma, Xiancai

TRIM28 mediates HIV-1 latency by hijacking SUMOyaltion system

talk

Maiti, Atanu

Crystal structure of the human APOBEC3G-catalytic domain complex with ssDNA reveals substrate specificity

talk

Malim, Michael

Multiple components of the nuclear pore complex interact with the amino-terminus of MX2 to facilitate HIV-1 restriction

poster

Mallery, Donna L

IP6 is an HIV pocket factor that prevents capsid collapse and promotes DNA synthesis

talk

Mammano, Fabrizio

Characterization of replication-competent HIV clones from patients’ reservoir

poster

Martin, Jessica

Critical role of the HTLV-1 capsid N-terminal domain for Gag-Gag interactions and virus particle assembly

poster

Matsuda, Zene

Development of a quantitative split NanoLuc luciferase-based HIV-1 virus-cell fusion assay

poster

Meissner, Morgan

The actin cortex as a physical barrier in retroviral assembly

poster

Melamed, Anat

The human leukemia virus HTLV-1 alters the structure and transcription of host chromatin in cis

talk

Menager, Mickael M

Network inference as a new approach to better understand transcriptomic pathways engaged upon Dendritic cell response to HIV infection

poster

Menendez-Arias, Luis -

Effects of template-primer binding kinetics on strand transfer mediated by HIV-1 reverse transcriptase

poster

Michaels, Daniel

The strength of T-cell receptor signaling differentially modulates recruitment of transcriptional regulators at the time of HIV infection

poster

Miyagi, Eri

Competition for CBFβ binding between wild type Vif and Vif mutants inhibits APOBEC3G degradation by wild type Vif

poster

Moghadasi, Seyed A

The presence and impact of the genomic RNA packaging enhancer element in lentiviruses

poster

Muecksch, Frauke

Lipid-protein interactions at the HIV-1 assembly site

talk

Mukherjee, Dishari

Genetic evidence for RNA- and lipid-dependent regulation of HIV-1 Gag localization to the plasma membrane

talk

Murakami, Tomoyuki

The highly basic region within MA promotes virion incorporation of CD44

poster

Murakami, Tsutomu

Biological and molecular characterization of a novel anti-HIV-1 compound created by in silico design and de novo organic synthesis

poster

Myint, Wazo

2'-endo sugar pucker is conformationally selected for APOBEC3G binding and deaminase activity

poster

Nakano, Yusuke

Evolutionary journey of primate lentivirus transmission from chimpanzee to gorilla focusing on relationship between Vif and APOBEC3

poster

Neil, Stuart

Mechanistic insights into the inhibition of the NF-κB signalling pathway by HIV-1 Vpu

poster

Neil, Stuart

The closed conformation of the HIV-1 envelope glycoprotein is an important determinant of the type 1 interferon resistance of transmitted viruses

talk

Nguyen, Phuong D.M.

RNA aptamers and HIV-1 reverse transcriptase—The molecular basis of their interface and its impact on the reverse transcriptase maturation by protease

poster

Ning, Jiying

Truncated CPSF6 forms higher order complexes that bind and disrupt HIV-1 capsid

poster

Novikova, Mariia

Elucidating the role of the capsid PPIP motif in HIV-1 replication

talk

Ode, Hirotaka

A novel detection approach of HIV-1 integration sites based on split read mapping

poster

Ohainle, Molly

HIV-CRISPR—Massively-parallel HIV restriction factor screening finds novel and known host genes that affect HIV replication

talk

Olety, Balaji

The matrix metalloproteinase ADAM10 promotes aberrant cleavage of HIV-1 gp41

poster

Osei Kuffour, Edmund

HIV-1 innate immune sensing escape is in part mediated by UBP43 (USP18)

poster

Pache, Lars

Smac mimetics as a novel class of HIV-1 latency reversing agents

poster

Painter, Mark M

Discovery and characterization of natural product-derived inhibitors of HIV Nef

talk

Pandey, Krishan K

Integrase subunit and DNA requirements for assembly of the RSV octameric intasome

poster

Panfil, Amanda R

Stability of the HTLV-1 antisense-derived protein, HBZ, is regulated by the E3 ubiquitin-protein ligase, UBR5

poster

Pedro, Kyle D

The impact of signaling from the infectious synapse on HIV-1 infection

poster

Perilla, Juan R

Transport of deoxyribonucleoside triphosphates (dNTPs) through the HIV-1 capsid

poster

Persaud, Mirjana

Role of human SUN1 and SUN2 proteins in HIV-1 replication

poster

Pi, Ruoxi

A protective role for CD169 against pathogenic retrovirus

poster

Pornillos, Owen

Do “domesticated” Gag proteins assemble virus-like particles?

poster

Prévost, Jérémie

Impact of CD4 downregulation on HIV-1 Env conformation and ADCC responses

poster

Prévost, Jérémie

Envelope glycoproteins sampling states 2/3 are susceptible to ADCC mediated by sera from HIV-1-infected individuals

poster

Qin, Zhihua

The HD domain of human SAMHD1 is required for its suppression of interferon regulatory factor 7 (IRF7)-mediated type I interferon induction

poster

Quigley, Bonnie

Understanding koala retrovirus (KoRV) in the wild—Prevalence, diversity, transmission and links to serious disease in Queensland koalas

talk

Ramirez, Peter W

A conserved acidic cluster motif reduces the sensitivity of SERINC5 to antagonism by Nef

poster

Rawle, Daniel J

HIV-1 RT mutations and small molecules inhibit the RT-eEF1A interaction and highlight its importance in uncoating, reverse transcription and replication

poster

Reed, Jonathan C

Analysis of HIV-1 capsid assembly intermediates confirms that they are derived from non-translating host RNA granules and are distinct from similarly-sized ribosomal complexes

poster

Rein, Alan

Selective initiation of HIV-1 particle assembly by genomic RNA in vitro

talk

Rheinemann, Lara

A retrotransposed ESCRT-III factor blocks HIV-1 budding without inducing cytotoxicity

talk

Richard, Jonathan

Uninfected bystander cells impact the measurement of HIV-specific ADCC responses

talk

Richards, Christopher M

HIV-1 protease directly modulates the antiviral activity of a common human APOBEC3H variant

poster

Rousso, Itay

The effect of the small-molecule inhibitor PF74 on HIV-1 capsid stability and reverse transcription-induced uncoating

talk

Russell, Ronnie M

CD4 receptor diversity protects against SIV infection

poster

Sabo, Yosef

HIV-1 Vpr protein relieves a block to formation of cytoplasmic mRNAS induced by Aladin, a nuclear pore complex-associated protein

poster

Saito, Akatsuki

Multiple pathways to avoid IFN-β sensitivity of HIV-1 by mutants in capsid

poster

Sakuragi, Jun-ichi

The analysis of HIV-1 genome packaging by comparison of subtype sequences

poster

Santos da Silva, Eveline

Identification of a novel HIV-1 capsid-interacting protein required for transport and uncoating of incoming viral cores

talk

Sapp, Nicklas E

Examining the role of chromatin in HIV-1 preintegration complex associated viral DNA integration

poster

Sauter, Daniel

Guanylate-binding proteins 2 and 5 reduce virion infectivity by inhibiting furin-mediated Env processing

talk

Schmidt, Fabian

Derivation of HIV-1 strains pathogenic in pigtail macaques involves CA adaptation

poster

Schorn, Andrea

Endogenous retrovirus control by tRNA-derived small RNA

poster

Selyutina, Anastasia

Novel capsid-binding assay with washing steps

poster

Selyutina, Anastasia

SERINC5 interacts with the HIV-1 envelope and prevents delivery of the HIV-1 core into the cytosol

talk

Sharma, Amit

Pig-tailed macaque IFITMs limit replication of unadapted SHIVs in an envelope-dependent manner

talk

Shepherd, Jason

The neuronal gene Arc encodes a repurposed retrotransposon Gag protein

talk

Shi, Guoli

mTOR inhibition relieves an intrinsic antiviral barrier imposed by IFITM3

poster

Siddiqui, Mohammad A

A novel phenotype links HIV-1 capsid stability to cGAS-mediated DNA sensing

talk

Siehr, Allison M

Self-assembling protein conjugated GNPs for HIV-1 entry inhibition

poster

Silverstein, Noah J

Mutational tolerance of HIV-1 protease in tissue culture and selection for protease inhibitor resistance in humanized mice

poster

Singh, Gurvani

MMTV antagonism of multiple APOBEC family members

talk

Sinha, Anindita

Envelope glycoproteins of retroviruses in the RDR interference supergroup are host-specific Tetherin antagonists

talk

Skorupka, Katarzyna A

Cryo-electron tomography and sub-tomogram averaging studies of HIV-1 capsid recognition by the restriction factor, TRIM5α

poster

Smith, Steven J

Integrase inhibitors (INSTIs) that are broadly effective against INSTI-resistant HIV-1 mutants

poster

Soper, Andrew J

Investigation of HIV-1 heterogeneity and compartmentalization in humanized mouse model

poster

Spearman, Paul

Visualization of HIV-1 envelope protein trafficking from the plasma membrane to the endosomal recycling compartment and cellular periphery by fluorogen-activating peptide tagging

talk

Stoneham, Charlotte A

Mapping HIV-1 Vpu-host interactions using a combined EM-proteomics approach

poster

Sukegawa, Sayaka

Human mannose receptor 1 not only affects virus production but also has an impact on viral infectivity

poster

Sumner, Christopher A

The role of tRNA post-transcriptional modifications in inhibition of HIV-1 Gag membrane binding

poster

Sutton, Richard

Whole exome sequencing identifies SNVs and Indels associated with HIV+ elite and viremic control

talk

Swanstrom, Ronald

Decoding major determinants of HIV-1 protease cleavage rate specificity

poster

Swartz, Talia H

P2X Purinergic antagonists are HIV-1 entry inhibitors of envelope-dependent infection and inflammatory cytokines IL-10 and IL-1β

poster

Symeonides, Menelaos

Do HIV-1-induced small, T cell-based syncytia prompt stronger immune responses than mononucleated virus-infected cells?

poster

Symeonides, Menelaos

Long term, minimally invasive imaging of HIV-1 spread in 3D primary T cell cultures using single plane illumination microscopy

talk

TADA, TAKUYA

In vivo suppression of HIV-1 replication by a gene modified dendritic cell based vaccine

talk

Takata, Matthew

Mechanistic insights into the zinc-finger antiviral protein (ZAP) and TRIM25 dependent inhibition of CG-enriched HIV

talk

Tan, Xu

Proteomic profiling of HIV infection of human CD4 T cells identifies SEP as an HIV restriction factor

talk

Taura, Manabu

Apobec3A maintains HIV-1 latency through recruitment of silencing machinery to the long terminal repeat

talk

Tavakoli-Tameh, Aidin

Mutations in Nef that disrupt tetherin and SERINC5 antagonism impair SIV replication during acute infection of rhesus macaques

poster

Taylor, Harry

mTOR overcomes metabolic restrictions of HIV-1 replication in resting CD4 T cells

poster

Tedbury, Philip R

Loss of LEDGF/p75 targeted integration enhances transcription of HIV-1 antisense RNA

talk

Trivedi, Shubhendu

HIV-1 Vpr and Vpu modulate innate immune signaling via TRAF 3and TRAF6 to enhance viral replication

poster

Umunnakwe, Chijioke N

Elements in the HIV-2 genome that are important for RNA packaging

poster

Uno, Naoki

Flow cytometric detection of proviral DNA in human lymphocytes

poster

van Duyne, Rachel

Identification of HIV-1 Env mutations that confer broad resistance to antiretrovirals

talk

Ventura, John D

In vivo imaging of HIV-1 dissemination in humanized mice before, during, and after antiretroviral therapy (ART)

talk

Waheed, Abdul A

The Vpu-interacting protein ATP6V0C regulates expression of tetherin and HIV-1 release

poster

Wanaguru, Madushi K

MLV p12 tethers the capsid-containing pre-integration complex to chromatin by binding directly to host nucleosomes in mitosis

talk

Wang, Yetao

Effect of HIV-1 infection on IFN-γ and IL-22 production by CD4+T cells

poster

Wei, Wei

SAMHD1 mediates MxB/MX2 anti-viral activity by targeting HIV-1 capsid

poster

Whitaker, Emily E

EWI-2 inhibits cell-cell fusion during transmission of HIV-1 particles at the virological synapse

poster

Williams, Zachary

Characterization of a recombinant, HERV-K (HML-2) related clade of endogenous retroviruses in the rhesus macaque genome

poster

Winans, Shelby

The FACT complex promotes avian leukosis virus DNA integration

talk

Wojcechowskyj, Jason

A genetic interaction screen in CD4 T cells reveals novel HIV-1 Rev-dependent host factors

talk

Wu, Li

N6-methyladenosine binding proteins negatively regulate HIV-1 infectivity and viral production

poster

XIE, MAORONG

HIV-1 cell-to-cell transfer and dissemination in myeloid target cells are mediated by an envelope-dependent two-step cell fusion mechanism

talk

Xue, Guangai

The HIV-1 capsid core functions as a nuclear transport receptor regulated by soluble protein interactions

poster

Yamasoba, Daichi

Identification of a host RNA binding protein as a novel HIV-1 restriction factor

talk

Yang, Jinyu

Structure of Schlafen13 reveals a new class of tRNA/rRNA- targeting RNase engaged in translational control

poster

Yoh, Sunnie M

HIV-1 uncoating regulates the assembly and signaling of PQBP1/cGAS innate immune sensor complex during the viral infection

poster

Young, George R

The evolutionary journey of Fv1

talk

Yu, Xiaofang M

Negative regulation of HIV-1 Vif-CRL5 E3 ubiquitin ligase function

talk

Yu, Xiaofang M

SAMHD1-independent function of Vpx

poster

Yurkovetskiy, Leonid

Primate immunodeficiency virus Vpx and Vpr counteract transcriptional repression of proviruses by degrading the HUSH complex

talk

Zamborlini, Alessia

Regulation of SAMHD1 restriction activity by SUMOylation

poster

Zhang, Hui

Development of an attenuated Tat protein and Tat-like small molecule compounds as highly-effective agents to specifically activate HIV-1 latency

talk

Zhang, Shijian

Conformational plasticity of the full-length HIV-1 envelope trimer precursor

poster

Zhang, Yumeng

Reverse transcriptase diversity provides insights into a multifaceted antiviral mechanism

poster

Zhao, Connie A

Strain-dependent activation and inhibition of HIV-1 entry by a PF-68742 diastereomer

poster

Zheng, Yong-Hui

HIV-1 Nef targets SERINC5 to endocytic pathway for degradation

poster

Zheng, Yong-Hui

Mechanistic understanding of how SERINC5 blocks HIV-1 entry

poster

Zheng, Yue

Knockout of cleavage and polyadenylation specific factor 6 inhibits reactivation of HIV latently infected cells

poster

Zhong, Zhou

Microtubule trafficking of HIV-1 complexes is altered by cytoplasmic expression of CPSF6

poster

Zhu, Yiping

NP220 mediates epigenetic silencing of unintegrated retroviral DNA

talk